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Each of 4 male alcoholic subjects received 0.7 mg/kg calcium carbimide (CC) orally 12 hr before ingestion of 0.25 gm/kg ethanol on 3 separate occasions. The CC-ethanol interaction consisted of increased blood acetaldehyde level and elevated heart rate. For each individual there was small variability in the area under the curve (AUC) values of the blood ethanol level--time course profiles for the 3 experiments, indicating a consistent extent of ethanol absorption. For subjects 1, 2, and 3 there was appreciable intraindividual variability in the AUC and the peak blood acetaldehyde levels of the blood acetaldehyde level--time course curves; the variation in these parameters was small for subjects 4. The intraindividual variability in the peak heart rate response was small for subjects 1 and 2 and appreciable for subjects 3 and 4. Regression analysis of the blood acetaldehyde level--heart rate data for each of the 3 experiments conducted on the 4 subjects revealed that there were positive, linear correlations. There was appreciable intraindividual variability in the slope values for the 3 experiments. The results of this study, conducted on 4 male alcoholics, suggest that for other alcoholic subjects there could be appreciable intraindividual variability in the intensity of the CC-ethanol interaction.

Aims The aim of this study was to determine whether the sequential application of povidone iodine-alcohol (PVI) followed by chlorhexidine gluconate-alcohol (CHG) would reduce surgical wound contamination to a greater extent than PVI applied twice in patients undergoing spinal surgery. Patients and Methods A single-centre, interventional, two arm, parallel group randomised controlled trial was undertaken, involving 407 patients who underwent elective spinal surgery. For 203 patients, the skin was disinfected before surgery using PVI (10% [w/w (1% w/w available iodine)] in 95% industrial denatured alcohol, povidone iodine; Videne Alcoholic Tincture) twice, and for 204 patients using PVI once followed by CHG (2% [w/v] chlorhexidine gluconate in 70% [v/v] isopropyl alcohol; Chloraprep with tint). The primary outcome measure was contamination of the wound determined by aerobic and anaerobic bacterial growth from samples taken after disinfection. Results The detection of viable bacteria in any one of the samples taken after disinfection (culture-positive) was significantly lower in the group treated with both PVI and CHG than in the group treated with PVI alone (59 (29.1%) versus 85 (41.7%), p = 0.009; odds ratio 0.574; 95% confidence interval, 0.380 to 0.866). Conclusions Antisepsis of the skin with the sequential application of PVI and CHG more effectively reduces the contamination of a surgical wound than PVI alone. Cite this article: Bone Joint J 2017;99-B:1354–65.

Variation in food resources can result in dramatic fluctuations in the body condition of animals dependent on those resources. Decreases in body mass can disrupt patterns of energy allocation and impose stress, thereby altering immune function. In this study we investigated links between changes in body mass of captive cane toads (Rhinella marina), their circulating white blood cell populations, and their performance in immune assays. Captive toads that lost weight over a 3-month period had increased levels of monocytes and heterophils and reduced levels of eosinophils. Basophil and lymphocyte levels were unrelated to changes in mass. Because individuals that lost mass had higher heterophil levels but stable lymphocyte levels, the ratio of these cell types was also higher, partially consistent with a stress response. Phagocytic ability of whole blood was higher in toads that lost mass, due to increased circulating levels of phagocytic cells. Other measures of immune performance were unrelated to mass change. These results highlight the challenges faced by invasive species as they expand their range into novel environments which may impose substantial seasonal changes in food availability that were not present in the native range. Individuals facing energy restrictions may shift their immune function towards more economical and general avenues of combating pathogens.

1. Predicted changes in the frequency and intensity of extreme rainfall events in the UK have the potential to disrupt terrestrial ecosystem function. However, responses of different trophic levels to these changes in rainfall patterns, and the underlying mechanisms, are not well characterised. 2. This study aimed to investigate how changes in both the quantity and frequency of rainfall events will affect the outcome of interactions between plants, insect herbivores (above- and below- ground) and natural enemies. 3. Hordeum vulgare L. plants were grown in controlled conditions and in the field, and subjected to three precipitation scenarios: ambient (based on a local 10 year average rainfall); continuous drought (40% reduction compared to ambient); drought/ deluge (40% reduction compared to ambient at a reduced frequency). The effects of these watering regimes and wireworm (Agriotes species) root herbivory on the performance of the plants, aphid herbivores above-ground (Sitobion avenae, Metapolophium dirhodum and Rhopalosiphum padi), and natural enemies of aphids including ladybirds (Harmonia axyridis) were assessed from measurements of plant growth, insect abundance and mass, and assays of feeding behaviour. 4. Continuous drought decreased plant biomass, whereas reducing the frequency of watering events did not affect plant biomass but did alter plant chemical composition. In controlled conditions, continuous drought ameliorated the negative impact of wireworms on plant biomass. 5. Compared to the ambient treatment, aphid mass was increased by 15% when feeding on plants subjected to drought/ deluge; and ladybirds were 66% heavier when feeding on these aphids but this did not affect ladybird prey choice. In field conditions, wireworms feeding below-ground reduced the number of shoot-feeding aphids under ambient and continuous drought conditions but not under drought/ deluge. 6. Predicted changes in both the frequency and intensity of precipitation events under climate change have the potential to limit plant growth, but reduce wireworm herbivory, while simultaneously promoting above-ground aphid numbers and mass, with these effects transferring to the third trophic level. Understanding the effect of future changes in precipitation on species interactions is critical for determining their potential impact on ecosystem functioning and constructing accurate predictions under global change scenarios. Controlled environment and field experimental dataData file containing all data reported in the paper including plant, soil and insect data from controlled environment and field experiments. First spreadsheet in the data file contains a key to explain all abbreviations used throughout the file.Experimental data.xlsx

Understanding variation in the diet of widely distributed species can help us to predict how they respond to future environmental and anthropogenic changes. We studied the diet of the red fox Vulpes vulpes, one of the world’s most widely distributed carnivores. We compiled dietary data from 217 studies at 276 locations in five continents to assess how fox diet composition varied according to geographic location, climate, anthropogenic impact and sampling method. The diet of foxes showed substantial variation throughout the species’ range, but with a general trend for small mammals and invertebrates to be the most frequently occurring dietary items. The incidence of small and large mammals and birds in fox diets was greater away from the equator. The incidence of invertebrates and fruits increased with mean elevation, while the occurrence of medium-sized mammals and birds decreased. Fox diet differed according to climatic and anthropogenic variables. Diet richness decreased with increasing temperature and precipitation. The incidence of small and large mammals decreased with increasing temperature. The incidence of birds and invertebrates decreased with increasing mean annual precipitation. Higher Human Footprint Index was associated with lower incidence of large mammals and higher incidence of birds and fruit in fox diet. Sampling method influenced fox diet estimation: estimated percentage of small and medium-sized mammals and fruit was lower in studies based on stomach contents, while large mammals were more likely to be recorded in studies of stomach contents than in studies of scats. Our study confirms the flexible and opportunistic dietary behaviour of foxes at the global scale. This behavioural trait allows them to thrive in a range of climatic conditions, and in areas with different degrees of human-induced habitat change. This knowledge can help place the results of local-scale fox diet studies into a broader context and to predict how foxes will respond to future environmental changes. Castañeda et al. 2022 Mammal Review (Variation in red fox Vulpes vulpes diet in five continents)

Background and purpose:The contribution of endothelin‐1 (ET‐1) to vascular hyper‐reactivity associated with chronic ethanol intake, a major risk factor in several cardiovascular diseases, remains to be investigated.Experimental approach:The biphasic haemodynamic responses to ET‐1 (0.01–0.1 nmol kg−1, i.v.) or to the selective ETB agonist, IRL1620 (0.001–1.0 nmol kg−1, i.v.), with or without ETA or ETB antagonists (BQ123 (c(DTrp‐Dasp‐Pro‐Dval‐Leu)) at 1 and 2.5 mg kg−1 and BQ788 (N‐cis‐2,6‐dimethyl‐piperidinocarbonyl‐L‐γ‐methylleucyl1‐D‐1methoxycarbonyltryptophanyl‐D‐norleucine) at 0.25 mg kg−1, respectively) were tested in anaesthetized rats, after 2 weeks' chronic ethanol treatment. Hepatic parameters and ET receptor protein levels were also determined.Key results:The initial hypotensive responses to ET‐1 or IRL1620 were unaffected by chronic ethanol intake, whereas the subsequent pressor effects induced by ET‐1, but not by IRL1620, were potentiated. BQ123 at 2.5 but not 1 mg kg−1 reduced the pressor responses to ET‐1 in ethanol‐treated rats. Conversely, BQ788 (0.25 mg kg−1) potentiated ET‐1‐induced increases in mean arterial blood pressure in control as well as in ethanol‐treated rats. Interestingly, in the latter group, increases in heart rate, induced by ET‐1 at a dose of 0.025 mg kg−1 were enhanced following ETB receptor blockade. Finally, we observed higher levels of ETA receptor in the heart and mesenteric artery and a reduction of ETB receptor protein levels in the aorta and kidney from rats chronically treated with ethanol.Conclusions and implications:Increased vascular reactivity to ET‐1 and altered protein levels of ETA and ETB receptors could play a role in the pathogenesis of cardiovascular complications associated with chronic ethanol consumption.British Journal of Pharmacology (2008) 154, 971–981; doi:10.1038/bjp.2008.157; published online 12 May 2008

The impacts of increasing natural climate disasters are threatening food security in the Asia-Pacific region. Rice is Asia’s most important staple food. Climate variability and change directly impact rice production, through changes in rainfall, temperature and CO2 concentrations. The key for sustainable rice crop is water management. Adaptation can occur through shifts of cropping to higher latitudes and can profit from river systems (via irrigation) so far not considered. New opportunities arise to produce more than one crop per year in cooler areas. Asian wheat production in 2005 represents about 43 % of the global total. Changes in agronomic practices, such as earlier plant dates and cultivar substitution will be required. Fisheries play a crucial role in providing food security with the contribution of fish to dietary animal protein being very high in the region – up to 90 % in small island developing states (SIDS). With the warming of the Pacific and Indian Oceans and increased acidification, marine ecosystems are presently under stress. Despite these trends, maintaining or enhancing food production from the sea is critical. However, future sustainability must be maintained whilst also securing biodiversity conservation. Improved fisheries management to address the existing non-climate threats remains paramount in the Indian and Pacific Oceans with sustainable management regimes being established. Climate-related impacts are expected to increase in magnitude over the coming decades, thus preliminary adaptation to climate change is valuable.

Twenty-minute neighbourhoods highlight the importance of well-connected and mixed-used neighbourhoods and communities with proximate access to employment, essential services, public transport, and open spaces. Shorter distances together with re-prioritised public spaces encourage more active transport choices, resulting in public health benefits and reduced environmental pollution. Higher liveability brought about by mixed-use developments enables people to have equitable access to local facilities, amenities, and employment opportunities, promoting vibrancy, social cohesion, and intergenerational connections. The attributes of 20-minute neighbourhoods also combine to create places, that are acknowledged as friendly for all ages, address changing needs across the life course, and provide better support for the ageing population. Furthermore, there are indications that 20-minute neighbourhoods may be more resilient against many of the negative impacts of stringent public health protocols such as those implemented in periods of lockdown during the Covid-19 pandemic. In this article, we evaluate and compare planning policies and practices aimed at establishing 20-minute neighbourhoods in Melbourne (Australia) and Scotland (the UK). Using case studies, we discuss similarities and differences involved in using place-based approaches of 20-minute neighbourhoods to address 21st-century challenges in key areas of health and wellbeing, equity, environmental sustainability, and community resilience.