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AbstractIntroductionFoetal alcohol spectrum disorders (FASD) are a set of preventable conditions where the foetus is exposed to alcohol in utero and as a result suffers adverse consequences. To develop a public health strategy related to FASD, it is important to first establish what is known by the public about this condition. This study aimed to assess the current level of knowledge about FASD in the UK general population.MethodsA mixed methodology study was conducted using a 17‐item questionnaire and focus group sessions. Four focus groups were held with an average of 10 people in each group. Semi‐structured questions and thematic analysis of interviews alongside quantitative analysis of the questionnaire data was completed. The research was approved by an National Health service (NHS) research ethical committee.ResultsA total of 674 people responded to the questionnaire and a majority (86.7%) had heard about FASD, with most receiving their information from the media (26.2%) or from their work (27.7%). Four broad themes emerged. Overall these were: a general lack of knowledge about the subject; information about the subject needed to be personally relevant; there was a need for further education; and there was a lack of clarity in the current guidance on alcohol use in pregnancy.Discussion and conclusionsCurrently there appears to be a superficial level of knowledge about FASD in the UK general public. More detailed work in subgroups, such as young women, to identify their specific needs may be necessary before targeted public health and educational interventions can be developed to meet the needs of the general public.

Residential energy consumption in China increased dramatically over the period of 2002-2010. In this paper, we undertake a decomposition analysis of changes in energy use by Chinese households for five energy-using activities: space heating/cooling, cooking, lighting and electric appliances. We investigate to what extent changes in energy use are due to changes from appliances and to change in floor space, population and energy mix. Our decomposition analysis is based on the logarithmic mean Divisia index technique using data from the China statistical yearbook and China energy statistical yearbook in the period of 2002-2010. According to our results, the increase in energy-using appliances is the biggest contributor to the increase of residential energy consumption during 2002-2010 but the effect declines over time, due to energy efficiency improvements in those appliances. The second most important contributor is floor space per capita, which increased with 28%. Of the four factors, population is the most stable factor and energy mix is the least important factor. We predicted electricity use, with the help of regression-based predictions for ownership of appliances and the energy efficiency of appliances. We found that electricity use will continue to rise despite a gradual saturation of demand

To reduce human causes of global warming, large scale implementation of innovative products that save energy is necessary. Innovative products first reach the early market actors who are driven by a visionary attitude. Hereafter, the products must reach the much larger mainstream market whose actors are driven by a pragmatic attitude. Many innovations, however, only appeal to the visionary early market and do not meet the more pragmatic needs of the mainstream. For that reason, innovations often fall in a "chasm" between the early market and the mainstream and fail to reach the mainstream. We developed a strategy and a protocol to aid governmental agencies in influencing the mainstream members of housing associations to adopt energy conservation innovations. Our method is an adaptation of an existing marketing method and applicable to other target groups. The first step in crossing this chasm is to find a niche segment in the mainstream as the starting point for winning the rest of the mainstream. By surveying the target group and analyzing the data, we identified 29 housing associations (234 interviewed) that belong to this niche segment. Identifying the niche segment and its determinants of behaviour is part of our 4-step protocol that leads to adapting the innovative product to meet the needs of the niche and setting up a marketing plan to win the rest of the mainstream.

This study investigated the effectiveness of a targeted intervention program aimed at at-risk adolescents in a randomized clinical trial design (N=107). This program combined intervention methods which have been proven effective in reducing drinking in young adults, such as an expectancy challenge, cognitive behavioral skill training and brief motivational feedback. Additionally, this intervention contained the new element of discussing biological, cognitive and social risk factors for developing alcohol problems. We investigated whether this seven session program was successful in changing cognitive determinants of drinking behavior and consequently in moderating alcohol use and the development of alcohol-related problems in at-risk adolescents. The intervention was effective in changing several of the targeted cognitive determinants. However, despite the changes in these cognitive determinants of drinking, the experimental group did not show a significant difference in decrease of drinking at posttest compared with the control group. The results did not yield support for any differential long term effects of the intervention. We concluded that although the present intervention successfully changed important cognitive determinants of drinking more is needed to change subsequent drinking behavior in at-risk adolescents.

This paper investigates the effects of the energy efficiency and sustainability of commercial properties on the operating and stock performance of a sample of US REITs, providing insight into the net benefits of green buildings. We match data on LEED- and Energy Star-certified buildings with detailed information on REIT portfolios and calculate the share of green properties for each REIT over the 2000-2011 period. We estimate a two-stage regression model and document that the greenness of REITs is positively related to three measures of operating performance - return on assets, return on equity and the ratio of funds from operations to total revenue. We also document that there is no significant relationship between the greenness of property portfolios and abnormal stock returns, suggesting that stock prices already reflect the higher cash flows deriving from investments in more efficient properties. However, REITs with a higher fraction of green properties display significantly lower market betas.

The functionalized soluble poly(p-phenylene vinylene) derivative bearing polar molecules (nlo-ppv) was designed and synthesized to investigate effects of molecular orientation in single-layer polymer photovoltaic devices. The active molecule is the 4-(n-butyl-n-2-hydroxyethyl)-1-nitro-benzene group on the copolymer. The grafting of the molecule with a donor/transmitter/acceptor structure, possessing a large ground state dipole moment, enables their orientation by a dc-electric field. An internal electric field in such layer facilitates exciton dissociation and improves charge transport. We report increase of the external quantum efficiency by a factor of 1.5 to 2 upon orientation. The associated effects on the carrier injection and transport depending on the orientation direction were evidenced.

Evidence indicates that ethanol-induced intestinal barrier dysfunction and subsequent endotoxemia plays a key role in the pathogenesis of alcoholic liver disease. Recently, it has been demonstrated that ethanol induces RhoA kinase activation in intestinal epithelium, thereby disrupting barrier integrity. In this study, the role of a rise in intracellular calcium concentration ([Ca2+]i) in ethanol-induced Rho-associated coiled coil-forming kinase (Rho/ROCK) activation and barrier disruption was investigated in Caco-2 cell monolayers. Treatment of Caco-2 monolayers with 40 mmol/l ethanol induced [Ca2+]irelease as indicated by increased relative fluorescent units of Fluo-3 from 0.06 ± 0.02 to 2.27 ± 1.96 ( P < 0.0001). Pretreatment with 1,2-bis(2-aminophenoxy) ethane- N,N,N′,N′-tetraacetic acid (BAPTA-AM) completely inhibited the release, whereas the inositol 1,4,5-triphosphate receptor (IP3R)-antagonist, Xestospongin C, partially inhibited the ethanol-induced [Ca2+]irelease (from 2.27 ± 1.96 to 0.03 ± 0.01; P < 0.0001 and from 2.27 ± 1.96 to 1.19 ± 1.80; P < 0.001, respectively). The rise in [Ca2+]iwas paralleled with increased intestinal permeability, which could be attenuated by either BAPTA-AM or Xestospongin C. Furthermore, ethanol induced Rho/ROCK activation, as indicated by increased phosphorylation of myosin-binding subunit, which could be prevented either by BAPTA, Xestospongin C, or the specific Rho/ROCK inhibitor Y27632. Finally, inhibition of Rho/ROCK kinase by Y27632 ameliorated the ethanol-induced redistribution of zonula occluden-1, adherens junction proteins including E-cadherin and β-catenin, and also disorganization of F-actin. These findings suggest that ethanol-induced [Ca2+]irelease, mediated by stimulating IP3R-gated Ca2+channel, activates Rho/ROCK in Caco-2 cells, thereby contributing to ethanol-induced intestinal barrier dysfunction.

Results from epidemiological studies suggest that alcohol drinkers have a decreased risk of lymphoid neoplasms, whereas results for myeloid neoplasms are inconsistent. However, most of these studies have used retrospective data. We examined prospectively whether alcohol consumption decreases the risk of both lymphoid and myeloid neoplasms, including most common subtypes. Moreover, we investigated whether this decreased risk is due to ethanol or other contents of specific alcoholic beverages (i.e., beer, wine and liquor). The Netherlands cohort study consisted of 120,852 individuals who completed a baseline questionnaire in 1986. After 17.3 years of follow‐up, 1,375 cases of lymphoid and 245 cases of myeloid neoplasms with complete exposure information were available for analysis. Compared with abstinence, we observed for plasma cell neoplasms hazard rate ratios (HR) of 1.66 (95% confidence interval (CI), 1.21–2.29), 1.63 (95% CI, 1.17–2.27), 1.11 (95% CI, 0.75–1.64) and 0.85 (95% CI, 0.51–1.42) with daily ethanol consumption of 0.1–<5, 5–<15, 15–<30 and ≥30 g, respectively. A similar pattern was observed for chronic lymphocytic leukemia/small lymphocytic lymphoma. No associations were observed for other subtypes and for myeloid neoplasms. When results were analyzed by beverage type, no clear associations were observed. In conclusion, our study did not show an inverse association between alcohol consumption and lymphoid neoplasms. Also, no inverse association was observed with myeloid neoplasms. If any association between alcohol consumption and lymphoid neoplasms exists, our study suggests an increased risk rather than a decreased risk.