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  • Energy Research
  • AR
  • Spanish; Castilian
  • Neuroscience

  • Consecuencias del estrés postnatal repetido y la exposición a etanol sobre la actividad del transportador de glutamato y la conducta en ratas ; Consequences of chronic postnatal stress and exposure to ethanol on glutamate transporter activity and behavior in rats

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Doctoral thesis 2015 Argentina Publisher:Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales
    Authors: Odeon, María Mercedes;

    handle: 20.500.12110/tesis_n5703_Odeon

    La exposición a situaciones de estrés durante los primeros años de vida hademostrado tener profundas consecuencias en el crecimiento y en el desarrollo de unindividuo. Los efectos adversos tempranos aumentan el riesgo de sufrir estréspostraumático, depresión y adicción a las drogas de abuso, como el alcohol. Nuestroobjetivo fue evaluar las consecuencias a nivel conductual, bioquímico y molecular delestrés postnatal crónico (EPC) y su posible reversión por un ambiente enriquecido enratas adultas enfocándonos en la ingesta voluntaria de alcohol. Nuestros resultados mostraron que el EPC indujo la ingesta de etanol en ratasadultas, comportamiento que fue revertido por un ambiente enriquecido. Una vez puesto apunto este modelo experimental, se realizaron estudios de los parámetros bioquímicos yconductuales que lo subyacen. El EPC y la ingesta de etanol modificaron la captación deglutamato en dos áreas cerebrales y alteraron la expresión de los transportadores deglutamato, tanto gliales como neuronales. Los niveles basales de la hormona liberadorade corticotrofina, de la hormona adrenocorticotrofina y de la corticosterona también sevieron modificados en nuestro modelo. Por último, el EPC alteró la conducta de losanimales en pruebas de conflicto, aumentando significativamente la exploración de losambientes aversivos. En conclusión, el EPC induce la ingesta voluntaria de etanol y tieneconsecuencias a nivel conductual afectando claramente al sistema glutamatérgico y al ejehipotálamo-hipófisis-adrenal. ; Exposure to stress during the first years of life has been shown to haveprofound effects on the growth and development of an individual. Early adverseeffects increase the risk of postraumatic disorder, depression and addiction todrugs of abuse, such as alcohol. Our objective was to assess the consequences ona behavioral, biochemical and molecular level of chronic postnatal stress (CPS)and its possible reversion by an enriched environment in adult rats focusing onvoluntary alcohol intake. Our results showed that CPS ...

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    Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
    Doctoral thesis . 2015
    License: CC BY ND SA
    Full-Text: https://hdl.handle.net/20.500.12110/tesis_n5703_Odeon
    Data sources: Bielefeld Academic Search Engine (BASE)
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      Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
      Doctoral thesis . 2015
      License: CC BY ND SA
      Full-Text: https://hdl.handle.net/20.500.12110/tesis_n5703_Odeon
      Data sources: Bielefeld Academic Search Engine (BASE)
      Claim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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  • Consecuencias del estrés postnatal repetido y la exposición a etanol sobre la actividad del transportador de glutamato y la conducta en ratas ; Consequences of chronic postnatal stress and exposure to ethanol on glutamate transporter activity and behavior in rats

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Doctoral thesis 2015 Argentina Publisher:Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales
    Authors: Odeon, María Mercedes;

    handle: 20.500.12110/tesis_n5703_Odeon

    La exposición a situaciones de estrés durante los primeros años de vida hademostrado tener profundas consecuencias en el crecimiento y en el desarrollo de unindividuo. Los efectos adversos tempranos aumentan el riesgo de sufrir estréspostraumático, depresión y adicción a las drogas de abuso, como el alcohol. Nuestroobjetivo fue evaluar las consecuencias a nivel conductual, bioquímico y molecular delestrés postnatal crónico (EPC) y su posible reversión por un ambiente enriquecido enratas adultas enfocándonos en la ingesta voluntaria de alcohol. Nuestros resultados mostraron que el EPC indujo la ingesta de etanol en ratasadultas, comportamiento que fue revertido por un ambiente enriquecido. Una vez puesto apunto este modelo experimental, se realizaron estudios de los parámetros bioquímicos yconductuales que lo subyacen. El EPC y la ingesta de etanol modificaron la captación deglutamato en dos áreas cerebrales y alteraron la expresión de los transportadores deglutamato, tanto gliales como neuronales. Los niveles basales de la hormona liberadorade corticotrofina, de la hormona adrenocorticotrofina y de la corticosterona también sevieron modificados en nuestro modelo. Por último, el EPC alteró la conducta de losanimales en pruebas de conflicto, aumentando significativamente la exploración de losambientes aversivos. En conclusión, el EPC induce la ingesta voluntaria de etanol y tieneconsecuencias a nivel conductual afectando claramente al sistema glutamatérgico y al ejehipotálamo-hipófisis-adrenal. ; Exposure to stress during the first years of life has been shown to haveprofound effects on the growth and development of an individual. Early adverseeffects increase the risk of postraumatic disorder, depression and addiction todrugs of abuse, such as alcohol. Our objective was to assess the consequences ona behavioral, biochemical and molecular level of chronic postnatal stress (CPS)and its possible reversion by an enriched environment in adult rats focusing onvoluntary alcohol intake. Our results showed that CPS ...

    downloadFull-Text
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Biblioteca Digital F...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
    Doctoral thesis . 2015
    License: CC BY ND SA
    Full-Text: https://hdl.handle.net/20.500.12110/tesis_n5703_Odeon
    Data sources: Bielefeld Academic Search Engine (BASE)
    Claim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Biblioteca Digital F...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
      Doctoral thesis . 2015
      License: CC BY ND SA
      Full-Text: https://hdl.handle.net/20.500.12110/tesis_n5703_Odeon
      Data sources: Bielefeld Academic Search Engine (BASE)
      Claim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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