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The adenine nucleotide translocation in mitochondria has previously been established as an exchange between exogenous and endogenous adenine nucleotides across the inner membrane. The specificity and the control of the exchange are examined with the following major results: The adenine nucleotide translocation is relatively specific for exogenous ADP and ATP, AMP being nearly inactive. Among other nucleotides tested, only dADP and dATP exchange with a noticeable activity. In the controlled state ADP exchanges 2–4 times faster than ATP. If simultaneously added, ADP and ATP compete for the exchange, with ADP being about tenfold more active than ATP. The specificity of the exit of adenine nucleotides in the exchange is similar to the specificity of the entrance with the difference that ADP and ATP are released with equal activity in proportion to their intramitochondrial content. AMP is released only after a slow conversion to ADP. Therefore the short time exchange is limited by the endogenous content of ADP plus ATP. The exchange is influenced by the metabolic state of the mitochondria. The ATP exchange is more variable than the ADP exchange. Two effects are elucidated: (a) the influence of the metabolic state on the relative content of AMP which inhibits both the ADP and ATP exchange (b) the coupling of the energy transfer system which inhibits only the ATP exchange. An example for case (a) is the inhibition of the ADP and ATP exchange by arsenate and an example for case (b) is the strong increase of the ATP exchange on uncoupling. The following effects are relevant to the mechanism of the control of the exchange by ATP. The stimulation of the ATP exchange by uncoupler has the same concentration dependence as the uncoupling of oxidative phosphorylation (Km [CCP] = 0.08 μM, where CCP = carbonyl‐cyanide‐phenylhydrazone). Oligomycin does not abolish the uncoupler effect on the ATP exchange. “Endogenous uncoupling” on aging of mitochondria also stimulates the ATP exchange. Valinomycin plus K+ only slightly stimulate the ATP exchange. Anaerobiosis stimulates the ATP exchange to a smaller extent than uncoupling.In competition with ADP the effects of energy transfer on ATP exchange are more strongly revealed. On uncoupling the more than tenfold preference for ADP is fully abolished. It is concluded that basically the exchange for ADP and ATP has equal specificity in forward and reverse reaction. In the controlled state a superimposed force makes the specificity asymmetric and inhibits the entrance of ATP. This control of the ATP exchange is concluded to be based on the anionic character of the adenine nucleotides. Thus the ATP4‐ex–ADP3‐in exchange is inhibited unless the charge difference is compensated for by an uncoupler stimulated H+ movement across the membrane. Furthermore an electric potential gradient appears to be effective in the controlled state which is abolished on uncoupling.

Abstract This study investigates the non-linear relationship between urbanization paths and CO2 emissions in selected South, South-East, and East Asian countries over the period 1971–2014. Based on the STIRPAT (Stochastic Impacts by Regression on Population, Affluence, and Technology) framework, we applied the advanced and robust methods of dynamic seemingly unrelated regression (DSUR), dynamic OLS (DOLS), and fully modified OLS (FMOLS) to estimate the long-term effects. The empirical findings revealed the inverted U-shaped effects of urbanization and urban agglomeration and the U-shaped impact of the largest city ratio on CO2 emissions. Urbanization and urban agglomerations improve environmental quality in the long-run and support ecological modernization theory. However, excessive concentration in the largest cities have severely affected the environmental quality and violates the notion of compact-city efficiencies. Moreover, energy intensity and economic growth positively affect CO2 emissions, while trade openness negatively influences CO2 emissions. Our robustness analysis at the country-level applies the augmented mean group (AMG) panel ARDL technique, which further supports the non-linear effect of urbanization paths on CO2 emissions except for a few countries. The results of the panel Granger non-causality approach unveil bidirectional causality of energy efficiency, economic growth, urbanization, and largest city ratio with CO2 emissions. In contrast, unidirectional causality runs from urban agglomeration to CO2 emissions. Our findings have important policy implications as we suggest green urban infrastructures, eco-friendly dwellings, smart cities, country-specific trade policies, and renewable energy options to improve the environmental quality.

Innovation ability has become one of the core elements in the pursuit of China’s green growth, and high-tech industries are playing a leading role in technological innovation in China. With the rapid development of China’s high-tech industries, their innovation efficiency has attracted widespread attention. This article aims to illustrate a shared inputs two-stage network Data Envelopment Analysis (DEA), to measure the innovation efficiency of high-tech industries in China’s 29 provinces from 1999 to 2018. The results indicate that there are obvious differences in the innovation efficiency of the provinces. The technology development efficiency, the technical transformation efficiency, and the overall innovation efficiency of the developed east coast provinces are generally higher than those of the backward central and western provinces. This article further applies the spatial econometrics model to analyze the factors influencing the innovation efficiency of high-tech industries. We have found that government support, R&D input intensity, industries aggregation, economic extroversion, and the level of development of the modern service industries cause varying degrees of impact on innovation efficiency.

Abstract As a burgeoning theoretical framework, energy justice has been mostly focused on the energy transition in Western countries, where socio-political settings are largely featured by liberalism and democracy, leaving an obvious gap in its application in other socio-political contexts. As a major energy consumer and a leader of the global low-carbon transition, China is characterized by a distinctive socio-political regime. An array of grand strategies to transform its coal-dominant energy structure have been initiated to ameliorate deteriorating environmental crises in particular and materialize a low-carbon transition in general. Based on extensive evidence, this article incorporates the energy justice framework into the analysis of an ongoing energy transition project in rural Northern China. It contributes to the related research in three dimensions. First, empirically, it demonstrates that the coal-to-gas heating transition project has been swamped with social injustices; the absence of measures to address these would lead this mega-project to profound failure. Second, theoretically, it illustrates that the concerns of justice are even more paramount in an authoritarian context where policy processes are characterized by strong political-administrative intervention and the pursuit of efficiency at all cost. In light of this, it stresses the indispensable role of restorative justice as a core tenet in achieving energy justice in authoritarian socio-political contexts, such as China. Third, this study advocates expanding the evaluation parameters of authoritarian environmentalism to include social consequences.

AbstractThere is close relationship between science & technology inputs and economic growth. Based on the data of science & technology input and economic growth, the paper makes the econometric models analysis on the economic growth and science & technology input of the three major coastal economic regions of China. The paper analyzes and compares the contribution rate of science & technology inputs to economic growth of the three major economic regions.

Points out that sustainability as such does not provide a clearcut guide to policy. First one has to decide what is to be sustained. If this is agreed, it must be in an operational from. However, difficulties may still emerge since opinions may differ about how to achieve. This is illustrated by differences in the views of economists about how sustainable development is to be achieved. Orthodox economists stress the importance of the accumulation of man-made capital to achieve this end whereas neo-Malthusians stress the importance of conserving natural resource and environmental capital. Both take an anthropocentric point of view. For political reasons the neo-Malthusian has had little support but it may eventually turn out to be correct. Economics is concerned with reducing economic scarcity and economists have traditionally suggested four main ways of doing this of which economic growth is one. However, neo-Malthusian economists believe that this may not be a sustainable strategy – it may result in future poverty. It should be noted that economic systems are embedded in social and natural systems and depend on these. Economic sustainability depends on the sustainability of these other systems. So from this point of view, it is just one of several bottom lines. Values must be considered in relation to sustainability. Economics is completely anthropocentric in its approach. Therefore, economic approaches to conservation and sustainability can be at odds with the values of deep ecologists or those willing to accord rights to other sentient beings or ecosystems independent of human wishes, or those who want to make use of value judgments other than those based on the measuring rod of money. Consequently economics evaluation is sometimes ineffective in resolving social conflict, including conflict about what should be sustained. As a rule economics alone should not be the final arbiter of social decisions. It is a part (often an important part) of the social evaluation process but not the bottom line, or just one of many lines.

In recent years, food security, especially supply, has been an important issue in China’s agricultural production. The stability of grain prices is related to the stability and development of the grain market. Based on agricultural production data from 1970 to 2015, this paper explores the influence of agricultural product price fluctuation on grain production by using the cobweb theory and vector error correction (VEC) model. The results show that changes in grain production in China are affected by fluctuations in agricultural product prices, that the production change lags behind the price change, and that there is a long-term equilibrium relationship between grain yield and agricultural product price. A Granger causality test shows that the change in agricultural product price is the Granger cause of grain yield change.

The interconversion of the ethanolate, hydrate and amorphous form of TMC114 ((3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxypropyl)-carbamic acid hexahydrofuro-[2,3-b]furan-3-yl ester) in open conditions was characterized. TMC114 hydrate and ethanolate form isostructural channel solvates. The crystal structure of TMC114 was obtained from single crystal X-ray diffraction, confirming that it is a channel solvate. Ethanol and water can exchange with one another. TMC114 ethanolate converts into TMC114 hydrate at moderate or high relative humidity (RH) at 25 degrees C, and it converts back into the ethanolate in ethanol atmosphere. The hydration level of the hydrate is determined by the environmental humidity. TMC114 hydrate collapses to the amorphous product when water is removed by drying at low RH or increasing temperature. TMC114 ethanolate becomes amorphous at elevated temperature in a dry environment below the desolvation temperature. Amorphous TMC114 obtained by dehydrating the hydrate during storage at room temperature/<5% RH, by increasing the temperature, or via desolvating the ethanolate by heating, converts into the hydrate at moderate or high RH at ambient conditions, and into TMC114 ethanolate in an ethanol atmosphere. Under ambient conditions, TMC114 ethanolate may convert into the hydrate, whereas the opposite will not occur under these conditions. The amorphous form, prepared by melting-quenching shows a limited water uptake. Whereas TMC114 ethanolate is stable in the commercialized drug product, special conditions can trigger its conversion.

AbstractObjectiveTo assess the epidemiological evidence on the joint effects of climate variability and socioecological factors on dengue transmission.MethodsFollowing PRISMA guidelines, a detailed literature search was conducted in PubMed, Web of Science and Scopus. Peer‐reviewed, freely available and full‐text articles, considering both climate and socioecological factors in relation to dengue, published in English from January 1993 to October 2015 were included in this review.ResultsTwenty studies have met the inclusion criteria and assessed the impact of both climatic and socioecological factors on dengue dynamics. Among those, four studies have further investigated the relative importance of climate variability and socioecological factors on dengue transmission. A few studies also developed predictive models including both climatic and socioecological factors.ConclusionsDue to insufficient data, methodological issues and contextual variability of the studies, it is hard to draw conclusion on the joint effects of climate variability and socioecological factors on dengue transmission. Future research should take into account socioecological factors in combination with climate variables for a better understanding of the complex nature of dengue transmission as well as for improving the predictive capability of dengue forecasting models, to develop effective and reliable early warning systems.

Alcoholic liver disease (ALD) is characterized by hepatocyte damage, inflammatory cell activation, and increased intestinal permeability leading to the clinical manifestations of alcoholic hepatitis. Selected members of the family of microRNAs (miRNAs) are affected by alcohol, resulting in an abnormal miRNA profile in the liver and circulation in ALD. Increasing evidence suggests that miRNAs that regulate inflammation, lipid metabolism and promote cancer are affected by excessive alcohol administration in mouse models of ALD. This communication highlights recent findings in miRNA expression and functions as they relate to the pathogenesis of ALD. The cell‐specific distribution of miRNAs, as well as the significance of circulating extracellular miRNAs, is discussed as potential biomarkers. Finally, the prospects of miRNA‐based therapies are evaluated in ALD.