Pinho, Paula Guedes de; Pinho, Paula Guedes de
Harvested from ORCID Public Data FilePinho, Paula Guedes de in OpenAIRE Ferreira, António C. Silva; Pinto, Manuela Mendes;Ferreira, António C. Silva
Harvested from ORCID Public Data FileFerreira, António C. Silva in OpenAIRE Benitez, Juan Gomez; +1 AuthorsBenitez, Juan Gomez
Harvested from ORCID Public Data FileBenitez, Juan Gomez in OpenAIRE Pinho, Paula Guedes de; Pinho, Paula Guedes de
Harvested from ORCID Public Data FilePinho, Paula Guedes de in OpenAIRE Ferreira, António C. Silva; Pinto, Manuela Mendes;Ferreira, António C. Silva
Harvested from ORCID Public Data FileFerreira, António C. Silva in OpenAIRE Benitez, Juan Gomez; Benitez, Juan Gomez
Harvested from ORCID Public Data FileBenitez, Juan Gomez in OpenAIRE Hogg, Tim; beta-Carotene and six xanthophylls (lutein, neoxanthin, violaxanthin, luteoxanthin, cryptoxanthin, and echinenone) have been identified and semiquantitatively or quantitatively determined in musts and port wines for the first time. An HPLC method was developed and compared with that of one based on thin layer cromatography with scanning densitometry. The most abundant carotenoids present in red grape varieties are beta-carotene and lutein. In wines, significant quantities of violaxanthin, luteoxanthin, and neoxanthin were found. This study was done with berries (skin and pulp), musts, and fortified wines. Some experiments were performed to follow carotenoid content from grapes to wines. Although the levels of beta-carotene and lutein found in fortified wines were lower than those found in musts, other xanthophylls, such as neoxanthin, violaxanthin, and luteoxanthin, exist in appreciable amounts in young ports.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/jf010515p&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu- Pinho, Paula Guedes de;
Pinho, Paula Guedes de
Harvested from ORCID Public Data FilePinho, Paula Guedes de in OpenAIRE Ferreira, António C. Silva; Pinto, Manuela Mendes;Ferreira, António C. Silva
Harvested from ORCID Public Data FileFerreira, António C. Silva in OpenAIRE Benitez, Juan Gomez; +1 AuthorsBenitez, Juan Gomez
Harvested from ORCID Public Data FileBenitez, Juan Gomez in OpenAIRE Pinho, Paula Guedes de; Pinho, Paula Guedes de
Harvested from ORCID Public Data FilePinho, Paula Guedes de in OpenAIRE Ferreira, António C. Silva; Pinto, Manuela Mendes;Ferreira, António C. Silva
Harvested from ORCID Public Data FileFerreira, António C. Silva in OpenAIRE Benitez, Juan Gomez; Benitez, Juan Gomez
Harvested from ORCID Public Data FileBenitez, Juan Gomez in OpenAIRE Hogg, Tim; beta-Carotene and six xanthophylls (lutein, neoxanthin, violaxanthin, luteoxanthin, cryptoxanthin, and echinenone) have been identified and semiquantitatively or quantitatively determined in musts and port wines for the first time. An HPLC method was developed and compared with that of one based on thin layer cromatography with scanning densitometry. The most abundant carotenoids present in red grape varieties are beta-carotene and lutein. In wines, significant quantities of violaxanthin, luteoxanthin, and neoxanthin were found. This study was done with berries (skin and pulp), musts, and fortified wines. Some experiments were performed to follow carotenoid content from grapes to wines. Although the levels of beta-carotene and lutein found in fortified wines were lower than those found in musts, other xanthophylls, such as neoxanthin, violaxanthin, and luteoxanthin, exist in appreciable amounts in young ports.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/jf010515p&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Berrang-Ford, L.; Dingle, K.;
Berrang-Ford, L.
Harvested from ORCID Public Data FileBerrang-Ford, L. in OpenAIRE Ford, J.D.; Lee, C.; +6 AuthorsFord, J.D.
Harvested from ORCID Public Data FileFord, J.D. in OpenAIRE Berrang-Ford, L.; Dingle, K.;Berrang-Ford, L.
Harvested from ORCID Public Data FileBerrang-Ford, L. in OpenAIRE Ford, J.D.; Lee, C.;Ford, J.D.
Harvested from ORCID Public Data FileFord, J.D. in OpenAIRE Lwasa, S.; Namanya, D.B.; Henderson, J.; Llanos Cuentas, Elmer Alejandro; Cárcamo Cavagnaro, César Paul Eugenio;Namanya, D.B.
Harvested from ORCID Public Data FileNamanya, D.B. in OpenAIRE Edge, V.; The potential impacts of climate change on human health in sub-Saharan Africa are wide-ranging, complex, and largely adverse. The region's Indigenous peoples are considered to be at heightened risk given their relatively poor health outcomes, marginal social status, and resource-based livelihoods; however, little attention has been given to these most vulnerable of the vulnerable. This paper contributes to addressing this gap by taking a bottom-up approach to assessing health vulnerabilities to climate change in two Batwa Pygmy communities in rural Uganda. Rapid Rural Appraisal and PhotoVoice field methods complemented by qualitative data analysis were used to identify key climate-sensitive, community-identified health outcomes, describe determinants of sensitivity at multiple scales, and characterize adaptive capacity of Batwa health systems. The findings stress the importance of human drivers of vulnerability and adaptive capacity and the need to address social determinants of health in order to reduce the potential disease burden of climate change.
84 citations 84 popularity Top 1% influence Top 10% impulse Top 10% 
Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.socscimed.2012.04.016&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Berrang-Ford, L.; Dingle, K.;
Berrang-Ford, L.
Harvested from ORCID Public Data FileBerrang-Ford, L. in OpenAIRE Ford, J.D.; Lee, C.; +6 AuthorsFord, J.D.
Harvested from ORCID Public Data FileFord, J.D. in OpenAIRE Berrang-Ford, L.; Dingle, K.;Berrang-Ford, L.
Harvested from ORCID Public Data FileBerrang-Ford, L. in OpenAIRE Ford, J.D.; Lee, C.;Ford, J.D.
Harvested from ORCID Public Data FileFord, J.D. in OpenAIRE Lwasa, S.; Namanya, D.B.; Henderson, J.; Llanos Cuentas, Elmer Alejandro; Cárcamo Cavagnaro, César Paul Eugenio;Namanya, D.B.
Harvested from ORCID Public Data FileNamanya, D.B. in OpenAIRE Edge, V.; The potential impacts of climate change on human health in sub-Saharan Africa are wide-ranging, complex, and largely adverse. The region's Indigenous peoples are considered to be at heightened risk given their relatively poor health outcomes, marginal social status, and resource-based livelihoods; however, little attention has been given to these most vulnerable of the vulnerable. This paper contributes to addressing this gap by taking a bottom-up approach to assessing health vulnerabilities to climate change in two Batwa Pygmy communities in rural Uganda. Rapid Rural Appraisal and PhotoVoice field methods complemented by qualitative data analysis were used to identify key climate-sensitive, community-identified health outcomes, describe determinants of sensitivity at multiple scales, and characterize adaptive capacity of Batwa health systems. The findings stress the importance of human drivers of vulnerability and adaptive capacity and the need to address social determinants of health in order to reduce the potential disease burden of climate change.
84 citations 84 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.socscimed.2012.04.016&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - EC| EARLYWARNING ,EC| BACCHUS Egbert H. van Nes;
Egbert H. van Nes
Harvested from ORCID Public Data FileEgbert H. van Nes in OpenAIRE
Marten Scheffer; Milena Holmgren;Marten Scheffer
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesMarten Scheffer in OpenAIRE Chi Xu; +3 Authors Egbert H. van Nes; Egbert H. van Nes
Harvested from ORCID Public Data FileEgbert H. van Nes in OpenAIRE Marten Scheffer; Milena Holmgren;Marten Scheffer
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesMarten Scheffer in OpenAIRE Chi Xu; Chi Xu; Arie Staal; Arie Staal
Harvested from ORCID Public Data FileArie Staal in OpenAIRE Stijn Hantson; Stijn Hantson
Harvested from ORCID Public Data FileStijn Hantson in OpenAIREAbstractAlthough canopy height has long been a focus of interest in ecology, it has remained difficult to study at large spatial scales. Recently, satellite‐borne LiDAR equipment produced the first systematic high resolution maps of vegetation height worldwide. Here we show that this new resource reveals three marked modes in tropical canopy height ~40, ~12, and ~2 m corresponding to forest, savanna, and treeless landscapes. The distribution of these modes is consistent with the often hypothesized forest‐savanna bistability and suggests that both states can be stable in areas with a mean annual precipitation between ~1,500 and ~2,000 mm. Although the canopy height states correspond largely to the much discussed tree cover states, there are differences, too. For instance, there are places with savanna‐like sparse tree cover that have a forest‐like high canopy, suggesting that rather than true savanna, those are thinned relicts of forest. This illustrates how complementary sets of remotely sensed indicators may provide increasingly sophisticated ways to study ecological phenomena at a global scale.
47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ecy.1470&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - EC| EARLYWARNING ,EC| BACCHUS Egbert H. van Nes;
Egbert H. van Nes
Harvested from ORCID Public Data FileEgbert H. van Nes in OpenAIRE Marten Scheffer; Milena Holmgren;Marten Scheffer
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesMarten Scheffer in OpenAIRE Chi Xu; +3 Authors Egbert H. van Nes; Egbert H. van Nes
Harvested from ORCID Public Data FileEgbert H. van Nes in OpenAIRE Marten Scheffer; Milena Holmgren;Marten Scheffer
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesMarten Scheffer in OpenAIRE Chi Xu; Chi Xu; Arie Staal; Arie Staal
Harvested from ORCID Public Data FileArie Staal in OpenAIRE Stijn Hantson; Stijn Hantson
Harvested from ORCID Public Data FileStijn Hantson in OpenAIREAbstractAlthough canopy height has long been a focus of interest in ecology, it has remained difficult to study at large spatial scales. Recently, satellite‐borne LiDAR equipment produced the first systematic high resolution maps of vegetation height worldwide. Here we show that this new resource reveals three marked modes in tropical canopy height ~40, ~12, and ~2 m corresponding to forest, savanna, and treeless landscapes. The distribution of these modes is consistent with the often hypothesized forest‐savanna bistability and suggests that both states can be stable in areas with a mean annual precipitation between ~1,500 and ~2,000 mm. Although the canopy height states correspond largely to the much discussed tree cover states, there are differences, too. For instance, there are places with savanna‐like sparse tree cover that have a forest‐like high canopy, suggesting that rather than true savanna, those are thinned relicts of forest. This illustrates how complementary sets of remotely sensed indicators may provide increasingly sophisticated ways to study ecological phenomena at a global scale.
47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ecy.1470&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Bassler, N.; Kantemiris, I.;
Bassler, N.
Harvested from ORCID Public Data FileBassler, N. in OpenAIRE Karaiskos, P.; Engelke, J.; +2 AuthorsKaraiskos, P.
Harvested from ORCID Public Data FileKaraiskos, P. in OpenAIRE Bassler, N.; Kantemiris, I.;Bassler, N.
Harvested from ORCID Public Data FileBassler, N. in OpenAIRE Karaiskos, P.; Engelke, J.; Holzscheiter, M.H.; Petersen, J.B.;Karaiskos, P.
Harvested from ORCID Public Data FileKaraiskos, P. in OpenAIREAntiprotons have been suggested as a possibly superior modality for radiotherapy, due to the energy released when antiprotons annihilate, which enhances the Bragg peak and introduces a high-LET component to the dose. However, concerns are expressed about the inferior lateral dose distribution caused by the annihilation products.We use the Monte Carlo code FLUKA to generate depth-dose kernels for protons, antiprotons, and carbon ions. Using these we then build virtual treatment plans optimized according to ICRU recommendations for the different beam modalities, which then are recalculated with FLUKA. Dose-volume histograms generated from these plans can be used to compare the different irradiations.The enhancement in physical and possibly biological dose from annihilating antiprotons can significantly lower the dose in the entrance channel; but only at the expense of a diffuse low dose background from long-range secondary particles. Lateral dose distributions are improved using active beam delivery methods, instead of flat fields.Dose-volume histograms for different treatment scenarios show that antiprotons have the potential to reduce the volume of normal tissue receiving medium to high dose, however, in the low dose region antiprotons are inferior to both protons and carbon ions. This limits the potential usage to situations where dose to normal tissue must be reduced as much as possible.
30 citations 30 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.radonc.2010.02.026&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Bassler, N.; Kantemiris, I.;
Bassler, N.
Harvested from ORCID Public Data FileBassler, N. in OpenAIRE Karaiskos, P.; Engelke, J.; +2 AuthorsKaraiskos, P.
Harvested from ORCID Public Data FileKaraiskos, P. in OpenAIRE Bassler, N.; Kantemiris, I.;Bassler, N.
Harvested from ORCID Public Data FileBassler, N. in OpenAIRE Karaiskos, P.; Engelke, J.; Holzscheiter, M.H.; Petersen, J.B.;Karaiskos, P.
Harvested from ORCID Public Data FileKaraiskos, P. in OpenAIREAntiprotons have been suggested as a possibly superior modality for radiotherapy, due to the energy released when antiprotons annihilate, which enhances the Bragg peak and introduces a high-LET component to the dose. However, concerns are expressed about the inferior lateral dose distribution caused by the annihilation products.We use the Monte Carlo code FLUKA to generate depth-dose kernels for protons, antiprotons, and carbon ions. Using these we then build virtual treatment plans optimized according to ICRU recommendations for the different beam modalities, which then are recalculated with FLUKA. Dose-volume histograms generated from these plans can be used to compare the different irradiations.The enhancement in physical and possibly biological dose from annihilating antiprotons can significantly lower the dose in the entrance channel; but only at the expense of a diffuse low dose background from long-range secondary particles. Lateral dose distributions are improved using active beam delivery methods, instead of flat fields.Dose-volume histograms for different treatment scenarios show that antiprotons have the potential to reduce the volume of normal tissue receiving medium to high dose, however, in the low dose region antiprotons are inferior to both protons and carbon ions. This limits the potential usage to situations where dose to normal tissue must be reduced as much as possible.
30 citations 30 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.radonc.2010.02.026&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu 34 citations 34 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1600-0838.2012.01467.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu34 citations 34 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1600-0838.2012.01467.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu- Verde C; di Prisco G; Giordano D; Russo R; +2 Authors
Giordano D
Harvested from ORCID Public Data FileGiordano D in OpenAIRE Verde C; di Prisco G; Giordano D; Russo R;Giordano D
Harvested from ORCID Public Data FileGiordano D in OpenAIRE Anderson D; Anderson D
Harvested from ORCID Public Data FileAnderson D in OpenAIRE Cowan D; Antarctic biota evolved under the influence of a suite of geological and climatic factors, including geographic isolation of the landmass and continental shelves, extremely low temperatures and seasonality. Current warming trends in the continent and surrounding oceans may trigger substantial shifts in community composition and biodiversity, impacting the dominance of cold-adapted over more generalist species. Until recently, the diversity of microorganisms in cold environments was investigated only in terms of distribution, with little attention to their functional roles in important environmental processes. The 'omic' methodologies now offer effective tools to investigate the relationships between biodiversity and ecosystem functioning and to understand the evolutionary principles of adaptation and tolerance/resistance to extreme conditions. In this review we summarise how cold temperatures affect the physiology of microorganisms and focus on the molecular mechanisms of cold adaptation revealed by recent biochemical and genetic studies.
26 citations 26 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/14888386.2012.706703&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Verde C; di Prisco G; Giordano D; Russo R; +2 Authors
Giordano D
Harvested from ORCID Public Data FileGiordano D in OpenAIRE Verde C; di Prisco G; Giordano D; Russo R;Giordano D
Harvested from ORCID Public Data FileGiordano D in OpenAIRE Anderson D; Anderson D
Harvested from ORCID Public Data FileAnderson D in OpenAIRE Cowan D; Antarctic biota evolved under the influence of a suite of geological and climatic factors, including geographic isolation of the landmass and continental shelves, extremely low temperatures and seasonality. Current warming trends in the continent and surrounding oceans may trigger substantial shifts in community composition and biodiversity, impacting the dominance of cold-adapted over more generalist species. Until recently, the diversity of microorganisms in cold environments was investigated only in terms of distribution, with little attention to their functional roles in important environmental processes. The 'omic' methodologies now offer effective tools to investigate the relationships between biodiversity and ecosystem functioning and to understand the evolutionary principles of adaptation and tolerance/resistance to extreme conditions. In this review we summarise how cold temperatures affect the physiology of microorganisms and focus on the molecular mechanisms of cold adaptation revealed by recent biochemical and genetic studies.
26 citations 26 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/14888386.2012.706703&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - D'aloisio, Génesis; Acevedo, María Belén; Macchione, Ana Fabiola;
D'aloisio, Génesis
Harvested from ORCID Public Data FileD'aloisio, Génesis in OpenAIRE Anunziata, Florencia; +1 AuthorsAnunziata, Florencia
Harvested from ORCID Public Data FileAnunziata, Florencia in OpenAIRE D'aloisio, Génesis; Acevedo, María Belén; Macchione, Ana Fabiola;D'aloisio, Génesis
Harvested from ORCID Public Data FileD'aloisio, Génesis in OpenAIRE Anunziata, Florencia; Molina, Juan Carlos;Anunziata, Florencia
Harvested from ORCID Public Data FileAnunziata, Florencia in OpenAIREIn rats, high ethanol doses during early postnatal life exert deleterious effects upon brain development that impact diverse social and cognitive abilities. This stage in development partially overlaps with the third human gestational trimester, commonly referred to as the brain growth spurt period. At this stage in development, human fetuses and rat neonates (postnatal days [PD] 3-9) exhibit relatively high respiratory rates that are affected by subteratogenic ethanol doses. Recent studies suggest conditioned breathing responses in the developing organism, given that there are explicit associations between exteroceptive stimuli and the state of ethanol intoxication. Furthermore, studies performed with near-term rat fetuses suggest heightened sensitivity to ethanol's motivational effects. The present study was meant to analyze the unconditioned effects of ethanol intoxication and the possible co-occurrence of learning mechanisms that can impact respiratory plasticity, and to analyze the preference for cues that signal the state of intoxication as well as the effects of the drug, related with motor stimulation. Neonatal rats were subjected to differential experiences with salient tactile cues explicitly paired or not paired with the effects of vehicle or ethanol (2.0 g/kg). A tactile discrimination procedure applied during PDs 3, 5, 7, and 9 allowed the identification of the emergence of ethanol-derived non-associative and associative learning processes that affect breathing plasticity, particularly when considering apneic disruptions. Ethanol was found to partially inhibit the disruptions that appeared to be intimately related with stressful circumstances defined by the experimental procedure. Tactile cues paired with the drug's effects were also observed to exert an inhibitory effect upon these breathing disruptions. The level of contingency between a given tactile cue and ethanol intoxication also resulted in significant changes in the probability of seeking this cue in a tactile preference test. In addition, the state of intoxication exerted motor-stimulating effects. When contrasting the data obtained via the analysis of the different dependent variables, it appears that most ethanol-derived changes are modulated by positive and/or negative (anti-anxiety) reinforcing effects of the drug. As a whole, the study indicates co-existence of ethanol-related functional changes in the developing organism that simultaneously affect respiratory plasticity and preference patterns elicited by stimuli that signal ethanol's motivational effects. These results emphasize the need to consider significant alterations due to minimal ethanol experiences that argue against "safe" levels of exposure in a critical stage in brain development.
6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2019.11.001&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - D'aloisio, Génesis; Acevedo, María Belén; Macchione, Ana Fabiola;
D'aloisio, Génesis
Harvested from ORCID Public Data FileD'aloisio, Génesis in OpenAIRE Anunziata, Florencia; +1 AuthorsAnunziata, Florencia
Harvested from ORCID Public Data FileAnunziata, Florencia in OpenAIRE D'aloisio, Génesis; Acevedo, María Belén; Macchione, Ana Fabiola;D'aloisio, Génesis
Harvested from ORCID Public Data FileD'aloisio, Génesis in OpenAIRE Anunziata, Florencia; Molina, Juan Carlos;Anunziata, Florencia
Harvested from ORCID Public Data FileAnunziata, Florencia in OpenAIREIn rats, high ethanol doses during early postnatal life exert deleterious effects upon brain development that impact diverse social and cognitive abilities. This stage in development partially overlaps with the third human gestational trimester, commonly referred to as the brain growth spurt period. At this stage in development, human fetuses and rat neonates (postnatal days [PD] 3-9) exhibit relatively high respiratory rates that are affected by subteratogenic ethanol doses. Recent studies suggest conditioned breathing responses in the developing organism, given that there are explicit associations between exteroceptive stimuli and the state of ethanol intoxication. Furthermore, studies performed with near-term rat fetuses suggest heightened sensitivity to ethanol's motivational effects. The present study was meant to analyze the unconditioned effects of ethanol intoxication and the possible co-occurrence of learning mechanisms that can impact respiratory plasticity, and to analyze the preference for cues that signal the state of intoxication as well as the effects of the drug, related with motor stimulation. Neonatal rats were subjected to differential experiences with salient tactile cues explicitly paired or not paired with the effects of vehicle or ethanol (2.0 g/kg). A tactile discrimination procedure applied during PDs 3, 5, 7, and 9 allowed the identification of the emergence of ethanol-derived non-associative and associative learning processes that affect breathing plasticity, particularly when considering apneic disruptions. Ethanol was found to partially inhibit the disruptions that appeared to be intimately related with stressful circumstances defined by the experimental procedure. Tactile cues paired with the drug's effects were also observed to exert an inhibitory effect upon these breathing disruptions. The level of contingency between a given tactile cue and ethanol intoxication also resulted in significant changes in the probability of seeking this cue in a tactile preference test. In addition, the state of intoxication exerted motor-stimulating effects. When contrasting the data obtained via the analysis of the different dependent variables, it appears that most ethanol-derived changes are modulated by positive and/or negative (anti-anxiety) reinforcing effects of the drug. As a whole, the study indicates co-existence of ethanol-related functional changes in the developing organism that simultaneously affect respiratory plasticity and preference patterns elicited by stimuli that signal ethanol's motivational effects. These results emphasize the need to consider significant alterations due to minimal ethanol experiences that argue against "safe" levels of exposure in a critical stage in brain development.
6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2019.11.001&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu 20 citations 20 popularity Top 10% influence Top 10% impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1600-051x.2008.01230.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu20 citations 20 popularity Top 10% influence Top 10% impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1600-051x.2008.01230.x&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu- Felipe Bastida; Irene F. Torres;
Felipe Bastida
Harvested from ORCID Public Data FileFelipe Bastida in OpenAIRE Manuela Andrés‐Abellán; Petr Baldrian; +8 AuthorsManuela Andrés‐Abellán
Harvested from ORCID Public Data FileManuela Andrés‐Abellán in OpenAIRE Felipe Bastida; Irene F. Torres;Felipe Bastida
Harvested from ORCID Public Data FileFelipe Bastida in OpenAIRE Manuela Andrés‐Abellán; Petr Baldrian;Manuela Andrés‐Abellán
Harvested from ORCID Public Data FileManuela Andrés‐Abellán in OpenAIRE Rubén López‐Mondéjar; Tomáš Větrovský; Hans H. Richnow;Rubén López‐Mondéjar
Harvested from ORCID Public Data FileRubén López‐Mondéjar in OpenAIRE Robert Starke; Sara Ondoño;Robert Starke
Harvested from ORCID Public Data FileRobert Starke in OpenAIRE Carlos García; Carlos García
Harvested from ORCID Public Data FileCarlos García in OpenAIRE Francisco R. López‐Serrano; Francisco R. López‐Serrano
Harvested from ORCID Public Data FileFrancisco R. López‐Serrano in OpenAIRE Nico Jehmlich; Nico Jehmlich
Harvested from ORCID Public Data FileNico Jehmlich in OpenAIREAbstractClimate change will affect semiarid ecosystems through severe droughts that increase the competition for resources in plant and microbial communities. In these habitats, adaptations to climate change may consist of thinning—that reduces competition for resources through a decrease in tree density and the promotion of plant survival. We deciphered the functional and phylogenetic responses of the microbial community to 60 years of drought induced by rainfall exclusion and how forest management affects its resistance to drought, in a semiarid forest ecosystem dominated byPinus halepensisMill. A multiOMICapproach was applied to reveal novel, community‐based strategies in the face of climate change. The diversity and the composition of the total and active soil microbiome were evaluated by 16SrRNAgene (bacteria) andITS(fungal) sequencing, and by metaproteomics. The microbial biomass was analyzed by phospholipid fatty acids (PLFAs), and the microbially mediated ecosystem multifunctionality was studied by the integration of soil enzyme activities related to the cycles of C, N, and P. The microbial biomass and ecosystem multifunctionality decreased in drought‐plots, as a consequence of the lower soil moisture and poorer plant development, but this decrease was more notable in unthinned plots. The structure and diversity of the total bacterial community was unaffected by drought at phylum and order level, but did so at genus level, and was influenced by seasonality. However, the total fungal community and the active microbial community were more sensitive to drought and were related to ecosystem multifunctionality. Thinning in plots without drought increased the active diversity while the total diversity was not affected. Thinning promoted the resistance of ecosystem multifunctionality to drought through changes in the active microbial community. The integration of total and active microbiome analyses avoids misinterpretations of the links between the soil microbial community and climate change.
170 citations 170 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/gcb.13790&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Felipe Bastida; Irene F. Torres;
Felipe Bastida
Harvested from ORCID Public Data FileFelipe Bastida in OpenAIRE Manuela Andrés‐Abellán; Petr Baldrian; +8 AuthorsManuela Andrés‐Abellán
Harvested from ORCID Public Data FileManuela Andrés‐Abellán in OpenAIRE Felipe Bastida; Irene F. Torres;Felipe Bastida
Harvested from ORCID Public Data FileFelipe Bastida in OpenAIRE Manuela Andrés‐Abellán; Petr Baldrian;Manuela Andrés‐Abellán
Harvested from ORCID Public Data FileManuela Andrés‐Abellán in OpenAIRE Rubén López‐Mondéjar; Tomáš Větrovský; Hans H. Richnow;Rubén López‐Mondéjar
Harvested from ORCID Public Data FileRubén López‐Mondéjar in OpenAIRE Robert Starke; Sara Ondoño;Robert Starke
Harvested from ORCID Public Data FileRobert Starke in OpenAIRE Carlos García; Carlos García
Harvested from ORCID Public Data FileCarlos García in OpenAIRE Francisco R. López‐Serrano; Francisco R. López‐Serrano
Harvested from ORCID Public Data FileFrancisco R. López‐Serrano in OpenAIRE Nico Jehmlich; Nico Jehmlich
Harvested from ORCID Public Data FileNico Jehmlich in OpenAIREAbstractClimate change will affect semiarid ecosystems through severe droughts that increase the competition for resources in plant and microbial communities. In these habitats, adaptations to climate change may consist of thinning—that reduces competition for resources through a decrease in tree density and the promotion of plant survival. We deciphered the functional and phylogenetic responses of the microbial community to 60 years of drought induced by rainfall exclusion and how forest management affects its resistance to drought, in a semiarid forest ecosystem dominated byPinus halepensisMill. A multiOMICapproach was applied to reveal novel, community‐based strategies in the face of climate change. The diversity and the composition of the total and active soil microbiome were evaluated by 16SrRNAgene (bacteria) andITS(fungal) sequencing, and by metaproteomics. The microbial biomass was analyzed by phospholipid fatty acids (PLFAs), and the microbially mediated ecosystem multifunctionality was studied by the integration of soil enzyme activities related to the cycles of C, N, and P. The microbial biomass and ecosystem multifunctionality decreased in drought‐plots, as a consequence of the lower soil moisture and poorer plant development, but this decrease was more notable in unthinned plots. The structure and diversity of the total bacterial community was unaffected by drought at phylum and order level, but did so at genus level, and was influenced by seasonality. However, the total fungal community and the active microbial community were more sensitive to drought and were related to ecosystem multifunctionality. Thinning in plots without drought increased the active diversity while the total diversity was not affected. Thinning promoted the resistance of ecosystem multifunctionality to drought through changes in the active microbial community. The integration of total and active microbiome analyses avoids misinterpretations of the links between the soil microbial community and climate change.
170 citations 170 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/gcb.13790&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Zoethout, R.W.M.; Iannone, R.; Bloem, B.R.; Palcza, J.; Murphy, G.; Chodakewitz, J.; Buntinx, A.; Gottesdiener, K.; Marsilio, S.; Rosen, L.; Dyck, K. van; Louis, E.D.; Cohen, A.F.; Schoemaker, R.C.; Tokita, S.; Sato, N.; Koblan, K.S.; Hargreaves, R.H.;
Schoemaker, R.C.
Harvested from ORCID Public Data FileSchoemaker, R.C. in OpenAIRE Renger, J.J.; Renger, J.J.
Harvested from ORCID Public Data FileRenger, J.J. in OpenAIRE Gerven, J.M.A. van; Gerven, J.M.A. van
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGerven, J.M.A. van in OpenAIREEssential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA) have demonstrated attenuating effects on ET in the harmaline rat model. In this double-blind, three-way cross-over, single-dose, double-dummy study the effects of 25 mg of a novel H3RIA (MK-0249) and a stable alcohol level (0.6 g L−1) were compared with placebo, in 18 patients with ET. Tremor was evaluated using laboratory tremorography, portable tremorography and a clinical rating scale. The Leeds Sleep Evaluation Questionnaire (LSEQ) and a choice reaction time (CRT) test were performed to evaluate potential effects on sleep and attention, respectively. A steady state of alcohol significantly diminished tremor as assessed by laboratory tremorography, portable tremorography and clinical ratings compared with placebo. A high single MK-0249 dose was not effective in reducing tremor, but caused significant effects on the LSEQ and the CRT test. These results suggest that treatment with a single dose of MK-0249 does not improve tremor in alcohol-responsive patients with ET, whereas stable levels of alcohol as a positive control reproduced the commonly reported tremor-diminishing effects of alcohol.
20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881111398685&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Zoethout, R.W.M.; Iannone, R.; Bloem, B.R.; Palcza, J.; Murphy, G.; Chodakewitz, J.; Buntinx, A.; Gottesdiener, K.; Marsilio, S.; Rosen, L.; Dyck, K. van; Louis, E.D.; Cohen, A.F.; Schoemaker, R.C.; Tokita, S.; Sato, N.; Koblan, K.S.; Hargreaves, R.H.;
Schoemaker, R.C.
Harvested from ORCID Public Data FileSchoemaker, R.C. in OpenAIRE Renger, J.J.; Renger, J.J.
Harvested from ORCID Public Data FileRenger, J.J. in OpenAIRE Gerven, J.M.A. van; Gerven, J.M.A. van
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGerven, J.M.A. van in OpenAIREEssential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA) have demonstrated attenuating effects on ET in the harmaline rat model. In this double-blind, three-way cross-over, single-dose, double-dummy study the effects of 25 mg of a novel H3RIA (MK-0249) and a stable alcohol level (0.6 g L−1) were compared with placebo, in 18 patients with ET. Tremor was evaluated using laboratory tremorography, portable tremorography and a clinical rating scale. The Leeds Sleep Evaluation Questionnaire (LSEQ) and a choice reaction time (CRT) test were performed to evaluate potential effects on sleep and attention, respectively. A steady state of alcohol significantly diminished tremor as assessed by laboratory tremorography, portable tremorography and clinical ratings compared with placebo. A high single MK-0249 dose was not effective in reducing tremor, but caused significant effects on the LSEQ and the CRT test. These results suggest that treatment with a single dose of MK-0249 does not improve tremor in alcohol-responsive patients with ET, whereas stable levels of alcohol as a positive control reproduced the commonly reported tremor-diminishing effects of alcohol.
20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881111398685&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
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