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All benzodiazepines and benzodiazepine site agonists impair motor performance dose-dependently and potentiate the effects of ethanol. In order to evaluate the risk of benzodiazepine and ethanol interaction with the direct acting GABA(A) receptor agonist 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (gaboxadol), we studied impairment of motor coordination for combinations of gaboxadol, ethanol and a series of benzodiazepines (flunitrazepam, zolpidem and indiplon) in a rat rotarod model. All compounds produced a dose-dependent motor impairment and, in agreement with earlier data, a supra-additive effect of the benzodiazepine ligands and ethanol 1 g/kg was seen. In contrast, no significant potentiation of the effects of gaboxadol by ethanol was detected, and furthermore, no synergistic interaction between gaboxadol and any of the benzodiazepines was seen. A 30-day tolerance study was conducted with daily injections of gaboxadol (7.9 mg/kg) and zolpidem (1.25 mg/kg), respectively. A time-dependent tolerance developed to the motor impairment produced by both compounds. On day 31, cross-tolerance studies between zolpidem/gaboxadol and gaboxadol/zolpidem were conducted. No cross-tolerance was observed, indicating that the motor coordination effects observed with gaboxadol and zolpidem may arise from interaction with different receptor populations.

The rapid growth of agriculture has led to a significant increase in energy utilization and CO2 emissions. Agriculture performs a pivotal role in improving every country’s economy. The current study has the main objective to analyses the long-run impact of agricultural CO2 discharge on economic growth, energy consumption (electricity utilization in the agriculture sector), financial development, foreign direct investment (FDI), and population for India. For the period 1978–2018, we applied ADF, PP, ERS, and KPSS unit root and Z&A and CMR structural interval tests to evaluate the stability and breaks in the data set. We check the cointegration of study variables through ARDL, Engle–Granger, and Johansen’s cointegration approaches. The findings of the long-run analysis showed a cointegration among the variables, which reveals that an escalation in economic growth and financial development refine the natural environment, while the upsurge in FDI and population further deteriorate the climate in India. However, agricultural sector electricity use shows an insignificant association with CO2 emissions for both periods. On the basis of results, we recommend that legislators should offer an environment that provides opportunities for financial development and economic growth.

The study investigated the protective effect of walnut oligopeptides (WOPs) against ethanol-induced gastric injury using Sprague-Dawley (SD) rats. Rats were randomly divided into seven groups based on body weight (10/group), normal group, ethanol group, whey protein group (220 mg/kg body weight), omeprazole group (20 mg/kg body weight), and three WOPs groups (220, 440, 880 mg/kg body weight). After 30 days of treatment with WOPs, rats were given 5 mL/kg absolute ethanol by gavage to induce gastric mucosal injury. Gastric ulcer index (GUI) were determined and the following measured; gastric content pH, gastric mucin, endogenous pepsinogens (PG), prostaglandin E2 (PGE2), inflammatory cytokines, oxidative stress indicators, and the expression of apoptosis-related proteins were measured to evaluate the gastroprotective effect of WOPs. The results showed that the administration with WOPs markedly mitigated the hemorrhagic gastric lesions caused by ethanol in rats, and decreased the GUI, the gastric content pH, PG1, PG2, and NO levels, enhanced mucin and PGE2. Also, WOPs repressed gastric inflammation through the reduction of TNF-α, IL-6, IL-1β and increase IL-10 levels, and revealed antioxidant properties with the enhancement of superoxide dismutase, glutathione, and catalase activity, while reduction of malondialdehyde. Moreover, WOPs treatment significantly down-regulated Bax, caspase-3 and nuclear factor-κB p65 (NF-κB p65) expression, while up-regulating the expression of Bcl-2 and inhibitor kappa Bα (IκBα) protein. These results indicated that WOPs have protective effects against ethanol-induced gastric mucosal injury in rats through anti-inflammatory, anti-oxidation, and anti-apoptosis mechanisms.

Ethanol ablation (EA) is a safe and effective method for treating small liver cancer. However, the ethanol is rapidly washed out by blood perfusion, preventing its accumulation within tumors. Microbubble-enhanced ultrasound (MEUS) is capable of disrupting tumor and liver circulation. We hypothesized that this disruption could be used to enhance EA of normal liver tissue. We treated surgically exposed rabbit liver with a combination of MEUS and EA. The controls were treated with only MEUS or 0.05 mL EA. MEUS treatment was administered with a high-pressure-amplitude, pulsed therapeutic ultrasound device and intra-venous injection of microbubbles. Therapeutic ultrasound was delivered at an acoustic pressure of 4.3 MPa and a duty cycle of 0.22%. Contrast-enhanced ultrasound was performed to estimate liver blood perfusion. Livers were harvested for necrotic volume measurements 48 h after treatment. Contrast-enhanced ultrasound demonstrated that liver perfusion was temporally arrested, with a significant peak intensity decline from -46.9 ± 3.8 to -64.0 ± 3.3 dB, after MEUS treatment. The mean volume ablated in MEUS + EA-treated livers (3.3 ± 2.3 cm(3)) was more than 10 times larger than that in livers treated only with EA (0.3 ± 0.2 cm(3)). The volume of liver ablated by MEUS treatment alone was minor, scattered and immeasurable. These results indicate that MEUS disruption of the liver circulation can greatly promote EA of liver.

China faces growing environmental problems as rapid economic growth comes at the cost of excessive resource consumption. Sustainable development can only be realized by reducing energy intensity. Although some general factors that influence energy intensity have been described, less information is available to compare energy intensity in different regions. Here we use existing literature to assess the effects of three internal factors (economic structure, energy consumption structure, and technological progress) on energy intensity in three regions of China. We use panel data from 2000 to 2009 and find that the effects of each factor differ in each region. We further differentiate these effects by decomposing technological progress into three parts using the DEA-Malmquist approach. We find three components of technological change have completely different effects in each region. Furthermore, these findings are applied to propose relevant suggestions to reduce energy intensity in different regions of China.

Abstract City has always been a concentrated area of consumption and pollution in a country or region. Solutions to the dematerialization of city would exert a profound impact on the entire socio-economic system. And the issue of resources and environment in Beijing, the center of China’s politics, economy, and culture, becomes a focus of attention both domestically and internationally. In this paper, we used the economy-wide material flow analysis to describe the socio-economic development and the current situation of resources and environment in Beijing during the period 1992–2015. Based on this, Tapio decoupling model and the logarithmic mean divisia index method were used to analyze the level and influencing factors of dematerialization in Beijing. The results of the study showed that: From 1992 to 2015, GDP of Beijing increased from 61.25 billion yuan to 623.45 billion yuan, at the same time, direct material input and domestic processed output also increased from 139.88 million tons and 78.63 million tons in 1992 to 205.17 million tons and 166.27 million tons in 2015 respectively. Judging from the change of the decoupling relationship between economic growth and resources and environment, the level of dematerialization in Beijing was continuously increasing. And the dematerialization level of resource consumption was slightly better than that of pollution discharge. The high expansion of population and economy was not conducive to the realization of dematerialization in Beijing. However, the decrease of the intensity of material utilization played a crucial role in the process of dematerialization in Beijing. Moreover, increases in material circulation and social overall level of cleaner production were beneficial to the realization of dematerialization.

© 2021 Elsevier LtdDespite extensive research to address the impact of environmental reforms under the Paris Climate Agreement, current literature has failed to provide sufficient insights into Regional Comprehensive Economic Partnership (RCEP) countries. To this end, the current study attempts to address the impact of the economic complexity on environmental quality in the presence of renewable energy consumption, financial development, urbanization and energy innovation in RCEP countries from 1990 to 2019. Our empirical estimates confirm a significant association between environmental quality, economic complexity index, renewable energy consumption, financial development, urbanization and energy innovation in the short-run and long run. Based on extensive econometric analysis (CS-ARDL, AMG, PMG, FMOLS, and DOLS), we conclude that economic complexity, renewable energy, and energy innovation effectively mitigate environmental degradation. At the same time, financial development and urbanization have an adverse impact on the environment. These findings have extensive policy implications for policymakers and environmental stakeholders, who are aiming to achieve sustainable energy policy and economic growth to meet the environmental commitments under Paris Climate Agreement.

Abstract The rapid urbanization in the Belt and Road Initiative (BRI) area has aggravated the cross-regional pollution of PM2.5 and aroused concern about the conflicts between urban development and air quality. This study aims to examine the spatial-temporal PM2.5 variations in the BRI region, in which area many countries are undergoing rapid urbanization and the main field of future urbanization, to delineate the driving mechanism of PM2.5 accumulation or dissipation. Previous studies have analyzed the PM2.5 distribution at the national level, providing limited information regarding regional heterogeneity in urbanization and PM2.5 concentrations within each country. Additionally, the regional differences in the driving mechanisms of urbanization factors on PM2.5 concentrations have not been thoroughly investigated within the BRI areas. In this study, remote sensing raster data was combined with geographic grid units to examine variations in urbanization and PM2.5 within the BRI region, identifying “typical regions” where urbanization could enhance PM2.5 accumulation. The main results are as follows: i) The spatial autocorrelation of urbanization and PM2.5 concentrations has gradually strengthened, showing consistent high-value distributions in the North China Plain, Ganges Plain and indicating a synergistic growth among emerging developing regions such as China, India, and the Persian Gulf Coast. ii) The correlation between urbanization and PM2.5 concentrations exhibited a distinct trend of differentiation within the BRI regions. The influence of urbanization on PM2.5 changed from agglomeration to dispersion, forming a “typical region” category composed of ten countries, including China, India, and Morocco. iii) The three main urbanization-related factors for PM2.5 accumulation in the “typical regions” for 2005–2016 were energy pollution emission, economic activities, and human activities. By 2023, the effects of energy pollution and economic activities are expected to converge in some “typical region” countries. Targeted urban strategies and governance actions based on the different driving-types of “typical regions” in BRI have been proposed to coordinate relationship between urban construction and atmospheric environmental protection.