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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Alexander-Haw, Abigail; Dütschke, Elisabeth; Helferich, Marvin; Preuß, Sabine; +1 Authors

    This dataset and codebook correspond to the initial round of survey data gathered in France in 2022, within the project FULFILL - Fundamental Decarbonisation Through Sufficiency By Lifestyle Changes. As part of Work Package 3 (WP3) in the FULFILL project, we collected quantitative data from six countries: Denmark, France, Germany, Italy, Latvia, and India. In the first round of the survey, we recruited a representative sample of approximately 2000 households in each country, taking into account both the individual and household perspectives. The survey includes a quantitative assessment of the carbon footprint in various domains of life, such as housing, mobility, and diet. In addition to this, the survey also measures socio-economic factors such as age, gender, income, education, household size, life stage, and political orientation. Furthermore, the survey includes measures of quality of life, encompassing aspects such as health and well-being, environmental quality, financial security, and comfort.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: Datacite
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: ZENODO
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Naegel, Paul;

    Au milieu des années 1950, Électricité de France, opérateur largement dominant dans la production et la distribution d'énergie sous forme électrique, du fait de l'avenir encore incertain du nucléaire civil, a opté, avec la construction de l''usine marémotrice sur l'estuaire de la Rance, pour une énergie renouvelable d'un type encore inusité à l'échelle industrielle. Cette centrale hydroélectrique, en de nombreux points particulièrement innovante, inaugurée en 1967, sera pourtant la seule de ce type réalisée en France. Elle est toujours en service. A un moment où la question des énergies renouvelables est pour le moins à l'ordre du jour, même si les réalisations restent modestes en termes industriels en France, il nous a semblé intéressant de mobiliser l'histoire d'une réalisation qui a, depuis des lustres, produit ce que nous considérons comme une bifurcation énergétique, dont l'avenir reste largement à construire.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ INRIA a CCSD electro...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ INRIA a CCSD electro...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    The abstract gives an overview over geographical, environmental and political changes in Tunisia from 2000 to 2018. The focus is on wildfire evolution and climate change processes in Tunisia. L' augmentation des incendies de forêts, la littoralisation, la californisation, risque de voir les espèces invasives se multiplier-telle fut le résultat de l'étude GTZ « Stratégie nationale d'adaptation de l'agriculture tunisienne et des écosystèmes aux changements climatiques» sottie en 2007 - et dont l'auteur fut le responsable du groupe d'analyse des écosystèmes. Le diagnostic concernant l'évolution de risques de feux de forêts fut assez alarmant : « Nous pensons que les changements climatiques vont accroître considérablement les risques de feux de végétation. Le Nord de la Tunisie serait particulièrement affecté par cette évolution car en plus de l'augmentation des températures le stock combustible pourrait considérablement augmenter ... La progression des incendies, surtout de grands incendies nécessitant des grands stocks de combustibles, dans le Nord tunisien, peut avoir des conséquences particulièrement négatives pour toute l'économie tunisienne car elle met en danger les systèmes des barrages et l'approvisionnement en eau d'une grande partie de la Tunisie. (Neff, C. 2007., p.37-38)».Dix ans après la sortie de l' étude l' auteur essai d'évaluerà quel point les scenarios dessinés dans l'étude de 2007 sont encore d'actualité en Tunisie contemporaine (2017/18). Est-ce que les changements politiques, la révolution tunisienne de 2011 et la phase transitoire vers une démocratielibérale qui suivait cette révolution, ont pesé sur l' état de l'environnement. Quel est la tendance des fréquences d'incendies de forêts des dernières années en Tunisie. Est-ce que les pouvoirs politiques actuelsprennent en considération les «risques» que les changements climatiques peuvent engendrer pour les écosystèmes& les paysages tunisiennes. Le tout sera complété, par une vue globale d'extérieure sur la Tunisie-l'auteur est bloggeur sur le Monde.fr depuis 2009, et il suit les évènements tunisiens avec attention. Quel est la vue d'un bloggeur franco-allemande sur une Tunisie changeante et confronté à des défis politiques considérable: la phase de transition démocratique, les changements climatiques, mais aussi le futur des terres intérieures tunisiennes, les paysages ruraux à l'abandonet dont la jeunesse cherche à fuir vers des destinations meilleurs ...

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ KITopen (Karlsruhe I...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://dx.doi.org/10.5445/ir/...
    Conference object . 2018
    Data sources: Datacite
    https://dx.doi.org/10.5445/ir/...
    Conference object . 2018
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ KITopen (Karlsruhe I...arrow_drop_down
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      https://dx.doi.org/10.5445/ir/...
      Conference object . 2018
      Data sources: Datacite
      https://dx.doi.org/10.5445/ir/...
      Conference object . 2018
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Gohin, Alexandre; Gohin, Alexandre;

    [Paper in French] The European public policy in favor of the biodiesel consumption is highly debated. Available estimates of the induced land use changes conclude that this policy is inefficient to reduce emissions of GreenHouse Gas. We show that the crop yield evolutions in these estimates are significantly lower than the observed and expected evolutions. This difference is directly related to biased calibration choice of behavioral parameters. We show using the GTAP-BIO framework that a consistent calibration of these parameters leads to a strong reduction (by around 80% in the long run) of the land use changes and induced emissions.

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    ProdInra
    External research report . 2013
    License: CC BY SA
    Data sources: ProdInra
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://dx.doi.org/10.22004/ag...
    Other literature type . 2013
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hyper Article en Lig...arrow_drop_down
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      ProdInra
      External research report . 2013
      License: CC BY SA
      Data sources: ProdInra
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      https://dx.doi.org/10.22004/ag...
      Other literature type . 2013
      Data sources: Datacite
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    Authors: Tomassetti, Paolo;

    Cet article explique pourquoi et comment différents paradigmes énergétiques et leur économie politique ont affecté les institutions de relations professionnelles et industrielles au fil du temps. S’appuyant sur une nouvelle littérature qui considère les sources d’énergie comme un référent analytique central, sont discutés et présentés les contextes économiques reposant successivement sur le charbon, le pétrole, le nucléaire et le solaire. Alors que la possibilité d’un contrôle de la main-d’œuvre sur l’extraction et la distribution du charbon a favorisé le développement d’institutions démocratiques et d’un État-providence dans les régimes occidentaux et dans les économies récemment développées de ce que l’on appelle les pays du Sud, le « pétro-capitalisme » et l’économie politique de l’énergie nucléaire ont contribué au démantèlement des marchés internes du travail et à la crise des institutions classiques du droit du travail et des relations professionnelles1. Contrairement au pétrole et au nucléaire, les énergies renouvelables pourraient favoriser le passage d’un modèle économique extractif à un modèle génératif et participatif : en introduisant plus de démocratie dans le pouvoir politique et économique de l’énergie, les énergies renouvelables pourraient mieux servir le bien-être humain, le travail et l’environnement. This article discusses how and why different energy paradigms and their political economies have affected labour and industrial relations institutions over time. Drawing on a novel literature that considers energy sources as a core analytical referent, the following trajectories are presented and discussed. While the possibility of labour control over the mining and distribution of coal has favoured the development of democratic institutions and welfare state in Western jurisdictions and in recently developed economies in the so-called Global South, ‘petro-capitalism’ and the political economy of nuclear energy have contributed to the dismantling of internal labour markets and to the crisis of classical labour law and industrial relations institutions. In contrast to oil and nuclear power, renewable energy sources could favour the transition from an extractive economic model to one that is generative and participatory: by re-democratising the political and economic power of energy, renewables might be able to better serve human welfare, labour and the environment.

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    OpenEdition
    Article . 2024
    Data sources: OpenEdition
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    Authors: Stolyarova, Elena;

    Little research has been done to date on French households’ preferences for energy retrofits in the dwelling. However, the economic role of these choices is crucial for implementing an effective and realistic energy policy in the residential sector, both in terms of proposed aid and targets. Are households interested in retrofits with high energy-savings potential? How much are they willing to pay and is it sufficient to cover the up-front costs? How many households have no choice of heating system, and what is their profile?This work sets out to answer these questions empirically using discrete choice models. It starts by analyzing the technical, socio-demographic and spatial constraints that face households and create barriers to domestic energy choices. A method to detect household constraint is devised and applied to the choice of space heating system in 2006 and 2013. The second stage analyzes household preferences for heating equipment and retrofits. This second part is based on a discrete choice experiment specially carried out for this research among 2,000 households. This work sheds light on households’ preferences and heterogeneity, as well as their willingness to pay, the implicit discount rate and other economic impacts. Les préférences des ménages français pour les travaux de rénovation énergétique dans le logement ont été peu étudiées jusqu’à présent. Or, elles sont la clé d’une politique énergétique efficace et réaliste pour le secteur résidentiel, tant au niveau des aides proposées, qu’au niveau des objectifs à réaliser. Les ménages sont-ils intéressés par des travaux à fort potentiel d’économie d’énergie ? Combien sont-ils prêt à payer et est-ce que c’est suffisant pour couvrir les coûts réels ? Combien de ménages n’ont pas le choix de leur mode de chauffage et quel est leur profil ?La thèse s'attache à répondre à ces questions de façon empirique à l’aide de modèles de choix discrets. Il s’agit, dans un premier temps, d’analyser les contraintes techniques, sociodémographiques et spatiales que rencontrent les ménages et qui entravent les choix énergétiques dans le logement. Une méthodologie de détection des ménages contraints a été proposée, puis appliquée au choix du chauffage en 2006 et 2013. Dans un deuxième temps, les préférences des ménages pour les équipements de chauffage et les travaux de rénovation ont été analysées. Cette deuxième partie utilise une enquête expérimentale qui a été réalisée spécialement pour ce travail de recherche auprès de 2000 ménages. Ce travail a permis de comprendre les préférences des ménages, leur hétérogénéité, et d’en déduire les consentements à payer, les taux d’actualisation implicites et les différents effets économiques.

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    Authors: Alexander-Haw, Abigail; Dütschke, Elisabeth; Janßen, Hannah; Preuß, Sabine; +3 Authors

    This dataset and codebook correspond to the second round of survey data gathered in France in 2023, within the project FULFILL - Fundamental Decarbonisation Through Sufficiency By Lifestyle Changes. As part of Work Package 3 (WP3) in the FULFILL project, we collected quantitative data from six countries: Denmark, France, Germany, Italy, Latvia, and India. The first round of the survey, consisted of recruiting a representative sample of approximately 2000 households in each country. In this second survey round, we recruit around 500 respondents from the initial survey round, ensuring representativity is maintained. This survey is very similar to the survey in the first round and includes a lot of identical items, including a quantitative assessment of the carbon footprint in the housing, mobility, and diet sectors, socio-economic factors such as age, gender, income, education, household size, life stage, and political orientation. Furthermore, the survey includes measures of quality of life, encompassing aspects such as health and well-being, environmental quality, financial security, and comfort. New for this second round, we have incorporated questions regarding the measures respondents adopted in response to the 2022 energy crisis.

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    ZENODO
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    ZENODO
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    ZENODO
    Dataset . 2024
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  • Authors: Morena, Edouard; Flipo, Fabrice; Felli, Romain; Grisoni, Anahita;
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    Authors: Adami, Salah-Eddine;

    Les progrès réalisés durant ces dernières années dans le domaine de la microélectronique et notamment vis-à-vis de l'augmentation exponentielle de la densité d'intégration des composants et des systèmes a participé activement à l'apparition et au développement de systèmes portables communicants de plus en plus performants et polyvalents. La R&D dans les technologies de stockage d'énergie n'a pas suivi cette tendance d'évolution très rapide ; ce qui constitue un handicap majeur dans les évolutions futures des systèmes portables. La transmission d'énergie sans fils sur des distances considérables (plusieurs dizaines de mètres) grâce aux microondes constitue une solution très prometteuse pour pallier aux problèmes d'autonomie dans le cas des systèmes sans fils communicants. De plus, du fait de l'omniprésence des ondes électromagnétiques dans notre environnement avec des niveaux plus ou moins importants, la récupération et l'exploitation de cette énergie libre est également possible. La rectenna (Rectifying Antenna) est le dispositif permettant de capter et de convertir une onde électromagnétique en une tension continue. Plusieurs travaux de thèse axés sur l'étude et l'optimisation de la rectenna ont été réalisés au sein du laboratoire. Ces travaux avaient montré que pour des faibles niveaux de champs les tensions délivrées par la rectenna sont généralement très faibles et inexploitables. Aussi, comme la majorité des micro-sources d'énergie et à cause de son impédance interne, les performances de la rectenna dépendent fortement de sa charge de sortie. Ainsi, le développement d'un système d'interfaçage de la rectenna est nécessaire afin de pallier ces manquements inhérents du convertisseur RF/DC. Ce genre de système d'interfaçage est généralement absent dans la littérature à cause des faibles niveaux de puissance exploités. Par conséquent, la rectenna est très souvent utilisée tel quelle ; ce qui limite fortement le champ applicatif. Dans ce projet de recherche, un système de gestion énergétique de la rectenna complètement autonome a été conçu, développé et optimisé afin de garantir les performances optimales de la rectenna quelques soient les fluctuations de la puissance d'entrée et celles de la charge de sortie. Le circuit d'interfaçage permet également de fournir à la charge des niveaux de tension utilisables. Le système réalisé est basé tout d'abord sur l'utilisation d'un convertisseur DC/DC résonant pouvant fonctionner d'une manière complètement autonome à partir de niveaux très bas de la tension et de la puissance de la source. Ce convertisseur permet donc de garantir l'autonomie du système en éliminant la nécessité d'une source d'énergie auxiliaire. A cause de ses faibles performances énergétiques, ce convertisseur ne sera utilisé que durant la phase de démarrage. L'efficacité du système en termes de rendement énergétique et d'adaptation d'impédance est garantie grâce à l'utilisation d'un convertisseur Flyback fonctionnant dans son régime de conduction discontinu. Ainsi, une adaptation d'impédance très efficace est réalisée entre la rectenna et la charge de sortie. Ce convertisseur principal fonctionnera durant le régime permanent. Les deux convertisseurs ont été optimisés pour des niveaux de tension et de puissance aussi bas que quelques centaines de mV et quelques μW respectivement. Des mesures expérimentales réalisées sur plusieurs prototypes ont démontré le bon fonctionnement et les excellentes performances prédites par la procédure de conception ; ce qui nous permet de valider notre approche. De plus, les performances obtenues se distinguent parfaitement vis-à-vis de l'état de l'art. Enfin, en fonction de l'application désirée, plusieurs synoptiques d'association des deux structures sont proposés. Ceci inclut également la gestion énergétique de la charge de sortie.

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    Authors: Martz, François;

    During this PhD thesis we developped two new molecular modeling methods applied to enzymes containing flavin-type prosthetic groups.The first method, PredFace, predicts the stereochemistry of products from a reaction catalyzed by enzymes containing prosthetic groups, by automatically identifying the solvent-exposed face of the prosthetic group. The protocol involves the use of eigth complexes as "probes", obtained by symmetry operations starting from the transition state of a hydrogen atom transfer reaction between nicotinamide and lumiflavin. These complexes are positioned in the binding site with the prosthetic group as reference and the energy of the protein-ligand interaction is evaluated by the scoring function implemented in the docking software (AutoDock). The most favorable interaction energy allows the identification of the prosthetic group face that is available for the enzymatic reaction in the binding site. The PredFace method has been validated by analyzing all the structures in the Protein Data Bank containing flavin-derived prosthetic groups (2170). This method is very fast (less than a minute), which allowed us to develop a web site open to the scientific community.The second method, ProsthDock, is a new mechanism-based molecular docking method guided by prosthetic groups present in the active sites of enzymes. The development of this method was motivated by the incapacity of the currently available docking methods to provide, in the presence of prosthetic groups, ligand conformations that are compatible with the enzymatic reactions. In this regard, we have added a new term to the classical scoring function, to take into account the interaction between ligand and prosthetic group. We have built a simplified model of the NADH/FMN complex and calculated the transition state of the hydrogen transfer reaction between the two partners. Potential energy surfaces have been calculated for this reaction by variating the angle, diedral angle and distance between the two reaction partners. A subsequent docking with constraints provides binding site conformations of the ligand for which the new term of the scoring function is calculated using the potential energy surfaces. This results in a new ranking of the docking poses, favoring those in agreement with the enzymatic reaction. Les travaux de cette thèse ont porté sur le développement de deux méthodes de modélisation des enzymes contenant des groupes prosthétiques de la famille des flavines.La première méthode, PredFace, permet de prédire la stéréochimie des produits d'une réaction catalysée par des enzymes contenant des groupes prosthétiques, en identifiant la face libre d'interaction avec les substrats. Le protocole mis en place pour cette méthode implique l'utilisation de huit complexes "sondes", obtenus par des opérations de symétrie à partir de l'état de transition de la réaction de transfert d'un atome d'hydrogène entre le nicotinamide et la lumiflavine. Ces complexes sont positionnés dans le site actif avec le groupe prosthétique comme référence et dans chaque cas l'énergie d'interaction protéine-ligand est évaluée par la fonction de score implémentée dans le logiciel de docking utilisé (AutoDock). L'énergie d'interaction la plus favorable permet d'identifier la face du groupe prosthétique accessible pour la réaction enzymatique dans le site actif. La méthode PredFace a été validée par l'analyse de l'ensemble des structures de la Protein Data Bank contenant des groupes prosthétiques de la famille des flavines (2170). Le protocole mis au point est très rapide (moins d'une minute), ce qui nous a permis de développer un site web afin de mettre cette méthode à la disposition de la communauté.La seconde méthode, ProsthDock, est une nouvelle méthode de docking basée sur le mécanisme d'une réaction enzymatique catalysée par un groupe prosthétique et guidée par la présence de ce groupe prosthétique dans le site actif de l'enzyme. Le développement de cette méthode a été motivé par le fait que les méthodes actuelles de docking, en présence de groupes prosthétiques, se révèlent incapables de produire des poses correctes pour des substrats, en accord avec les réactions enzymatiques. Afin de remédier à ce problème nous avons ajouté à la fonction de score classique un terme supplémentaire, qui rendra compte de l'interaction du ligand avec le groupe prosthétique. Dans un premier temps, nous avons construit un modèle simplifié du complexe NADH/FMN et calculé l'état de transition de la réaction de transfert d'hydrogène entre les deux partenaires. Des surfaces d'énergie potentielle pour cette réaction ont été calculées en variant la distance, l'angle et l'angle dièdre entre les deux réactifs. Un docking sous contrainte est ensuite réalisé et en fonction du positionnement de chaque pose de docking dans le site actif le terme supplémentaire de la fonction de score est calculé à partir des surfaces d'énergie potentielle, ce qui nous permet de modifier le classement des résultats de docking en favorisant les poses qui sont en accord avec la réaction enzymatique.

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28 Research products
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Alexander-Haw, Abigail; Dütschke, Elisabeth; Helferich, Marvin; Preuß, Sabine; +1 Authors

    This dataset and codebook correspond to the initial round of survey data gathered in France in 2022, within the project FULFILL - Fundamental Decarbonisation Through Sufficiency By Lifestyle Changes. As part of Work Package 3 (WP3) in the FULFILL project, we collected quantitative data from six countries: Denmark, France, Germany, Italy, Latvia, and India. In the first round of the survey, we recruited a representative sample of approximately 2000 households in each country, taking into account both the individual and household perspectives. The survey includes a quantitative assessment of the carbon footprint in various domains of life, such as housing, mobility, and diet. In addition to this, the survey also measures socio-economic factors such as age, gender, income, education, household size, life stage, and political orientation. Furthermore, the survey includes measures of quality of life, encompassing aspects such as health and well-being, environmental quality, financial security, and comfort.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: Datacite
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      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: ZENODO
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      ZENODO
      Dataset . 2024
      License: CC BY
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Naegel, Paul;

    Au milieu des années 1950, Électricité de France, opérateur largement dominant dans la production et la distribution d'énergie sous forme électrique, du fait de l'avenir encore incertain du nucléaire civil, a opté, avec la construction de l''usine marémotrice sur l'estuaire de la Rance, pour une énergie renouvelable d'un type encore inusité à l'échelle industrielle. Cette centrale hydroélectrique, en de nombreux points particulièrement innovante, inaugurée en 1967, sera pourtant la seule de ce type réalisée en France. Elle est toujours en service. A un moment où la question des énergies renouvelables est pour le moins à l'ordre du jour, même si les réalisations restent modestes en termes industriels en France, il nous a semblé intéressant de mobiliser l'histoire d'une réalisation qui a, depuis des lustres, produit ce que nous considérons comme une bifurcation énergétique, dont l'avenir reste largement à construire.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ INRIA a CCSD electro...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    The abstract gives an overview over geographical, environmental and political changes in Tunisia from 2000 to 2018. The focus is on wildfire evolution and climate change processes in Tunisia. L' augmentation des incendies de forêts, la littoralisation, la californisation, risque de voir les espèces invasives se multiplier-telle fut le résultat de l'étude GTZ « Stratégie nationale d'adaptation de l'agriculture tunisienne et des écosystèmes aux changements climatiques» sottie en 2007 - et dont l'auteur fut le responsable du groupe d'analyse des écosystèmes. Le diagnostic concernant l'évolution de risques de feux de forêts fut assez alarmant : « Nous pensons que les changements climatiques vont accroître considérablement les risques de feux de végétation. Le Nord de la Tunisie serait particulièrement affecté par cette évolution car en plus de l'augmentation des températures le stock combustible pourrait considérablement augmenter ... La progression des incendies, surtout de grands incendies nécessitant des grands stocks de combustibles, dans le Nord tunisien, peut avoir des conséquences particulièrement négatives pour toute l'économie tunisienne car elle met en danger les systèmes des barrages et l'approvisionnement en eau d'une grande partie de la Tunisie. (Neff, C. 2007., p.37-38)».Dix ans après la sortie de l' étude l' auteur essai d'évaluerà quel point les scenarios dessinés dans l'étude de 2007 sont encore d'actualité en Tunisie contemporaine (2017/18). Est-ce que les changements politiques, la révolution tunisienne de 2011 et la phase transitoire vers une démocratielibérale qui suivait cette révolution, ont pesé sur l' état de l'environnement. Quel est la tendance des fréquences d'incendies de forêts des dernières années en Tunisie. Est-ce que les pouvoirs politiques actuelsprennent en considération les «risques» que les changements climatiques peuvent engendrer pour les écosystèmes& les paysages tunisiennes. Le tout sera complété, par une vue globale d'extérieure sur la Tunisie-l'auteur est bloggeur sur le Monde.fr depuis 2009, et il suit les évènements tunisiens avec attention. Quel est la vue d'un bloggeur franco-allemande sur une Tunisie changeante et confronté à des défis politiques considérable: la phase de transition démocratique, les changements climatiques, mais aussi le futur des terres intérieures tunisiennes, les paysages ruraux à l'abandonet dont la jeunesse cherche à fuir vers des destinations meilleurs ...

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ KITopen (Karlsruhe I...arrow_drop_down
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    https://dx.doi.org/10.5445/ir/...
    Conference object . 2018
    Data sources: Datacite
    https://dx.doi.org/10.5445/ir/...
    Conference object . 2018
    Data sources: Datacite
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      https://dx.doi.org/10.5445/ir/...
      Conference object . 2018
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      https://dx.doi.org/10.5445/ir/...
      Conference object . 2018
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Gohin, Alexandre; Gohin, Alexandre;

    [Paper in French] The European public policy in favor of the biodiesel consumption is highly debated. Available estimates of the induced land use changes conclude that this policy is inefficient to reduce emissions of GreenHouse Gas. We show that the crop yield evolutions in these estimates are significantly lower than the observed and expected evolutions. This difference is directly related to biased calibration choice of behavioral parameters. We show using the GTAP-BIO framework that a consistent calibration of these parameters leads to a strong reduction (by around 80% in the long run) of the land use changes and induced emissions.

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    ProdInra
    External research report . 2013
    License: CC BY SA
    Data sources: ProdInra
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    https://dx.doi.org/10.22004/ag...
    Other literature type . 2013
    Data sources: Datacite
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      ProdInra
      External research report . 2013
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      https://dx.doi.org/10.22004/ag...
      Other literature type . 2013
      Data sources: Datacite
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    Authors: Tomassetti, Paolo;

    Cet article explique pourquoi et comment différents paradigmes énergétiques et leur économie politique ont affecté les institutions de relations professionnelles et industrielles au fil du temps. S’appuyant sur une nouvelle littérature qui considère les sources d’énergie comme un référent analytique central, sont discutés et présentés les contextes économiques reposant successivement sur le charbon, le pétrole, le nucléaire et le solaire. Alors que la possibilité d’un contrôle de la main-d’œuvre sur l’extraction et la distribution du charbon a favorisé le développement d’institutions démocratiques et d’un État-providence dans les régimes occidentaux et dans les économies récemment développées de ce que l’on appelle les pays du Sud, le « pétro-capitalisme » et l’économie politique de l’énergie nucléaire ont contribué au démantèlement des marchés internes du travail et à la crise des institutions classiques du droit du travail et des relations professionnelles1. Contrairement au pétrole et au nucléaire, les énergies renouvelables pourraient favoriser le passage d’un modèle économique extractif à un modèle génératif et participatif : en introduisant plus de démocratie dans le pouvoir politique et économique de l’énergie, les énergies renouvelables pourraient mieux servir le bien-être humain, le travail et l’environnement. This article discusses how and why different energy paradigms and their political economies have affected labour and industrial relations institutions over time. Drawing on a novel literature that considers energy sources as a core analytical referent, the following trajectories are presented and discussed. While the possibility of labour control over the mining and distribution of coal has favoured the development of democratic institutions and welfare state in Western jurisdictions and in recently developed economies in the so-called Global South, ‘petro-capitalism’ and the political economy of nuclear energy have contributed to the dismantling of internal labour markets and to the crisis of classical labour law and industrial relations institutions. In contrast to oil and nuclear power, renewable energy sources could favour the transition from an extractive economic model to one that is generative and participatory: by re-democratising the political and economic power of energy, renewables might be able to better serve human welfare, labour and the environment.

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    Authors: Stolyarova, Elena;

    Little research has been done to date on French households’ preferences for energy retrofits in the dwelling. However, the economic role of these choices is crucial for implementing an effective and realistic energy policy in the residential sector, both in terms of proposed aid and targets. Are households interested in retrofits with high energy-savings potential? How much are they willing to pay and is it sufficient to cover the up-front costs? How many households have no choice of heating system, and what is their profile?This work sets out to answer these questions empirically using discrete choice models. It starts by analyzing the technical, socio-demographic and spatial constraints that face households and create barriers to domestic energy choices. A method to detect household constraint is devised and applied to the choice of space heating system in 2006 and 2013. The second stage analyzes household preferences for heating equipment and retrofits. This second part is based on a discrete choice experiment specially carried out for this research among 2,000 households. This work sheds light on households’ preferences and heterogeneity, as well as their willingness to pay, the implicit discount rate and other economic impacts. Les préférences des ménages français pour les travaux de rénovation énergétique dans le logement ont été peu étudiées jusqu’à présent. Or, elles sont la clé d’une politique énergétique efficace et réaliste pour le secteur résidentiel, tant au niveau des aides proposées, qu’au niveau des objectifs à réaliser. Les ménages sont-ils intéressés par des travaux à fort potentiel d’économie d’énergie ? Combien sont-ils prêt à payer et est-ce que c’est suffisant pour couvrir les coûts réels ? Combien de ménages n’ont pas le choix de leur mode de chauffage et quel est leur profil ?La thèse s'attache à répondre à ces questions de façon empirique à l’aide de modèles de choix discrets. Il s’agit, dans un premier temps, d’analyser les contraintes techniques, sociodémographiques et spatiales que rencontrent les ménages et qui entravent les choix énergétiques dans le logement. Une méthodologie de détection des ménages contraints a été proposée, puis appliquée au choix du chauffage en 2006 et 2013. Dans un deuxième temps, les préférences des ménages pour les équipements de chauffage et les travaux de rénovation ont été analysées. Cette deuxième partie utilise une enquête expérimentale qui a été réalisée spécialement pour ce travail de recherche auprès de 2000 ménages. Ce travail a permis de comprendre les préférences des ménages, leur hétérogénéité, et d’en déduire les consentements à payer, les taux d’actualisation implicites et les différents effets économiques.

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    Authors: Alexander-Haw, Abigail; Dütschke, Elisabeth; Janßen, Hannah; Preuß, Sabine; +3 Authors

    This dataset and codebook correspond to the second round of survey data gathered in France in 2023, within the project FULFILL - Fundamental Decarbonisation Through Sufficiency By Lifestyle Changes. As part of Work Package 3 (WP3) in the FULFILL project, we collected quantitative data from six countries: Denmark, France, Germany, Italy, Latvia, and India. The first round of the survey, consisted of recruiting a representative sample of approximately 2000 households in each country. In this second survey round, we recruit around 500 respondents from the initial survey round, ensuring representativity is maintained. This survey is very similar to the survey in the first round and includes a lot of identical items, including a quantitative assessment of the carbon footprint in the housing, mobility, and diet sectors, socio-economic factors such as age, gender, income, education, household size, life stage, and political orientation. Furthermore, the survey includes measures of quality of life, encompassing aspects such as health and well-being, environmental quality, financial security, and comfort. New for this second round, we have incorporated questions regarding the measures respondents adopted in response to the 2022 energy crisis.

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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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    ZENODO
    Dataset . 2024
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    ZENODO
    Dataset . 2024
    License: CC BY
    Data sources: Datacite
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      ZENODO
      Dataset . 2024
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  • Authors: Morena, Edouard; Flipo, Fabrice; Felli, Romain; Grisoni, Anahita;
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    Authors: Adami, Salah-Eddine;

    Les progrès réalisés durant ces dernières années dans le domaine de la microélectronique et notamment vis-à-vis de l'augmentation exponentielle de la densité d'intégration des composants et des systèmes a participé activement à l'apparition et au développement de systèmes portables communicants de plus en plus performants et polyvalents. La R&D dans les technologies de stockage d'énergie n'a pas suivi cette tendance d'évolution très rapide ; ce qui constitue un handicap majeur dans les évolutions futures des systèmes portables. La transmission d'énergie sans fils sur des distances considérables (plusieurs dizaines de mètres) grâce aux microondes constitue une solution très prometteuse pour pallier aux problèmes d'autonomie dans le cas des systèmes sans fils communicants. De plus, du fait de l'omniprésence des ondes électromagnétiques dans notre environnement avec des niveaux plus ou moins importants, la récupération et l'exploitation de cette énergie libre est également possible. La rectenna (Rectifying Antenna) est le dispositif permettant de capter et de convertir une onde électromagnétique en une tension continue. Plusieurs travaux de thèse axés sur l'étude et l'optimisation de la rectenna ont été réalisés au sein du laboratoire. Ces travaux avaient montré que pour des faibles niveaux de champs les tensions délivrées par la rectenna sont généralement très faibles et inexploitables. Aussi, comme la majorité des micro-sources d'énergie et à cause de son impédance interne, les performances de la rectenna dépendent fortement de sa charge de sortie. Ainsi, le développement d'un système d'interfaçage de la rectenna est nécessaire afin de pallier ces manquements inhérents du convertisseur RF/DC. Ce genre de système d'interfaçage est généralement absent dans la littérature à cause des faibles niveaux de puissance exploités. Par conséquent, la rectenna est très souvent utilisée tel quelle ; ce qui limite fortement le champ applicatif. Dans ce projet de recherche, un système de gestion énergétique de la rectenna complètement autonome a été conçu, développé et optimisé afin de garantir les performances optimales de la rectenna quelques soient les fluctuations de la puissance d'entrée et celles de la charge de sortie. Le circuit d'interfaçage permet également de fournir à la charge des niveaux de tension utilisables. Le système réalisé est basé tout d'abord sur l'utilisation d'un convertisseur DC/DC résonant pouvant fonctionner d'une manière complètement autonome à partir de niveaux très bas de la tension et de la puissance de la source. Ce convertisseur permet donc de garantir l'autonomie du système en éliminant la nécessité d'une source d'énergie auxiliaire. A cause de ses faibles performances énergétiques, ce convertisseur ne sera utilisé que durant la phase de démarrage. L'efficacité du système en termes de rendement énergétique et d'adaptation d'impédance est garantie grâce à l'utilisation d'un convertisseur Flyback fonctionnant dans son régime de conduction discontinu. Ainsi, une adaptation d'impédance très efficace est réalisée entre la rectenna et la charge de sortie. Ce convertisseur principal fonctionnera durant le régime permanent. Les deux convertisseurs ont été optimisés pour des niveaux de tension et de puissance aussi bas que quelques centaines de mV et quelques μW respectivement. Des mesures expérimentales réalisées sur plusieurs prototypes ont démontré le bon fonctionnement et les excellentes performances prédites par la procédure de conception ; ce qui nous permet de valider notre approche. De plus, les performances obtenues se distinguent parfaitement vis-à-vis de l'état de l'art. Enfin, en fonction de l'application désirée, plusieurs synoptiques d'association des deux structures sont proposés. Ceci inclut également la gestion énergétique de la charge de sortie.

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    Authors: Martz, François;

    During this PhD thesis we developped two new molecular modeling methods applied to enzymes containing flavin-type prosthetic groups.The first method, PredFace, predicts the stereochemistry of products from a reaction catalyzed by enzymes containing prosthetic groups, by automatically identifying the solvent-exposed face of the prosthetic group. The protocol involves the use of eigth complexes as "probes", obtained by symmetry operations starting from the transition state of a hydrogen atom transfer reaction between nicotinamide and lumiflavin. These complexes are positioned in the binding site with the prosthetic group as reference and the energy of the protein-ligand interaction is evaluated by the scoring function implemented in the docking software (AutoDock). The most favorable interaction energy allows the identification of the prosthetic group face that is available for the enzymatic reaction in the binding site. The PredFace method has been validated by analyzing all the structures in the Protein Data Bank containing flavin-derived prosthetic groups (2170). This method is very fast (less than a minute), which allowed us to develop a web site open to the scientific community.The second method, ProsthDock, is a new mechanism-based molecular docking method guided by prosthetic groups present in the active sites of enzymes. The development of this method was motivated by the incapacity of the currently available docking methods to provide, in the presence of prosthetic groups, ligand conformations that are compatible with the enzymatic reactions. In this regard, we have added a new term to the classical scoring function, to take into account the interaction between ligand and prosthetic group. We have built a simplified model of the NADH/FMN complex and calculated the transition state of the hydrogen transfer reaction between the two partners. Potential energy surfaces have been calculated for this reaction by variating the angle, diedral angle and distance between the two reaction partners. A subsequent docking with constraints provides binding site conformations of the ligand for which the new term of the scoring function is calculated using the potential energy surfaces. This results in a new ranking of the docking poses, favoring those in agreement with the enzymatic reaction. Les travaux de cette thèse ont porté sur le développement de deux méthodes de modélisation des enzymes contenant des groupes prosthétiques de la famille des flavines.La première méthode, PredFace, permet de prédire la stéréochimie des produits d'une réaction catalysée par des enzymes contenant des groupes prosthétiques, en identifiant la face libre d'interaction avec les substrats. Le protocole mis en place pour cette méthode implique l'utilisation de huit complexes "sondes", obtenus par des opérations de symétrie à partir de l'état de transition de la réaction de transfert d'un atome d'hydrogène entre le nicotinamide et la lumiflavine. Ces complexes sont positionnés dans le site actif avec le groupe prosthétique comme référence et dans chaque cas l'énergie d'interaction protéine-ligand est évaluée par la fonction de score implémentée dans le logiciel de docking utilisé (AutoDock). L'énergie d'interaction la plus favorable permet d'identifier la face du groupe prosthétique accessible pour la réaction enzymatique dans le site actif. La méthode PredFace a été validée par l'analyse de l'ensemble des structures de la Protein Data Bank contenant des groupes prosthétiques de la famille des flavines (2170). Le protocole mis au point est très rapide (moins d'une minute), ce qui nous a permis de développer un site web afin de mettre cette méthode à la disposition de la communauté.La seconde méthode, ProsthDock, est une nouvelle méthode de docking basée sur le mécanisme d'une réaction enzymatique catalysée par un groupe prosthétique et guidée par la présence de ce groupe prosthétique dans le site actif de l'enzyme. Le développement de cette méthode a été motivé par le fait que les méthodes actuelles de docking, en présence de groupes prosthétiques, se révèlent incapables de produire des poses correctes pour des substrats, en accord avec les réactions enzymatiques. Afin de remédier à ce problème nous avons ajouté à la fonction de score classique un terme supplémentaire, qui rendra compte de l'interaction du ligand avec le groupe prosthétique. Dans un premier temps, nous avons construit un modèle simplifié du complexe NADH/FMN et calculé l'état de transition de la réaction de transfert d'hydrogène entre les deux partenaires. Des surfaces d'énergie potentielle pour cette réaction ont été calculées en variant la distance, l'angle et l'angle dièdre entre les deux réactifs. Un docking sous contrainte est ensuite réalisé et en fonction du positionnement de chaque pose de docking dans le site actif le terme supplémentaire de la fonction de score est calculé à partir des surfaces d'énergie potentielle, ce qui nous permet de modifier le classement des résultats de docking en favorisant les poses qui sont en accord avec la réaction enzymatique.

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