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description Publicationkeyboard_double_arrow_right Article , Journal 2021 Italy, Spain, SpainPublisher:Wiley John D. Salamone; Mercè Correa; Laura López-Cruz; Elio Maria Gioachino Acquas; Simona Porru; Simona Porru; Carla Carratalá-Ros;BackgroundCaffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)‐related markers in accumbens (Acb), and Acb DA is involved in voluntary locomotion and locomotor sensitization. The present study determined whether caffeine can affect locomotion induced by acute and repeated ethanol administration in adult male CD‐1 mice.MethodsAcute administration of caffeine (7.5 to 30.0 mg/kg) was evaluated for its effects on acute ethanol‐induced (1.5 to 3.5 g/kg) changes in open‐field horizontal locomotion, supported rearing, and rearing not supported by the wall. DA receptor‐dependent phosphorylation markers were assessed: extracellular signal‐regulated kinase (pERK), and dopamine‐and cAMP‐regulated phosphoprotein Mr32kDa phosphorylated at threonine 75 site (pDARPP‐32‐Thr75) in Acb core and shell. Acutely administered caffeine was also evaluated in ethanol‐sensitized (1.5 g/kg) mice.ResultsAcute ethanol decreased both types of rearing. Caffeine increased supported rearing but did not block ethanol ‐induced decreases in rearing. Both substances increased horizontal locomotion in a biphasic manner, and caffeine potentiated ethanol‐induced locomotion. Although ethanol administered repeatedly induced sensitization of locomotion and unsupported rearing, acute administration of caffeine to ethanol‐sensitized mice in an ethanol‐free state resulted in blunted stimulant effects compared with those seen in ethanol‐naïve mice. Ethanol increased pERK immunoreactivity in both subregions of the Acb, but coadministration with caffeine blunted this increase. There were no effects on pDARPP‐32(Thr75) immunoreactivity.ConclusionsThe present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant or ataxic effects. Moreover, our results show that caffeine has less activating effects in ethanol‐sensitized animals.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 29visibility views 29 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 Italy, Spain, SpainPublisher:Wiley John D. Salamone; Mercè Correa; Laura López-Cruz; Elio Maria Gioachino Acquas; Simona Porru; Simona Porru; Carla Carratalá-Ros;BackgroundCaffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)‐related markers in accumbens (Acb), and Acb DA is involved in voluntary locomotion and locomotor sensitization. The present study determined whether caffeine can affect locomotion induced by acute and repeated ethanol administration in adult male CD‐1 mice.MethodsAcute administration of caffeine (7.5 to 30.0 mg/kg) was evaluated for its effects on acute ethanol‐induced (1.5 to 3.5 g/kg) changes in open‐field horizontal locomotion, supported rearing, and rearing not supported by the wall. DA receptor‐dependent phosphorylation markers were assessed: extracellular signal‐regulated kinase (pERK), and dopamine‐and cAMP‐regulated phosphoprotein Mr32kDa phosphorylated at threonine 75 site (pDARPP‐32‐Thr75) in Acb core and shell. Acutely administered caffeine was also evaluated in ethanol‐sensitized (1.5 g/kg) mice.ResultsAcute ethanol decreased both types of rearing. Caffeine increased supported rearing but did not block ethanol ‐induced decreases in rearing. Both substances increased horizontal locomotion in a biphasic manner, and caffeine potentiated ethanol‐induced locomotion. Although ethanol administered repeatedly induced sensitization of locomotion and unsupported rearing, acute administration of caffeine to ethanol‐sensitized mice in an ethanol‐free state resulted in blunted stimulant effects compared with those seen in ethanol‐naïve mice. Ethanol increased pERK immunoreactivity in both subregions of the Acb, but coadministration with caffeine blunted this increase. There were no effects on pDARPP‐32(Thr75) immunoreactivity.ConclusionsThe present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant or ataxic effects. Moreover, our results show that caffeine has less activating effects in ethanol‐sensitized animals.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 29visibility views 29 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 Spain, Italy, SpainPublisher:Elsevier BV Correa M; Salamone JD; Segovia KN; Pardo M; LONGONI, ROSANNA; SPINA, LILIANA; Peana AT; VINCI, STEFANIA; ACQUAS, ELIO MARIA GIOACHINO;Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol.
UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu104 citations 104 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
visibility 21visibility views 21 Powered bymore_vert UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 Spain, Italy, SpainPublisher:Elsevier BV Correa M; Salamone JD; Segovia KN; Pardo M; LONGONI, ROSANNA; SPINA, LILIANA; Peana AT; VINCI, STEFANIA; ACQUAS, ELIO MARIA GIOACHINO;Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol.
UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu104 citations 104 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
visibility 21visibility views 21 Powered bymore_vert UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017 ItalyPublisher:Frontiers Media SA Alessandra T. Peana; María J. Sánchez-Catalán; Lucia Hipólito; Michela Rosas; Simona Porru; Federico Bennardini; Patrizia Romualdi; Francesca F. Caputi; Sanzio Candeletti; Ana Polache; Luis Granero; Elio Acquas; Elio Acquas;After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.
Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 46 citations 46 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017 ItalyPublisher:Frontiers Media SA Alessandra T. Peana; María J. Sánchez-Catalán; Lucia Hipólito; Michela Rosas; Simona Porru; Federico Bennardini; Patrizia Romualdi; Francesca F. Caputi; Sanzio Candeletti; Ana Polache; Luis Granero; Elio Acquas; Elio Acquas;After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.
Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 46 citations 46 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014 ItalyPublisher:Elsevier BV ROSAS, MICHELA; Zaru, A; Sabariego, M; Giugliano, V; CARBONI, EZIO; Colombo, G; ACQUAS, ELIO MARIA GIOACHINO;Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats have been selectively bred for opposite ethanol preference and consumption; sP rats represent a validated experimental tool to model several aspects of excessive ethanol drinking in humans. Phosphorylated Extracellular signal-Regulated Kinase (pERK) in dopamine-rich terminal areas plays a critical role in several psychopharmacological effects of addictive drugs, including ethanol. This study was aimed at investigating whether ethanol-elicited ERK activation may differ in key brain areas of ethanol-naïve sP and sNP rats. To this end, the effects of ethanol (0, 0.5, 1, and 2 g/kg, administered intra-gastrically [i.g.]) on ERK phosphorylation were assessed by pERK immunohistochemistry in the shell (AcbSh) and core (AcbC) of the nucleus accumbens (Acb) as well as in the prelimbic (PrL) and infralimbic (IL) prefrontal cortex (PFCx), in the bed nucleus of stria terminalis (BSTL) and in the central nucleus of the amygdala (CeA). Ethanol (1 g/kg) significantly increased pERK immunoreactivity in AcbSh and AcbC of sP but not sNP rats. Conversely, ethanol failed to affect pERK expression in PrL and IL PFCx as well as in BSTL and CeA of both sP and sNP rats. These results suggest that selective breeding of these rat lines results in differential effects of acute ethanol on ERK phosphorylation in brain regions critical for the psychopharmacological effects of ethanol.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014 ItalyPublisher:Elsevier BV ROSAS, MICHELA; Zaru, A; Sabariego, M; Giugliano, V; CARBONI, EZIO; Colombo, G; ACQUAS, ELIO MARIA GIOACHINO;Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats have been selectively bred for opposite ethanol preference and consumption; sP rats represent a validated experimental tool to model several aspects of excessive ethanol drinking in humans. Phosphorylated Extracellular signal-Regulated Kinase (pERK) in dopamine-rich terminal areas plays a critical role in several psychopharmacological effects of addictive drugs, including ethanol. This study was aimed at investigating whether ethanol-elicited ERK activation may differ in key brain areas of ethanol-naïve sP and sNP rats. To this end, the effects of ethanol (0, 0.5, 1, and 2 g/kg, administered intra-gastrically [i.g.]) on ERK phosphorylation were assessed by pERK immunohistochemistry in the shell (AcbSh) and core (AcbC) of the nucleus accumbens (Acb) as well as in the prelimbic (PrL) and infralimbic (IL) prefrontal cortex (PFCx), in the bed nucleus of stria terminalis (BSTL) and in the central nucleus of the amygdala (CeA). Ethanol (1 g/kg) significantly increased pERK immunoreactivity in AcbSh and AcbC of sP but not sNP rats. Conversely, ethanol failed to affect pERK expression in PrL and IL PFCx as well as in BSTL and CeA of both sP and sNP rats. These results suggest that selective breeding of these rat lines results in differential effects of acute ethanol on ERK phosphorylation in brain regions critical for the psychopharmacological effects of ethanol.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 Spain, Spain, ItalyPublisher:SAGE Publications Porru Simona; Maccioni Riccardo; Bassareo Valentina; Peana Alessandra Tiziana; Salamone John D; Correa Mercé; Acquas Elio;Background: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored. Aims: To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning. Results: In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined. Conclusions: The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 40visibility views 40 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 Spain, Spain, ItalyPublisher:SAGE Publications Porru Simona; Maccioni Riccardo; Bassareo Valentina; Peana Alessandra Tiziana; Salamone John D; Correa Mercé; Acquas Elio;Background: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored. Aims: To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning. Results: In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined. Conclusions: The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 40visibility views 40 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 ItalyPublisher:Wiley Authors: Elio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; +2 AuthorsElio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; Michela Rosas; Valentina Giugliano;BackgroundAlcoholism is a neuroadaptive disorder, and the understanding of the mechanisms of the high rates of relapse, which characterize it, represents one of the most demanding challenges in alcoholism and addiction research. The extracellular signal–regulated kinase (ERK) is an intracellular kinase, critical for neuroplasticity in the adult brain that is suggested to play a fundamental role in the molecular mechanisms underlying drug addiction and relapse. We previously observed that a nonessential amino acid, l‐cysteine, significantly decreases oral ethanol (EtOH) self‐administration, reinstatement of EtOH‐drinking behavior, and EtOH self‐administration break point.MethodsHere, we tested whether l‐cysteine can affect the ability of EtOH priming to induce reinstatement of EtOH‐seeking behavior. In addition, we determined the ability of EtOH priming to induce ERK phosphorylation as well as the ability of l‐cysteine to affect reinstatement‐elicited ERK activation. To these purposes, Wistar rats were trained to nose‐poke for a 10% v/v EtOH solution. After stable drug‐taking behavior was obtained, nose‐poking for EtOH was extinguished, and reinstatement of drug seeking, as well as reinstatement‐elicited pERK, was determined after an oral, noncontingent, priming of EtOH (0.08 g/kg). Rats were pretreated with either saline or l‐cysteine (80 to 120 mg/kg) 30 minutes before testing for reinstatement.ResultsThe findings of this study confirm that the noncontingent delivery of a nonpharmacologically active dose of EtOH to rats, whose previous self‐administration behavior had been extinguished, results in significant reinstatement into EtOH‐seeking behavior. In addition, the results indicate that reinstatement selectively activates ERK phosphorylation in the shell of the nucleus accumbens (Acb) and that pretreatment with l‐cysteine reduces either reinstatement of EtOH seeking and reinstatement‐elicited pERK in the AcbSh.ConclusionsAltogether, these results indicate that l‐cysteine could be an effective pharmacological agent for the prevention of behavioral and molecular correlates of EtOH‐primed reinstatement of EtOH seeking and that the shell of the Acb represents a critical neural substrate for priming‐elicited reinstatement mechanisms involving ERK phosphorylation.
UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 ItalyPublisher:Wiley Authors: Elio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; +2 AuthorsElio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; Michela Rosas; Valentina Giugliano;BackgroundAlcoholism is a neuroadaptive disorder, and the understanding of the mechanisms of the high rates of relapse, which characterize it, represents one of the most demanding challenges in alcoholism and addiction research. The extracellular signal–regulated kinase (ERK) is an intracellular kinase, critical for neuroplasticity in the adult brain that is suggested to play a fundamental role in the molecular mechanisms underlying drug addiction and relapse. We previously observed that a nonessential amino acid, l‐cysteine, significantly decreases oral ethanol (EtOH) self‐administration, reinstatement of EtOH‐drinking behavior, and EtOH self‐administration break point.MethodsHere, we tested whether l‐cysteine can affect the ability of EtOH priming to induce reinstatement of EtOH‐seeking behavior. In addition, we determined the ability of EtOH priming to induce ERK phosphorylation as well as the ability of l‐cysteine to affect reinstatement‐elicited ERK activation. To these purposes, Wistar rats were trained to nose‐poke for a 10% v/v EtOH solution. After stable drug‐taking behavior was obtained, nose‐poking for EtOH was extinguished, and reinstatement of drug seeking, as well as reinstatement‐elicited pERK, was determined after an oral, noncontingent, priming of EtOH (0.08 g/kg). Rats were pretreated with either saline or l‐cysteine (80 to 120 mg/kg) 30 minutes before testing for reinstatement.ResultsThe findings of this study confirm that the noncontingent delivery of a nonpharmacologically active dose of EtOH to rats, whose previous self‐administration behavior had been extinguished, results in significant reinstatement into EtOH‐seeking behavior. In addition, the results indicate that reinstatement selectively activates ERK phosphorylation in the shell of the nucleus accumbens (Acb) and that pretreatment with l‐cysteine reduces either reinstatement of EtOH seeking and reinstatement‐elicited pERK in the AcbSh.ConclusionsAltogether, these results indicate that l‐cysteine could be an effective pharmacological agent for the prevention of behavioral and molecular correlates of EtOH‐primed reinstatement of EtOH seeking and that the shell of the Acb represents a critical neural substrate for priming‐elicited reinstatement mechanisms involving ERK phosphorylation.
UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2014 Italy, Spain, SpainPublisher:Frontiers Media SA Funded by:NIH | Effort-related Functions ...NIH| Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsAuthors: Correa M; ACQUAS, ELIO MARIA GIOACHINO; Salamone JD;As with many events in the history of science, the development of the hypothesis that acetaldehyde is a plausible psychoactive substance with specific central effects (not related to its toxic- ity) has not been either incremental or progressive. Rather, it has evolved through a process of fits and starts. Initial clinical obser- vations suggesting that accumulation of acetaldehyde could be used as a therapy for alcoholism did not lead to a highly effective treatment, and in fact, it was noted early on that small amounts of ethanol consumed under these conditions (i.e., blockade of aldehyde dehydrogenase) could be perceived as being even more pleasurable ( Chevens, 1953 ). Although some laboratory data in animals appeared at that time ( Carpenter and Macleod, 1952), it took a decade for the pre-clinical studies to focus on the poten- tial importance of acetaldehyde. Since Myers proposed in the late 60’s that acetaldehyde could be a mediator of some of the effects of ethanol ( Myers and Veale, 1969), advances in this field have gone through a push-pull process.
Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
visibility 36visibility views 36 download downloads 27 Powered bymore_vert Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2014 Italy, Spain, SpainPublisher:Frontiers Media SA Funded by:NIH | Effort-related Functions ...NIH| Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsAuthors: Correa M; ACQUAS, ELIO MARIA GIOACHINO; Salamone JD;As with many events in the history of science, the development of the hypothesis that acetaldehyde is a plausible psychoactive substance with specific central effects (not related to its toxic- ity) has not been either incremental or progressive. Rather, it has evolved through a process of fits and starts. Initial clinical obser- vations suggesting that accumulation of acetaldehyde could be used as a therapy for alcoholism did not lead to a highly effective treatment, and in fact, it was noted early on that small amounts of ethanol consumed under these conditions (i.e., blockade of aldehyde dehydrogenase) could be perceived as being even more pleasurable ( Chevens, 1953 ). Although some laboratory data in animals appeared at that time ( Carpenter and Macleod, 1952), it took a decade for the pre-clinical studies to focus on the poten- tial importance of acetaldehyde. Since Myers proposed in the late 60’s that acetaldehyde could be a mediator of some of the effects of ethanol ( Myers and Veale, 1969), advances in this field have gone through a push-pull process.
Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
visibility 36visibility views 36 download downloads 27 Powered bymore_vert Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Journal 2021 Italy, Spain, SpainPublisher:Wiley John D. Salamone; Mercè Correa; Laura López-Cruz; Elio Maria Gioachino Acquas; Simona Porru; Simona Porru; Carla Carratalá-Ros;BackgroundCaffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)‐related markers in accumbens (Acb), and Acb DA is involved in voluntary locomotion and locomotor sensitization. The present study determined whether caffeine can affect locomotion induced by acute and repeated ethanol administration in adult male CD‐1 mice.MethodsAcute administration of caffeine (7.5 to 30.0 mg/kg) was evaluated for its effects on acute ethanol‐induced (1.5 to 3.5 g/kg) changes in open‐field horizontal locomotion, supported rearing, and rearing not supported by the wall. DA receptor‐dependent phosphorylation markers were assessed: extracellular signal‐regulated kinase (pERK), and dopamine‐and cAMP‐regulated phosphoprotein Mr32kDa phosphorylated at threonine 75 site (pDARPP‐32‐Thr75) in Acb core and shell. Acutely administered caffeine was also evaluated in ethanol‐sensitized (1.5 g/kg) mice.ResultsAcute ethanol decreased both types of rearing. Caffeine increased supported rearing but did not block ethanol ‐induced decreases in rearing. Both substances increased horizontal locomotion in a biphasic manner, and caffeine potentiated ethanol‐induced locomotion. Although ethanol administered repeatedly induced sensitization of locomotion and unsupported rearing, acute administration of caffeine to ethanol‐sensitized mice in an ethanol‐free state resulted in blunted stimulant effects compared with those seen in ethanol‐naïve mice. Ethanol increased pERK immunoreactivity in both subregions of the Acb, but coadministration with caffeine blunted this increase. There were no effects on pDARPP‐32(Thr75) immunoreactivity.ConclusionsThe present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant or ataxic effects. Moreover, our results show that caffeine has less activating effects in ethanol‐sensitized animals.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 29visibility views 29 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 Italy, Spain, SpainPublisher:Wiley John D. Salamone; Mercè Correa; Laura López-Cruz; Elio Maria Gioachino Acquas; Simona Porru; Simona Porru; Carla Carratalá-Ros;BackgroundCaffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)‐related markers in accumbens (Acb), and Acb DA is involved in voluntary locomotion and locomotor sensitization. The present study determined whether caffeine can affect locomotion induced by acute and repeated ethanol administration in adult male CD‐1 mice.MethodsAcute administration of caffeine (7.5 to 30.0 mg/kg) was evaluated for its effects on acute ethanol‐induced (1.5 to 3.5 g/kg) changes in open‐field horizontal locomotion, supported rearing, and rearing not supported by the wall. DA receptor‐dependent phosphorylation markers were assessed: extracellular signal‐regulated kinase (pERK), and dopamine‐and cAMP‐regulated phosphoprotein Mr32kDa phosphorylated at threonine 75 site (pDARPP‐32‐Thr75) in Acb core and shell. Acutely administered caffeine was also evaluated in ethanol‐sensitized (1.5 g/kg) mice.ResultsAcute ethanol decreased both types of rearing. Caffeine increased supported rearing but did not block ethanol ‐induced decreases in rearing. Both substances increased horizontal locomotion in a biphasic manner, and caffeine potentiated ethanol‐induced locomotion. Although ethanol administered repeatedly induced sensitization of locomotion and unsupported rearing, acute administration of caffeine to ethanol‐sensitized mice in an ethanol‐free state resulted in blunted stimulant effects compared with those seen in ethanol‐naïve mice. Ethanol increased pERK immunoreactivity in both subregions of the Acb, but coadministration with caffeine blunted this increase. There were no effects on pDARPP‐32(Thr75) immunoreactivity.ConclusionsThe present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant or ataxic effects. Moreover, our results show that caffeine has less activating effects in ethanol‐sensitized animals.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 29visibility views 29 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2021Data sources: Repositori Institucional de la Universitat Jaume IAlcoholism Clinical and Experimental ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/acer.14553&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 Spain, Italy, SpainPublisher:Elsevier BV Correa M; Salamone JD; Segovia KN; Pardo M; LONGONI, ROSANNA; SPINA, LILIANA; Peana AT; VINCI, STEFANIA; ACQUAS, ELIO MARIA GIOACHINO;Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol.
UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu104 citations 104 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
visibility 21visibility views 21 Powered bymore_vert UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 Spain, Italy, SpainPublisher:Elsevier BV Correa M; Salamone JD; Segovia KN; Pardo M; LONGONI, ROSANNA; SPINA, LILIANA; Peana AT; VINCI, STEFANIA; ACQUAS, ELIO MARIA GIOACHINO;Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol.
UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu104 citations 104 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
visibility 21visibility views 21 Powered bymore_vert UnissResearch arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2012Data sources: Repositori Institucional de la Universitat Jaume INeuroscience & Biobehavioral ReviewsArticle . 2012 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neubiorev.2011.07.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017 ItalyPublisher:Frontiers Media SA Alessandra T. Peana; María J. Sánchez-Catalán; Lucia Hipólito; Michela Rosas; Simona Porru; Federico Bennardini; Patrizia Romualdi; Francesca F. Caputi; Sanzio Candeletti; Ana Polache; Luis Granero; Elio Acquas; Elio Acquas;After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.
Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 46 citations 46 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017 ItalyPublisher:Frontiers Media SA Alessandra T. Peana; María J. Sánchez-Catalán; Lucia Hipólito; Michela Rosas; Simona Porru; Federico Bennardini; Patrizia Romualdi; Francesca F. Caputi; Sanzio Candeletti; Ana Polache; Luis Granero; Elio Acquas; Elio Acquas;After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.
Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 46 citations 46 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Frontiers in Behavio... arrow_drop_down UnissResearchArticle . 2017License: CC BYFull-Text: https://iris.uniss.it/bitstream/11388/174614/5/Peana%20Sanchez%20Catalan%20et%20al.%2c%202017.pdfData sources: UnissResearchadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2017.00081&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014 ItalyPublisher:Elsevier BV ROSAS, MICHELA; Zaru, A; Sabariego, M; Giugliano, V; CARBONI, EZIO; Colombo, G; ACQUAS, ELIO MARIA GIOACHINO;Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats have been selectively bred for opposite ethanol preference and consumption; sP rats represent a validated experimental tool to model several aspects of excessive ethanol drinking in humans. Phosphorylated Extracellular signal-Regulated Kinase (pERK) in dopamine-rich terminal areas plays a critical role in several psychopharmacological effects of addictive drugs, including ethanol. This study was aimed at investigating whether ethanol-elicited ERK activation may differ in key brain areas of ethanol-naïve sP and sNP rats. To this end, the effects of ethanol (0, 0.5, 1, and 2 g/kg, administered intra-gastrically [i.g.]) on ERK phosphorylation were assessed by pERK immunohistochemistry in the shell (AcbSh) and core (AcbC) of the nucleus accumbens (Acb) as well as in the prelimbic (PrL) and infralimbic (IL) prefrontal cortex (PFCx), in the bed nucleus of stria terminalis (BSTL) and in the central nucleus of the amygdala (CeA). Ethanol (1 g/kg) significantly increased pERK immunoreactivity in AcbSh and AcbC of sP but not sNP rats. Conversely, ethanol failed to affect pERK expression in PrL and IL PFCx as well as in BSTL and CeA of both sP and sNP rats. These results suggest that selective breeding of these rat lines results in differential effects of acute ethanol on ERK phosphorylation in brain regions critical for the psychopharmacological effects of ethanol.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014 ItalyPublisher:Elsevier BV ROSAS, MICHELA; Zaru, A; Sabariego, M; Giugliano, V; CARBONI, EZIO; Colombo, G; ACQUAS, ELIO MARIA GIOACHINO;Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats have been selectively bred for opposite ethanol preference and consumption; sP rats represent a validated experimental tool to model several aspects of excessive ethanol drinking in humans. Phosphorylated Extracellular signal-Regulated Kinase (pERK) in dopamine-rich terminal areas plays a critical role in several psychopharmacological effects of addictive drugs, including ethanol. This study was aimed at investigating whether ethanol-elicited ERK activation may differ in key brain areas of ethanol-naïve sP and sNP rats. To this end, the effects of ethanol (0, 0.5, 1, and 2 g/kg, administered intra-gastrically [i.g.]) on ERK phosphorylation were assessed by pERK immunohistochemistry in the shell (AcbSh) and core (AcbC) of the nucleus accumbens (Acb) as well as in the prelimbic (PrL) and infralimbic (IL) prefrontal cortex (PFCx), in the bed nucleus of stria terminalis (BSTL) and in the central nucleus of the amygdala (CeA). Ethanol (1 g/kg) significantly increased pERK immunoreactivity in AcbSh and AcbC of sP but not sNP rats. Conversely, ethanol failed to affect pERK expression in PrL and IL PFCx as well as in BSTL and CeA of both sP and sNP rats. These results suggest that selective breeding of these rat lines results in differential effects of acute ethanol on ERK phosphorylation in brain regions critical for the psychopharmacological effects of ethanol.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.alcohol.2014.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 Spain, Spain, ItalyPublisher:SAGE Publications Porru Simona; Maccioni Riccardo; Bassareo Valentina; Peana Alessandra Tiziana; Salamone John D; Correa Mercé; Acquas Elio;Background: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored. Aims: To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning. Results: In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined. Conclusions: The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 40visibility views 40 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 Spain, Spain, ItalyPublisher:SAGE Publications Porru Simona; Maccioni Riccardo; Bassareo Valentina; Peana Alessandra Tiziana; Salamone John D; Correa Mercé; Acquas Elio;Background: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored. Aims: To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning. Results: In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined. Conclusions: The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction.
Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 40visibility views 40 Powered bymore_vert Archivio istituziona... arrow_drop_down Repositori Institucional de la Universitat Jaume IArticle . 2020Data sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881120965892&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 ItalyPublisher:Wiley Authors: Elio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; +2 AuthorsElio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; Michela Rosas; Valentina Giugliano;BackgroundAlcoholism is a neuroadaptive disorder, and the understanding of the mechanisms of the high rates of relapse, which characterize it, represents one of the most demanding challenges in alcoholism and addiction research. The extracellular signal–regulated kinase (ERK) is an intracellular kinase, critical for neuroplasticity in the adult brain that is suggested to play a fundamental role in the molecular mechanisms underlying drug addiction and relapse. We previously observed that a nonessential amino acid, l‐cysteine, significantly decreases oral ethanol (EtOH) self‐administration, reinstatement of EtOH‐drinking behavior, and EtOH self‐administration break point.MethodsHere, we tested whether l‐cysteine can affect the ability of EtOH priming to induce reinstatement of EtOH‐seeking behavior. In addition, we determined the ability of EtOH priming to induce ERK phosphorylation as well as the ability of l‐cysteine to affect reinstatement‐elicited ERK activation. To these purposes, Wistar rats were trained to nose‐poke for a 10% v/v EtOH solution. After stable drug‐taking behavior was obtained, nose‐poking for EtOH was extinguished, and reinstatement of drug seeking, as well as reinstatement‐elicited pERK, was determined after an oral, noncontingent, priming of EtOH (0.08 g/kg). Rats were pretreated with either saline or l‐cysteine (80 to 120 mg/kg) 30 minutes before testing for reinstatement.ResultsThe findings of this study confirm that the noncontingent delivery of a nonpharmacologically active dose of EtOH to rats, whose previous self‐administration behavior had been extinguished, results in significant reinstatement into EtOH‐seeking behavior. In addition, the results indicate that reinstatement selectively activates ERK phosphorylation in the shell of the nucleus accumbens (Acb) and that pretreatment with l‐cysteine reduces either reinstatement of EtOH seeking and reinstatement‐elicited pERK in the AcbSh.ConclusionsAltogether, these results indicate that l‐cysteine could be an effective pharmacological agent for the prevention of behavioral and molecular correlates of EtOH‐primed reinstatement of EtOH seeking and that the shell of the Acb represents a critical neural substrate for priming‐elicited reinstatement mechanisms involving ERK phosphorylation.
UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2012 ItalyPublisher:Wiley Authors: Elio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; +2 AuthorsElio Maria Gioachino Acquas; Marta Sabariego; Marta Sabariego; Alessandra Tiziana Peana; Michela Rosas; Valentina Giugliano;BackgroundAlcoholism is a neuroadaptive disorder, and the understanding of the mechanisms of the high rates of relapse, which characterize it, represents one of the most demanding challenges in alcoholism and addiction research. The extracellular signal–regulated kinase (ERK) is an intracellular kinase, critical for neuroplasticity in the adult brain that is suggested to play a fundamental role in the molecular mechanisms underlying drug addiction and relapse. We previously observed that a nonessential amino acid, l‐cysteine, significantly decreases oral ethanol (EtOH) self‐administration, reinstatement of EtOH‐drinking behavior, and EtOH self‐administration break point.MethodsHere, we tested whether l‐cysteine can affect the ability of EtOH priming to induce reinstatement of EtOH‐seeking behavior. In addition, we determined the ability of EtOH priming to induce ERK phosphorylation as well as the ability of l‐cysteine to affect reinstatement‐elicited ERK activation. To these purposes, Wistar rats were trained to nose‐poke for a 10% v/v EtOH solution. After stable drug‐taking behavior was obtained, nose‐poking for EtOH was extinguished, and reinstatement of drug seeking, as well as reinstatement‐elicited pERK, was determined after an oral, noncontingent, priming of EtOH (0.08 g/kg). Rats were pretreated with either saline or l‐cysteine (80 to 120 mg/kg) 30 minutes before testing for reinstatement.ResultsThe findings of this study confirm that the noncontingent delivery of a nonpharmacologically active dose of EtOH to rats, whose previous self‐administration behavior had been extinguished, results in significant reinstatement into EtOH‐seeking behavior. In addition, the results indicate that reinstatement selectively activates ERK phosphorylation in the shell of the nucleus accumbens (Acb) and that pretreatment with l‐cysteine reduces either reinstatement of EtOH seeking and reinstatement‐elicited pERK in the AcbSh.ConclusionsAltogether, these results indicate that l‐cysteine could be an effective pharmacological agent for the prevention of behavioral and molecular correlates of EtOH‐primed reinstatement of EtOH seeking and that the shell of the Acb represents a critical neural substrate for priming‐elicited reinstatement mechanisms involving ERK phosphorylation.
UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu17 citations 17 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert UnissResearch arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2012 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2012.01877.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2014 Italy, Spain, SpainPublisher:Frontiers Media SA Funded by:NIH | Effort-related Functions ...NIH| Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsAuthors: Correa M; ACQUAS, ELIO MARIA GIOACHINO; Salamone JD;As with many events in the history of science, the development of the hypothesis that acetaldehyde is a plausible psychoactive substance with specific central effects (not related to its toxic- ity) has not been either incremental or progressive. Rather, it has evolved through a process of fits and starts. Initial clinical obser- vations suggesting that accumulation of acetaldehyde could be used as a therapy for alcoholism did not lead to a highly effective treatment, and in fact, it was noted early on that small amounts of ethanol consumed under these conditions (i.e., blockade of aldehyde dehydrogenase) could be perceived as being even more pleasurable ( Chevens, 1953 ). Although some laboratory data in animals appeared at that time ( Carpenter and Macleod, 1952), it took a decade for the pre-clinical studies to focus on the poten- tial importance of acetaldehyde. Since Myers proposed in the late 60’s that acetaldehyde could be a mediator of some of the effects of ethanol ( Myers and Veale, 1969), advances in this field have gone through a push-pull process.
Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
visibility 36visibility views 36 download downloads 27 Powered bymore_vert Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2014 Italy, Spain, SpainPublisher:Frontiers Media SA Funded by:NIH | Effort-related Functions ...NIH| Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsAuthors: Correa M; ACQUAS, ELIO MARIA GIOACHINO; Salamone JD;As with many events in the history of science, the development of the hypothesis that acetaldehyde is a plausible psychoactive substance with specific central effects (not related to its toxic- ity) has not been either incremental or progressive. Rather, it has evolved through a process of fits and starts. Initial clinical obser- vations suggesting that accumulation of acetaldehyde could be used as a therapy for alcoholism did not lead to a highly effective treatment, and in fact, it was noted early on that small amounts of ethanol consumed under these conditions (i.e., blockade of aldehyde dehydrogenase) could be perceived as being even more pleasurable ( Chevens, 1953 ). Although some laboratory data in animals appeared at that time ( Carpenter and Macleod, 1952), it took a decade for the pre-clinical studies to focus on the poten- tial importance of acetaldehyde. Since Myers proposed in the late 60’s that acetaldehyde could be a mediator of some of the effects of ethanol ( Myers and Veale, 1969), advances in this field have gone through a push-pull process.
Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
visibility 36visibility views 36 download downloads 27 Powered bymore_vert Frontiers in Behavio... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2014Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2014License: CC BYData sources: Repositori Institucional de la Universitat Jaume Iadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnbeh.2014.00249&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu