1 citations 1 popularity Average influence Average impulse Average 
Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1471-4159.1977.tb10445.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1471-4159.1977.tb10445.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=11388/150346&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=11388/150346&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0278-2391(10)80088-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0278-2391(10)80088-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
BASSAREO, VALENTINA; BASSAREO, VALENTINA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBASSAREO, VALENTINA in OpenAIRE
DE LUCA, MARIA ANTONIETTA; ARESU M; ASTE A; +2 AuthorsDE LUCA, MARIA ANTONIETTA
Harvested from ORCID Public Data FileDE LUCA, MARIA ANTONIETTA in OpenAIRE BASSAREO, VALENTINA; BASSAREO, VALENTINA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBASSAREO, VALENTINA in OpenAIRE DE LUCA, MARIA ANTONIETTA; ARESU M; ASTE A; ARIU T;DE LUCA, MARIA ANTONIETTA
Harvested from ORCID Public Data FileDE LUCA, MARIA ANTONIETTA in OpenAIRE DI CHIARA, GAETANO; DI CHIARA, GAETANO
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesDI CHIARA, GAETANO in OpenAIREAbstractNon‐adaptive activation of dopamine transmission in the nucleus accumbens shell by drugs of abuse has been attributed a fundamental role in the mechanism of drug addiction. In order to test this hypothesis, we compared in the same subject the effect of an addictive drug (ethanol) and of taste stimuli, including ethanol's own taste, on dialysate dopamine in the nucleus accumbens shell as an estimate of dopamine transmission and on taste reactivity as an expression of motivational valence. Ethanol was also monitored in the dialysates. In naive rats, intraoral infusion of a 20% sucrose + chocolate solution elicited a monophasic increase of dialysate dopamine immediately after the intraoral infusion. In contrast, intraoral infusion of 10% ethanol, 10% ethanol + 20% sucrose or 10% ethanol + 20% sucrose + chocolate solutions elicited a biphasic increase of nucleus accumbens dopamine with an early taste‐related rise and a late rise related to dialysate ethanol. Pre‐exposure to the ethanol solutions 24 h before resulted in the absence of the early dopamine rise and permanence of the late dopamine rise. This late dopamine rise was actually increased as compared with that of the nonpre‐exposed group when sucrose‐containing ethanol solutions were tested. The results indicate that single trial pre‐exposure to the ethanol solutions differentially affects the responsiveness of nucleus accumbens shell dopamine to the direct intracerebral action of ethanol and to the effect of its taste with potentiation, or no change of the first and abolition of the second. These observations point to the existence of major differences in the adaptive regulation of nucleus accumbens dopamine transmission in the shell after drug as compared with taste reward. These differences, in turn, are consistent with a role of nucleus accumbens shell dopamine in the mechanism of the behavioural effects of addictive drugs.
52 citations 52 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1046/j.1460-9568.2003.02556.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu- BASSAREO, VALENTINA;
BASSAREO, VALENTINA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBASSAREO, VALENTINA in OpenAIRE DE LUCA, MARIA ANTONIETTA; ARESU M; ASTE A; +2 AuthorsDE LUCA, MARIA ANTONIETTA
Harvested from ORCID Public Data FileDE LUCA, MARIA ANTONIETTA in OpenAIRE BASSAREO, VALENTINA; BASSAREO, VALENTINA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBASSAREO, VALENTINA in OpenAIRE DE LUCA, MARIA ANTONIETTA; ARESU M; ASTE A; ARIU T;DE LUCA, MARIA ANTONIETTA
Harvested from ORCID Public Data FileDE LUCA, MARIA ANTONIETTA in OpenAIRE DI CHIARA, GAETANO; DI CHIARA, GAETANO
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesDI CHIARA, GAETANO in OpenAIREAbstractNon‐adaptive activation of dopamine transmission in the nucleus accumbens shell by drugs of abuse has been attributed a fundamental role in the mechanism of drug addiction. In order to test this hypothesis, we compared in the same subject the effect of an addictive drug (ethanol) and of taste stimuli, including ethanol's own taste, on dialysate dopamine in the nucleus accumbens shell as an estimate of dopamine transmission and on taste reactivity as an expression of motivational valence. Ethanol was also monitored in the dialysates. In naive rats, intraoral infusion of a 20% sucrose + chocolate solution elicited a monophasic increase of dialysate dopamine immediately after the intraoral infusion. In contrast, intraoral infusion of 10% ethanol, 10% ethanol + 20% sucrose or 10% ethanol + 20% sucrose + chocolate solutions elicited a biphasic increase of nucleus accumbens dopamine with an early taste‐related rise and a late rise related to dialysate ethanol. Pre‐exposure to the ethanol solutions 24 h before resulted in the absence of the early dopamine rise and permanence of the late dopamine rise. This late dopamine rise was actually increased as compared with that of the nonpre‐exposed group when sucrose‐containing ethanol solutions were tested. The results indicate that single trial pre‐exposure to the ethanol solutions differentially affects the responsiveness of nucleus accumbens shell dopamine to the direct intracerebral action of ethanol and to the effect of its taste with potentiation, or no change of the first and abolition of the second. These observations point to the existence of major differences in the adaptive regulation of nucleus accumbens dopamine transmission in the shell after drug as compared with taste reward. These differences, in turn, are consistent with a role of nucleus accumbens shell dopamine in the mechanism of the behavioural effects of addictive drugs.
52 citations 52 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1046/j.1460-9568.2003.02556.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Pilar Marín; Gustavo Egea; Jaime Renau-Piqueras; Juan M. Duran; +2 Authors
Gustavo Egea
Harvested from ORCID Public Data FileGustavo Egea in OpenAIREPilar Marín; Gustavo Egea; Jaime Renau-Piqueras; Juan M. Duran;Gustavo Egea
Harvested from ORCID Public Data FileGustavo Egea in OpenAIRE Mónica Tomás; Mónica Tomás
Harvested from ORCID Public Data FileMónica Tomás in OpenAIRE Francisco Lázaro-Diéguez; Francisco Lázaro-Diéguez
Harvested from ORCID Public Data FileFrancisco Lázaro-Diéguez in OpenAIREAbstractEthanol induces severe alterations in membrane trafficking in hepatocytes and astrocytes, the molecular basis of which is unclear. One of the main candidates is the cytoskeleton and the molecular components that regulate its organization and dynamics. Here, we examine the effect of chronic exposure to ethanol on the organization and dynamics of actin and microtubule cytoskeletons and glucose uptake in rat astrocytes. Ethanol‐treated cells cultured in either the presence or absence of fetal calf serum showed a significant increase in 2‐deoxyglucose uptake. Ethanol also caused alterations in actin organization, consisting of the dissolution of stress fibres and the appearance of circular filaments beneath the plasma membrane. When lysophosphatidic acid (LPA), which is a normal constituent of serum and a potent intercellular lipid mediator with growth factor and actin rearrangement activities, was added to ethanol‐treated astrocytes cultured without fetal calf serum, it induced the re‐appearance of actin stress fibres and the normalization of 2‐deoxyglucose uptake. Furthermore, ethanol also perturbed the microtubule dynamics, which delayed the recovery of the normal microtubule organization following removal of the microtubule‐disrupting agent nocodazole. Again, pre‐treatment with LPA prevented this alteration. Ethanol‐treated rodent fibroblast NIH3T3 cells that constitutively express an activated Rho mutant protein (GTP‐bound form) were insensitive to ethanol, as they showed no alteration either in actin stress‐fibre organization or in 2‐deoxyglucose uptake. We discuss the putative signalling targets by which ethanol could alter the cytoskeleton and hexose uptake and the cytoprotective effect of LPA against ethanol‐induced damages. The latter opens the possibility that LPA or a similar non‐hydrolysable lipid derivative could be used as a cytoprotective agent against the noxious effects of ethanol.
44 citations 44 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1046/j.1471-4159.2003.01993.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Pilar Marín; Gustavo Egea; Jaime Renau-Piqueras; Juan M. Duran; +2 Authors
Gustavo Egea
Harvested from ORCID Public Data FileGustavo Egea in OpenAIREPilar Marín; Gustavo Egea; Jaime Renau-Piqueras; Juan M. Duran;Gustavo Egea
Harvested from ORCID Public Data FileGustavo Egea in OpenAIRE Mónica Tomás; Mónica Tomás
Harvested from ORCID Public Data FileMónica Tomás in OpenAIRE Francisco Lázaro-Diéguez; Francisco Lázaro-Diéguez
Harvested from ORCID Public Data FileFrancisco Lázaro-Diéguez in OpenAIREAbstractEthanol induces severe alterations in membrane trafficking in hepatocytes and astrocytes, the molecular basis of which is unclear. One of the main candidates is the cytoskeleton and the molecular components that regulate its organization and dynamics. Here, we examine the effect of chronic exposure to ethanol on the organization and dynamics of actin and microtubule cytoskeletons and glucose uptake in rat astrocytes. Ethanol‐treated cells cultured in either the presence or absence of fetal calf serum showed a significant increase in 2‐deoxyglucose uptake. Ethanol also caused alterations in actin organization, consisting of the dissolution of stress fibres and the appearance of circular filaments beneath the plasma membrane. When lysophosphatidic acid (LPA), which is a normal constituent of serum and a potent intercellular lipid mediator with growth factor and actin rearrangement activities, was added to ethanol‐treated astrocytes cultured without fetal calf serum, it induced the re‐appearance of actin stress fibres and the normalization of 2‐deoxyglucose uptake. Furthermore, ethanol also perturbed the microtubule dynamics, which delayed the recovery of the normal microtubule organization following removal of the microtubule‐disrupting agent nocodazole. Again, pre‐treatment with LPA prevented this alteration. Ethanol‐treated rodent fibroblast NIH3T3 cells that constitutively express an activated Rho mutant protein (GTP‐bound form) were insensitive to ethanol, as they showed no alteration either in actin stress‐fibre organization or in 2‐deoxyglucose uptake. We discuss the putative signalling targets by which ethanol could alter the cytoskeleton and hexose uptake and the cytoprotective effect of LPA against ethanol‐induced damages. The latter opens the possibility that LPA or a similar non‐hydrolysable lipid derivative could be used as a cytoprotective agent against the noxious effects of ethanol.
44 citations 44 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1046/j.1471-4159.2003.01993.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - L. Aloe; A. Iannitelli; F. Angelucci; BERSANI, Giuseppe; +1 Authors
BERSANI, Giuseppe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBERSANI, Giuseppe in OpenAIREL. Aloe; A. Iannitelli; F. Angelucci; BERSANI, Giuseppe; BERSANI, Giuseppe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBERSANI, Giuseppe in OpenAIRE M. Fiore; Neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are known to play a crucial role in growth, differentiation and function in a variety of brain neurons during development and in adult life. We have recently shown that environmental changes, aggressive behavior and anxiety-like responses alter both circulating and brain basal NGF levels. In the present review, we present data obtained using animal models which suggest that neurotrophic factors, particularly NGF and BDNF, might be implicated in mechanism(s) leading to a condition associated with schizophrenic-like behaviors. The hypothesis that neurotrophins of the NGF family can be implicated in some maldevelopmental aspects of schizophrenia is supported by findings indicating that the constitutive levels of NGF and BDNF are affected in schizophrenic patients.
47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/00008877-200006000-00007&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - L. Aloe; A. Iannitelli; F. Angelucci; BERSANI, Giuseppe; +1 Authors
BERSANI, Giuseppe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBERSANI, Giuseppe in OpenAIREL. Aloe; A. Iannitelli; F. Angelucci; BERSANI, Giuseppe; BERSANI, Giuseppe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesBERSANI, Giuseppe in OpenAIRE M. Fiore; Neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are known to play a crucial role in growth, differentiation and function in a variety of brain neurons during development and in adult life. We have recently shown that environmental changes, aggressive behavior and anxiety-like responses alter both circulating and brain basal NGF levels. In the present review, we present data obtained using animal models which suggest that neurotrophic factors, particularly NGF and BDNF, might be implicated in mechanism(s) leading to a condition associated with schizophrenic-like behaviors. The hypothesis that neurotrophins of the NGF family can be implicated in some maldevelopmental aspects of schizophrenia is supported by findings indicating that the constitutive levels of NGF and BDNF are affected in schizophrenic patients.
47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/00008877-200006000-00007&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Philip Winn; Jay S. Dunbar; Wendy L. Inglis;
Philip Winn
Harvested from ORCID Public Data FilePhilip Winn in OpenAIREWe have previously demonstrated that ibotenate (IBO) injected into the pedunculopontine tegmental nucleus (PPTg) damages all neurones there while quinolinate (QUIN) makes relatively selective lesions of cholinergic neurones. We now compare the effects of two anaesthetics, sodium pentobarbitone and Avertin (tribromoethanol/tert-amylalcohol dissolved in ethanol, saline and phosphate buffer) on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABAA receptor.
20 citations 20 popularity Average influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0304-3940(93)90444-p&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Philip Winn; Jay S. Dunbar; Wendy L. Inglis;
Philip Winn
Harvested from ORCID Public Data FilePhilip Winn in OpenAIREWe have previously demonstrated that ibotenate (IBO) injected into the pedunculopontine tegmental nucleus (PPTg) damages all neurones there while quinolinate (QUIN) makes relatively selective lesions of cholinergic neurones. We now compare the effects of two anaesthetics, sodium pentobarbitone and Avertin (tribromoethanol/tert-amylalcohol dissolved in ethanol, saline and phosphate buffer) on three doses of IBO and QUIN in the PPTg. Diaphorase-positive cell loss after QUIN was attenuated under barbiturate, the relative selectivity of QUIN for diaphorase-positive neurones was lost and lesion volumes were uniformly small compared with lesions made under Avertin anaesthesia. IBO toxicity was unaffected by anaesthesia. These data are discussed with reference to the actions of excitotoxins at glutamate receptor subtypes and interactions of barbiturates with the GABAA receptor.
20 citations 20 popularity Average influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0304-3940(93)90444-p&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Tsuneo Iwasaki; Yutaka Nakagawa;
Yutaka Nakagawa
Harvested from ORCID Public Data FileYutaka Nakagawa in OpenAIREInvolvement of N-methyl-D-aspartate (NMDA) receptor complex and 5-hydroxytryptamine3 (5-HT3) receptors in state-dependent learning (SDL) induced by ethanol (EtOH) was investigated in the step-through passive avoidance task in rats. Pre-training injections of EtOH or MK-801 reduced step-through latency in the test session conducted 24 h after the training session. Pre-test as well as pre-training injections of EtOH failed to reduce the latency, while pre-training and pre-test injections of MK-801 reduced the latency. These results show that EtOH but not MK-801 produces SDL. SDL induced by EtOH was blocked by ICS205-930 injected before either the training or test session. However, ICS205-930 failed to block SDL induced by diazepam and muscimol. These results suggest that NMDA receptor complex may not be involved in SDL, and that 5-HT3 receptors may contribute to SDL induced by EtOH but not by diazepam and muscimol.
43 citations 43 popularity Average influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0006-8993(95)01040-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Tsuneo Iwasaki; Yutaka Nakagawa;
Yutaka Nakagawa
Harvested from ORCID Public Data FileYutaka Nakagawa in OpenAIREInvolvement of N-methyl-D-aspartate (NMDA) receptor complex and 5-hydroxytryptamine3 (5-HT3) receptors in state-dependent learning (SDL) induced by ethanol (EtOH) was investigated in the step-through passive avoidance task in rats. Pre-training injections of EtOH or MK-801 reduced step-through latency in the test session conducted 24 h after the training session. Pre-test as well as pre-training injections of EtOH failed to reduce the latency, while pre-training and pre-test injections of MK-801 reduced the latency. These results show that EtOH but not MK-801 produces SDL. SDL induced by EtOH was blocked by ICS205-930 injected before either the training or test session. However, ICS205-930 failed to block SDL induced by diazepam and muscimol. These results suggest that NMDA receptor complex may not be involved in SDL, and that 5-HT3 receptors may contribute to SDL induced by EtOH but not by diazepam and muscimol.
43 citations 43 popularity Average influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0006-8993(95)01040-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu 20 citations 20 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0924-977x(90)90008-x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu20 citations 20 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0924-977x(90)90008-x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu- DE MONTIS G;
DE MONTIS G
Harvested from ORCID Public Data FileDE MONTIS G in OpenAIRE DEVOTO, PAOLA; GIORGI G; TAGLIAMONTE A; +1 AuthorsDEVOTO, PAOLA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesDEVOTO, PAOLA in OpenAIRE DE MONTIS G; DE MONTIS G
Harvested from ORCID Public Data FileDE MONTIS G in OpenAIRE DEVOTO, PAOLA; GIORGI G; TAGLIAMONTE A; GESSA GL;DEVOTO, PAOLA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesDEVOTO, PAOLA in OpenAIREThe present report shows that at micromolar concentrations ethanol, like glutamate and glycine, positively modulates [ 3 H]MK-801 binding in rat cortical membranes. Very high ethanol concentrations, however, negatively modulate [ 3 H]MK-801 binding. Cerebral cortices from male Sprague-Dawley rats (200-250 g) were dissected
7 citations 7 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0014-2999(91)90651-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - DE MONTIS G;
DE MONTIS G
Harvested from ORCID Public Data FileDE MONTIS G in OpenAIRE DEVOTO, PAOLA; GIORGI G; TAGLIAMONTE A; +1 AuthorsDEVOTO, PAOLA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesDEVOTO, PAOLA in OpenAIRE DE MONTIS G; DE MONTIS G
Harvested from ORCID Public Data FileDE MONTIS G in OpenAIRE DEVOTO, PAOLA; GIORGI G; TAGLIAMONTE A; GESSA GL;DEVOTO, PAOLA
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesDEVOTO, PAOLA in OpenAIREThe present report shows that at micromolar concentrations ethanol, like glutamate and glycine, positively modulates [ 3 H]MK-801 binding in rat cortical membranes. Very high ethanol concentrations, however, negatively modulate [ 3 H]MK-801 binding. Cerebral cortices from male Sprague-Dawley rats (200-250 g) were dissected
7 citations 7 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0014-2999(91)90651-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
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