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  • Energy Research
  • Neuroscience

  • Brain mitochondrial alterations after chronic alcohol consumption

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Article , Journal 2009 Spain Publisher:Springer Science and Business Media LLC
    Authors: Carmen García-Ruiz; María Miranda; María Muriach; Jorge M. Barcia; +4 Authors

    doi: 10.1007/bf03180583

    pmid: 20119825

    handle: 10261/35177

    The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Recolector de Cienci...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Recolector de Ciencia Abierta, RECOLECTA
    Article . 2009 . Peer-reviewed
    Data sources: Recolector de Ciencia Abierta, RECOLECTA
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Journal of Physiology and Biochemistry
    Article . 2009 . Peer-reviewed
    License: Springer TDM
    Data sources: Crossref
    Journal of Physiology and Biochemistry
    Article . 2010
    Data sources: Europe PubMed Central
    Journal of Physiology and Biochemistry
    Journal
    Data sources: Microsoft Academic Graph
    Digital.CSIC
    Article . 2009 . Peer-reviewed
    Data sources: Digital.CSIC
    Claim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    Access Routes
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    bronze
    18
    citations18
    popularityTop 10%
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    visibility17
    visibilityviews17
    downloaddownloads35
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Recolector de Cienci...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Recolector de Ciencia Abierta, RECOLECTA
      Article . 2009 . Peer-reviewed
      Data sources: Recolector de Ciencia Abierta, RECOLECTA
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of Physiology and Biochemistry
      Article . 2009 . Peer-reviewed
      License: Springer TDM
      Data sources: Crossref
      Journal of Physiology and Biochemistry
      Article . 2010
      Data sources: Europe PubMed Central
      Journal of Physiology and Biochemistry
      Journal
      Data sources: Microsoft Academic Graph
      Digital.CSIC
      Article . 2009 . Peer-reviewed
      Data sources: Digital.CSIC
      Claim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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Advanced search in Research products
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The following results are related to Energy Research. Are you interested to view more results? Visit OpenAIRE - Explore.
1 Research products
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  • Brain mitochondrial alterations after chronic alcohol consumption

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Article , Journal 2009 Spain Publisher:Springer Science and Business Media LLC
    Authors: Carmen García-Ruiz; María Miranda; María Muriach; Jorge M. Barcia; +4 Authors

    doi: 10.1007/bf03180583

    pmid: 20119825

    handle: 10261/35177

    The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Recolector de Cienci...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Recolector de Ciencia Abierta, RECOLECTA
    Article . 2009 . Peer-reviewed
    Data sources: Recolector de Ciencia Abierta, RECOLECTA
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Journal of Physiology and Biochemistry
    Article . 2009 . Peer-reviewed
    License: Springer TDM
    Data sources: Crossref
    Journal of Physiology and Biochemistry
    Article . 2010
    Data sources: Europe PubMed Central
    Journal of Physiology and Biochemistry
    Journal
    Data sources: Microsoft Academic Graph
    Digital.CSIC
    Article . 2009 . Peer-reviewed
    Data sources: Digital.CSIC
    Claim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    Access Routes
    Green
    bronze
    18
    citations18
    popularityTop 10%
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    visibility17
    visibilityviews17
    downloaddownloads35
    Powered by Usage counts
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Recolector de Cienci...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Recolector de Ciencia Abierta, RECOLECTA
      Article . 2009 . Peer-reviewed
      Data sources: Recolector de Ciencia Abierta, RECOLECTA
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of Physiology and Biochemistry
      Article . 2009 . Peer-reviewed
      License: Springer TDM
      Data sources: Crossref
      Journal of Physiology and Biochemistry
      Article . 2010
      Data sources: Europe PubMed Central
      Journal of Physiology and Biochemistry
      Journal
      Data sources: Microsoft Academic Graph
      Digital.CSIC
      Article . 2009 . Peer-reviewed
      Data sources: Digital.CSIC
      Claim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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