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Innovation Districts are rising as the banners of the new urban, economic, and social paradigm and as a solution to the renaissance of inner cities since they expedite the creation and commercialization of new ideas which leverage the city goals and its technologic and economic attributes. The configuration of accurate indicators to measure the degree of achievement of the innovation district goals is one of the main requirements to ensure district proper development. Even when the study of innovation districts is a topic that is increasingly under study, little is still known about the insight, and it is still needed tools that favor their evolution and development. The aim of this paper is two-fold: on the one hand, it seeks to collect and analyze the indicators that have been used in literature to measure the degree of maturity over the course of the 20-year existence of the 22@Barcelona, an area of innovation that transformed an old industrial district into a knowledge-based one. On the other hand, guided by the four dimensions of the Knowledge Base Urban Development theory and the main actors that make up Triple Helix approach, the paper designs a framework of indicators in the four spheres that shape the regeneration of the district, that is, urban, economic, social and governance. As we shall see, a total of 47 indicators are proposed, indicating for each of them: the environment in which it is applied, the main purpose to which it responds, and the main actor with the greatest power of action over it.

In recent years, solar price drops and regulations have helped residential users to invest in grid-connected photovoltaic (PV) facilities. In Spain, a novel law promotes self-consumption by discounting electricity fed into the grid from the utility bill. However, the performance of PV-based facilities depends on diverse factors. The contribution of this paper is to evaluate the techno-economic performance of such installations for different considerations linked to the Spanish law. A simulation model is used to examine different representative cities, load profiles and alternative objectives: maximising profitability and self-sufficiency. For profit maximisation, results show that load profile variations entail PV size changes up to 5 kWp for the same location, together with huge economic and self-sufficiency differences. In contrast, the solar radiation and compensation rate have a more limited influence. For self-sufficiency maximisation, the economic performance drops close to EUR 0, as benefits are used to double the PV size, buy batteries and reach close to 70% self-sufficiency. Finally, a sensitivity analysis shows a limited impact of the utility tariff and the technology cost on the PV size, but a relevant influence on the benefits. These results can help investors and families to quantify the risks and benefits of domestic self-consumption facilities.

Anaerobic digestion is a commercial reality for several kinds of waste. Nonetheless, anaerobic digestion of single substrates presents some drawbacks linked to substrate characteristics. Anaerobic co-digestion, the simultaneous digestion of two or more substrates, is a feasible option to overcome the drawbacks of mono-digestion and to improve plants economic feasibility. At present, since 50% of the publication has been published in the last two years, anaerobic co-digestion can be considered the most relevant topic within anaerobic digestion research. The aim of this paper is to present a review of the achievements and perspectives of anaerobic co-digestion within the period 2010-2013, which represents a continuation of the previous review made by the authors [3]. In the present review, the publications have been classified as for the main substrate, i.e., animal manures, sewage sludge and biowaste. Animal manures stand as the most reported substrate, agro-industrial waste and the organic fraction of the municipal solid waste being the most reported co-substrate. Special emphasis has been made to the effect of the co-digestion over digestate quality, since land application seems to be the best option for digestate recycling. Traditionally, anaerobic co-digestion between sewage sludge and the organic fraction of the municipal solid waste has been the most reported co-digestion mixture. However, between 2010 and 2013 the publications dealing with fats, oils and greases and algae as sludge co-substrate have increased. This is because both co-substrates can be obtained at the same wastewater treatment plant. In contrast, biowaste as a main substrate has not been as studied as manures or sewage sludge. Finally, three interdisciplinary sections have been written for addressing novelty aspects in anaerobic co-digestion, i.e., pre-treatments, microbial dynamics and modeling. However, much effort needs to be done in these later aspects to better understand and predict anaerobic co-digestion.

The aim of this study was to estimate the carbon footprint (CFP) of constructed wetlands for winery wastewater treatment. In particular, a constructed wetland scenario was compared to the previous scenario (third-party management) and to an activated sludge system. CFP considered both indirect and direct greenhouse gas (GHG) emissions measured on-site. Moreover, an economic analysis of the considered scenarios was also addressed. The results showed that the constructed wetland scenario had the lowest CFP (1.2 kg CO2eq mwater-3), while the third-party management was the worst scenario (52 kg CO2eq mwater-3) followed by the activated sludge system (4.5 kg CO2eq mwater-3). This was mainly due to the high GHG emissions generated by wastewater and sludge transportation as well as chemicals and electricity consumption in the third-party and activated sludge scenarios compared to the constructed wetlands. In terms of costs, the constructed wetland system was shown to be a low-cost technology which would reduce the capital, operation and maintenance costs associated with winery wastewater treatment up to 50% and 98%, respectively. Finally, constructed wetlands are low-cost and environmentally friendly technologies which constitute a sustainable alternative to conventional solutions for winery wastewater treatment. This research was funded by the European Regional Development Fund (Interreg V-B SUDOE programme, WETWINE SOE1/P5/E0300). Laura Flores is grateful to the Ministry of Education and Culture (MECD) (Spain) for the FPU16/01491 scholarship. Joan García, Marianna Garfí and Laura Flores are grateful to the Government of Catalonia (Consolidated Research Group 2017 SGR 1029). Marianna Garfí acknowledges the Spanish Ministry of Economy and Competitiveness (RYC-2016-20059). The authors are grateful for the support provided by the WETWINE consortium and the wineries involved in this study. Peer Reviewed

A quantitative study was carried out with the aim of analyzing the perspective of the students in relation to the factors that have influenced quality teaching during the confinement period resulting from the SARS-CoV-2 pandemic. To do this, an ad hoc questionnaire was designed and conducted in the months of June–July 2020. The sample consisted of 893 people who were studying at various Spanish universities. The results show little diversity in teaching methodologies; virtual teaching was carried out with the same parameters as face-to-face teaching. The role of the student body was one of passivity, consisting of little interaction with the teachers. Although it is true that there were no difficulties in following the course, there was limited attention paid to the emotional well-being of the students. Amongst the conclusions garnered significant, we point out the need to develop the adaptability of university teaching staff to unforeseen situations, as well as a continuing reflection on the model used in the teaching process mediated by digital technologies and the importance of promoting greater autonomy and self-regulation during learning.

The effects of chronic ethanol treatment on intravenous glucose tolerance and insulin response in non-pregnant and pregnant rats were studied. Basal circulating glucose, insulin, and ketone bodies levels were also determined during the treatment. Basal blood glucose concentration did not change during the ethanol treatment whereas plasma insulin levels were lower at the beginning of gestation and at the 15 and 18 days of pregnancy in ethanol-treated rats. Blood beta-OH-butyrate levels were higher and acetoacetate concentrations unchanged during the ethanol treatment, resulting in augmented beta-OH-butyrate/acetoacetate ratio. Intravenous glucose tolerance was not modified in ethanol-treated rats whilst the associated insulin response was lower in both non-pregnant and pregnant ethanol-treated rats. Data show that ethanol treatment during pregnancy alters glucose-insulin relationships despite being associated with unchanged maternal glycemia.

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third cause of cancer-related death. Despite therapeutic advances, the overall survival of patients with HCC has not significantly improved in the last two decades. In the majority of the cases there is underlying cirrhosis, so the prognosis of HCC depends on not only tumor stage but also liver function. There is not a widely accepted HCC staging system. In our group we have developed a new staging classification that stratifies HCC patients into four major categories and simultaneously links staging with treatment. Patients at an early stage are those who present with an asymptomatic single HCC with a maximum diameter of 5 cm or up to three nodules each less than 3 cm. They will benefit from curative therapies, including resection, liver transplantation (LT), and percutaneous ablation. Patients exceeding these limits, but who are free of cancer-related symptoms and vascular invasion or extrahepatic spread fit into the intermediate stage and may benefit from palliation with chemoembolization. The patients with mild cancer-related symptoms and/or vascular invasion or extrahepatic spread are included in the advanced stage. In this stage there is not effective therapy, and these patients may profit from new therapies in the setting of randomized controlled trials (RCTs). Finally, the patients with severe cancer-related symptoms or great tumor burden belong to the terminal stage and only benefit from symptomatic treatment. © 2006 Elsevier Ireland Ltd. All rights reserved.