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We and others have shown that chronic alcohol consumption results in the induction of CYP2E1 in the liver. We have also detected for the first time such an induction in the mucosa of the small intestine and the colon. The overall induction of CYP2E1 shows interindividual variations and occurs already following a daily ingestion of 40 g of ethanol after 1 week. CYP2E1 induction is associated with an increased metabolism of ethanol resulting in the generation of reactive oxygen species (ROS) with direct and indirect carcinogenic action. ROS generated by CYP2E1 may lead to lipid peroxidation and lipid peroxidation products such as 4-hydroxynonenal bind to DNA forming highly carcinogenic exocyclic etheno DNA-adducts. The generation of these adducts has been shown in cell cultures in animal experiments as well as in human liver biopsies. CYP2E1 also metabolizes various procarcinogens present in diets and in tobacco smoke to their carcinogenic metabolites. Among these, nitrosamines seem to be the most important carcinogens. CYP2E1 also degrades retinoic acid and retinol to polar metabolites. Metabolism of retinoic acid not only results in the loss of retinoic acid promoting carcinogenesis through an increase in cell proliferation and dedifferentiation but also in generation of polar metabolites with apoptotic properties. We have shown that chlormethiazole is a specific CYP2E1 inhibitor in humans. Chlormethiazole inhibits CYP2E1 activity and thus blocks the formation of DNA adducts in cell cultures, restores retinoic acids in alcohol fed animals and inhibits chemical induced ethanol mediated hepatocarcinogenesis. Thus, there is increasing evidence that CYP2E1 induced by chronic alcohol consumption plays an important role in alcohol mediated carcinogenesis.

The goal of this paper is to prove the necessity for a more thorough consideration and more active use of the modern ICTs for the technological support for the practical implementation of the SDGs’ ecological block in the aspect of the increase of energy efficiency and environmental pollution control. The originality of this paper is as follows: it develops a proprietary methodology of evaluating the technical readiness (level of the development of ICTs) for implementing the ecological block of the SDGs, which envisage the increase of energy efficiency and the growth of environmental pollution control. The highest (but moderate) technological readiness to implement the ecological block of the SDGs among developed countries has been shown by Canada (14.42 points) and Denmark (11.03 points), among developing countries—China (7.72 points). As a result, it has been proved that UCTs are a perspective tool of the practical implementation of the ecological block of the SDGs, stimulating the increase of energy efficiency and improving the environment pollution control. For developed countries, it is recommended to increase the use of Big data and AI analytics by 90.36% and increase the use of ICTs in E-government by 89.74%. This will allow achieving the growth of energy efficiency by 8.28% and the decrease of environmental pollution by 28.41%. In developing countries, it is recommended to increase world robots distribution by 14.17% and increase the use of ICTs in E-government by 76.74%. This will allow increasing the energy efficiency by 16.77% and decreasing the level of environmental pollution by 15.54%. This paper’s contribution to literature (innovative aspect of research) consists in filling the gap of the uncertainty (underdevelopment) of the tools for practical implementation of the SDGs ecological block. This paper has demonstrated the substantial potential of ICTs in the stimulation of the growth of energy efficiency and reduction of environmental pollution in developed and developing countries.

A new technique for tracer gas experiments in turbomachinery environments is presented. Instead of ethylene or carbon dioxide - as in previous publications - carbon monoxide is used as tracer gas. The measuring device is a miniaturized solid state electrolyte sensor built into the head of a traverse probe. Due to the lack of extensive tubing the design of the probe allows a short response time of the measuring system. The sensor characteristics, the calibration of the probe and the data analysis are described, and an estimation of measurement uncertainties as well as results from measurements within a two-stage low pressure turbine featuring hot streak injection are provided. Despite different sensor characteristics the results show good agreement between measurements with different probes. The overall quality of the results indicates that the developed technique is a valuable tool for the investigation of migration and mixing.

ABSTRACTPhosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self‐reported alcohol consumption. Fifty‐seven alcohol‐dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean carbohydrate deficient transferrin (%CDT) was 8.68, and mean total ethanol intake in the last 7 days was 1653 g. PEth was measured in heparinized whole blood with a high‐pressure liquid chromatography method, while GGT, MCV and %CDT were measured using routine methods. PEth levels at day 1 of detoxification ranged between 0.63 and 26.95 µmol/l (6.22 mean, 4.70 median, SD 4.97). There were no false negatives at day 1. Sensitivities for the other biomarkers were 40.4% for MCV, 73.1% for GGT and 69.2% for %CDT, respectively. No gender differences were found for PEth levels at any time point. Our data suggest that PEth is (1) a suitable intermediate term marker of ethanol intake in both sexes; and (2) sensitivity is extraordinary high in alcohol dependent patients. The results add further evidence to the data that suggest that PEth has potential as a candidate for a sensitive and specific biomarker, which reflects longer‐lasting intake of higher amounts of alcohol and seemingly has the above mentioned certain advantages over traditional biomarkers.

The quantum dynamics of transport networks in the presence of noisy environments has recently received renewed attention with the discovery of long-lived coherences in different photosynthetic complexes. This experimental evidence has raised two fundamental questions: firstly, what are the mechanisms supporting long-lived coherences; and, secondly, how can we assess the possible functional role that the interplay of noise and quantum coherence might play in the seemingly optimal operation of biological systems under natural conditions? Here, we review recent results, illuminate them by means of two paradigmatic systems (the Fenna–Matthew–Olson complex and the light-harvesting complex LHII) and present new progress on both questions.

The last decade witnessed a rapid increase in the knowledge of the etiopathology and treatment of alcoholism. The current disease concept includes psychosocial and neurobiological foundations and consequences of alcoholism. Neurobiological research points to dispositional factors such as a low level of response to alcohol, which is partly heritable and seems to be associated with monoaminergic dysfunction and reduced GABAergic alcohol effects. Chronic alcohol intake stimulates counteradaptive neuroadaptation in central GABAergic and glutamatergic neurotransmission, which increases alcohol tolerance. Neuroadaptation to chronic alcohol effects is not immediately reversed during detoxification and can cause clinical withdrawal once alcohol intake is terminated. Sensitization of the dopaminergic and opioidergic reward system may contribute to alcohol craving and reduced control of alcohol intake. New treatment options include pharmacological approaches and indicate that behavior or motivational therapy and the attendance of patient groups may equally reduce the relapse risk.

Analysis of the relative expression of radiation responsive genes (previously shown to respond to gamma-radiations) after exposure of human lymphocytes to (211)At alpha-particles and the suitability of these genes as potential markers for alpha-biodosimetry.Lymphocytes isolated from the peripheral blood of two healthy human donors were exposed in triplicate for 30 min to different concentrations of Na(211)At at 37 degrees C (absorbed doses: 0.05-1.6 Gy). Following an incubation period (2 h), the total RNA was isolated from the irradiated lymphocytes and the relative expression of the following 18 genes was tested for change using TaqMan probes based upon the real-time quantitative polymerase chain reaction.BBC3 (B-cell lymphoma 2 binding component 3), CD69 (cluster of differentiation 69), CDKN1A (cyclin-dependent kinase inhibitor 1A), DUSP8 (dual specificity phosphatase 8) EGR1 (early growth response 1), EGR4 (early growth response 4), GADD45A (growth arrest and DNA-damage-inducible, alpha), GRAP (growth factor receptor-bound protein 2-related adaptor protein), LAP1B (TOR1AIP1; torsin A interacting protein 1), IFNG (interferon gamma), ISG20L1 (interferon-stimulated exonuclease gene 20kDa - like 1), c-JUN (jun oncogene), MDM2 (mouse double minute 2), PCNA (proliferating cell nuclear antigen), PLK2 (polo-like kinase 2), RND1 (rho family GTPase 1), TNFSF9 (tumour necrosis factor superfamily member 9) and TRAF4 (tumour necrosis factor receptor-associated factor 4).The expressions of the 18 genes, except GRAP, were up-regulated following exposure to alpha-radiation. A comparison of the results of two individuals tested here showed great variability. Dependence of gene expression upon alpha-dose was observed in certain dose intervals for BBC3 (R(2) = 0.61 [individual 1] / 0.81 [individual 2], significance 0.2-1.6 Gy [1] / 0.05-0.1 Gy [2]) and MDM2 (R(2) = 0.78/0.54; 0.8-1.6 Gy [1], 0.05-0.1 Gy [2]) genes in both individuals. Additionally, for individual 1 the dose dependence was found for the following genes: ISG20L1 (R(2) = 0.69, 0.05-0.1 Gy), PCNA (R(2) = 0.59, 0.8-1.6 Gy) and IFNG (R(2) = 0.74 up to 0.4 Gy, 0.05-0.1 Gy).Candidate genes for a possible role in future early-phase (2 h) alpha-biodosimetry are BBC3, ISG20L1, MDM2, PCNA and IFNG.

Abstract This paper offers a novel comprehensive conceptualization of Energy Technology Foresight (ETF) in emerging economies, including development trajectories, key methodological tools and elements, major challenges and weaknesses. ETF allows the emerging economies to provide the basis for government's energy policy, to create a common vision among the various actors and to strengthen RD integration of foresight outcomes in national and corporate strategic planning; constant revision of ETF methodology; dominance of economic, technological and security considerations; and the inability to catch-up with the energy technology development of the world leaders. Three case-studies (Russia, Brazil and China) of ETF in emerging markets are presented to illustrate and substantiate the conceptual approach. The paper is of interest for researchers that are involved in future studies, as well as decision-makers, who commission such studies and use their outcomes to advance the policy processes and documents.