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Clostridium kluyveri is an anaerobic microorganism that is well-known for producing butyrate and hexanoate using ethanol and acetate. It is also an important bacterium in the production of Chinese strong flavour baijiu (SFB). To obtain a comprehensive understanding of its metabolism, a curated genome-scale metabolic model (GSMM) of C. kluyveri, including 708 genes, 994 reactions, and 804 metabolites, was constructed and named iCKL708. This model was used to simulate the growth of C. kluyveri on different carbon substrates and the results agreed well with the experimental data. The butyrate, pentanoate, and hexanoate biosynthesis pathways were also elucidated. Flux balance analysis indicated that the ratio of ethanol to acetate, as well as the uptake rate of carbon dioxide, affected hexanoate production. The GSMM iCKL708 described here provides a platform to further our understanding and exploration of the metabolic potential of C. kluyveri.

An extensive body of research using concurrent‐chains schedules of reinforcement has shown that choice for one of two differentially valued food‐associated stimuli is dependent upon the overall temporal context in which those stimuli are embedded. The present experiments examined whether the concurrent chains procedure was useful for the study of behavior maintained by alcohol and alcohol‐associated stimuli. In Experiment 1, rats responded on concurrent‐chains schedules with equal variable‐interval (VI) 10‐s schedules in the initial links. Across conditions, fixed‐interval schedules in the terminal links were varied to yield 1:1, 9:1, and 1:9 ratios of alcohol delivery. Initial‐link response rates reflected changes in terminal‐link schedules, with greater relative responding in the rich terminal link. In Experiment 2, terminal‐link schedules remained constant with a 9:1 ratio of alcohol delivery rates while the length of two equal duration initial‐link schedules was varied. Preference for the rich terminal link was less extreme when initial links were longer (i.e., the initial‐link effect), as has been previously reported with food reinforcers. This result suggests that the conditioned reinforcing value of an alcohol‐associated stimulus depends on the temporal context in which it is embedded. The concurrent‐chains procedure and quantitative models of concurrent chains performance may provide a useful framework within which to study how contextual variables modulate preference for drug‐associated conditioned reinforcers.

Impulsive stress in repeated shock waves administered during extracorporeal shock-wave lithotripsy (ESWL) causes injury to kidney tissue. In a study of the mechanical input of ESWL, the effects of focused shock waves on thin planar polymeric membranes immersed in a variety of tissue-mimicking fluids have been examined. A direct mechanism of failure by shock compression and an indirect mechanism by bubble collapse have been observed. Thin membranes are easily damaged by bubble collapse. After propagating through cavitation-free acoustically heterogeneous media (liquids mixed with hollow glass spheres, and tissue) shock waves cause membranes to fail in fatigue by a shearing mechanism. As is characteristic of dynamic fatigue, the failure stress increases with strain rate, determined by the amplitude and rise time of the attenuated shock wave. Shocks with large amplitude and short rise time (i.e., in uniform media) cause no damage. Thus the inhomogeneity of tissue is likely to contribute to injury in ESWL. A definition of dose is proposed which yields a criterion for damage based on measurable shock wave properties.

Abstract The accurate information of the thermal stresses and temperature in isotropic elastic solids is the key for many engineering applications. At present the classical linear coupled theory of thermoelasticity deduced with the assumptions of small temperature changes is widely used to solve the thermoelastic problems in engineering. In this paper, to describe the thermoelastic behavior in isotropic solids undergoing large temperature changes more accurately, the novel coupled models of thermoelasticity and the corresponding finite element models have been presented explicitly and validated by experimental measurement. The effect of large temperature changes on the solutions of thermoelastic problems is discussed. For the heat transfer process, if the isotropic elastic solids will expand when heated and contract when cooled and the condition d E E d T · σ i j E − δ i j 1 − 2 ν α 0 can be met in the context of small deformations, the effect of large temperature changes can be regarded as increasing the specific heat. The proposed models are applied to solve two thermoelastic problems. From the obtained numerical results, the effect of large temperature changes will increase with the amplitude of temperature change and may be considerably even when the temperature changes slowly.

This edited volume examines the opportunities to think, do, and/or create jointly afforded by digital storytelling. The contributors discuss digital storytelling in the context of educational programs, teaching anthropology, and ethnographic research involving a variety of populations and subjects that will appeal to researchers and practitioners engaged with qualitative methods and pedagogies that rely on media technology.

Blockchain is described as having endless theoretical potential. In reality however, it is hard toestablish how blockchain can be utilized and what opportunities blockchain may create. Theunclear future of blockchain constitutes a challenge for many companies. Many large incumbentsare uncertain of how to implement blockchain technology in their organization and are anxiousabout the consequences of the new technology. The purpose of this exploratory study is to evaluateblockchain applications for a district heating company in Stockholm to understand favorable areas,necessary criteria for successful implementation and how blockchain could enable new businessopportunities in the district heating market. To be able to reach the purpose of the thesis aliterature study and an empirical study were performed. The literature study is in the form of anextensive investigation about the areas of blockchain and district heating. The empirical studyincludes 17 interviews, both internal interviews with employees at Stockholm Exergi and externalinterviews conducted with professionals with knowledge about blockchain, district heating and theenergy sector. Furthermore, two workshops, in collaboration with Stockholm Exergi, wereperformed at the end of the thesis to evaluate and prioritize the developed blockchain applications.This thesis proposes 32 blockchain applications within 10 areas in the district heating industry.The applications are categorized after their potential, in three categories; green for the blockchainapplications that are valuable to investigate further, orange for the applications that potentiallycould be interesting to investigate further, and red for the applications that are not interesting toinvestigate further. Some applications focus on solving inefficiencies within district heating andsome on exploiting the benefits of blockchain. Eight applications are categorized with greenprioritization, and thus presented in more detail. To take into account that blockchain probablywill have a greater impact in the future, a future scenario was developed and used in the situationalanalysis for the applications. Furthermore, a framework was developed with the aim to be a toolfor a district heating company to utilize while considering if a blockchain implementation wouldbe beneficial, and if so, in what way. The framework is focused on district heating companies butcan be utilized by other actors as well.Our recommendation for a district heating company in Stockholm is to wait one or two yearswhile staying updated. Especially important for the companies are to stay updated on whether newblockchain standardizations will emerge in the energy sector. However, if a district heatingcompany want to initialize a blockchain project we advise the companies to start a pilot projectthat does not affect the current business model but has the potential to be scaled. Since theblockchain technology enhances collaboration, it is important to consider which partners shouldbe included and how the application can create value for all involved parties. However, due to theuncertainty of the technology, companies need to be well aware of that assumed created value maynot be reached as expected. Furthermore, district heating companies also need to bear in mindthat other parameters, for example additional technologies, policies or infrastructure systems, maybe necessary to implement in order to create value from a blockchain solution. Blockchain beskrivs ofta som något med ändlös teoretisk potential. I verkligheten är det dock svårtatt fastställa hur blockchain kan användas och vilka möjligheter blockchain kan skapa. Den osäkraframtiden för blockchain är en utmaning för många företag att förhålla sig till. Inte minst för storaetablerade företag då blockchain kan användas för att decentralisera en centraliseradmarknadsstruktur. Syftet med denna undersökande studie är att utvärdera blockchainapplikationerför ett fjärrvärmeföretag i Stockholm, för att förstå gynnsamma områden,nödvändiga kriterier vid genomförande och hur blockchain skulle kunna möjliggöra nyaaffärsmöjligheter på fjärrvärmemarknaden. För att uppfylla uppsatsens syfte genomfördes enlitteraturstudie och en empirisk studie. Inom litteraturstudien genomfördes en omfattandeundersökning av blockchain och fjärrvärme. Den empiriska studien bestod av 17 intervjuer, bådeinterna intervjuer med anställda från Stockholm Exergi och externa intervjuer med experter inomblockchain, fjärrvärme och energisektorn. Vidare genomfördes under slutfasen två workshops isamarbete med Stockholm Exergi, för att utvärdera och prioritera de skapade blockchainapplikationerna.Rapporten presenterar 32 blockchain-applikationer inom 10 olika områden inomfjärrvärmeindustrin. Applikationerna är kategoriserade efter sin potential i tre grupper, grön för deapplikationer som kan vara fördelaktiga för ett fjärrvärmeföretag och bör fortsätta undersökas,orange för de applikationer som sannolikt inte skulle vara fördelaktiga och röd för de applikationersom inte är intressanta för ett fjärrvärmeföretag att fortsätta undersöka. Vissa applikationerfokuserar på att lösa de ineffektiviteter som finns för fjärrvärme och vissa på att utnyttja fördelarnamed blockchain. Det åtta applikationer med grön prioritering presenteras mer detaljerat. Ettframtida scenario togs fram för att ta hänsyn till att blockchain sannolikt kommer att ha störrepåverkan i framtiden. Detta används som hjälpmedel när situationsanalysen för applikationernagenomförs. Dessutom utvecklades ett ramverk som har som syfte att vara ett verktyg för ettfjärrvärmeföretag att utnyttja när en blockchain implementering övervägs. Ramverket är inriktatpå fjärrvärmeföretag men kan även användas av andra aktörer.Vår rekommendation till ett fjärrvärmeföretag i Stockholm är att vänta ett eller två år, samtidigtsom de håller sig uppdaterade om marknadsförändringar för blockchain. Särskilt viktigt för ettfjärrvärmeföretag är att hålla sig uppdaterad om huruvida nya blockchain-standardiseringar uppstårinom energisektorn. Om ett fjärrvärmeföretag vill initiera ett blockchain-projekt, rekommenderarvi att starta med ett pilotprojekt som inte påverkar den nuvarande affärsmodellen, men harpotential att skalas. Eftersom blockchain-teknologin möjliggör samarbete är det viktigt attöverväga vilka partners som kan ingå i lösningen och hur applikationen kan skapa värde för allaberörda parter. Företag måste emellertid vara väl medvetna om att det förväntade värdet kanskeinte uppnås på grund av teknologins osäkerhet. Dessutom måste företagen också överväga attandra parametrar, till exempel andra teknologier, politik eller infrastruktur, är nödvändiga, för atten blockchain implementering ska skapa värde.