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In 2015, an estimated 429,000 deaths and 212 million cases of malaria occurred worldwide, while 70% of the deaths occurred in children under five years old. Changes in climatic exposure such as temperature and precipitation makes malaria one of the most climate sensitive outcomes. Using a global malaria mortality dataset for 105 countries between 1980 and 2010, we estimate that the global optimal temperature maximizing all-age malaria mortality is 20.6, lower than previously predicted in the literature. While in the case of child mortality, a significantly lower optimum temperature of 19.3° is estimated. Our results also suggest that in Africa and Asia, the continents where malaria is most prevalent malaria, mortality is maximized at 28.4 and 26.3, respectively. Furthermore, we estimate that child mortality (ages 0-4) is likely to increase by up to 20 percent in some areas due to climate change by the end of the 21st century.

Solid waste management (SWM) is one of the most critical global challenges nowadays. It has a severe negative effect on the triple bottom line of sustainability. Construction and demolition waste (CDW) contributes about 50% of the total global annual generated SW. In the particular case of the Middle East and North Africa (MENA) region including Egypt, the SW problem has become a major challenge, and the need to find sustainable solutions is overwhelming. However, the region faces several challenges that hinder the development of an effective and efficient SWM system. This has resulted in the predominance of unsustainable SWM practices such as indiscriminate disposals. The aim of this paper is to investigate the escalating problem of SW in the MENA region, while focusing on CDW in Egypt as a part of the total generated SW, by reviewing the most recent research papers, and technical and governmental reports on the SW problem. The main challenges towards effective and efficient SWM systems and recommendations for improvement are gathered in this study based on the explored literature. Findings from this study are expected to be beneficial to local and central governments, academics, construction industry practitioners, and policymakers contending with the problems of SW in the MENA region and especially CDW in Egypt.

In the past decade, prescriptions for opioid medicines have been exponentially increasing, instigating opioid abuse as a global health crisis associated with high morbidity and mortality. In particular, diversion from the intended mode of opioid administration, such as injecting and snorting the opioid, is a major problem that contributes to this epidemic. In light of this, novel formulation strategies are needed to support efforts in reducing the prevalence and risks of opioid abuse. Here, modified release tramadol printlets (3D printed tablets) with alcohol-resistant and abuse-deterrent properties were prepared by direct powder extrusion three-dimensional (3D) printing. The printlets were fabricated using two grades of hydroxypropylcellulose (HPC). Both formulations displayed strong ethanol-resistance and had moderate abuse-deterrent properties. Polyethylene oxide (PEO) was subsequently added into the formulations, which improved the printlets' resistance to physical tampering in nasal inhalation tests and delayed their dissolution in solvent extraction tests. Overall, this article reports for the first time the use of direct powder extrusion 3D printing to prepare drug products with both alcohol-resistant and abuse-deterrent properties. These results offer a novel approach for the safe and effective use of opioids that can contribute to the advantages that 3D printing provides in terms of on-demand dose personalisation.

Climate change and an increased interest in renewable energy have resulted in a burgeoning wind energy sector. However, in the recent past, wind farms have faced resistance in acquiring permits due to concerns about their long-term effects on the local community. To understand the extent of these externalities, this study qualitatively meta-analyses four socio-economic impacts of interest, namely: house prices, tourism, catalytic effects of supply chain clustering, and social change. Geographically, the analysed reports include Europe, Canada and the US, and deductions are made for the EU. In order to bridge the gap of unavailability of primary data on the wind sector, relevant conclusions are drawn from other comparable sectors. Based on a rigorous review of primary qualitative research, this study concludes that offshore wind farms should be located more than 40 km away from the coast to eliminate risks of housing price devaluation and tourist activity reduction, which would directly affect the economic value of the region. In addition, the study found limited evidence to acknowledge the employment benefits in the local economy and social change in the community due to offshore wind farms. Monitoring mechanisms should be set up to prove or disprove the creation of local employment, crime and substance abuse. Furthermore, the study finds that adequate planning and management can ensure better socioeconomic outcomes in the community. Further research is recommended for the specific impact of overhead transmission lines and substations on property values and tourism.

AbstractWe construct long-run sustainability indicators based on changes in Comprehensive Wealth - which we refer to as Genuine Savings (GS) - for Germany over the period 1850-2000. We find that German sustainability indicators are positive for the most part, although they are negative during and after the two World Wars and also the Great Depression. We also test the relationship between these wealth changes and a number of measures of well-being over the long-run: changes in consumption as well as changes in average height and infant mortality rates. We find a positive relationship between GS and our well-being indicators over different time horizons, however, the relationship breaks down during WWII. We also test if the GS/Comprehensive Wealth framework is able to cope with massive disinvestment at the end of the Second World War due to war-related destructions and dismantlement. We find that negative rates of GS were by and large avoided due to the accumulation of technology and growth-friendly institutions. We demonstrate the importance of broader measures of capital, including measures of technological progress, and its role in the process of economic development; and the limits of conventional measures of investment to understand why future German consumption did not collapse.

Water resource management in the UK is multifaceted, with a complexity of issues arising from acute and chronic stressors. Below average rainfall in spring 2020 coincided with large-scale changes to domestic water consumption patterns, arising from the first UK-wide COVID-19 lockdown, resulting in increased pressure on nationwide resources. A sector wide survey, semi-structured interviews with sector executives, meteorological data, water resource management plans and market information were used to evaluate the impact of acute and chronic threats on water demand in the UK, and how resilience to both can be increased. The COVID-19 pandemic was a particularly acute threat: water demand increased across the country, it was unpredictable and hard to forecast, and compounding this, below average rainfall resulted in some areas having to tanker in water to ‘top up’ the network. This occurred in regions of the UK that are ‘water stressed’ as well as those that are not. We therefore propose a need to look beyond ‘design droughts’ and ‘dry weather average demand’ to characterise the management and resilience of future water resources. As a sector, we can learn from this acute threat and administer a more integrated approach, combining action on the social value of water, the implementation of water trading and the development of nationwide multi-sectoral resilience plans to better respond to short and long-term disruptors.