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Domestic heating represents the most dominant energy function in Dutch households nowadays. Using district heat from CHP (combined heat and power) by means of a NGCC (natural gas-fired combined cycle) plants is generally acknowledged as an effective option to reduce primary energy consumption for heating. However, methods to calculate energy savings from CHP differ widely. This paper compares a number of different methods, including the method from the EU CHP Directive, to estimate primary energy savings in comparison with the typically used domestic gas-fired condensing boiler. Real hourly CHP plant performance data is used. An estimation of the CO2 mitigation cost of delivering district heat to Dutch dwellings is made. We find that supplying dwellings with district heat from an NGCC-CHP saves energy, regardless of the calculation method and for a rather wide range of reference efficiencies. CO2 mitigation costs are acceptable from a social perspective (at discount rates up to 4%, excluding fuel taxes) and negative from a private perspective (at discount rates up to 10%, including fuel taxes).

It has been suggested that the relationship between income and the associated environmental pressure in terms of derived materials inputs and pollution levels may take an inverted-U shape, indicating a 'delinking' of environmental pressure from economic growth in relation to rising per capita incomes. The likelihood of such a relationship being persistent is discussed in the context of a simple macro model of industrial metabolism, and the possibility of 'relinking' clearly emerges. Data on specific indicators of environmental pressure (i.e., the throughput of materials, energy and the volume of transport) in 19 countries have been used to investigate patterns of delinking. The results suggest that delinking may not be persistent; already some advanced economies may be entering a new period of relinking. The relationships between environmental pressure and welfare in the medium long term may be N-shaped rather than inverted-U-shaped.

The potential of renewable energy should be fully exploited in the transportation sector to achieve a cleaner production. Therefore, this paper proposes an on-grid hybrid hydrogen refueling and battery swapping station powered by wind energy. This novel concept can promote the development of low-carbon emission vehicles including hydrogen-based vehicle and battery electric vehicle. During the daily operation of the station, the multiple uncertainties may lead to a higher operational cost. To address this problem, a hybrid stochastic/distributionally robust optimization method is proposed to handle different uncertainties for the energy management problem. The first type of uncertainties can be depicted by a certain distribution, i.e. electricity price and wind power, which is processed by a stochastic optimization method. The second type of uncertainties is associated with human behaviors and is difficult to find its probability distribution, i.e. the hydrogen demand of hydrogen-based vehicles, so the second type is processed by a distributionally robust optimization method. The overall objective is to minimize the total operational cost of the station, which also considers the battery swapping station overstock punishment. Because a reasonable battery swapping scheduling can reduce the waiting time of users and operational cost of the station. The results indicate that the proposed method can effectively address the conservatism of solutions as its total operational cost is 4.4% lower than that of the hybrid stochastic/robust optimization method under a high confidence level.

In medial tibial stress syndrome (MTSS) bone marrow and periosteal edema of the tibia on the magnetic resonance imaging (MRI) is frequently reported. The relationship between these MRI findings and recovery has not been previously studied. This prospective study describes MRI findings of 52 athletes with MTSS. Baseline characteristics were recorded and recovery was related to these parameters and MRI findings to examine for prognostic factors. Results showed that 43.5% of the symptomatic legs showed bone marrow or periosteal edema. Absence of periosteal and bone marrow edema on MRI was associated with longer recovery (P = 0.033 and P = 0.013). A clinical scoring system for sports activity (SARS score) was significantly higher in the presence of bone marrow edema (P = 0.027). When clinical scoring systems (SARS score and the Lower Extremity Functional Scale) were combined in a model, time to recovery could be predicted substantially (explaining 54% of variance, P = 0.006). In conclusion, in athletes with MTSS, bone marrow or periosteal edema is seen on MRI in 43,5% of the symptomatic legs. Furthermore, periosteal and bone marrow edema on MRI and clinical scoring systems are prognostic factors. Future studies should focus on MRI findings in symptomatic MTSS and compare these with a matched control group.

This study assesses the environmental impact of polyethylene terephthalate (PET) bottle-to-fibre recycling using the methodology of life-cycle assessment (LCA). Four recycling cases, including mechanical recycling, semi-mechanical recycling, back-to-oligomer recycling and back-to-monomer recycling were analysed. Three allocation methods are applied for open-loop recycling, i.e. the “cut-off” approach, the “waste valuation” approach and the “system expansion” approach. Nine environmental impact indicators were analysed, i.e. non-renewable energy use (NREU), global warming potential (GWP), abiotic depletion, acidification, eutrophication, human toxicity, fresh water aquatic ecotoxicity, terrestrial ecotoxicity and photochemical oxidant formation. The LCA results are compared with virgin PET fibre and other commodity fibre products, i.e. cotton, viscose, PP (polypropylene) and PLA (polylactic acid). The LCA results show that recycled PET fibres offer important environmental benefits over virgin PET fibre. Depending on the allocation methods applied for open-loop-recycling, NREU savings of 40–85% and GWP savings of 25–75% can be achieved. Recycled PET fibres produced by mechanical recycling cause lower environmental impacts than virgin PET in at least eight out of a total of nine categories. Recycled fibres produced from chemical recycling allow to reduce impacts in six to seven out of a total of nine categories compared to virgin PET fibres. Note that while mechanical recycling has a better environmental profile than chemical recycling, chemically recycled fibres can be applied in a wider range of applications than mechanically recycled fibres.

This study investigated the effectiveness of a targeted intervention program aimed at at-risk adolescents in a randomized clinical trial design (N=107). This program combined intervention methods which have been proven effective in reducing drinking in young adults, such as an expectancy challenge, cognitive behavioral skill training and brief motivational feedback. Additionally, this intervention contained the new element of discussing biological, cognitive and social risk factors for developing alcohol problems. We investigated whether this seven session program was successful in changing cognitive determinants of drinking behavior and consequently in moderating alcohol use and the development of alcohol-related problems in at-risk adolescents. The intervention was effective in changing several of the targeted cognitive determinants. However, despite the changes in these cognitive determinants of drinking, the experimental group did not show a significant difference in decrease of drinking at posttest compared with the control group. The results did not yield support for any differential long term effects of the intervention. We concluded that although the present intervention successfully changed important cognitive determinants of drinking more is needed to change subsequent drinking behavior in at-risk adolescents.

Previous studies in 5-HT(1A) receptor knockout (1AKO) mice on a mixed Swiss Websterx129/Sv (SWx129/Sv) and a pure 129/Sv genetic background suggest a differential gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor complex sensitivity in both strains, independent from the anxious phenotype. To further investigate these discrepancies, various GABA(A)-benzodiazepine receptor ligands were tested in different behavioral paradigms in 1AKO and wild type (WT) mice on a 129/Sv background. 1AKO and WT mice responded comparably to alprazolam, flumazenil, alcohol and pentylenetetrazol as measured in the stress-induced hyperthermia paradigm. In addition, sedative-anesthetic effects of pentobarbital measured via the righting reflex were similar and a selected dose of diazepam exerted similar anxiolytic effects in both genotypes in the elevated plus maze. In conclusion, 1AKO mice on a 129/Sv background have undisturbed GABA(A)-benzodiazepine receptor sensitivity in contrast to those described on a mixed Swiss Websterx129/Sv background. The anxious phenotype of 1AKO mice seems to occur independent of the GABA(A)-benzodiazepine receptor complex functioning.