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description Publicationkeyboard_double_arrow_right Article , Journal 2014 Australia, Australia, NetherlandsPublisher:Springer Science and Business Media LLC Rick A. Vreman; Thomas Roth; Berend Olivier; Adriana C. Bervoets; Suzanne de Klerk; Joris C. Verster; Joris C. Verster; Karel Brookhuis;The purpose of this study was to examine the effects of alcohol hangover on simulated highway driving performance.Driving performance of forty-two social drinkers was tested the morning following an evening of consuming on average 10.2 (SD = 4.2) alcoholic drinks (alcohol hangover) and on a control day (no alcohol consumed). Subjects performed a standardized 100-km highway driving test in the STISIM driving simulator. In addition to the standard deviation of lateral position (SDLP; i.e., the weaving of the car), lapses of attention were examined. Self-reported driving quality and driving style were scored, as well as mental effort to perform the test, sleepiness before and after driving, and hangover severity.Driving performance was significantly impaired during alcohol hangover as expressed by an SDLP increase of +1.9 cm (t (1,41) = 2.851, p = 0.007), increased number of lapses relative to the control day (7.7 versus 5.3 lapses, t (1,41) = 2.125, p = 0.019), and an increased total lapse time (182.7 versus 127.3 s, p = 0.040). During alcohol hangover, subjects reported their driving quality to be significantly poorer (t (1,41) = 4.840, p = 0.001) and less safe (t (1,41) = 5.078, p = 0.001), wise (t (1,41) = 4.061, p = 0.001), predictable (t (1,41) = 3.475, p = 0.001), and responsible (t (1,41) = 4.122, p = 0.001). Subjects further reported being significantly more tense while driving (t (1,41) = 3.280, p = 0.002), and more effort was needed to perform the driving test (t (1,41) = 2.941, p = 0.001). There was a significant interaction with total sleep time and hangover effects on SDLP and the number of lapses.In conclusion, driving is significantly impaired during alcohol hangover, as expressed in an elevated SDLP and increased number of lapses. Total sleep time has a significant impact on the magnitude of driving impairment.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 66 citations 66 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00213-014-3474-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008 NetherlandsPublisher:SAGE Publications Dumont, G.J.H.; Kramers, C.; Kramers, C.; Sweep, C.G.J.; Willemsen, J.J.; Touw, D.J.; Schoemaker, R.C.; van Gerven, J.M.; Buitelaar, J.K.; Verkes, R.J.;Alcohol is frequently used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Both drugs affect cardiovascular function, hydration and temperature regulation, but may have partly opposing effects. The present study aims to assess the acute physiologic effects of (co-) administration of MDMA and ethanol over time. A four-way, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers (9 male and 7 female) between the ages of 18 and 29. MDMA (100 mg) was given orally and blood ethanol concentration was maintained at pseudo-steady state levels of 0.6‰ by a three-hour 10% intravenous ethanol clamp. Cardiovascular function, temperature and hydration measures were recorded throughout the study days. Ethanol did not significantly affect physiologic function, with the exception of a short lasting increase in heart rate. MDMA potently increased heart rate and blood pressure and induced fluid retention as well as an increase in temperature. Co-administration of ethanol with MDMA did not affect cardiovascular function compared to the MDMA alone condition, but attenuated the effects of MDMA on fluid retention and showed a trend for attenuation of MDMA-induced temperature increase. In conclusion, co-administration of ethanol and MDMA did not exacerbate physiologic effects compared to all other drug conditions, and moderated some effects of MDMA alone.
Radboud Repository arrow_drop_down Journal of PsychopharmacologyArticle . 2010Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881108100020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 22 citations 22 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Radboud Repository arrow_drop_down Journal of PsychopharmacologyArticle . 2010Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881108100020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Review , Journal 2020 NetherlandsPublisher:Elsevier BV Kuypers, K.; Verkes, R.J.; Verkes, R.J.; van den Brink, W.; van Amsterdam, J.; Ramaekers, J.G.;pmid: 29941239
Violence and drug use are significant public health challenges that are strongly linked. It is known that alcohol plays a major role in the causation of unnatural deaths and that stimulants like cocaine and amphetamine are often implicated in aggressive acts or violence. However, a clear causal relationship between these substances and aggression, and more specifically a blood concentration threshold at which intoxicated aggression emerges is lacking. In case of a crime and subsequent law enforcement, knowledge about dose-response relationships could be of pivotal importance when evaluating the role of alcohol and drugs in aggressive offences.The present review aimed to determine whether there is a causal relation between intoxication with these psychoactive substances and aggression, and to define blood concentration thresholds above which these substances elicit aggression.Empirical articles published between 2013 and 2017 and review papers containing the predefined search strings were identified through searches in the PubMed and Embase databases and additional reference list searches. The complete search query yielded 1578 publications. Initially all articles were manually screened by title and abstract. Articles with irrelevant titles, given the selected search terms and review aims were discarded. Remaining articles were carefully studied and those that did not comply with the main objectives of this review were discarded. At the end of this process, 167 titles were found eligible for review.While placebo-controlled experimental studies clearly showed a causal link between alcohol and aggression, it is evident that such a link has not yet been established for cocaine and amphetamines. In case of alcohol, it is clear that there are various individual and contextual factors that may contribute to the occurrence of an aggressive act during intoxication. A clear threshold blood alcohol concentration has not been defined yet for alcohol, but a statistically significant increase of aggression has been demonstrated at a dose of 0.75 g/kg and higher. Future studies into intoxicated aggression should include multiple doses of alcohol and stimulants and take into account individual and contextual factors.
Radboud Repository arrow_drop_down European NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyOther literature type . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyReview . 2018Data sources: Maastricht University | MUMC+ Research Informationadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.euroneuro.2018.06.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 42 citations 42 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Radboud Repository arrow_drop_down European NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyOther literature type . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyReview . 2018Data sources: Maastricht University | MUMC+ Research Informationadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.euroneuro.2018.06.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2005 NetherlandsPublisher:Elsevier BV Terhaard, C.H.J.; Lubsen, H.; Rasch, C.R.; Levendag, P.C.; Kaanders, J.H.A.M.; Tjho-Heslinga, R.E.; Ende, P.L. van den; Burlage, F.R.;We analyzed the role of primary and postoperative low linear energy transfer radiotherapy in 538 patients treated for salivary gland cancer in centers of the Dutch Head and Neck Oncology Cooperative Group, in search for prognostic factors and dose response.The tumor was located in the parotid gland in 59%, submandibular gland in 14%, oral cavity in 23%, and elsewhere in 5%. In 386 of 498 patients surgery was combined with radiotherapy, with a median dose of 62 Gy. Median delay between surgery and radiotherapy was 6 weeks. In the postoperative radiotherapy group, adverse prognostic factors prevailed. Elective radiotherapy to the neck was given in 40%, with a median dose of 50 Gy. Primary radiotherapy (n = 40) was given for unresectable disease or M(1), with a dose range of 28-74 Gy.Postoperative radiotherapy improved 10-year local control significantly compared with surgery alone in T(3-4) tumors (84% vs. 18%), in patients with close (95% vs. 55%) and incomplete resection (82% vs. 44%), in bone invasion (86% vs. 54%), and perineural invasion (88% vs. 60%). Local control was not correlated with interval between surgery and radiotherapy. No dose-response relationship was shown. Postoperative radiotherapy significantly improved regional control in the pN(+) neck (86% vs. 62% for surgery alone). A rating scale for different sites, T stage, and histologic type may be applied to calculate the risk of disease in the neck at presentation, and so indicate the need for elective neck treatment. A marginal dose-response was seen, in favor of a dose > or =46 Gy. A clear dose-response relationship was shown for patients treated with primary radiotherapy. Five-year local control was 50% with a dose of 66-70 Gy.Postoperative radiotherapy with a dose of at least 60 Gy is indicated for patients with T(3-4) tumors, incomplete or close resection, bone invasion, perineural invasion, and pN(+). In unresectable tumors, a dose of at least 66 Gy is advisable.
Radboud Repository arrow_drop_down International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: Europe PubMed CentralInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: University of Groningen Research PortalInternational Journal of Radiation Oncology*Biology*PhysicsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijrobp.2004.03.018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 362 citations 362 popularity Top 1% influence Top 1% impulse Top 10% Powered by BIP!
more_vert Radboud Repository arrow_drop_down International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: Europe PubMed CentralInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: University of Groningen Research PortalInternational Journal of Radiation Oncology*Biology*PhysicsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijrobp.2004.03.018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 NetherlandsPublisher:Elsevier BV M-K.H Winkler; K.F. Ettwig; T.P.W. Vannecke; K. Stultiens; A. Bogdan; B. Kartal; E.I.P. Volcke;Anaerobic nitrogen removal technologies offer advantages in terms of energy and cost savings over conventional nitrification-denitrification systems. A mathematical model was constructed to evaluate the influence of process operation on the coexistence of nitrite dependent anaerobic methane oxidizing bacteria (n-damo) and anaerobic ammonium oxidizing bacteria (anammox) in a single granule. The nitrite and methane affinity constants of n-damo bacteria were measured experimentally. The biomass yield of n-damo bacteria was derived from experimental data and a thermodynamic state analysis. Through simulations, it was found that the possible survival of n-damo besides anammox bacteria was sensitive to the nitrite/ammonium influent ratio. If ammonium was supplied in excess, n-damo bacteria were outcompeted. At low biomass concentration, n-damo bacteria lost the competition against anammox bacteria. When the biomass loading closely matched the biomass concentration needed for full nutrient removal, strong substrate competition occurred resulting in oscillating removal rates. The simulation results further reveal that smaller granules enabled higher simultaneous ammonium and methane removal efficiencies. The implementation of simultaneous anaerobic methane and ammonium removal will decrease greenhouse gas emissions, but an economic analysis showed that adding anaerobic methane removal to a partial nitritation/anammox process may increase the aeration costs with over 20%. Finally, some considerations were given regarding the practical implementation of the process.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.watres.2015.01.039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 71 citations 71 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.watres.2015.01.039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Serbia, Serbia, Serbia, Italy, SerbiaPublisher:IOP Publishing Funded by:EC | ENSAR2EC| ENSAR2S Fattori; G Petringa; S Agosteo; D Bortot; V Conte; G Cuttone; A Di Fini; F Farokhi; D Mazzucconi; L Pandola; I Petrović; A Ristić-Fira; A Rosenfeld; U Weber; G A P Cirrone;Abstract Objective. In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, y D ¯ and y ¯ F , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of L ¯ d Total and L ¯ t Total with y ¯ D and y ¯ T experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.
VinaR - Repository o... arrow_drop_down Physics in Medicine and BiologyArticle . 2022 . Peer-reviewedLicense: IOP Copyright PoliciesData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1361-6560/ac776f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!
visibility 64visibility views 64 download downloads 148 Powered bymore_vert VinaR - Repository o... arrow_drop_down Physics in Medicine and BiologyArticle . 2022 . Peer-reviewedLicense: IOP Copyright PoliciesData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1361-6560/ac776f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2006 Netherlands, BelgiumPublisher:Wiley Dom, Geert; Wilde, de, Bieke; Hulstijn, Wouter; Brink, van den, Wim; Sabbe, Bernard;Background: Impairments in decision making are a consistent finding in substance use disorder (SUD) populations. However, decision‐making deficits are not specific for SUDs and are also reported in the context of other psychiatric disorders such as antisocial and borderline personality disorders (PDs). Given the frequent comorbidity between SUD and cluster B PD, it might be questioned whether the decision‐making impairments typically reported in SUD populations reflect the addictive disorder, the cluster B PD, or a combination of the 2.Methods: In the current study, we compare the decision‐making performance of non–substance‐abusing controls (n=53) on the Iowa Gambling Task (IGT) with the decision‐making performance of 3 abstinent alcohol‐dependent samples, i.e., alcoholic patients without any PD (n=38), alcoholic patients with a cluster A or C PD (n=19), and alcoholic patients with a cluster B PD (n=23).Results: Overall, all 3 alcohol‐dependent subsamples performed inferior compared with controls. Between alcoholic subsamples, the alcoholic patients with a cluster A or C PD had the highest IGT score, followed by the alcoholic patients without a PD, while the cluster B alcoholic patients were the most impaired.Conclusion: These findings suggest that impairments in decision making underlie both alcohol dependence and cluster B PD, and alcoholic patients with a comorbid cluster B PD are particularly impaired in their decision making. These deficits may underlie the severe problems that characterize cluster B alcoholic patients specifically in inappropriate behaviors (e.g., poly substance abuse, legal, and professional dysfunction).
Radboud Repository arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: CrossrefAlcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2006.00202.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 90 citations 90 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Radboud Repository arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: CrossrefAlcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2006.00202.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2004 NetherlandsPublisher:Springer Science and Business Media LLC Laheij, R.J.F.; Verlaan, M.; Oijen, M.G.H. van; Doelder, M.S. de; Jong, C.A.J. de; Jansen, J.B.M.J.;Excessive alcohol intake frequently results in gastrointestinal discomfort. It is an empirical fact that the severity of gastrointestinal discomfort induced by alcohol abuse is subject to interindividual variation. The aim of this study was to determine whether genetic polymorphism in alcohol dehydrogenase 3 (ADH3) and cytochrome P450 2E1 (CYP2E1), important first-pass enzymes in the metabolism of ethanol, predispose to the development of gastrointestinal symptoms in alcoholics, Blood samples were obtained from 92 adult alcoholics admitted for detoxification. The samples were analyzed for genetic polymorphism in ADH3 and CYP2E1 by polymerase chain reaction followed by restriction fragment length polymorphism analyses. During an interview on the first day of hospital admission, patient characteristics and gastrointestinal symptoms in the week before admission were assessed. A total of 75 of 92 alcoholics (83%) reported symptoms: 66 patients had upper gastrointestinal symptoms (72%), 70 patients had lower gastrointestinal symptoms (76%), and 59 patients reported alarming symptoms (64%). Patients with gastrointestinal symptoms less often abused beer in comparison to those without gastrointestinal symptoms (P = 0.05). The numbers of patients with the homozygous y1y1 genotype, the heterozygous y1y2 genotype, and the homozygous y2y2 genotype in ADH3 who reported gastrointestinal symptoms were 20 (83%), 34 (76%), and 15 (88%), respectively. The number of patients with the heterozygous c1c2 CYP2E1 genotype (5%) and the heterozygous DC CYP2E1 genotype (14%) was low and also unrelated to gastrointestinal symptoms. Our data suggest that the ethanol concentrations of the consumed beverages, and not interindividual variations in the activities of first-pass alcohol-metabolizing enzymes, are associated with gastrointestinal symptoms in alcoholics.
Radboud Repository arrow_drop_down Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/b:ddas.0000034563.02099.78&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert Radboud Repository arrow_drop_down Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008 NetherlandsPublisher:Elsevier BV Bouchard, A.; Jovanovic, N.; Hofland, G.W.; Jiskoot, W.; Mendes, E.; Crommelin, D.J.A.; Witkamp, G.J.;pmid: 17702554
The processibility of 15 carbohydrates, more or less commonly used, was investigated as excipients in supercritical fluid drying. The focus was on the ability to produce amorphous powder, the stability of the powders towards crystallisation, and the residual water and ethanol content. The aqueous solutions were sprayed into a pressurised carbon dioxide-ethanol mixture flowing cocurrently through a coaxial two-fluid nozzle. The powder characteristics appeared to be influenced by the supersaturation level reached during the SCF-drying process and by the properties of the sugar species, such as water solubility and glass transition temperature, or the solution viscosities. The stability and the residual solvent content of a selected set of sugars and some mixtures were further analysed. The stability of amorphous powders was investigated at 4 degrees C, room temperature, 40 and 50 degrees C. Lactose, maltose, trehalose, raffinose, cyclodextrin, low-molecular-weight dextran and inulin could form free-flowing powders that remained amorphous during the 3-month stability study. Sucrose had to be mixed with other sugars to form a stable amorphous powder. Ethanol could be entrapped in supercritical fluid dried low-molecular-weight sugars, whereas polysaccharide powders were free of ethanol. Measures to prevent or overcome the presence of ethanol are discussed.
Utrecht University R... arrow_drop_down European Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Pure Utrecht UniversityEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Europe PubMed CentralEuropean Journal of Pharmaceutics and BiopharmaceuticsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ejpb.2007.06.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 31 citations 31 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Utrecht University R... arrow_drop_down European Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Pure Utrecht UniversityEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Europe PubMed CentralEuropean Journal of Pharmaceutics and BiopharmaceuticsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ejpb.2007.06.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2006 NetherlandsPublisher:Springer Science and Business Media LLC Authors: Teusink, B.; Smid, E.J.;Lactic acid bacteria (LAB) have a long tradition of use in the food industry, and the number and diversity of their applications has increased considerably over the years. Traditionally, process optimization for these applications involved both strain selection and trial and error. More recently, metabolic engineering has emerged as a discipline that focuses on the rational improvement of industrially useful strains. In the post-genomic era, metabolic engineering increasingly benefits from systems biology, an approach that combines mathematical modelling techniques with functional-genomics data to build models for biological interpretation and--ultimately--prediction. In this review, the industrial applications of LAB are mapped onto available global, genome-scale metabolic modelling techniques to evaluate the extent to which functional genomics and systems biology can live up to their industrial promise.
Radboud Repository arrow_drop_down Nature Reviews MicrobiologyArticle . 2006 . Peer-reviewedLicense: Springer TDMData sources: CrossrefNature Reviews MicrobiologyArticle . 2006Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nrmicro1319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 125 citations 125 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Radboud Repository arrow_drop_down Nature Reviews MicrobiologyArticle . 2006 . Peer-reviewedLicense: Springer TDMData sources: CrossrefNature Reviews MicrobiologyArticle . 2006Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Journal 2014 Australia, Australia, NetherlandsPublisher:Springer Science and Business Media LLC Rick A. Vreman; Thomas Roth; Berend Olivier; Adriana C. Bervoets; Suzanne de Klerk; Joris C. Verster; Joris C. Verster; Karel Brookhuis;The purpose of this study was to examine the effects of alcohol hangover on simulated highway driving performance.Driving performance of forty-two social drinkers was tested the morning following an evening of consuming on average 10.2 (SD = 4.2) alcoholic drinks (alcohol hangover) and on a control day (no alcohol consumed). Subjects performed a standardized 100-km highway driving test in the STISIM driving simulator. In addition to the standard deviation of lateral position (SDLP; i.e., the weaving of the car), lapses of attention were examined. Self-reported driving quality and driving style were scored, as well as mental effort to perform the test, sleepiness before and after driving, and hangover severity.Driving performance was significantly impaired during alcohol hangover as expressed by an SDLP increase of +1.9 cm (t (1,41) = 2.851, p = 0.007), increased number of lapses relative to the control day (7.7 versus 5.3 lapses, t (1,41) = 2.125, p = 0.019), and an increased total lapse time (182.7 versus 127.3 s, p = 0.040). During alcohol hangover, subjects reported their driving quality to be significantly poorer (t (1,41) = 4.840, p = 0.001) and less safe (t (1,41) = 5.078, p = 0.001), wise (t (1,41) = 4.061, p = 0.001), predictable (t (1,41) = 3.475, p = 0.001), and responsible (t (1,41) = 4.122, p = 0.001). Subjects further reported being significantly more tense while driving (t (1,41) = 3.280, p = 0.002), and more effort was needed to perform the driving test (t (1,41) = 2.941, p = 0.001). There was a significant interaction with total sleep time and hangover effects on SDLP and the number of lapses.In conclusion, driving is significantly impaired during alcohol hangover, as expressed in an elevated SDLP and increased number of lapses. Total sleep time has a significant impact on the magnitude of driving impairment.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 66 citations 66 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00213-014-3474-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008 NetherlandsPublisher:SAGE Publications Dumont, G.J.H.; Kramers, C.; Kramers, C.; Sweep, C.G.J.; Willemsen, J.J.; Touw, D.J.; Schoemaker, R.C.; van Gerven, J.M.; Buitelaar, J.K.; Verkes, R.J.;Alcohol is frequently used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Both drugs affect cardiovascular function, hydration and temperature regulation, but may have partly opposing effects. The present study aims to assess the acute physiologic effects of (co-) administration of MDMA and ethanol over time. A four-way, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers (9 male and 7 female) between the ages of 18 and 29. MDMA (100 mg) was given orally and blood ethanol concentration was maintained at pseudo-steady state levels of 0.6‰ by a three-hour 10% intravenous ethanol clamp. Cardiovascular function, temperature and hydration measures were recorded throughout the study days. Ethanol did not significantly affect physiologic function, with the exception of a short lasting increase in heart rate. MDMA potently increased heart rate and blood pressure and induced fluid retention as well as an increase in temperature. Co-administration of ethanol with MDMA did not affect cardiovascular function compared to the MDMA alone condition, but attenuated the effects of MDMA on fluid retention and showed a trend for attenuation of MDMA-induced temperature increase. In conclusion, co-administration of ethanol and MDMA did not exacerbate physiologic effects compared to all other drug conditions, and moderated some effects of MDMA alone.
Radboud Repository arrow_drop_down Journal of PsychopharmacologyArticle . 2010Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881108100020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 22 citations 22 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Radboud Repository arrow_drop_down Journal of PsychopharmacologyArticle . 2010Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/0269881108100020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Review , Journal 2020 NetherlandsPublisher:Elsevier BV Kuypers, K.; Verkes, R.J.; Verkes, R.J.; van den Brink, W.; van Amsterdam, J.; Ramaekers, J.G.;pmid: 29941239
Violence and drug use are significant public health challenges that are strongly linked. It is known that alcohol plays a major role in the causation of unnatural deaths and that stimulants like cocaine and amphetamine are often implicated in aggressive acts or violence. However, a clear causal relationship between these substances and aggression, and more specifically a blood concentration threshold at which intoxicated aggression emerges is lacking. In case of a crime and subsequent law enforcement, knowledge about dose-response relationships could be of pivotal importance when evaluating the role of alcohol and drugs in aggressive offences.The present review aimed to determine whether there is a causal relation between intoxication with these psychoactive substances and aggression, and to define blood concentration thresholds above which these substances elicit aggression.Empirical articles published between 2013 and 2017 and review papers containing the predefined search strings were identified through searches in the PubMed and Embase databases and additional reference list searches. The complete search query yielded 1578 publications. Initially all articles were manually screened by title and abstract. Articles with irrelevant titles, given the selected search terms and review aims were discarded. Remaining articles were carefully studied and those that did not comply with the main objectives of this review were discarded. At the end of this process, 167 titles were found eligible for review.While placebo-controlled experimental studies clearly showed a causal link between alcohol and aggression, it is evident that such a link has not yet been established for cocaine and amphetamines. In case of alcohol, it is clear that there are various individual and contextual factors that may contribute to the occurrence of an aggressive act during intoxication. A clear threshold blood alcohol concentration has not been defined yet for alcohol, but a statistically significant increase of aggression has been demonstrated at a dose of 0.75 g/kg and higher. Future studies into intoxicated aggression should include multiple doses of alcohol and stimulants and take into account individual and contextual factors.
Radboud Repository arrow_drop_down European NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyOther literature type . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyReview . 2018Data sources: Maastricht University | MUMC+ Research Informationadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.euroneuro.2018.06.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 42 citations 42 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Radboud Repository arrow_drop_down European NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean NeuropsychopharmacologyArticle . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyOther literature type . 2020Data sources: DANS (Data Archiving and Networked Services)European NeuropsychopharmacologyReview . 2018Data sources: Maastricht University | MUMC+ Research Informationadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.euroneuro.2018.06.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2005 NetherlandsPublisher:Elsevier BV Terhaard, C.H.J.; Lubsen, H.; Rasch, C.R.; Levendag, P.C.; Kaanders, J.H.A.M.; Tjho-Heslinga, R.E.; Ende, P.L. van den; Burlage, F.R.;We analyzed the role of primary and postoperative low linear energy transfer radiotherapy in 538 patients treated for salivary gland cancer in centers of the Dutch Head and Neck Oncology Cooperative Group, in search for prognostic factors and dose response.The tumor was located in the parotid gland in 59%, submandibular gland in 14%, oral cavity in 23%, and elsewhere in 5%. In 386 of 498 patients surgery was combined with radiotherapy, with a median dose of 62 Gy. Median delay between surgery and radiotherapy was 6 weeks. In the postoperative radiotherapy group, adverse prognostic factors prevailed. Elective radiotherapy to the neck was given in 40%, with a median dose of 50 Gy. Primary radiotherapy (n = 40) was given for unresectable disease or M(1), with a dose range of 28-74 Gy.Postoperative radiotherapy improved 10-year local control significantly compared with surgery alone in T(3-4) tumors (84% vs. 18%), in patients with close (95% vs. 55%) and incomplete resection (82% vs. 44%), in bone invasion (86% vs. 54%), and perineural invasion (88% vs. 60%). Local control was not correlated with interval between surgery and radiotherapy. No dose-response relationship was shown. Postoperative radiotherapy significantly improved regional control in the pN(+) neck (86% vs. 62% for surgery alone). A rating scale for different sites, T stage, and histologic type may be applied to calculate the risk of disease in the neck at presentation, and so indicate the need for elective neck treatment. A marginal dose-response was seen, in favor of a dose > or =46 Gy. A clear dose-response relationship was shown for patients treated with primary radiotherapy. Five-year local control was 50% with a dose of 66-70 Gy.Postoperative radiotherapy with a dose of at least 60 Gy is indicated for patients with T(3-4) tumors, incomplete or close resection, bone invasion, perineural invasion, and pN(+). In unresectable tumors, a dose of at least 66 Gy is advisable.
Radboud Repository arrow_drop_down International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: Europe PubMed CentralInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: University of Groningen Research PortalInternational Journal of Radiation Oncology*Biology*PhysicsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijrobp.2004.03.018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 362 citations 362 popularity Top 1% influence Top 1% impulse Top 10% Powered by BIP!
more_vert Radboud Repository arrow_drop_down International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: DANS (Data Archiving and Networked Services)International Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: Europe PubMed CentralInternational Journal of Radiation Oncology*Biology*PhysicsArticle . 2005Data sources: University of Groningen Research PortalInternational Journal of Radiation Oncology*Biology*PhysicsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijrobp.2004.03.018&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 NetherlandsPublisher:Elsevier BV M-K.H Winkler; K.F. Ettwig; T.P.W. Vannecke; K. Stultiens; A. Bogdan; B. Kartal; E.I.P. Volcke;Anaerobic nitrogen removal technologies offer advantages in terms of energy and cost savings over conventional nitrification-denitrification systems. A mathematical model was constructed to evaluate the influence of process operation on the coexistence of nitrite dependent anaerobic methane oxidizing bacteria (n-damo) and anaerobic ammonium oxidizing bacteria (anammox) in a single granule. The nitrite and methane affinity constants of n-damo bacteria were measured experimentally. The biomass yield of n-damo bacteria was derived from experimental data and a thermodynamic state analysis. Through simulations, it was found that the possible survival of n-damo besides anammox bacteria was sensitive to the nitrite/ammonium influent ratio. If ammonium was supplied in excess, n-damo bacteria were outcompeted. At low biomass concentration, n-damo bacteria lost the competition against anammox bacteria. When the biomass loading closely matched the biomass concentration needed for full nutrient removal, strong substrate competition occurred resulting in oscillating removal rates. The simulation results further reveal that smaller granules enabled higher simultaneous ammonium and methane removal efficiencies. The implementation of simultaneous anaerobic methane and ammonium removal will decrease greenhouse gas emissions, but an economic analysis showed that adding anaerobic methane removal to a partial nitritation/anammox process may increase the aeration costs with over 20%. Finally, some considerations were given regarding the practical implementation of the process.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.watres.2015.01.039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 71 citations 71 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.watres.2015.01.039&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Serbia, Serbia, Serbia, Italy, SerbiaPublisher:IOP Publishing Funded by:EC | ENSAR2EC| ENSAR2S Fattori; G Petringa; S Agosteo; D Bortot; V Conte; G Cuttone; A Di Fini; F Farokhi; D Mazzucconi; L Pandola; I Petrović; A Ristić-Fira; A Rosenfeld; U Weber; G A P Cirrone;Abstract Objective. In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, y D ¯ and y ¯ F , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of L ¯ d Total and L ¯ t Total with y ¯ D and y ¯ T experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.
VinaR - Repository o... arrow_drop_down Physics in Medicine and BiologyArticle . 2022 . Peer-reviewedLicense: IOP Copyright PoliciesData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1361-6560/ac776f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!
visibility 64visibility views 64 download downloads 148 Powered bymore_vert VinaR - Repository o... arrow_drop_down Physics in Medicine and BiologyArticle . 2022 . Peer-reviewedLicense: IOP Copyright PoliciesData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1088/1361-6560/ac776f&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2006 Netherlands, BelgiumPublisher:Wiley Dom, Geert; Wilde, de, Bieke; Hulstijn, Wouter; Brink, van den, Wim; Sabbe, Bernard;Background: Impairments in decision making are a consistent finding in substance use disorder (SUD) populations. However, decision‐making deficits are not specific for SUDs and are also reported in the context of other psychiatric disorders such as antisocial and borderline personality disorders (PDs). Given the frequent comorbidity between SUD and cluster B PD, it might be questioned whether the decision‐making impairments typically reported in SUD populations reflect the addictive disorder, the cluster B PD, or a combination of the 2.Methods: In the current study, we compare the decision‐making performance of non–substance‐abusing controls (n=53) on the Iowa Gambling Task (IGT) with the decision‐making performance of 3 abstinent alcohol‐dependent samples, i.e., alcoholic patients without any PD (n=38), alcoholic patients with a cluster A or C PD (n=19), and alcoholic patients with a cluster B PD (n=23).Results: Overall, all 3 alcohol‐dependent subsamples performed inferior compared with controls. Between alcoholic subsamples, the alcoholic patients with a cluster A or C PD had the highest IGT score, followed by the alcoholic patients without a PD, while the cluster B alcoholic patients were the most impaired.Conclusion: These findings suggest that impairments in decision making underlie both alcohol dependence and cluster B PD, and alcoholic patients with a comorbid cluster B PD are particularly impaired in their decision making. These deficits may underlie the severe problems that characterize cluster B alcoholic patients specifically in inappropriate behaviors (e.g., poly substance abuse, legal, and professional dysfunction).
Radboud Repository arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: CrossrefAlcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2006.00202.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 90 citations 90 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Radboud Repository arrow_drop_down Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: CrossrefAlcoholism Clinical and Experimental ResearchArticle . 2006Data sources: DANS (Data Archiving and Networked Services)Alcoholism Clinical and Experimental ResearchArticle . 2006Data sources: Institutional Repository Universiteit Antwerpenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/j.1530-0277.2006.00202.x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2004 NetherlandsPublisher:Springer Science and Business Media LLC Laheij, R.J.F.; Verlaan, M.; Oijen, M.G.H. van; Doelder, M.S. de; Jong, C.A.J. de; Jansen, J.B.M.J.;Excessive alcohol intake frequently results in gastrointestinal discomfort. It is an empirical fact that the severity of gastrointestinal discomfort induced by alcohol abuse is subject to interindividual variation. The aim of this study was to determine whether genetic polymorphism in alcohol dehydrogenase 3 (ADH3) and cytochrome P450 2E1 (CYP2E1), important first-pass enzymes in the metabolism of ethanol, predispose to the development of gastrointestinal symptoms in alcoholics, Blood samples were obtained from 92 adult alcoholics admitted for detoxification. The samples were analyzed for genetic polymorphism in ADH3 and CYP2E1 by polymerase chain reaction followed by restriction fragment length polymorphism analyses. During an interview on the first day of hospital admission, patient characteristics and gastrointestinal symptoms in the week before admission were assessed. A total of 75 of 92 alcoholics (83%) reported symptoms: 66 patients had upper gastrointestinal symptoms (72%), 70 patients had lower gastrointestinal symptoms (76%), and 59 patients reported alarming symptoms (64%). Patients with gastrointestinal symptoms less often abused beer in comparison to those without gastrointestinal symptoms (P = 0.05). The numbers of patients with the homozygous y1y1 genotype, the heterozygous y1y2 genotype, and the homozygous y2y2 genotype in ADH3 who reported gastrointestinal symptoms were 20 (83%), 34 (76%), and 15 (88%), respectively. The number of patients with the heterozygous c1c2 CYP2E1 genotype (5%) and the heterozygous DC CYP2E1 genotype (14%) was low and also unrelated to gastrointestinal symptoms. Our data suggest that the ethanol concentrations of the consumed beverages, and not interindividual variations in the activities of first-pass alcohol-metabolizing enzymes, are associated with gastrointestinal symptoms in alcoholics.
Radboud Repository arrow_drop_down Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/b:ddas.0000034563.02099.78&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert Radboud Repository arrow_drop_down Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)Digestive Diseases and SciencesArticle . 2004Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/b:ddas.0000034563.02099.78&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008 NetherlandsPublisher:Elsevier BV Bouchard, A.; Jovanovic, N.; Hofland, G.W.; Jiskoot, W.; Mendes, E.; Crommelin, D.J.A.; Witkamp, G.J.;pmid: 17702554
The processibility of 15 carbohydrates, more or less commonly used, was investigated as excipients in supercritical fluid drying. The focus was on the ability to produce amorphous powder, the stability of the powders towards crystallisation, and the residual water and ethanol content. The aqueous solutions were sprayed into a pressurised carbon dioxide-ethanol mixture flowing cocurrently through a coaxial two-fluid nozzle. The powder characteristics appeared to be influenced by the supersaturation level reached during the SCF-drying process and by the properties of the sugar species, such as water solubility and glass transition temperature, or the solution viscosities. The stability and the residual solvent content of a selected set of sugars and some mixtures were further analysed. The stability of amorphous powders was investigated at 4 degrees C, room temperature, 40 and 50 degrees C. Lactose, maltose, trehalose, raffinose, cyclodextrin, low-molecular-weight dextran and inulin could form free-flowing powders that remained amorphous during the 3-month stability study. Sucrose had to be mixed with other sugars to form a stable amorphous powder. Ethanol could be entrapped in supercritical fluid dried low-molecular-weight sugars, whereas polysaccharide powders were free of ethanol. Measures to prevent or overcome the presence of ethanol are discussed.
Utrecht University R... arrow_drop_down European Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Pure Utrecht UniversityEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Europe PubMed CentralEuropean Journal of Pharmaceutics and BiopharmaceuticsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ejpb.2007.06.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 31 citations 31 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Utrecht University R... arrow_drop_down European Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Pure Utrecht UniversityEuropean Journal of Pharmaceutics and BiopharmaceuticsArticle . 2008Data sources: Europe PubMed CentralEuropean Journal of Pharmaceutics and BiopharmaceuticsJournalData sources: Microsoft Academic Graphadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ejpb.2007.06.019&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2006 NetherlandsPublisher:Springer Science and Business Media LLC Authors: Teusink, B.; Smid, E.J.;Lactic acid bacteria (LAB) have a long tradition of use in the food industry, and the number and diversity of their applications has increased considerably over the years. Traditionally, process optimization for these applications involved both strain selection and trial and error. More recently, metabolic engineering has emerged as a discipline that focuses on the rational improvement of industrially useful strains. In the post-genomic era, metabolic engineering increasingly benefits from systems biology, an approach that combines mathematical modelling techniques with functional-genomics data to build models for biological interpretation and--ultimately--prediction. In this review, the industrial applications of LAB are mapped onto available global, genome-scale metabolic modelling techniques to evaluate the extent to which functional genomics and systems biology can live up to their industrial promise.
Radboud Repository arrow_drop_down Nature Reviews MicrobiologyArticle . 2006 . Peer-reviewedLicense: Springer TDMData sources: CrossrefNature Reviews MicrobiologyArticle . 2006Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nrmicro1319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 125 citations 125 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Radboud Repository arrow_drop_down Nature Reviews MicrobiologyArticle . 2006 . Peer-reviewedLicense: Springer TDMData sources: CrossrefNature Reviews MicrobiologyArticle . 2006Data sources: DANS (Data Archiving and Networked Services)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nrmicro1319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu