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Abstract While it is generally accepted that our fossil fuel-dominated energy systems must undergo a sustainable transition, researchers have often neglected the potential impacts of this on water and land systems. However, if unintended environmental impacts from this process are to be avoided, understanding its implications for land use and water demand is of crucial importance. Moreover, developed countries may induce environmental stress beyond their own borders, for instance through extensive imports of bioenergy. In this paper, Germany serves as an example of a developed country with ambitious energy transformation targets. Results show that in particular, the politically-driven aspiration for more organic farming in Germany results in a higher import quota of biomass, especially biofuels. These imports translate into land demand, which will exceed the area available in Germany for bioenergy by a factor of 3–6.5 by 2050. As this will likely bring about land stress in the respective exporting countries, this effect of the German energy transformation ought to be limited as much as possible. In contrast, domestic water demand for the German energy system is expected to decrease by over 80% through 2050 due to declining numbers of fossil-fuelled power plants. However, possible future irrigation needs for bioenergy may reduce or even counterbalance this decreasing effect. In addition, energy policy targets specific to the transport sector show a high sensitivity to biomass imports. In particular, the sector-specific target for greenhouse gas reductions will seemingly promote biomass imports, leading to the above-described challenges in the pursuit of sustainability.

The purpose of this study was to examine the effects of alcohol hangover on simulated highway driving performance.Driving performance of forty-two social drinkers was tested the morning following an evening of consuming on average 10.2 (SD = 4.2) alcoholic drinks (alcohol hangover) and on a control day (no alcohol consumed). Subjects performed a standardized 100-km highway driving test in the STISIM driving simulator. In addition to the standard deviation of lateral position (SDLP; i.e., the weaving of the car), lapses of attention were examined. Self-reported driving quality and driving style were scored, as well as mental effort to perform the test, sleepiness before and after driving, and hangover severity.Driving performance was significantly impaired during alcohol hangover as expressed by an SDLP increase of +1.9 cm (t (1,41) = 2.851, p = 0.007), increased number of lapses relative to the control day (7.7 versus 5.3 lapses, t (1,41) = 2.125, p = 0.019), and an increased total lapse time (182.7 versus 127.3 s, p = 0.040). During alcohol hangover, subjects reported their driving quality to be significantly poorer (t (1,41) = 4.840, p = 0.001) and less safe (t (1,41) = 5.078, p = 0.001), wise (t (1,41) = 4.061, p = 0.001), predictable (t (1,41) = 3.475, p = 0.001), and responsible (t (1,41) = 4.122, p = 0.001). Subjects further reported being significantly more tense while driving (t (1,41) = 3.280, p = 0.002), and more effort was needed to perform the driving test (t (1,41) = 2.941, p = 0.001). There was a significant interaction with total sleep time and hangover effects on SDLP and the number of lapses.In conclusion, driving is significantly impaired during alcohol hangover, as expressed in an elevated SDLP and increased number of lapses. Total sleep time has a significant impact on the magnitude of driving impairment.

Green energy technologies (GETs) are environmentally friendly in nature, making a promising contribution to attaining net-zero carbon goals. Although the Pakistani government has begun using GETs to minimize the adverse effects of carbon emissions, consumers' adoption rate is quite low. There are few studies examining consumers' desire to adopt GETs in the country. This study attempts to fill this research gap and also contributes by adding three novel factors to the theory of planned behavior (i.e., green energy technology awareness, openness to experience, and green energy technology discomfort) to comprehensively analyze the impact of various factors influencing consumers' desire to adopt GETs. For this purpose, the study establishes a systematic research framework. Data were collected from (n = 330) households in the five major cities (Peshawar, Abbottabad, Mardan, Mingora, and Swabi) of Khyber Pakhtunkhwa Province via an inclusive questionnaire survey. The formulated hypotheses are evaluated and scrutinized using structural equation modeling. The results reveal that environmental concern (β = 0.245), green energy technology awareness (β = 0.362), openness to experience (β = 0.256), and green energy technology benefits (β = 0.225) positively affect consumers' desire to adopt GETs. On the other hand, green energy technology costs (β = 0.325) and green energy technology discomfort (β = 0.395) have a negative effect on consumers' adoption of GETs. The research findings emphasize the importance of increasing recognition of GETs, reforming policy frameworks, and providing budget-friendly and user-friendly technologies. Research limitations and future research perspectives are also addressed.

We analyzed the role of primary and postoperative low linear energy transfer radiotherapy in 538 patients treated for salivary gland cancer in centers of the Dutch Head and Neck Oncology Cooperative Group, in search for prognostic factors and dose response.The tumor was located in the parotid gland in 59%, submandibular gland in 14%, oral cavity in 23%, and elsewhere in 5%. In 386 of 498 patients surgery was combined with radiotherapy, with a median dose of 62 Gy. Median delay between surgery and radiotherapy was 6 weeks. In the postoperative radiotherapy group, adverse prognostic factors prevailed. Elective radiotherapy to the neck was given in 40%, with a median dose of 50 Gy. Primary radiotherapy (n = 40) was given for unresectable disease or M(1), with a dose range of 28-74 Gy.Postoperative radiotherapy improved 10-year local control significantly compared with surgery alone in T(3-4) tumors (84% vs. 18%), in patients with close (95% vs. 55%) and incomplete resection (82% vs. 44%), in bone invasion (86% vs. 54%), and perineural invasion (88% vs. 60%). Local control was not correlated with interval between surgery and radiotherapy. No dose-response relationship was shown. Postoperative radiotherapy significantly improved regional control in the pN(+) neck (86% vs. 62% for surgery alone). A rating scale for different sites, T stage, and histologic type may be applied to calculate the risk of disease in the neck at presentation, and so indicate the need for elective neck treatment. A marginal dose-response was seen, in favor of a dose > or =46 Gy. A clear dose-response relationship was shown for patients treated with primary radiotherapy. Five-year local control was 50% with a dose of 66-70 Gy.Postoperative radiotherapy with a dose of at least 60 Gy is indicated for patients with T(3-4) tumors, incomplete or close resection, bone invasion, perineural invasion, and pN(+). In unresectable tumors, a dose of at least 66 Gy is advisable.

Climate change and rising global temperatures pose significant challenges for natural resource management. While developed economies have made progress in addressing these issues, emerging economies are still striving to achieve carbon neutrality, sustainable resource use, and environmental sustainability. This research aims to identify the factors driving carbon emissions in emerging economies over the past three decades. The study establishes a long-run relationship among the factors under investigation by employing various panel diagnostic methods. Non-parametric approaches are used to account for the non-symmetric distribution of panel data. The findings reveal that natural resource components have asymmetric impacts on carbon emissions, with oil rents reducing emissions and mineral rents increasing them. Economic growth and agricultural value added are identified as significant contributors to carbon emissions in the region. On the other hand, renewable energy consumption plays a crucial role in achieving carbon neutrality targets. Gross capital formation exhibits a mixed influence on carbon emissions, being positive and significant in lower quantiles and significantly negative in upper quantiles. These estimates are robust and align with existing literature. The study recommends sustainable resource abstraction and utilization, renewable energy production and consumption improvements, and enhanced capital formation. By providing empirical evidence and policy recommendations, this research contributes to understanding the relationship between these factors and their impact on carbon emissions, facilitating effective strategies for sustainable development and environmental preservation. Xinyang Normal University

AbstractIn the wake of the growing threats to humanity from climate change, we analyzed the information and communications technology (ICT)/education—environmental nexus from three distinct blocs including BRICS, MINT, and the G7 economies between 1990 and 2020. Two models were examined to reach the study's objectives. The first model evaluates whether education and ICT are essential for environmental sustainability via potential reduction in carbon emission. On the other hand, the second model fills an existing gap in extant studies by examining the prospect of education and ICT in influencing citizens on the importance of transition to renewable energy usage. Driscoll and Kraay estimator was employed as a panacea tool for cross‐sectional dependence and slope homogeneity while the fixed effect approach provides sufficient robustness checks on the findings. While some outcomes vary per bloc, others are relatively similar across the three blocs. Education level in school enrollment perspectives shows a negative significant pollution reduction effect across the three blocs, while only the G7 bloc performed better from human capital perspectives. The combined sample bloc shows that ICT also significantly reduces carbon emission, however, an individual bloc analysis refutes this stance for the MINT bloc. Additionally, while renewable energy cushions emissions in all the blocs, rapid urbanization, shows a positive CO2 emission impact except in the G7 bloc. Last, ICT and education significantly boost renewable energy usage only in the G7. Hence, governments and stakeholders in the blocs should gravitate toward greater investments in quality education and greener ICT infrastructures for a sustainable environment.

The climate crisis is the biggest threat to the health, development, and wellbeing of the current and future generations. While there is extensive evidence on the direct impacts of climate change on human livelihood, there is little evidence on how children and young people are affected, and even less discussion and evidence on how the climate crisis could affect violence against children.In this commentary, we review selected research to assess the links between the climate crisis and violence against children.We employ a social-ecological perspective as an overarching framework to organize findings from the literature and call attention to increased violence against children as a specific, yet under-examined, direct and indirect consequence of the climate crisis.Using such a perspective, we examine how the climate crisis exacerbates the risk of violence against children at the continually intersecting and interacting levels of society, community, family, and the individual levels. We propose increased risk of armed conflict, forced displacement, poverty, income inequality, disruptions in critical health and social services, and mental health problems as key mechanisms linking the climate crisis and heightened risk of violence against children. Furthermore, we posit that the climate crisis serves as a threat multiplier, compounding existing vulnerabilities and inequities within populations and having harsher consequences in settings, communities, households, and for children already experiencing adversities.We conclude with a call for urgent efforts from researchers, practitioners, and policymakers to further investigate the specific empirical links between the climate crisis and violence against children and to design, test, implement, fund, and scale evidence-based, rights-based, and child friendly prevention, support, and response strategies to address violence against children.

Excessive alcohol intake frequently results in gastrointestinal discomfort. It is an empirical fact that the severity of gastrointestinal discomfort induced by alcohol abuse is subject to interindividual variation. The aim of this study was to determine whether genetic polymorphism in alcohol dehydrogenase 3 (ADH3) and cytochrome P450 2E1 (CYP2E1), important first-pass enzymes in the metabolism of ethanol, predispose to the development of gastrointestinal symptoms in alcoholics, Blood samples were obtained from 92 adult alcoholics admitted for detoxification. The samples were analyzed for genetic polymorphism in ADH3 and CYP2E1 by polymerase chain reaction followed by restriction fragment length polymorphism analyses. During an interview on the first day of hospital admission, patient characteristics and gastrointestinal symptoms in the week before admission were assessed. A total of 75 of 92 alcoholics (83%) reported symptoms: 66 patients had upper gastrointestinal symptoms (72%), 70 patients had lower gastrointestinal symptoms (76%), and 59 patients reported alarming symptoms (64%). Patients with gastrointestinal symptoms less often abused beer in comparison to those without gastrointestinal symptoms (P = 0.05). The numbers of patients with the homozygous y1y1 genotype, the heterozygous y1y2 genotype, and the homozygous y2y2 genotype in ADH3 who reported gastrointestinal symptoms were 20 (83%), 34 (76%), and 15 (88%), respectively. The number of patients with the heterozygous c1c2 CYP2E1 genotype (5%) and the heterozygous DC CYP2E1 genotype (14%) was low and also unrelated to gastrointestinal symptoms. Our data suggest that the ethanol concentrations of the consumed beverages, and not interindividual variations in the activities of first-pass alcohol-metabolizing enzymes, are associated with gastrointestinal symptoms in alcoholics.

During heterologous protein production with Escherichia coli, the formation of inclusion bodies (IBs) is often a major drawback as these aggregated proteins are usually inactive. However, different strategies for the generation of IBs consisting of catalytically active proteins have recently been described. In this study, the archaeal tetrameric coiled-coil domain of the cell-surface protein tetrabrachion was fused to a target reporter protein to produce fluorescent IBs (FIBs). As the cultivation conditions severely influence IB formation, the entire cultivation process resulting in the production of FIBs were thoroughly studied. First, the cultivation process was scaled down based on the maximum oxygen transfer capacity, combining online monitoring technologies for shake flasks and microtiter plates with offline sampling. The evaluation of culture conditions in complex terrific broth autoinduction medium showed strong oxygen limitation and leaky expression. Furthermore, strong acetate formation and pH changes from 6.5 to 8.8 led to sub-optimal cultivation conditions. However, in minimal Wilms-MOPS autoinduction medium, defined culture conditions and a tightly controlled expression were achieved. The production of FIBs is strongly influenced by the induction strength. Increasing induction strengths result in lower total amounts of functional protein. However, the amount of functional FIBs increases. Furthermore, to prevent the formation of conventional inactive IBs, a temperature shift from 37 °C to 15 °C is crucial to generate FIBs. Finally, the gained insights were transferred to a stirred tank reactor batch fermentation. Hereby, 12 g/L FIBs were produced, making up 43 % (w/w) of the total generated biomass.

AbstractEnvironmental degradation is a major challenge facing the world. Our view is that a country's productive structure, reflected through its knowledge content and technical capabilities (economic complexity), is strongly correlated with its environmental performance. To empirically confirm this view, the link between economic complexity and environmental performance in member countries of the Organization for Economic Co‐operation and Development (OECD) was examined within a modified version of the Stochastic Impacts by Regression on Population, Affluence and Technology (STIRPAT) model incorporating two alternative measures of economic complexity. The model was estimated using the fixed effects extension proposed by Driscoll and Kraay (DK‐FE) and Generalized Method of Moments (GMM) estimation techniques. Granger causality testing in frequency domain was also employed to examine country‐specific relationships. The sample period extended from 2007 to 2016. The study findings provided reliable empirical justification for our position. The coefficients for economic complexity in the long‐run estimations revealed that economic complexity positively impacted on environmental performance in the OECD countries. Granger causality outcomes also indicated economic complexity as a meaningful predictor of environmental performance in most of the OECD countries.