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description Publicationkeyboard_double_arrow_right Article 2024Publisher:Wiley Funded by:ARC | Discovery Early Career Re...ARC| Discovery Early Career Researcher Award - Grant ID: DE170100509Authors:Ameer Elena Rasool;
Teri Furlong; Asheeta A. Prasad;Ameer Elena Rasool
Ameer Elena Rasool in OpenAIREAbstractAlcohol use disorder (AUD) is characterized by cycles of abuse, withdrawal, and relapse. Neuroadaptations in the basal ganglia are observed in AUD; specifically in the putamen, globus pallidus (GP), and ventral pallidum (VP). These regions are associated with habit formation, drug‐seeking behaviors, and reward processing. While previous studies have shown the crucial role of glial cells in drug seeking, it remains unknown whether glial cells in the basal ganglia are altered in AUD. Glial cells in the putamen, GP, and VP were examined in human post‐mortem tissue of AUD and alcohol remission cases. Immunohistochemistry was performed to analyze cell count, staining intensity, and morphology of microglia and astrocytes, using markers Iba‐1 and GFAP. Morphological analysis revealed a significant decrease in microglia cell size and process retraction, indicating activation or a dystrophic microglia phenotype in individuals with AUD compared to controls. Microglia staining intensity was also higher in the GP and VP in AUD cases, whereas microglia staining intensity and cell size in remission cases were not different to control cases. In contrast, no astrocyte changes were observed in examined brain regions for both AUD and remission cases compared to controls. These results suggest alcohol exposure alters microglia, potentially contributing to dysfunctions in the basal ganglia that maintain addiction, and abstinence from alcohol may reverse microglia changes and associated dysfunctions. Overall, this study further characterizes AUD neuropathology and implicates microglia in the putamen, GP, and VP as a potential target for therapy.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/adb.13374&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/adb.13374&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2006Publisher:Elsevier BV Authors: Mark A. Hill;Minas T. Coroneo;
Shaojuan Li; Neeraj Agarwal; +1 AuthorsMinas T. Coroneo
Minas T. Coroneo in OpenAIREMark A. Hill;Minas T. Coroneo;
Shaojuan Li; Neeraj Agarwal; Ashish Agar;Minas T. Coroneo
Minas T. Coroneo in OpenAIREpmid: 16638612
Cellular responses to changes in pressure are implicated in numerous disease processes. In glaucoma apoptosis of retinal ganglion cells (RGCs) is associated with elevated intra-ocular pressure, however, the exact cellular mechanisms remain unclear. We have previously shown that pressure can induce apoptosis in B35 and PC12 neuronal cell lines, using an in vitro model for pressure elevation. A novel RGC line allows us to study the effects of pressure on retinal neurons. 'RGC-5' cultures were subjected to elevated ambient hydrostatic pressure conditions in our model. Experimental pressure conditions were 100 mm Hg and 30 mm Hg, representing acute (high) and chronic (lower-pressure) glaucoma, and 15 mm Hg for normal intra-ocular pressure, set above atmospheric pressure for 2 h. Negative controls were treated identically except for the application of pressure, while positive controls were generated by treatment with a known apoptotic stimulus. Apoptosis was determined by a combination of cell morphology and specific TUNEL and Annexin V fluorescent markers. These were assessed simultaneously by laser scanning cytometry (LSC), which also enabled quantitative marker analysis. RGC-5 neurons showed a significantly increased proportion of apoptotic cells compared with controls; maximal at 100 mm Hg, moderate at 30 mm Hg and not statistically significant at 15 mm Hg. This graded response, proportionate to the level of pressure elevation, is representative of the severity of analogous clinical settings (acute, chronic glaucoma and normal). These results complement earlier findings of pressure-induced apoptosis in other neuronal cultures. They suggest the possibility of novel mechanisms of pressure-related mechanotransduction and cell death, relevant to the pathogenesis of diseases such as glaucoma.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.brainres.2006.02.061&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 78 citations 78 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.brainres.2006.02.061&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2018Publisher:Elsevier BV Funded by:NHMRC | Brain circuits promoting ..., NHMRC | A memory retrieval - exti..., NHMRC | Unraveling the neural cir...NHMRC| Brain circuits promoting abstinence and preventing relapse to alcohol seeking ,NHMRC| A memory retrieval - extinction procedure to prevent relapse to drug seeking ,NHMRC| Unraveling the neural circuitry of context-induced relapse to alcohol seeking after punishment-imposed abstinenceAuthors:Simon Killcross;
Andrew J Lawrence;Simon Killcross
Simon Killcross in OpenAIRENathan J. Marchant;
Nathan J. Marchant; +10 AuthorsNathan J. Marchant
Nathan J. Marchant in OpenAIRESimon Killcross;
Andrew J Lawrence;Simon Killcross
Simon Killcross in OpenAIRENathan J. Marchant;
Nathan J. Marchant;Nathan J. Marchant
Nathan J. Marchant in OpenAIREJun Lim;
Gavan P. McNally;
Gavan P. McNally
Gavan P. McNally in OpenAIREErin J. Campbell;
Gabrielle D. Gibson;Erin J. Campbell
Erin J. Campbell in OpenAIREJohn M. Power;
John M. Power
John M. Power in OpenAIREPhilip Jean-Richard-dit-Bressel;
Philip Jean-Richard-dit-Bressel
Philip Jean-Richard-dit-Bressel in OpenAIREE. Zayra Millan;
E. Zayra Millan
E. Zayra Millan in OpenAIREAsheeta A. Prasad;
Asheeta A. Prasad
Asheeta A. Prasad in OpenAIREYu Liu;
Joanna Oi-Yue Yau;
Joanna Oi-Yue Yau
Joanna Oi-Yue Yau in OpenAIREpmid: 29656870
Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of context. However, the specific cell types, and projections, by which AcbSh serves these dual roles are unknown. Here, we show that contextual control over relapse and abstinence is embedded within distinct output circuits of dopamine 1 receptor (Drd1) expressing AcbSh neurons. We report anatomical and functional segregation of Drd1 AcbSh output pathways during context-induced reinstatement and extinction of alcohol seeking. The AcbSh→ventral tegmental area (VTA) pathway promotes relapse via projections to VTA Gad1 neurons. The AcbSh→lateral hypothalamus (LH) pathway promotes extinction via projections to LH Gad1 neurons. Targeting these opposing AcbSh circuit contributions may reduce propensity to relapse to, and promote abstinence from, drug use.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuron.2018.03.033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 63 citations 63 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuron.2018.03.033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 United StatesPublisher:American Psychiatric Association Publishing Authors: Lees, Briana; Mewton, Louise; Jacobus, Joanna;Valadez, Emilio A;
+4 AuthorsValadez, Emilio A
Valadez, Emilio A in OpenAIRELees, Briana; Mewton, Louise; Jacobus, Joanna;Valadez, Emilio A;
Stapinski, Lexine A;Valadez, Emilio A
Valadez, Emilio A in OpenAIRETeesson, Maree;
Teesson, Maree
Teesson, Maree in OpenAIRETapert, Susan F;
Squeglia, Lindsay M;Tapert, Susan F
Tapert, Susan F in OpenAIREData on the neurodevelopmental and associated behavioral effects of light to moderate in utero alcohol exposure are limited. This retrospective investigation tested for associations between reported maternal prenatal alcohol use and psychological, behavioral, and neurodevelopmental outcomes in substance-naive youths.Participants were 9,719 youths (ages 9.0 to 10.9 years) from the Adolescent Brain Cognitive Development Study. Based on parental reports, 2,518 (25.9%) had been exposed to alcohol in utero. Generalized additive mixed models and multilevel cross-sectional and longitudinal mediation models were used to test whether prenatal alcohol exposure was associated with psychological, behavioral, and cognitive outcomes, and whether differences in brain structure and resting-state functional connectivity partially explained these associations at baseline and 1-year follow-up, after controlling for possible confounding factors.Prenatal alcohol exposure of any severity was associated with greater psychopathology, attention deficits, and impulsiveness, with some effects showing a dose-dependent response. Children with prenatal alcohol exposure, compared with those without, displayed greater cerebral and regional volume and greater regional surface area. Resting-state functional connectivity was largely unaltered in children with in utero exposure. Some of the psychological and behavioral outcomes at baseline and at the 1-year follow-up were partially explained by differences in brain structure among youths who had been exposed to alcohol in utero.Any alcohol use during pregnancy is associated with subtle yet significant psychological and behavioral effects in children. Women should continue to be advised to abstain from alcohol consumption from conception throughout pregnancy.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1176/appi.ajp.2020.20010086&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 110 citations 110 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1176/appi.ajp.2020.20010086&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1997Publisher:Elsevier BV Authors: Henrich V Konovalov; Ken W.S. Ashwell; Yuri V. Bobryshev; Nickolaji S. Kovetsky;pmid: 9131316
Brain development has been studied in 44 embryos (gestational age: 5-12 weeks) and three fetuses (gestational age: 14 weeks) obtained from mothers who used alcohol during pregnancy, and compared with a control group comprising 16 cases of comparable ages. In 34 cases out of 47 in the alcohol group (75.5%), features indicative of abnormal morphological brain development were found. In all, nine variants of brain pathology are described. Abnormalities in the formation of the lateral ventricle walls and disorders of the development of the cortical laminae occurred most frequently (70.6% and 57.9%, respectively). When the cases were sorted according to maternal alcohol intake it was found that the children of severely alcoholic mothers (100-500 ml ethanol per day, 4-7 days per week) had abnormal brain morphology in 100% of cases. In those cases where maternal alcohol use was systematic and frequent (100-200 ml ethanol per day, 2-4 times per week), brain pathology was identified in 83.3% of cases. In systematic maternal use of alcohol (100-200 ml of ethanol taken on one day per week), and in episodic use (35-100 ml of ethanol taken on three occasions during pregnancy), 97.3% and 28.5% were affected, respectively.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0378-3782(96)01848-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 41 citations 41 popularity Average influence Top 10% impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0378-3782(96)01848-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015Publisher:Wiley Funded by:ARC | Future Fellowships - Gran..., NSF | Integrating and Extending...ARC| Future Fellowships - Grant ID: FT110100151 ,NSF| Integrating and Extending Decisions from Experience Phenomena with Instance-Based Learning ModelsAuthors: Arthur Kary; Chris P. Moore; Ben R. Newell; Cleotilde Gonzalez;doi: 10.1111/tops.12176
pmid: 26695816
AbstractThe majority of people show persistent poor performance in reasoning about “stock‐flow problems” in the laboratory. An important example is the failure to understand the relationship between the “stock” of CO2 in the atmosphere, the “inflow” via anthropogenic CO2 emissions, and the “outflow” via natural CO2 absorption. This study addresses potential causes of reasoning failures in the CO2 accumulation problem and reports two experiments involving a simple re‐framing of the task as managing an analogous financial (rather than CO2) budget. In Experiment 1 a financial version of the task that required participants to think in terms of controlling debt demonstrated significant improvements compared to a standard CO2 accumulation problem. Experiment 2, in which participants were invited to think about managing savings, suggested that this improvement was fortuitous and coincidental rather than due to a fundamental change in understanding the stock‐flow relationships. The role of graphical information in aiding or abetting stock‐flow reasoning was also explored in both experiments, with the results suggesting that graphs do not always assist understanding. The potential for leveraging the kind of reasoning exhibited in such tasks in an effort to change people's willingness to reduce CO2 emissions is briefly discussed.
Topics in Cognitive ... arrow_drop_down Topics in Cognitive ScienceArticle . 2015 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/tops.12176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 26 citations 26 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Topics in Cognitive ... arrow_drop_down Topics in Cognitive ScienceArticle . 2015 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/tops.12176&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020Publisher:Bentham Science Publishers Ltd. Authors:Mohammed Abul Kashem;
Mohammed Abul Kashem
Mohammed Abul Kashem in OpenAIREOmar Šerý;
Omar Šerý
Omar Šerý in OpenAIREDavid V. Pow;
David V. Pow
David V. Pow in OpenAIREBenjamin D. Rowlands;
+2 AuthorsBenjamin D. Rowlands
Benjamin D. Rowlands in OpenAIREMohammed Abul Kashem;
Mohammed Abul Kashem
Mohammed Abul Kashem in OpenAIREOmar Šerý;
Omar Šerý
Omar Šerý in OpenAIREDavid V. Pow;
David V. Pow
David V. Pow in OpenAIREBenjamin D. Rowlands;
Benjamin D. Rowlands
Benjamin D. Rowlands in OpenAIRECaroline D. Rae;
Caroline D. Rae
Caroline D. Rae in OpenAIREVladimir J. Balcar;
Vladimir J. Balcar
Vladimir J. Balcar in OpenAIREpmid: 32329706
We present an overview of genetic, metabolomic, proteomic and neurochemical studies done mainly in our laboratories that could improve prediction, mechanistic understanding and possibly extend to diagnostics and treatment of alcoholism and alcohol addiction. Specific polymorphisms in genes encoding for interleukins 2 and 6, catechol-O-methyl transferase (COMT), monaminooxidase B (MAO B) and several other enzymes were identified as associated with altered risks of alcoholism in humans. A polymorphism in the gene for BDNF has been linked to the risk of developing deficiences in colour vision sometimes observed in alcoholics. Metabolomic studies of acute ethanol effects on guinea pig brain cortex in vitro, lead to the identification of specific subtypes of GABA(A) receptors involved in the actions of alcohol at various doses. Acute alcohol affected energy metabolism, oxidation and the production of actaldehyde and acetate; this could have specific consequences not only for the brain energy production/utilization but could influence the cytotoxicity of alcohol and impact the epigenetics (histone acetylation). It is unlikely that brain metabolism of ethanol occurs to any significant degree; the reduction in glucose metabolism following alcohol consumption is due to ethanol effects on receptors, such as α4β3δ GABA(A) receptors. Metabolomics using post-mortem human brain indicated that the catecholaminergic signalling may be preferentially affected by chronic excessive drinking. Changes in the levels of glutathione were consistent with the presence of severe oxidative stress. Proteomics of the post-mortem alcoholic brains identified a large number of proteins, the expression of which was altered by chronic alcohol, with those associated with brain energy metabolism among the most numerous. Neurochemical studies found the increased expression of glutamate transporter GLAST/EAAT1 in brain as one of the largest changes caused by alcoholism. Given that GLAST/EAAT1 is one of the most abundant proteins in the nervous tissue and is intimately associated with the function of the excitatory (glutamatergic) synapses, this may be among the most important effects of chronic alcohol on brain function. It has so far been observed mainly in the prefrontal cortex. We show several experiments suggesting that acute alcohol can translocate GLAST/EAAT1 in astrocytes towards the plasma membrane (and this effect is inhibited by the GABA(B) agonist baclofen) but neither the mechanism nor the specificity (to alcohol) of this phenomenon have been established. Furthermore, as GLAST/EAAT1 is also expressed in testes and sperm (and could also be affected there by chronic alcohol), the levels of GLAST/EAAT1 in sperm could be used as a diagnostic tool in testing the severity of alcoholism in human males. We conclude that the reviewed studies present a unique set of data which could help to predict the risk of developing alcohol dependence (genetics), to improve the understanding of the intoxicating actions of alcohol (metabolomics), to aid in assessing the extent of damage to brain cells caused by chronic excessive drinking (metabolomics and proteomics) and to point to molecular targets that could be used in the treatment and diagnosis of alcoholism and alcohol addiction.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2174/1874467213666200424155244&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2174/1874467213666200424155244&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:eLife Sciences Publications, Ltd Authors:Mitchell Bestry;
Mitchell Bestry
Mitchell Bestry in OpenAIREAlexander N Larcombe;
Nina Kresoje; Emily K Chivers; +11 AuthorsAlexander N Larcombe
Alexander N Larcombe in OpenAIREMitchell Bestry;
Mitchell Bestry
Mitchell Bestry in OpenAIREAlexander N Larcombe;
Nina Kresoje; Emily K Chivers; Chloe Bakker; James P Fitzpatrick;Alexander N Larcombe
Alexander N Larcombe in OpenAIREElizabeth J Elliott;
Elizabeth J Elliott
Elizabeth J Elliott in OpenAIREJeffrey M Craig;
Jeffrey M Craig
Jeffrey M Craig in OpenAIREEvelyne Muggli;
Evelyne Muggli
Evelyne Muggli in OpenAIREJane Halliday;
Jane Halliday
Jane Halliday in OpenAIREDelyse Hutchinson;
Delyse Hutchinson
Delyse Hutchinson in OpenAIRESam Buckberry;
Sam Buckberry
Sam Buckberry in OpenAIRERyan Lister;
Martyn Symons;Ryan Lister
Ryan Lister in OpenAIREDavid Martino;
David Martino
David Martino in OpenAIREAlcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure (PAE) resembling common patterns of alcohol consumption in pregnancy in humans. Early moderate PAE was sufficient to affect site-specific DNA methylation in newborn pups without altering behavioural outcomes in adult littermates. Whole-genome bisulfite sequencing of neonatal brain and liver revealed stochastic influence on DNA methylation that was mostly tissue-specific, with some perturbations likely originating as early as gastrulation. DNA methylation differences were enriched in non-coding genomic regions with regulatory potential indicative of broad effects of alcohol on genome regulation. Replication studies in human cohorts with fetal alcohol spectrum disorder suggested some effects were metastable at genes linked to disease-relevant traits including facial morphology, intelligence, educational attainment, autism, and schizophrenia. In our murine model, a maternal diet high in folate and choline protected against some of the damaging effects of early moderate PAE on DNA methylation. Our studies demonstrate that early moderate exposure is sufficient to affect fetal genome regulation even in the absence of overt phenotypic changes and highlight a role for preventative maternal dietary interventions.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.92135.3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.92135.3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021Publisher:Wiley Authors:Mohsen Ahmadi;
Fatemeh Dashti Ahangar; Nikoo Astaraki;Mohsen Ahmadi
Mohsen Ahmadi in OpenAIREMohammad Abbasi;
+1 AuthorsMohammad Abbasi
Mohammad Abbasi in OpenAIREMohsen Ahmadi;
Fatemeh Dashti Ahangar; Nikoo Astaraki;Mohsen Ahmadi
Mohsen Ahmadi in OpenAIREMohammad Abbasi;
Behzad Babaei;Mohammad Abbasi
Mohammad Abbasi in OpenAIREIn this paper, we present a novel classifier based on fuzzy logic and wavelet transformation in the form of a neural network. This classifier includes a layer to predict the numerical feature corresponded to labels or classes. The presented classifier is implemented in brain tumor diagnosis. For feature extraction, a fractal model with four Gaussian functions is used. The classification is performed on 2000 MRI images. Regarding the results, the accuracy of the DT, KNN, LDA, NB, MLP, and SVM is 93.5%, 87.6%, 61.5%, 57.5%, 68.5%, and 43.6%, respectively. Based on the results, the presented FWNNet illustrates the highest accuracy of 100% with the fractal feature extraction method and brain tumor diagnosis based on MRI images. Based on the results, the best classifier for diagnosis of the brain tumor is FWNNet architecture. However, the second and third high‐performance classifiers are the DT and KNN, respectively. Moreover, the presented FWNNet method is implemented for the segmentation of brain tumors. In this paper, we present a novel supervised segmentation method based on the FWNNet layer. In the training process, input images with a sweeping filter should be reshaped to vectors that correspond to reshaped ground truth images. In the training process, we performed a PSO algorithm to optimize the gradient descent algorithm. For this purpose, 80 MRI images are used to segment the brain tumor. Based on the results of the ROC curve, it can be estimated that the presented layer can segment the brain tumor with a high true‐positive rate.
Computational Intell... arrow_drop_down Computational Intelligence and NeuroscienceArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1155/2021/8542637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 38 citations 38 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Computational Intell... arrow_drop_down Computational Intelligence and NeuroscienceArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1155/2021/8542637&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2011Publisher:Oxford University Press (OUP) Authors: Miriam Schneider;F. Markus Leweke;
Matthias Klugmann; Rainer Spanagel; +1 AuthorsF. Markus Leweke
F. Markus Leweke in OpenAIREMiriam Schneider;F. Markus Leweke;
Matthias Klugmann; Rainer Spanagel; Viktoria Klippenstein;F. Markus Leweke
F. Markus Leweke in OpenAIREpmid: 21211107
Recent evidence suggests an involvement of the endocannabinoid system in the regulation of emotional behaviour and ethanol intake. Here we investigated age-specific acute behavioural effects of the cannabinoid receptor agonist WIN 55,212-2 (WIN) on anxiety-related behaviour and voluntary ethanol consumption in rats. Animals were treated with WIN (1.2 mg/kg)/vehicle at puberty onset on postnatal day (PD) 40, or at adulthood (PD 100). Animals were tested in the elevated plus-maze (EPM) and the light/dark emergence test (EMT) and for the initial response to alcohol in a free-choice ethanol consumption paradigm. Acute WIN treatment increased anxiety-related behaviours, and this effect was found to be partially more pronounced in pubertal than adult rats. Additionally, increased intake of higher ethanol solutions after cannabinoid treatment was only observed in pubertal rats. These drug-induced behavioural changes during puberty are paralleled by induction of the NR1 subunit of the NMDA receptor in the medial prefrontal cortex and the striatum. Moreover, pubertal but not adult WIN administration increased the levels of the scaffold protein Homer in these brain regions. Enhanced CB₁ receptor levels in the reinforcement system were also observed in pubertal compared to adult rats. These data support the notion that puberty is a highly vulnerable period for the aversive effects of cannabinoid exposure. In particular, augmented ethanol intake in pubertal cannabinoid-exposed animals might be related to some extent to increased emotional behaviour and in particular to enhanced NMDA and CB₁ receptor signalling.
International Journa... arrow_drop_down International Journal of NeuropsychopharmacologyArticle . 2011 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s1461145710001562&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 33 citations 33 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert International Journa... arrow_drop_down International Journal of NeuropsychopharmacologyArticle . 2011 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s1461145710001562&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu