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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Haiyan Liu; Jaeyoung Lee;

    The COVID-19 pandemic has tremendously affected the whole of human society worldwide. Travel patterns have greatly changed due to the increased risk perception and the governmental interventions regarding COVID-19. This study aimed to identify contributing factors to the changes in public and private transportation mode choice behavior in China after COVID-19 based on an online questionnaire survey. In the survey, travel behaviors in three periods were studied: before the outbreak (before 27 December 2019), the peak (from 20 January to 17 March 2020), and after the peak (from 18 March to the date of the survey). A series of random-parameter bivariate Probit models was developed to quantify the relationship between individual characteristics and the changes in travel mode choice. The key findings indicated that individual sociodemographic characteristics (e.g., gender, age, ownership, occupation, residence) have significant effects on the changes in mode choice behavior. Other key findings included (1) a higher propensity to use a taxi after the peak compared to urban public transportation (i.e., bus and subway); (2) a significant impact of age on the switch from public transit to private car and two-wheelers; (3) more obvious changes in private car and public transportation modes in more developed cities. The findings from this study are expected to be useful for establishing partial and resilient policies and ensuring sustainable mobility and travel equality in the post-pandemic era.

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    Sustainability
    Article . 2023 . Peer-reviewed
    License: CC BY
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sustainability
    Article . 2023
    Data sources: DOAJ
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Sustainabilityarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Sustainability
      Article . 2023 . Peer-reviewed
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      Sustainability
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Rositsa T. Ilieva; Andreas Hernandez;

    To effectively address the sustainability crises our planet faces, decision-makers at different levels of government worldwide will have to get a handle on three key challenges: learning from Global North and South initiatives in tandem, taking stock of social innovations alongside technological fixes, and nurturing grassroots sustainable development initiatives next to, or in place of, top-down corporate and government interventions. Current scientific literature and grant-making institutions have often reinforced the compartmentalized fashion in which we learn and draw policy lessons from North/South, social/technical, and bottom-up/top-down sustainability initiatives, including local food system innovations. The strategic levers for global sustainable development lying in-between are thus left out. This paper uses exploratory, multiple case study analysis to address this omission. By concurrently drawing lessons from grassroots innovations in Brazil, New York, and Senegal—three profoundly different socioeconomic and geographic contexts—we identify common pressure points that have enabled local communities to drive system-wide transformations toward climate adaptation, resilience, and sustainability in the agri-food system. The findings of this paper would be of value to scholars, government officials, and community groups engaged in agri-food systems sustainability and interested in the processes of change that have allowed budding innovations to stabilize and scale up.

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    Sustainability
    Article . 2018 . Peer-reviewed
    License: CC BY
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sustainability
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sustainability
    Article . 2018
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Sustainabilityarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Sustainability
      Article . 2018 . Peer-reviewed
      License: CC BY
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      Sustainability
      Article
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Sustainability
      Article . 2018
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Chunxue Zhou; Henry H. Ruiz; Li Ling; Giulia Maurizi; +9 Authors

    Hepatic steatosis is a key initiating event in the pathogenesis of alcohol-associated liver disease (ALD), the most detrimental organ damage resulting from alcohol use disorder. However, the mechanisms by which alcohol induces steatosis remain incompletely understood. We have previously found that alcohol binging impairs brain insulin action, resulting in increased adipose tissue lipolysis by unrestraining sympathetic nervous system (SNS) outflow. Here, we examined whether an impaired brain-SNS-adipose tissue axis drives hepatic steatosis through unrestrained adipose tissue lipolysis and increased lipid flux to the liver.We examined the role of lipolysis, and the brain-SNS-adipose tissue axis and stress in alcohol induced hepatic triglyceride accumulation in a series of rodent models: pharmacological inhibition of the negative regulator of insulin signaling protein-tyrosine phosphatase 1β (PTP1b) in the rat brain, tyrosine hydroxylase (TH) knockout mice as a pharmacogenetic model of sympathectomy, adipocyte specific adipose triglyceride lipase (ATGL) knockout mice, wildtype (WT) mice treated with β3 adrenergic agonist or undergoing restraint stress.Intracerebral administration of a PTP1b inhibitor, inhibition of adipose tissue lipolysis and reduction of sympathetic outflow ameliorated alcohol induced steatosis. Conversely, induction of adipose tissue lipolysis through β3 adrenergic agonism or by restraint stress worsened alcohol induced steatosis.Brain insulin resistance through upregulation of PTP1b, increased sympathetic activity, and unrestrained adipose tissue lipolysis are key drivers of alcoholic steatosis. Targeting these drivers of steatosis may provide effective therapeutic strategies to ameliorate ALD.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Molecular Metabolismarrow_drop_down
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    Molecular Metabolism
    Article . 2023 . Peer-reviewed
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Molecular Metabolism
    Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Molecular Metabolismarrow_drop_down
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      Molecular Metabolism
      Article . 2023 . Peer-reviewed
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      Molecular Metabolism
      Article . 2023
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  • Authors: Craig Kennedy; John Glenn; Natalie La Balme; Pierangelo Isernia; +2 Authors

    The aim of this study was to identify the attitudes of the public in the United States and in 12 European countries towards foreign policy issues and transatlantic issues. The survey concentrated on issues such as: United States and European Union (EU) leadership and relations, favorability towards certain countries, institutions and people, security, cooperation and the perception of threat including issues of concern with Afghanistan, Iran, and Russia, energy dependence, economic downturn, and global warming, Turkey and Turkish accession to the EU, promotion of democracy in other countries, and the importance of economic versus military power. Several questions asked of respondents pertained to voting and politics including whether they discussed political matters with friends and whether they attempted to persuade others close to them to share their views on politics which they held strong opinions about, vote intention, their assessment of the current United States President and upcoming presidential election, political party attachment, and left-right political self-placement. Demographic and other background information includes age, gender, race, ethnicity, religious affiliation and participation, age when stopped full-time education and stage at which full-time education completed, occupation, number of people aged 18 years and older living in the household, type of locality, region of residence, prior travel to the United States or Europe, and language of interview. computer-assisted personal interview (CAPI); computer-assisted telephone interview (CATI); paper and pencil interview (PAPI)The original data collection was carried out by TNS, Fait et Opinion -- Brussels on request of the German Marshall Fund of the United States.The codebook and setup files for this collection contain characters with diacritical marks used in many European languages.A split ballot was used for one or more questions in this survey. The variable SPLIT defines the separate groups.For data collection, the computer-assisted face-to-face interview was used in Poland, the paper and pencil interview was used in Bulgaria, Romania, Slovakia and Turkey, and the computer-assisted telephone interview was used in all other countries.Additional information on the Transatlantic Trends Survey is provided on the Transatlantic Trends Web site. (1) Multistage random sampling was implemented in the countries using face-to-face interviewing. Sampling points were selected according to region, and then random routes were conducted within these sampling points. Four callbacks were used for each address. The birthday rule was used to randomly select respondents within a household. (2) Random Digit Dialing was implemented in the countries using telephone interviewing. Eight callbacks were used for each telephone number. The birthday rule was used to randomly select respondents within a household. The adult population aged 18 years and over in 13 countries: Bulgaria, France, Germany, Italy, the Netherlands, Poland, Portugal, Romania, Slovakia, Spain, Turkey, the United Kingdom, and the United States. Smallest Geographic Unit: country Response Rates: The total response rate for all countries surveyed is 23 percent. Please refer to the "Technical Note" in the ICPSR codebook for additional information about response rate. Please refer to the "Technical Note" in the ICPSR codebook for further information about weighting. Datasets: DS1: Transatlantic Trends Survey, 2008

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Somda, Jacques; Zougmoré, Robert B.; Sawadogo, Issa; Bationo, B. André; +2 Authors

    This chapter focuses on the evaluation of adaptive capacities of community-level human systems related to agriculture and food security. It highlights findings regarding approaches and domains to monitor and evaluate behavioral changes from CGIAR’s research program on climate change, agriculture and food security (CCAFS). This program, implemented in five West African countries, is intended to enhance adaptive capacities in agriculture management of natural resources and food systems. In support of participatory action research on climate-smart agriculture, a monitoring and evaluation plan was designed with the participation of all stakeholders to track changes in behavior of the participating community members. Individuals’ and groups’ stories of changes were collected using most significant change tools. The collected stories of changes were substantiated through field visits and triangulation techniques. Frequencies of the occurrence of characteristics of behavioral changes in the stories were estimated. The results show that smallholder farmers in the intervention areas adopted various characteristics of behavior change grouped into five domains: knowledge, practices, access to assets, partnership and organization. These characteristics can help efforts to construct quantitative indicators of climate change adaptation at local level. Further, the results suggest that application of behavioral change theories can facilitate the development of climate change adaptation indicators that are complementary to indicators of development outcomes. We conclude that collecting stories on behavioral changes can contribute to biophysical adaptation monitoring and evaluation.

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    https://doi.org/10.1007/978-3-...
    Part of book or chapter of book . 2017 . Peer-reviewed
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      https://doi.org/10.1007/978-3-...
      Part of book or chapter of book . 2017 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sebastien Carnicella; Patricia H. Janak; Dorit Ron; Somayeh Ahmadiantehrani;

    Background:  We previously found that activation of the glial cell line‐derived neurotrophic factor (GDNF) pathway in the ventral tegmental area (VTA) reduces ethanol‐drinking behaviors. In this study, we set out to assess the contribution of endogenous GDNF or its receptor GFRα1 to the regulation of ethanol‐related behaviors.Methods:  GDNF and GFRα1 heterozygote mice (HET) and their wild‐type littermate controls (WT) were used for the studies. Ethanol‐induced hyperlocomotion, sensitization, and conditioned place preference (CPP), as well as ethanol consumption before and after a period of abstinence were evaluated. Blood ethanol concentration (BEC) was also measured.Results:  We observed no differences between the GDNF HET and WT mice in the level of locomotor activity or in sensitization to ethanol‐induced hyperlocomotion after systemic injection of a nonhypnotic dose of ethanol and in BEC. However, GDNF and GFRα1 mice exhibited increased place preference to ethanol as compared with their WT littermates. The levels of voluntary ethanol or quinine consumption were similar in the GDNF HET and WT mice, however, a small but significant increase in saccharin intake was observed in the GDNF HET mice. No changes were detected in voluntary ethanol, saccharin or quinine consumption of GFRα1 HET mice as compared with their WT littermates. Interestingly, however, both the GDNF and GFRα1 HET mice consumed much larger quantities of ethanol after a period of abstinence from ethanol as compared with their WT littermates. Furthermore, the increase in ethanol consumption after abstinence was found to be specific for ethanol as similar levels of saccharin intake were measured in the GDNF and GFRα1 HET and WT mice after abstinence.Conclusions:  Our results suggest that endogenous GDNF negatively regulates the rewarding effect of ethanol and ethanol‐drinking behaviors after a period of abstinence.

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    Alcoholism Clinical and Experimental Research
    Article . 2009 . Peer-reviewed
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      Alcoholism Clinical and Experimental Research
      Article . 2009 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: awit Diriba, Dawit;

    Household Surveys performed in four villages selected from Oromia, Amhara and Southern Nations, Nationalities, and Peoples’ Region (SNNPR) following from the ‘Ethiopian Rural Household Survey’ (ERHS) conducted in 2004.It contains detailed data on household consumption and expenditures, assets, income, agricultural activities, land allocation, demographic characteristics, and other variables. From September 2011 to January 2012 another survey of 221 households was conducted in three major regions of central and southern Ethiopia. At the time of this latest survey effort the most recent ERHS survey data available was from 2004. The selection of respondents, determination of sample size, and apportionment of the sample were based on a proportional sampling technique.In addition to addressing important questions from the ERHS survey data, the field survey was designed to generate detailed information on household biomass energy production and consumption practices; as well as farming activities; labour and land allocation; economic and demographic characteristics; and expenditures on food, non-food items, and energy. The 2011 survey effort collected detailed household biomass energy use data. The measurement of household biomass energy use was obtained in traditional units and later converted into kilograms. The conversion factors for each of the biomass were collected from the closest urban centre of each of the study areas. Information obtained on household biomass energy use was collected for a time period of one week before the survey was conducted. It was then aggregated into annual figures, although household biomass energy use may vary seasonally. Quality/Lineage: The data was collected by qualified enumerators who had participated in previous ERHS survey. In addition to myself I recruited assistant supervisor to check the accuracy and quality of data on daily basis and followup interview process closely. Before the survey commenced a pilot survey was conducted in each of the study areas to identify the different types of energy households are using and other critical variables of interest for the research. This information was used to revise and improve questionnaire. Moreover, a one day in-depth training was given to enumerators and assistant supervisor to enrich their deeper understanding of each the question in the survey and to further improve questionnaire from their earlier experiences in those villages. Purpose: Over 90% of Ethiopian rural population rely on biomass energy. However, biomass energy utilization is linked to household livelihood as in rural households produce and consume biomass energy simultaneously with other (on and off-farm)activities. With the rampant rate of deforestation that Ethiopia is facing it is important to investigate the effect of deforestation or fuelwood scarcity which is assumed affect household welfare through influence on wage and price. In light of this, the survey effort collected information on household use of biomass energy sources, expenditure and labour allocation choices and amount of labour time used for each activities.This helped me to investigate the effect of fuelwood scarcity on household welfare from three aspects: labour allocation decision, energy expenditure and fuel choice and biomass energy consumption behavior to better understand the related linkage of household production and utilization of biomass with livelihoods or food security. This dataset was first published on the institutional Repository "Zentrum für Entwicklungsforschung: ZEF Data Portal" with ID={c08e08aa-3055-4651-801b-0383610c1987}.

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    https://dx.doi.org/10.60507/fk...
    Dataset . 2023
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      https://dx.doi.org/10.60507/fk...
      Dataset . 2023
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  • Authors: Mark A. Zacharek; Giant C. Lin;

    To discuss current evidence of global climate change and its implications for allergic rhinitis and other allergic respiratory diseases.Global climate change is evidenced by increasing average earth temperature, increasing anthropogenic greenhouse gas levels, and elevated pollen levels. Pollutants of interest include carbon dioxide (CO2), ozone (O3), and nitrous oxide (NO2) because they can enhance the allergic response and lead to increased symptoms of allergic respiratory diseases. Heightened CO2 levels stimulate pollen production via photosynthesis and increased growth in multiple plant species investigated. Although worsened air quality appears to increase prevalence of allergic rhinitis, the effects of increased temperature are less certain. The findings of increased aeroallergen levels likely contribute to increases in presentation of allergic diseases, although more healthcare impact studies are necessary.Although recent literature indicates and strongly supports changes in temperature, pollution levels, and aeroallergen levels, more longitudinal epidemiologic surveillance of allergic diseases in relation to climate change as well as pathophysiologic studies on changing aeroallergen effects on allergic diseases are needed.

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    Authors: Tingting Liu; Xiaoxian Zhu; Mengqiu Cao;

    Although the United Nations’ Sustainable Development Goals (SDGs) advocate, through SDG 4 and SDG 10, equitable quality education and the reduction of inequalities within and between countries, respectively, few studies have examined how inequalities in regional sustainability influence higher education. Therefore, this study aims to examine the relationship between regional sustainability and higher education in China using fixed-effects panel modelling. A systematic force framework showing how regional sustainability drives higher education was constructed from economic, social, and environmental perspectives, and the endogeneity in the process of how regional sustainability affects higher education was explored by introducing one-year lagged values as instrumental variables. Our results show that regional sustainability has a significant impact on higher educational attainment in China, with differing effects in the eastern, central, and western regions, respectively. In central China, economic sustainability plays a significant positive role in higher educational attainment; in the western region, economic and social sustainability have stronger positive effects, while environmental sustainability has significantly negative effects. In terms of policy implications, our findings can be used to support regional development policies to promote regional higher education.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Clark W. Bird; Glenna J. Chavez; Megan J. Barber; C. Fernando Valenzuela;

    ABSTRACTPrenatal ethanol exposure causes a variety of cognitive deficits that have a persistent impact on quality of life, some of which may be explained by ethanol-induced alterations in interneuron function. Studies from several laboratories, including our own, have demonstrated that a single binge-like ethanol exposure during the equivalent to the third trimester of human pregnancy leads to acute apoptosis and long-term loss of interneurons in the rodent retrosplenial cortex (RSC). The RSC is interconnected with the hippocampus, thalamus, and other neocortical regions and plays distinct roles in visuospatial processing and storage, as well as retrieval of hippocampal-dependent episodic memories. Here we used slice electrophysiology to characterize the acute effects of ethanol on GABAergic neurotransmission in the RSC of neonatal mice, as well as the long-term effects of neonatal ethanol exposure on parvalbumin-interneuron mediated neurotransmission in adolescent mice. Mice were exposed to ethanol using vapor inhalation chambers. In postnatal day (P) 7 mouse pups, ethanol unexpectedly failed to potentiate GABAAreceptor-mediated synaptic transmission. Binge-like ethanol exposure of P7 mice expressing channel rhodopsin in parvalbumin-positive interneurons enhanced the peak amplitudes, asynchronous activity and total charge, while decreasing the rise-times of optically-evoked GABAAreceptor-mediated inhibitory postsynaptic currents in adolescent animals. These effects could partially explain the learning and memory deficits that have been documented in adolescent and young adult mice exposed to ethanol during the third trimester-equivalent developmental period.

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    Scientific Reports
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Haiyan Liu; Jaeyoung Lee;

    The COVID-19 pandemic has tremendously affected the whole of human society worldwide. Travel patterns have greatly changed due to the increased risk perception and the governmental interventions regarding COVID-19. This study aimed to identify contributing factors to the changes in public and private transportation mode choice behavior in China after COVID-19 based on an online questionnaire survey. In the survey, travel behaviors in three periods were studied: before the outbreak (before 27 December 2019), the peak (from 20 January to 17 March 2020), and after the peak (from 18 March to the date of the survey). A series of random-parameter bivariate Probit models was developed to quantify the relationship between individual characteristics and the changes in travel mode choice. The key findings indicated that individual sociodemographic characteristics (e.g., gender, age, ownership, occupation, residence) have significant effects on the changes in mode choice behavior. Other key findings included (1) a higher propensity to use a taxi after the peak compared to urban public transportation (i.e., bus and subway); (2) a significant impact of age on the switch from public transit to private car and two-wheelers; (3) more obvious changes in private car and public transportation modes in more developed cities. The findings from this study are expected to be useful for establishing partial and resilient policies and ensuring sustainable mobility and travel equality in the post-pandemic era.

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    Article . 2023 . Peer-reviewed
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    Authors: Rositsa T. Ilieva; Andreas Hernandez;

    To effectively address the sustainability crises our planet faces, decision-makers at different levels of government worldwide will have to get a handle on three key challenges: learning from Global North and South initiatives in tandem, taking stock of social innovations alongside technological fixes, and nurturing grassroots sustainable development initiatives next to, or in place of, top-down corporate and government interventions. Current scientific literature and grant-making institutions have often reinforced the compartmentalized fashion in which we learn and draw policy lessons from North/South, social/technical, and bottom-up/top-down sustainability initiatives, including local food system innovations. The strategic levers for global sustainable development lying in-between are thus left out. This paper uses exploratory, multiple case study analysis to address this omission. By concurrently drawing lessons from grassroots innovations in Brazil, New York, and Senegal—three profoundly different socioeconomic and geographic contexts—we identify common pressure points that have enabled local communities to drive system-wide transformations toward climate adaptation, resilience, and sustainability in the agri-food system. The findings of this paper would be of value to scholars, government officials, and community groups engaged in agri-food systems sustainability and interested in the processes of change that have allowed budding innovations to stabilize and scale up.

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    Sustainability
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    Authors: Chunxue Zhou; Henry H. Ruiz; Li Ling; Giulia Maurizi; +9 Authors

    Hepatic steatosis is a key initiating event in the pathogenesis of alcohol-associated liver disease (ALD), the most detrimental organ damage resulting from alcohol use disorder. However, the mechanisms by which alcohol induces steatosis remain incompletely understood. We have previously found that alcohol binging impairs brain insulin action, resulting in increased adipose tissue lipolysis by unrestraining sympathetic nervous system (SNS) outflow. Here, we examined whether an impaired brain-SNS-adipose tissue axis drives hepatic steatosis through unrestrained adipose tissue lipolysis and increased lipid flux to the liver.We examined the role of lipolysis, and the brain-SNS-adipose tissue axis and stress in alcohol induced hepatic triglyceride accumulation in a series of rodent models: pharmacological inhibition of the negative regulator of insulin signaling protein-tyrosine phosphatase 1β (PTP1b) in the rat brain, tyrosine hydroxylase (TH) knockout mice as a pharmacogenetic model of sympathectomy, adipocyte specific adipose triglyceride lipase (ATGL) knockout mice, wildtype (WT) mice treated with β3 adrenergic agonist or undergoing restraint stress.Intracerebral administration of a PTP1b inhibitor, inhibition of adipose tissue lipolysis and reduction of sympathetic outflow ameliorated alcohol induced steatosis. Conversely, induction of adipose tissue lipolysis through β3 adrenergic agonism or by restraint stress worsened alcohol induced steatosis.Brain insulin resistance through upregulation of PTP1b, increased sympathetic activity, and unrestrained adipose tissue lipolysis are key drivers of alcoholic steatosis. Targeting these drivers of steatosis may provide effective therapeutic strategies to ameliorate ALD.

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    Molecular Metabolism
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    Molecular Metabolism
    Article . 2023
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      Molecular Metabolism
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      Molecular Metabolism
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  • Authors: Craig Kennedy; John Glenn; Natalie La Balme; Pierangelo Isernia; +2 Authors

    The aim of this study was to identify the attitudes of the public in the United States and in 12 European countries towards foreign policy issues and transatlantic issues. The survey concentrated on issues such as: United States and European Union (EU) leadership and relations, favorability towards certain countries, institutions and people, security, cooperation and the perception of threat including issues of concern with Afghanistan, Iran, and Russia, energy dependence, economic downturn, and global warming, Turkey and Turkish accession to the EU, promotion of democracy in other countries, and the importance of economic versus military power. Several questions asked of respondents pertained to voting and politics including whether they discussed political matters with friends and whether they attempted to persuade others close to them to share their views on politics which they held strong opinions about, vote intention, their assessment of the current United States President and upcoming presidential election, political party attachment, and left-right political self-placement. Demographic and other background information includes age, gender, race, ethnicity, religious affiliation and participation, age when stopped full-time education and stage at which full-time education completed, occupation, number of people aged 18 years and older living in the household, type of locality, region of residence, prior travel to the United States or Europe, and language of interview. computer-assisted personal interview (CAPI); computer-assisted telephone interview (CATI); paper and pencil interview (PAPI)The original data collection was carried out by TNS, Fait et Opinion -- Brussels on request of the German Marshall Fund of the United States.The codebook and setup files for this collection contain characters with diacritical marks used in many European languages.A split ballot was used for one or more questions in this survey. The variable SPLIT defines the separate groups.For data collection, the computer-assisted face-to-face interview was used in Poland, the paper and pencil interview was used in Bulgaria, Romania, Slovakia and Turkey, and the computer-assisted telephone interview was used in all other countries.Additional information on the Transatlantic Trends Survey is provided on the Transatlantic Trends Web site. (1) Multistage random sampling was implemented in the countries using face-to-face interviewing. Sampling points were selected according to region, and then random routes were conducted within these sampling points. Four callbacks were used for each address. The birthday rule was used to randomly select respondents within a household. (2) Random Digit Dialing was implemented in the countries using telephone interviewing. Eight callbacks were used for each telephone number. The birthday rule was used to randomly select respondents within a household. The adult population aged 18 years and over in 13 countries: Bulgaria, France, Germany, Italy, the Netherlands, Poland, Portugal, Romania, Slovakia, Spain, Turkey, the United Kingdom, and the United States. Smallest Geographic Unit: country Response Rates: The total response rate for all countries surveyed is 23 percent. Please refer to the "Technical Note" in the ICPSR codebook for additional information about response rate. Please refer to the "Technical Note" in the ICPSR codebook for further information about weighting. Datasets: DS1: Transatlantic Trends Survey, 2008

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    Authors: Somda, Jacques; Zougmoré, Robert B.; Sawadogo, Issa; Bationo, B. André; +2 Authors

    This chapter focuses on the evaluation of adaptive capacities of community-level human systems related to agriculture and food security. It highlights findings regarding approaches and domains to monitor and evaluate behavioral changes from CGIAR’s research program on climate change, agriculture and food security (CCAFS). This program, implemented in five West African countries, is intended to enhance adaptive capacities in agriculture management of natural resources and food systems. In support of participatory action research on climate-smart agriculture, a monitoring and evaluation plan was designed with the participation of all stakeholders to track changes in behavior of the participating community members. Individuals’ and groups’ stories of changes were collected using most significant change tools. The collected stories of changes were substantiated through field visits and triangulation techniques. Frequencies of the occurrence of characteristics of behavioral changes in the stories were estimated. The results show that smallholder farmers in the intervention areas adopted various characteristics of behavior change grouped into five domains: knowledge, practices, access to assets, partnership and organization. These characteristics can help efforts to construct quantitative indicators of climate change adaptation at local level. Further, the results suggest that application of behavioral change theories can facilitate the development of climate change adaptation indicators that are complementary to indicators of development outcomes. We conclude that collecting stories on behavioral changes can contribute to biophysical adaptation monitoring and evaluation.

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    https://doi.org/10.1007/978-3-...
    Part of book or chapter of book . 2017 . Peer-reviewed
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      https://doi.org/10.1007/978-3-...
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    Authors: Sebastien Carnicella; Patricia H. Janak; Dorit Ron; Somayeh Ahmadiantehrani;

    Background:  We previously found that activation of the glial cell line‐derived neurotrophic factor (GDNF) pathway in the ventral tegmental area (VTA) reduces ethanol‐drinking behaviors. In this study, we set out to assess the contribution of endogenous GDNF or its receptor GFRα1 to the regulation of ethanol‐related behaviors.Methods:  GDNF and GFRα1 heterozygote mice (HET) and their wild‐type littermate controls (WT) were used for the studies. Ethanol‐induced hyperlocomotion, sensitization, and conditioned place preference (CPP), as well as ethanol consumption before and after a period of abstinence were evaluated. Blood ethanol concentration (BEC) was also measured.Results:  We observed no differences between the GDNF HET and WT mice in the level of locomotor activity or in sensitization to ethanol‐induced hyperlocomotion after systemic injection of a nonhypnotic dose of ethanol and in BEC. However, GDNF and GFRα1 mice exhibited increased place preference to ethanol as compared with their WT littermates. The levels of voluntary ethanol or quinine consumption were similar in the GDNF HET and WT mice, however, a small but significant increase in saccharin intake was observed in the GDNF HET mice. No changes were detected in voluntary ethanol, saccharin or quinine consumption of GFRα1 HET mice as compared with their WT littermates. Interestingly, however, both the GDNF and GFRα1 HET mice consumed much larger quantities of ethanol after a period of abstinence from ethanol as compared with their WT littermates. Furthermore, the increase in ethanol consumption after abstinence was found to be specific for ethanol as similar levels of saccharin intake were measured in the GDNF and GFRα1 HET and WT mice after abstinence.Conclusions:  Our results suggest that endogenous GDNF negatively regulates the rewarding effect of ethanol and ethanol‐drinking behaviors after a period of abstinence.

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    Alcoholism Clinical and Experimental Research
    Article . 2009 . Peer-reviewed
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      Alcoholism Clinical and Experimental Research
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    Authors: awit Diriba, Dawit;

    Household Surveys performed in four villages selected from Oromia, Amhara and Southern Nations, Nationalities, and Peoples’ Region (SNNPR) following from the ‘Ethiopian Rural Household Survey’ (ERHS) conducted in 2004.It contains detailed data on household consumption and expenditures, assets, income, agricultural activities, land allocation, demographic characteristics, and other variables. From September 2011 to January 2012 another survey of 221 households was conducted in three major regions of central and southern Ethiopia. At the time of this latest survey effort the most recent ERHS survey data available was from 2004. The selection of respondents, determination of sample size, and apportionment of the sample were based on a proportional sampling technique.In addition to addressing important questions from the ERHS survey data, the field survey was designed to generate detailed information on household biomass energy production and consumption practices; as well as farming activities; labour and land allocation; economic and demographic characteristics; and expenditures on food, non-food items, and energy. The 2011 survey effort collected detailed household biomass energy use data. The measurement of household biomass energy use was obtained in traditional units and later converted into kilograms. The conversion factors for each of the biomass were collected from the closest urban centre of each of the study areas. Information obtained on household biomass energy use was collected for a time period of one week before the survey was conducted. It was then aggregated into annual figures, although household biomass energy use may vary seasonally. Quality/Lineage: The data was collected by qualified enumerators who had participated in previous ERHS survey. In addition to myself I recruited assistant supervisor to check the accuracy and quality of data on daily basis and followup interview process closely. Before the survey commenced a pilot survey was conducted in each of the study areas to identify the different types of energy households are using and other critical variables of interest for the research. This information was used to revise and improve questionnaire. Moreover, a one day in-depth training was given to enumerators and assistant supervisor to enrich their deeper understanding of each the question in the survey and to further improve questionnaire from their earlier experiences in those villages. Purpose: Over 90% of Ethiopian rural population rely on biomass energy. However, biomass energy utilization is linked to household livelihood as in rural households produce and consume biomass energy simultaneously with other (on and off-farm)activities. With the rampant rate of deforestation that Ethiopia is facing it is important to investigate the effect of deforestation or fuelwood scarcity which is assumed affect household welfare through influence on wage and price. In light of this, the survey effort collected information on household use of biomass energy sources, expenditure and labour allocation choices and amount of labour time used for each activities.This helped me to investigate the effect of fuelwood scarcity on household welfare from three aspects: labour allocation decision, energy expenditure and fuel choice and biomass energy consumption behavior to better understand the related linkage of household production and utilization of biomass with livelihoods or food security. This dataset was first published on the institutional Repository "Zentrum für Entwicklungsforschung: ZEF Data Portal" with ID={c08e08aa-3055-4651-801b-0383610c1987}.

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    https://dx.doi.org/10.60507/fk...
    Dataset . 2023
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  • Authors: Mark A. Zacharek; Giant C. Lin;

    To discuss current evidence of global climate change and its implications for allergic rhinitis and other allergic respiratory diseases.Global climate change is evidenced by increasing average earth temperature, increasing anthropogenic greenhouse gas levels, and elevated pollen levels. Pollutants of interest include carbon dioxide (CO2), ozone (O3), and nitrous oxide (NO2) because they can enhance the allergic response and lead to increased symptoms of allergic respiratory diseases. Heightened CO2 levels stimulate pollen production via photosynthesis and increased growth in multiple plant species investigated. Although worsened air quality appears to increase prevalence of allergic rhinitis, the effects of increased temperature are less certain. The findings of increased aeroallergen levels likely contribute to increases in presentation of allergic diseases, although more healthcare impact studies are necessary.Although recent literature indicates and strongly supports changes in temperature, pollution levels, and aeroallergen levels, more longitudinal epidemiologic surveillance of allergic diseases in relation to climate change as well as pathophysiologic studies on changing aeroallergen effects on allergic diseases are needed.

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    Authors: Tingting Liu; Xiaoxian Zhu; Mengqiu Cao;

    Although the United Nations’ Sustainable Development Goals (SDGs) advocate, through SDG 4 and SDG 10, equitable quality education and the reduction of inequalities within and between countries, respectively, few studies have examined how inequalities in regional sustainability influence higher education. Therefore, this study aims to examine the relationship between regional sustainability and higher education in China using fixed-effects panel modelling. A systematic force framework showing how regional sustainability drives higher education was constructed from economic, social, and environmental perspectives, and the endogeneity in the process of how regional sustainability affects higher education was explored by introducing one-year lagged values as instrumental variables. Our results show that regional sustainability has a significant impact on higher educational attainment in China, with differing effects in the eastern, central, and western regions, respectively. In central China, economic sustainability plays a significant positive role in higher educational attainment; in the western region, economic and social sustainability have stronger positive effects, while environmental sustainability has significantly negative effects. In terms of policy implications, our findings can be used to support regional development policies to promote regional higher education.

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    Authors: Clark W. Bird; Glenna J. Chavez; Megan J. Barber; C. Fernando Valenzuela;

    ABSTRACTPrenatal ethanol exposure causes a variety of cognitive deficits that have a persistent impact on quality of life, some of which may be explained by ethanol-induced alterations in interneuron function. Studies from several laboratories, including our own, have demonstrated that a single binge-like ethanol exposure during the equivalent to the third trimester of human pregnancy leads to acute apoptosis and long-term loss of interneurons in the rodent retrosplenial cortex (RSC). The RSC is interconnected with the hippocampus, thalamus, and other neocortical regions and plays distinct roles in visuospatial processing and storage, as well as retrieval of hippocampal-dependent episodic memories. Here we used slice electrophysiology to characterize the acute effects of ethanol on GABAergic neurotransmission in the RSC of neonatal mice, as well as the long-term effects of neonatal ethanol exposure on parvalbumin-interneuron mediated neurotransmission in adolescent mice. Mice were exposed to ethanol using vapor inhalation chambers. In postnatal day (P) 7 mouse pups, ethanol unexpectedly failed to potentiate GABAAreceptor-mediated synaptic transmission. Binge-like ethanol exposure of P7 mice expressing channel rhodopsin in parvalbumin-positive interneurons enhanced the peak amplitudes, asynchronous activity and total charge, while decreasing the rise-times of optically-evoked GABAAreceptor-mediated inhibitory postsynaptic currents in adolescent animals. These effects could partially explain the learning and memory deficits that have been documented in adolescent and young adult mice exposed to ethanol during the third trimester-equivalent developmental period.

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