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In this paper, we examine the effects of world energy price shocks on China's macroeconomy over the past two decades. We begin by showing that the use of oil prices as a proxy for more general energy price dynamics is not appropriate for the case of China. Having established this fact, we propose a new energy price index which accurately reflects the structure of China's energy expenditure shares, and intertemporal fluctuations in international energy prices. We then employ a sufficiently rich set of time varying VARs, identified through a new set of agnostic sign restrictions, to estimate the effects of energy price shocks on China's macroeconomy. Our main result is that positive energy price shocks generate statistically significant reductions in real GDP growth and increases in inflation. Interestingly, both the sets of responses have consistently declined over the sample period. Next, the interest rate responses are found to be consistently positive over the sample period. Given the aforementioned stagflation result, this suggests that the PBOC is more focused on inflation stabilization as compared to facilitating output growth. All presented results are shown to be robust under both official national data and those developed by Chang et al. (2015), thus strengthening our conclusion that energy price shocks have significant time varying effects on China's macroeconomy.

Background and PurposeVarenicline, a neuronal nicotinic acetylcholine receptor (nAChR) modulator, decreases ethanol consumption in rodents and humans. The proposed mechanism of action for varenicline to reduce ethanol consumption has been through modulation of dopamine (DA) release in the nucleus accumbens (NAc) via α4*‐containing nAChRs in the ventral tegmental area (VTA). However, presynaptic nAChRs on dopaminergic terminals in the NAc have been shown to directly modulate dopaminergic signalling independently of neuronal activity from the VTA. In this study, we determined whether nAChRs in the NAc play a role in varenicline's effects on ethanol consumption.Experimental ApproachRats were trained to consume ethanol using the intermittent‐access two‐bottle choice protocol for 10 weeks. Ethanol intake was measured after varenicline or vehicle was microinfused into the NAc (core, shell or core‐shell border) or the VTA (anterior or posterior). The effect of varenicline treatment on DA release in the NAc was measured using both in vivo microdialysis and in vitro fast‐scan cyclic voltammetry (FSCV).Key ResultsMicroinfusion of varenicline into the NAc core and core‐shell border, but not into the NAc shell or VTA, reduced ethanol intake following long‐term ethanol consumption. During microdialysis, a significant enhancement in accumbal DA release occurred following systemic administration of varenicline and FSCV showed that varenicline also altered the evoked release of DA in the NAc.Conclusion and ImplicationsFollowing long‐term ethanol consumption, varenicline in the NAc reduces ethanol intake, suggesting that presynaptic nAChRs in the NAc are important for mediating varenicline's effects on ethanol consumption.

Abstract Background Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered that liver glycogen structure is impaired in diabetic animals. Since mulberry leaves are able to improve the diabetic conditions through reducing blood glucose level, it would be interesting to investigate whether they have any positive effects on intestinal microbiota and liver glycogen structure. Methods In this study, we first determined the bioactive components of ethanol extract of mulberry leaves via high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS). Murine animal models were divided into three groups, normal Sprague-Dawley (SD) rats, high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rats, and HFD/STZ-induced rats administered with ethanol extract of mulberry leaves (200 mg/kg/day). Composition of intestinal microbiota was analyzed via metagenomics by sequencing the V3-V4 region of 16S rDNAs. Liver glycogen structure was characterized through size exclusion chromatography (SEC). Both Student’s t-test and Tukey’s test were used for statistical analysis. Results A group of type 2 diabetic rat models were successfully established. Intestinal microbiota analysis showed that ethanol extract of mulberry leaves could partially change intestinal microbiota back to normal conditions. In addition, liver glycogen was restored from fragile state to stable state through administration of ethanol extract of mulberry leaves. Conclusions This study confirms that the ethanol extract of mulberry leaves (MLE) ameliorates intestinal microbiota dysbiosis and strengthens liver glycogen fragility in diabetic rats. These finding can be helpful in discovering the novel therapeutic targets with the help of further investigations.

An extensive number of studies uses trade-to-GDP as a proxy for globalisation in environmental research. Globalisation encompasses much more than just trade in goods. Globalisation is the integration of various countries and includes spillovers of ideas and technology, financial flows, the worldwide movement of labour, and national governments meeting on an international level in a bid to solve social and political problems. This study considers the effect of globalisation on carbon dioxide emissions by using a more flexible and comprehensive measure based on the KOF globalisation index for a panel of 21 OECD nations covering the period 1970–2014. Since the globalisation process is not uniform across countries and time, we use a fully-fledged nonparametric technique to estimate the time-varying coefficient and trend functions. Our results show that the effect of globalization on CO2 emissions is positive up until 2000, then switches to turns negative thereafter.

As countries start to implement the Sustainable Development Goals in their national development agendas, reviews of the current policy environment are necessary to ensure that the goals are achievable by 2030. The present study assesses the effectiveness of energy policy in Indonesia in supporting progress towards universal energy access, a substantial increase in renewable energy deployment, and improvement in energy efficiency. Laws and regulations related to energy were reviewed, and their contribution to achieving the energy targets of the Sustainable Development Goals in Indonesia was evaluated in terms of policy effectiveness. Results show that providing electricity for the remaining 1.1 million households living in the outermost and least developed regions of the archipelago is very challenging. However, Indonesia is still on track to achieve 100% residential electrification by 2030 as long as enough budget is allocated annually. Indonesia may not be able to provide access to clean cooking fuels and technology for everyone by 2030. The current policy focusing mostly on gas for cooking will be less effective in reaching the remaining households that cook with solid biomass and usually live in poverty. Similarly, the current policy scenario is not sufficient to allow enough progress to achieve the renewable energy target. Finally, the assessment of energy efficiency policy suggests that sectoral energy use is shaped by variables and regulation not primarily intended to improve energy efficiency.

Abstract Climate change is already impacting the North American Great Lakes ecosystem and understanding the relationship between climate events and public health, such as waterborne acute gastrointestinal illnesses (AGIs), can help inform needed adaptive capacity for drinking water systems (DWSs). In this study, we assessed a harmonized binational dataset for the effects of extreme precipitation events (≥90th percentile) and preceding dry periods, source water turbidity, total coliforms, and protozoan AGIs – cryptosporidiosis and giardiasis – in the populations served by four DWSs that source surface water from Lake Ontario (Hamilton and Toronto, Ontario, Canada) and Lake Michigan (Green Bay and Milwaukee, Wisconsin, USA) from January 2009 through August 2014. We used distributed lag non-linear Poisson regression models adjusted for seasonality and found extreme precipitation weeks preceded by dry periods increased the relative risk of protozoan AGI after 1 and 3–5 weeks in three of the four cities, although only statistically significant in two. Our results suggest that the risk of protozoan AGI increases with extreme precipitation preceded by a dry period. As extreme precipitation patterns become more frequent with climate change, the ability to detect changes in water quality and effectively treat source water of varying quality is increasingly important for adaptive capacity and protection of public health.

The accuracy and reliability of a rapid blood alcohol estimation by means of a breath alcohol analyser has been evaluated under casualty department conditions in a series of 646 road-crash victims managed at the Dandenong and District Hospital. A higher correlation (r = 0.91) was found between the breath alcohol analyser readings in 633 casualties and those obtained by blood analysis in the police laboratory. In 13 unconscious casualties in whom a nasal breath test was performed, the correlation was lower (r = 0.76). In six casualties, the breath alcohol analyser readings showed lower alcohol concentrations than the legal limit of 0.05 g/100 mL (10.9 mmol/L), but blood analysis detected an illegal concentration. Further evaluation of the accuracy of the breath alcohol analyser in other casualty departments is necessary before it can be recommended as a screening device in States which have legislated for compulsory blood alcohol tests in adult road casualties.

Polymer electrolyte membrane (PEM) fuel cells convert the chemical energy of hydrogen and oxygen directly into electrical energy. Waste heat and water are the reaction by-products, making PEM fuel cells a promising zero-emission power source for transportation and stationary co-generation applications. In this study, a mathematical model of a PEM fuel cell stack is formulated. The distributions of the pressure and mass flow rate for the fuel and oxidant streams in the stack are determined with a hydraulic network analysis. Using these distributions as operating conditions, the performance of each cell in the stack is determined with a mathematical, single cell model that has been developed previously. The stack model has been applied to PEM fuel cell stacks with two common stack configurations: the U and Z stack design. The former is designed such that the reactant streams enter and exit the stack on the same end, while the latter has reactant streams entering and exiting on opposite ends. The stack analysed consists of 50 individual active cells with fully humidified H2 or reformate as fuel and humidified O2 or air as the oxidant. It is found that the average voltage of the cells in the stack is lower than the voltage of the cell operating individually, and this difference in the cell performance is significantly larger for reformate/air reactants when compared to the H2/O2 reactants. It is observed that the performance degradation for cells operating within a stack results from the unequal distribution of reactant mass flow among the cells in the stack. It is shown that strategies for performance improvement rely on obtaining a uniform reactant distribution within the stack, and include increasing stack manifold size, decreasing the number of gas flow channels per bipolar plate, and judicially varying the resistance to mass flow in the gas flow channels from cell to cell. Copyright © 2004 John Wiley & Sons, Ltd.