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The physical properties of both raw materials and excipients are closely correlated with the quality of traditional Chinese medicine preparations in oral solid dosage forms. In this paper, based on the concept of the chemical fingerprint for quality control of traditional Chinese medicine products, the method of physical fingerprint for quality evaluation of traditional Chinese medicine extract powders was proposed. This novel physical fingerprint was built by the radar map, and consisted of five primary indexes (i.e. stackablity, homogeneity, flowability, compressibility and stability) and 12 secondary indexes (i.e. bulk density, tap density, particle size<50 μm percentage, relative homogeneity index, hausner ratio, angle of repose, powder flow time, inter-particle porosity, Carr index, cohesion index, loss on drying, hygroscopicity). Panax notoginseng saponins (PNS) extract was taken for an example. This paper introduced the application of physical fingerprint in the evaluation of source-to-source and batch-to-batch quality consistence of PNS extract powders. Moreover, the physical fingerprint of PNS was built by calculating the index of parameters, the index of parametric profile and the index of good compressibility, in order to successfully predict the compressibility of the PNS extract powder and relevant formulations containing PNS extract powder and conventional pharmaceutical excipients. The results demonstrated that the proposed method could not only provide new insights into the development and process control of traditional Chinese medicine solid dosage forms.

A key factor in social development and sustainable urban expansion is the establishment of sustainable and affordable transport systems. This study aims to investigate the impact of transport infrastructure investment on environmental degradation and economic growth and to test the validity of the EKC hypothesis in China, India, Russia, and Japan over the period 1995-2020. The results show that GDP has a significant positive effect, and GDP2 and GDP3 have significant adverse effects on environmental degradation, respectively. These results confirm the validity of the inverted U-shaped EKC hypothesis in selected emerging Asian economies. Rail infrastructure investment has significant adverse effects, while road infrastructure investment and aviation infrastructure investment have significant positive effects on environmental degradation. Likewise, the impact of investment in transport infrastructure system (roads, rail, and aviation) on economic growth is positive and statistically significant. Country-level estimates confirm the validity of the inverted U-shaped EKC hypothesis in China, India, and Russia, while the N-shaped EKC is only valid in Japan. Investments in rail infrastructure based on modern rail systems that run on electricity are believed to be less polluting in the transport mix, help create sustainable and safe transport systems, and reduce emissions at the urban and intercity levels in emerging Asian countries. In addition, the growing impact of free trade on environmental pollution should be strengthened to harmonize the strict enforcement of environmental conditions dominated by trade agreements.

Climate disasters affect human security and development, moreso in fragile and conflict-affected contexts where population’ capacities to cope with climate change are compromised. Responses to such crises lie at the nexus of humanitarian assistance, development, and peacebuilding. Yet, there are still too few integrated programmatic responses coordinating peacebuilding and climate actions to ensure a progressive human development. This research develops a multi-scalar model to help actors identify thematic areas to inform synergistic efforts and programs at different scales to better coordinate their actions. Findings suggest that climate action and peacebuilding sectors can coordinate actions around climate and conflict risk assessments, the management of land and water resources, ecosystem restoration, nature-based climate adaptation, climate and conflict smart agriculture, natural resources governance, and sustainable market development. These collaborative efforts have the potential to generate co-benefits, such as increased social cohesion and livelihood creation.

As a financial innovation model to promote sustainable economic development, carbon finance promotes green and inclusive economic development by reshaping the financial system. As a big energy consumer, China has been committed to the green transformation of energy structure, and carbon finance has been regarded as an important tool to support carbon emission reduction. This paper divides carbon finance from three levels, financial macro, environmental governance, and technological development, and selects 17 indexes to measure the development level of carbon finance in China. Time series regression model and the entropy weight method (EWM) are used to analyze the impact of carbon finance on China's energy consumption structure. The empirical results show that carbon finance plays a positive role in promoting China's energy consumption structure, and developing carbon finance is conducive to the use of clean energy and the optimization of energy consumption structure in China; carbon finance can further optimize China's energy consumption structure by investing capital, resources, and technology in industries related to promoting clean energy consumption. Therefore, China should continue to develop carbon finance and promote the establishment of a unified national carbon trading market; at the same time, China should use the CCER trading mechanism to promote the development of renewable energy and enhance the endogenous driving force of energy transformation by promoting technological progress.

Ethanol exerts its behavioural effects largely by interacting with receptors for brain neurotransmitters. However, the molecular mechanisms involving these interactions and the pathogenesis of alcohol-withdrawal symptomatology are still not well understood. Until recently, no data were available about homocysteine (Hcy) levels in acute alcohol intoxication of chronic alcoholics and in patients undergoing withdrawal from alcohol. Hcy, blood-alcohol concentrations, vitamins B6, B12, and folate concentrations were assessed in 29 chronic alcoholics, who underwent withdrawal from alcohol. We observed increased Hcy levels in most patients. Hcy levels steadily decreased during the observation period. We postulate that hyperhomocysteinaemia and excitatory amino acid neurotransmitters, by their agonism at the N-methyl-D-aspartate receptor, may partly mediate alcohol-associated withdrawal symptomatology. The importance of assessing serum Hcy levels in order to detect methylation deficiency in patients with chronic alcoholism and for possible therapeutic strategies is discussed.

The aim of this study is to provide an overview of deaths caused by poisoning (especially illicit drugs) in Estonia from 2000 to 2009. The data on poisoning deaths (N = 4132) were collected from the autopsy reports of the Estonian Forensic Science Institute. Ethanol poisoning was the most frequent cause of death (N = 1449, 35.1%), followed by carbon monoxide (N = 1151, 27.9%) and poisoning from illicit drugs (N = 888, 21.5%). The study included 3267 male (79.1%) and 865 female fatalities, with the prevalent age group being 35-64 years. Since 2002, deaths from fentanyles have increased sharply and remained at a high level - from 63 cases in 2002 to 138 cases in 2009. This high number indicates that in spite of the state's drug policies, illegal drugs remain easily available and that this area requires more attention. Alcohol abuse prevention policies - restrictions on alcohol advertisements in the media, limitations on sale times and anti-alcohol campaigns concerning traffic - have not brought about a significant decrease in ethanol poisoning.

Sustainability development is a core issue and policy-priority in China to meet the long-term ecological civilization and economic growth. In this paper, the sustainability of the 31 Chinese provincial-level administrative regions (provinces for short) was investigated using a composite sustainability indicator (CSI). The CSI was constructed by aggregating thirty sustainability indicators involving economic, social, and environmental dimensions hierarchically. Moreover, a piecewise mean range normalization method was developed for weakening the impact of outlier(s). The results indicate that further improvement of the provinces’ sustainability is needed, since only three provinces (accounting for 9.68%) showed better performance and development momentum, simultaneously. However, over half of the provinces showed comparatively optimistic sustainability prospect, indicating a possibility of further sustainability improvement in China under a positive and effective guidance. In terms of the individual provinces, the decline of the sustainability of Liaoning and Tianjin was significant whereas Anhui, Hunan, and Hubei showed more optimistic development prospects. For the four regions, Middle China was on the rise, the decline of Northeastern China was serious, and East China and West China showed better development, but they should also keep vigilance on the possible decline because of the decline of competitive advantages.

Abstract Although the “resource curse” hypothesis has been supported by many empirical studies focusing on the transnational and regional levels, there has always been a point of contention about the proper method of estimating and selecting natural resource indicators in literature. This paper proposes a mixed estimation method for panel data of 10 typical oil and gas resource-based cities in China from 1998 to 2015. The results show that resource industry agglomeration can mirror the distribution and dependence on the resource industry by location rather than by merely measuring the influence of the relative scale of resource extraction on economic growth. Using resource industry agglomeration as the main explanatory variable for regional economic growth verifies the resource curse hypothesis and shows the nonlinear characteristics of the negative correlation between resources and economic growth. Despite mostly similar indicator parameter estimates, marked differences exist in measured effects for material capital investments and technological innovation investments. The result of using resource industry agglomeration as the main explanatory variable is basically consistent with the economic theory and is more in line with observed reality than the alternative indicator. The research conclusions can provide evidence and data for index selection in the studies on the mediating effect of resource curse transmission and international comparison.