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Abstract A change in the thermal environment of an urban area affects health, living conditions, and energy consumption. In urban planning, urban parks are one of the methods for improving the thermal environment and saving cooling energy. Urban park construction can mitigate temperature, but it also causes urban development by increasing local attractiveness. To achieve efficient energy saving through parks in urban planning, the purpose of this study is to investigate the relationship between building energy consumption and urban characteristics both before and after the construction of an urban park. This study targeted Seoul's Gyeongui line forest, which was recently converted into a linear park on the former railway as an urban regeneration project. We analyzed the relationship between energy consumption and urban characteristics using a regression model, focusing on the changes before and after the construction. In this study, urban characteristics include environment, building physical characteristics, and economic variables. The results show that the construction of the urban park reduced not only temperature but also building energy consumption. The energy reduction effect of the park was limited to a marginal distance. Meanwhile, the urban park construction caused land prices to rise and prompted new development, and this changed the urban characteristics of the area and affected energy consumption. Despite changes in urban characteristics, urban park planning is an effective methods of reducing the energy consumption involved in cooling urban areas. We recommend comprehensive consideration of the urban factors when making park policy to reduce urban temperature and energy consumption.

Project: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets - These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6). CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ). The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. Summary: These data include the subset used by IPCC AR6 WGI authors of the datasets originally published in ESGF for 'CMIP6.CMIP.SNU.SAM0-UNICON.piControl' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'. The SAM0-UNICON (SNU Atmosphere Model version 0 with Unified Convection Scheme) climate model, released in 2017, includes the following components: aerosol: MAM3, atmos: CAM5.3 with UNICON (1deg; 288 x 192 longitude/latitude; 30 levels; top level ~2 hPa), land: CLM4.0, ocean: POP2 (Displaced Pole; 320 x 384 longitude/latitude; 60 levels; top grid cell 0-10 m), seaIce: CICE4.0. The model was run by the Seoul National University, Seoul 08826, Republic of Korea (SNU) in native nominal resolutions: aerosol: 100 km, atmos: 100 km, land: 100 km, ocean: 100 km, seaIce: 100 km.

In 16 patients with unifocal thyroid autonomy suffering from hyperthyroidism and in 2 patients and euthyrosis 2-4 ml 96% alcohol was instilled to destroy the autonomous thyroid tissue while permanently monitoring the procedure by means of sonography. 17 of the patients were suffering from struma nodosa. Localization of the focally autonomous adenoma was possible, together with differentiation against concomitant thyroid nodes with normal or reduced function, by coinciding the findings obtained via colour Doppler sonography and scintiscanning. In one female patient local pain occurred during instillation that had to be alleviated by means of analgetics; there were no other noticeable side effects. 12 of 16 patients suffering from hyperthyroidism were euthyrotic 5 weeks after the first alcohol instillation; the thyrostatic dose had to be reduced in 4 patients. B-image sonography showed a reduction in size of the instilled adenomas and echo-poor and partly cystic transformation. Colour Doppler sonography revealed a marked reduction of internal vascularisation with preserved marginal vessels. Scintiscan control no longer visualised the autonomic foci (n = 10) or only with reduced activity (n = 7). Sonographically monitored on-target instillation of alcohol into autonomic thyroid adenoma is an effective, low-risk and low-cost procedure that can also be applied to outpatients by physicians well-versed in colour Doppler sonography and sonographic puncture technique. Colour Doppler sonographic localization of autonomic foci is methodically mandatory in patients suffering from struma multinodosa.

Abstract Supercritical carbon dioxide (S-CO2) power cycle has been under the spotlight for years as one of the promising solutions to resolve the energy and environmental problem. The most of previous studies focused on cycle performances and applicable configuration. In this study, detailed and extensive analysis on the recompression S-CO2 power cycle was carried out to reflect more practical and desirable conditions. This study focused on the optimization of the S-CO2 cycle by evaluation of the irreversibility of the recuperators using the effectiveness analysis and pinch point temperature difference (PPTD) analysis. Split ratio from the main stream to the recompressor and compression ratio were considered as independent parameters. From the simulation, the characteristics and performance of the recompression cycle were discussed. The optimum operating conditions were determined in combinations of PPTDs of the two recuperators. With the performance curves, control strategy of the two independent parameters is ranged for desirable operation of S-CO2 power cycle.

Minimally invasive treatment of symptomatic thyroid nodules is now commonplace. Ethanol ablation (EA) of thyroid cystic nodules has been performed since the 1990s, but there is no global consensus or guideline. Although various limitations of EA have been described, recommendations for practical application are necessary. Therefore, the Task Force Committee of the Korean Society of Thyroid Radiology initiated the present consensus statement and here we provide recommendations for the role of EA in the management of symptomatic thyroid nodules. These recommendations are based on evidence to date from the literature and expert opinion.

Abstract There might not be enough market demand to foster continuous technological development of eco-innovation in its initial stage due to its low-cost competitiveness. Therefore, demand induced by policy can play an important role for eco-innovation. Existing studies indicate that demand-side policy significantly impacts the development and diffusion of new technologies. However, the mechanism of how demand-side policy facilitates innovation is unclear. This study hypothesizes that policy-induced demand affects production activities, and verifies that these production activities promote innovative output. We analyze the solar photovoltaic sector of 14 major countries from 1999 to 2016. The estimations are conducted using panel fixed-effects regression and three-stage least squares (3SLS). The results confirm the mechanism by which policy-induced demand positively impacts production activities and the expansion of production contributes to innovation performance. This helps us to understand the importance of demand-side policy for eco-innovation. Furthermore, our study, by unpacking the mediating mechanisms of production that transmit the effects of demand-side policy, offers pragmatic reasons for the need for policy-makers pursuing eco-innovation to engage in encouraging production activity.

AbstractChronic ethanol consumption causes hepatic steatosis and inflammation, which are associated with liver hypoxia. Monocyte chemoattractant protein‐1 (MCP‐1) is a hypoxia response factor that determines recruitment and activation of monocytes to the site of tissue injury. The level of MCP‐1 is elevated in the serum and liver of patients with alcoholic liver disease (ALD); however, the molecular details regarding the regulation of MCP‐1 expression are not yet understood completely. Here, we show the role of liver X receptor α (LXRα) in the regulation of MCP‐1 expression during the development of ethanol‐induced fatty liver injury, using an antagonist, 22‐S‐hydroxycholesterol (22‐S‐HC). First, administration of 22‐S‐HC attenuated the signs of liver injury with decreased levels of MCP‐1 and its receptor CCR2 in ethanol‐fed mice. Second, hypoxic conditions or treatment with the LXRα agonist GW3965 significantly induced the expression of MCP‐1, which was completely blocked by treatment with 22‐S‐HC or infection by shLXRα lentivirus in the primary hepatocytes. Third, over‐expression of LXRα or GW3965 treatment increased MCP‐1 promoter activity by increasing the binding of hypoxia‐inducible factor‐1α to the hypoxia response elements, together with LXRα. Finally, treatment with recombinant MCP‐1 increased the level of expression of LXRα and LXRα‐dependent lipid droplet accumulation in both hepatocytes and Kupffer cells. These data show that LXRα and its ligand‐induced up‐regulation of MCP‐1 and MCP‐1‐induced LXRα‐dependent lipogenesis play a key role in the autocrine and paracrine activation of MCP‐1 in the pathogenesis of alcoholic fatty liver disease, and that this activation may provide a promising new target for ALD therapy.Copyright © 2014 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

We examined the potential of Azolla japonica as a remediating plant for leachate channels and post-accumulation use as fertilizer for landfill slope. The harvested biomass of Azolla after one month grown in leachate was 254% that of the initial biomass and the predicted annual harvestable biomass of Azolla using a growth model was 32 times that of the initial biomass. Na, Fe, Mn, Mg, and P were accumulated in Azolla at very high concentrations. Such rapid increase of biomass and high accumulation rates suggest that this plant could be an excellent remediating plant. The post-harvest use of Azolla as compost was studied for the management and use of phytoaccumulating Azolla. Metal contents of Azolla compost were below permissible limits for co-composting material. Nitrogen, organic matter, P, and Mg content of the Azolla compost improved the soil condition of the landfill and enhanced ecophysiological responses of the plants. The application of Azolla compost can improve management of sanitary landfills, including the restoration of vegetation. Considering its ease of harvesting, high accumulation rates, harvestable biomass and suitability for composting, Azolla can provide a suitable solution for sustainable management of leachate channels and landfill slopes.