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AbstractThe co‐occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co‐occur. There is also an indication of a gender‐dependent effect; males are more likely to use alcohol to cope with chronic pain problems than females. Recently, a new conceptualization has emerged, proposing that the negative affective component of pain drives and maintains alcohol‐related behaviors. We studied in a longitudinal fashion alterations in alcohol drinking patterns and pain thresholds in a mouse model of chronic neuropathic pain in a sex‐dependent manner. Following partial denervation (spared nerve injury [SNI]), stimulus‐evoked pain responses were measured before chronic alcohol consumption, during drinking, during a deprivation phase, and following an episode of excessive drinking. During the course of alcohol drinking, we observed pronounced sex differences in pain thresholds. Male mice showed a strong increase in pain thresholds, suggesting an analgesic effect induced by alcohol over time, an effect that was not observed in female mice. SNI mice did not differ from sham‐operated controls in baseline alcohol consumption. However, following a deprivation phase and the reintroduction of ethanol, male SNI mice but not female mice showed more pronounced excessive drinking than controls. Finally, we observed decreased central ethanol sensitivity in male SNI mice but not in females. Together with our finding, that ethanol is able to decrease a pain‐induced negative affective memory we come to following conclusion. We propose that a lower sensitivity to the intoxicating effects of alcohol together with the ability of alcohol to reduce the negative affective component of pain may explain the higher co‐occurrence of AUD in male chronic pain patients.

Ethanol is the most common human teratogen, and its consumption during pregnancy can produce a wide range of abnormalities in infants known as fetal alcohol spectrum disorder (FASD). The major characteristics of FASD can be divided into: (i) growth retardation, (ii) craniofacial abnormalities, and (iii) central nervous system (CNS) dysfunction. FASD is the most common cause of nongenetic mental retardation in Western countries. Although the underlying molecular mechanisms of ethanol neurotoxicity are not completely determined, the induction of oxidative stress is believed to be one central process linked to the development of the disease. Currently, there is no known effective strategy for prevention (other than alcohol avoidance) or treatment. In the present review we will provide the state of art in the evidence for the use of antioxidants as a potential therapeutic strategy for the treatment using whole‐embryo and culture cells models of FASD. We conclude that the imbalance of the intracellular redox state contributes to the pathogenesis observed in FASD models, and we suggest that antioxidant therapy can be considered a new efficient strategy to mitigate the effects of prenatal ethanol exposure. Birth Defects Research (Part A) 103:163–177, 2015. © 2014 Wiley Periodicals, Inc.

Background and ObjectiveThe root surface topography exerts a major influence on clinical attachment and bacterial recolonization after root planing. In‐vitro topographic studies have yielded variable results, and clinical studies are necessary to compare root surface topography after planing with current ultrasonic devices and with traditional manual instrumentation. The aim of this study was to compare the topography of untreated single‐rooted teeth planed in vivo with a curette, a piezoelectric ultrasonic (PU) scraper or a vertically oscillating ultrasonic (VOU) scraper.Material and MethodsIn a randomized experimental trial of 19 patients, 44 single‐rooted teeth were randomly assigned to one of four groups for: no treatment; manual root planing with a curette; root planing with a PU scraper; or root planing with a VOU scraper. Post‐treatment, the teeth were extracted and their topography was analyzed in 124 observations with white‐light confocal microscopy, measuring the roughness parameters arithmetic average height, root‐mean‐square roughness, maximum height of peaks, maximum depth of valleys, absolute height, skewness and kurtosis.ResultsThe roughness values arithmetic average height and root‐mean‐square roughness were similar after each treatment and lower than after no treatment ( p < 0.05). Absolute height was lower in the VOU group than in the untreated ( p = 0.0026) and PU (p = 0.045) groups. Surface morphology was similar after the three treatments and was less irregular than in the untreated group. Values for the remaining roughness parameters were similar among all treatment groups ( p > 0.05).ConclusionBoth ultrasonic devices reduce the roughness, producing a similar topography to that observed after manual instrumentation with a curette, to which they appear to represent a valid alternative.

In theoretical ecology, recent field experiments on terrestrial vertebrates observe that the predator-prey interaction can not only be curtailed by direct consumption but also governed by some indirect effects such as the fear of predator which may reduce the reproduction rate of prey individuals. Based on this fact, we have developed and explored the predator-prey interaction with the influence of both cost and benefit of fear effect (felt by prey). A Holling type III functional response with the effect of habitat complexity has been taken to consume the prey biomass. Positivity and boundedness of the studied system prove that the model is well-behaved. The uniform persistence of the studied system is derived analytically under some parametric restrictions. The feasibility conditions and stability criteria of each equilibrium points have been discussed. Next, we have exhibited the existence of Hopf-bifurcation around the interior equilibrium point. Our mathematical analyses show that habitat complexity and fear effect both have a great impact on the persistence of the predator biomass. Furthermore, we have investigated the effect of breeding delay parameter such that the system loses its stability behaviour and enters into a limit cycle oscillations through Hopf-bifurcation. Numerical simulations are illustrated to verify our analytical outcomes. Numerically, we have perturbed the death rates of prey and predator species with Gaussian white noise terms due to the effects of environmental fluctuations.

Dietary change presents an opportunity to meet the dual challenges of non-communicable diseases and the effects of climate change in China. Based on a food survey and reviewed data sets, we linked nutrient composition and carbon footprint data by aggregating 1950 types of foods into 28 groups. Nine dietary scenarios for both men and women were modeled based on the current diet and latest National Program for Food and Nutrition. Linear uncertainty optimization was used to produce diets meeting the Chinese Dietary Reference Intakes for adults aged 18-50years while minimizing carbon footprints. The theoretical optimal diet reduced daily footprints by 46%, but this diet was unrealistic due to limited food diversity. Constrained by acceptability, the optimal diet reduced the daily carbon footprints by 7-28%, from 3495 to 2517-3252g CO2e, for men and by 5-26%, from 3075 to 2280-2917g CO2e, for women. Dietary changes for adults are capable of benefiting China in terms of the considerable footprint reduction of 53-222Mt.CO2eyear-1, when magnified based on the Chinese population, which is the largest worldwide. Seven of eight scenarios showed that reductions in meat consumption resulted in greater reductions in greenhouse gas emissions. However, dramatic reductions in meat consumption may produce smaller reductions in emissions, as the consumption of other ingredients increases to compensate for the nutrients in meat. A trade-off between poultry and other meats (beef, pork, and lamb) is usually observed, and rice, which is a popular food in China, was the largest contributor to carbon footprint reductions. Our findings suggest that changing diets for climate change mitigation and human health is possible in China, though the per capital mitigation potential is slight lower than that in developed economies of France, Spain, Sweden, and New Zealand.

Deaths from the effects of alcohol intoxication are encountered routinely in forensic practice. In an important number of cases difficulty may arise in interpreting the significance of results obtained in the autopsy. In clinical practice biochemical markers, particularly serum gamma-glutamyl-transpeptidase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST), carbohydrate-deficient transferrin (CDT), and erythrocyte mean corpuscular volume are used to diagnose heavy alcohol consumption. CDT is used as a reliable and specific marker. In postmortem diagnosis, because of the difficulty in interpreting blood alcohol levels and relatively non-specific pathological features, biochemical compounds have been studied for use as possible markers. The aim of this study was to evaluate the usefulness of the postmortem determination of CDT in vitreous humor as a confirmation of antemortem alcoholism. CDT levels were studied in 66 male cadavers with a mean age of 55.9 years (S.D. 17.0, range 22-87 years) with a mean postmortem interval of 17.9 h (S.D. 11.4, range 4-72 h). Cases were assigned to two diagnostic groups according to the antemortem diagnosis of alcoholism. Statistically significant differences were found for CDT and ALT concentrations between the two diagnostic groups. The highest vitreous humor levels of CDT and ALT were obtained in the group of cases with a previous diagnosis of alcoholism. Our results suggest that vitreous humor CDT levels are useful in cases where the postmortem diagnosis of alcoholism is hindered by the non-specificity of data.

Installations that burn fossil fuels to generate power may represent a health problem due to the toxic substances which they release into the environment.To investigate whether there might be excess mortality due to tumors of lung, larynx and bladder in the population residing near Spanish combustion installations included in the European Pollutant Emission Register.Ecologic study designed to model sex-specific standardized mortality ratios for the above three tumors in Spanish towns, over the period 1994-2003. Population exposure to pollution was estimated on the basis of distance from town of residence to pollution source. Using mixed Poisson regression models, we analyzed: risk of dying from cancer in a 5-kilometer zone around installations that commenced operations before 1990; effect of type of fuel used; and risk gradient within a 50-kilometer radius of such installations.Excess mortality (relative risk, 95% confidence interval) was detected in the vicinity of pre-1990 installations for lung cancer (1.066, 1.041-1.091 in the overall population; 1.084, 1.057-1.111 in men), and laryngeal cancer among men (1.067, 0.992-1.148). Lung cancer displayed excess mortality for all types of fuel used, whereas in laryngeal and bladder cancer, the excess was associated with coal-fired industries. There was a risk gradient effect in the proximity of a number of installations.Our results could support the hypothesis of an association between risk of lung, laryngeal and bladder cancer mortality and proximity to Spanish combustion installations.

Previous studies have demonstrated that there is a bidirectional modulation of ethanol-induced locomotion produced by drugs that regulate brain catalase activity. In the present study we have assessed the effect in rats of intraperitoneal, intraventricular or intracraneal administration of the catalase inhibitor sodium azide in the locomotor changes observed after ethanol (1 g/kg) administration. Our results show that sodium azide prevents the effects of ethanol in rats locomotion not only when sodium azide was systemically administered but also when it was intraventricularly injected, then confirming that the interaction between catalase and ethanol takes place in Central Nervous System (CNS). Even more interestingly, the same results were observed when sodium azide administration was restricted to the hypothalamic Arcuate nucleus (ARC), a brain region which has one of the highest levels of expression of catalase. Therefore, the results of the present study not only confirm a role for brain catalase in the mediation of ethanol-induced locomotor changes in rodents but also point to the ARC as a major neuroanatomical location for this interaction. These results are in agreement with our reports showing that ethanol-induced locomotor changes are clearly dependent of the ARC integrity and, especially of the POMc-synthesising neurons of this nucleus. According to these data we propose a model in which ethanol oxidation via catalase could produce acetaldehyde into the ARC and to promote a release of beta-endorphins that would activate opioid receptors to produce locomotion and other ethanol-induced neurobehavioural changes.