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Experiments were carried out to determine the accuracy and validity of estimations of hepatic blood flow from systemic clearances of ethanol during very low dose (8 μmol∙min−1∙kg−1) infusions of ethanol in anesthetized cats. Systemic clearances were compared with directly measured hepatic blood flow using a hepatic venous long-circuit technique. This technique allowed direct measurement and alteration of hepatic blood flow and collection of arterial, portal, and hepatic venous blood samples without depletion of the animal's blood volume. In 18 cats, Vmax for ethanol was 93 ± 7 μmol∙min−1 per 100 g liver or 21 ± 2 μmol∙min−1∙kg·body weight−1 and Km was 144 ± 19 μM in terms of logarithmic mean sinusoidal concentration. At the dose of 8 μmol∙min−1∙kg body weight−1 used for estimation of hepatic blood flow, extraction was 0.95 ± 0.07 (mean ± SD). Systemic clearance of ethanol overestimated directly measured hepatic blood flow by 15 ± 16%. Hepatic blood flow changes expressed as percentages of the control level were accurately estimated from systemic ethanol clearance (100 ± 10%). Since 73 ± 12% of the infused ethanol was eliminated by the liver and 83 ± 11% was eliminated by the splanchnic bed, an extrasplanchnic uptake of 17% accounted for the overestimation of hepatic blood flow. Estimation of hepatic blood flow from systemic clearances of ethanol during very low dose infusions may have advantages over other clearance methods. Its use in cats was illustrated in a separate series of experiments and it was shown that surgery significantly reduced hepatic blood flow. The method may merit trial for estimation of hepatic blood flow in humans.

Molecular dynamics simulations have been performed to study photosystem II structure and function. Structural information obtained from simulations was combined with ab initio computations of chromophore excited states. In contrast to calculations based on the x-ray structure, the molecular-dynamics-based calculations accurately predicted the experimental absorbance spectrum. In addition, our calculations correctly assigned the energy levels of reaction-center (RC) chromophores, as well as the lowest-energy antenna chlorophyll. The primary and secondary quinone electron acceptors, Q(A) and Q(B), exhibited independent changes in position over the duration of the simulation. Q(B) fluctuated between two binding sites similar to the proximal and distal sites previously observed in light- and dark-adapted RC from purple bacteria. Kinetic models were used to characterize the relative influence of chromophore geometry, site energies, and electron transport rates on RC efficiency. The fluctuating energy levels of antenna chromophores had a larger impact on quantum yield than did their relative positions. Variations in electron transport rates had the most significant effect and were sufficient to explain the experimentally observed multi-component decay of excitation in photosystem II. The implications of our results are discussed in the context of competing evolutionary selection pressures for RC structure and function.

The Climate Change Adaptation in Africa (CCAA) program aims to improve the capacity of African countries to adapt to climate change in ways that benefit the most vulnerable.

Abstract Thermal performance of three naturally ventilated public buildings in which the wind tower is an important architectural freature is studied. One of the three builidings as well as it's wind tower is instrumented for temperature, relative humidity and airflow velocity measurements, and the other two are instrumented for temperature measurement. The results have led to a discussion concerning the degree of wind tower effectiveness in achieving thermal comfort.

Incident solar irradiance was measured using an ACC (Advanced-Cosine-Collector) RAMSES hyper-spectral radiometer (TriOS) installed on-board the ship during the ARTofMELT2023 expedition in May and June 2023. All times are given in Universal Coordinated Time (UTC).

Abstract Bio-based polyurethane (BPU) foams were successfully prepared using hydrothermally liquefied wheat straw (WS) to substitute a mass fraction of up to 50% of polyols. Response surface methodology (RSM) based on central composite design (CCD) was employed to optimize four process parameters: NCO/OH molar ratio, loading of crosslinking agent (glycerol), loading of catalyst (a mixture of triethylene diamine, stannous octoate, and triethanolamine), and loading of blowing agent (water) for the maximum compression strength of the rigid BPU foams. With the quadratic orthogonal regression model, verified by experimentation, the maximum compression strength of approximately 180 kPa was obtained at the following optimal conditions: NCO/OH molar ratio of 1.24:1, glycerol addition of 12.11%, catalyst loading of 0.76%, and blowing agent addition of 1.31% in relation to the total mass of polyols. The BPU foam prepared at the optimal conditions exhibits good thermal conductivity (0.045 Wm−1K−1) and thermal stability, comparable to those of a reference foam prepared with 100% PPG400.

The assessment of voltage stability margins is a promising direction for wide-area monitoring systems. Accurate monitoring architectures for long-term voltage instability are typically centralized and lack scalability, while completely decentralized approaches relying on local measurements tend towards inaccuracy. Here we present distributed linear algorithms for the online computation of voltage collapse sensitivity indices. The computations are collectively performed by processors embedded at each bus in the smart grid, using synchronized phasor measurements and communication of voltage phasors between neighboring buses. Our algorithms provably converge to the proper index values, as would be calculated using centralized information, but but do not require any central decision maker for coordination. Modifications of the algorithms to account for generator reactive power limits are discussed. We illustrate the effectiveness of our designs with a case study of the New England 39 bus system. 10 pages, submitted for publication

AbstractThe presented synthesis of the title compounds (II), (IV), (VI) and (VIII) is extremely simple and highly efficient without the use of any chromatographic purification.