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  • Biocompatibility of Poly-Lactic Acid/Nanohydroxyapatite/Graphene Nanocomposites for Load Bearing Bone Implants

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    descriptionPublicationkeyboard_double_arrow_right Article 2023Publisher:The Electrochemical Society
    Authors: Feven Mattews Michael; Lim Siew Shee; Gunasundari Raju; Sarvesh Rustagi; +3 Authors

    doi: 10.1149/1945-7111/acb7a2

    In this study, poly-lactic acid (PLA), nanohydroxyapatite (NHA), and graphene nanoplatelets (GNP) were blended to develop a nanocomposite material suitable for load-bearing bone implants with the potential for strain-sensing applications. The tensile properties and impact strength of the PLA-NHA nanocomposite were analyzed, as these are crucial biomechanical properties for load-bearing and strain-sensing applications. It was found that the impact strength decreased by 7.9% (0.05 wt% GNP) and 25.7% (0.1 wt% GNP) with increasing GNP loading compared to 0.01 wt% GNP. Besides, the biocompatibility of nanocomposites (PLA-NHA, PLA-mNHA, and PLA-mNHA-GNP) was evaluated through in-vitro analysis by attaching MG63 cells to the nanocomposites and observing their proliferation and differentiation over 7 and 21 days of incubation. The biocompatibility of the prepared nanocomposites was determined based on their ability to attach with MG63 cells, thus allowing the cells to proliferate and enhance their ability to differentiate. Results showed that the PLA-5wt%NHA nanocomposite provided better cell spreading compared to pure PLA, while the PLA-5wt%mNHA nanocomposite had the highest rate of cell proliferation. The biocompatibility of the nanocomposites was further confirmed by field emission scanning electron microscope (FESEM) imaging, MTT assays, and alkaline phosphatase (ALP) assays.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of The Elect...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Journal of The Electrochemical Society
    Article . 2023 . Peer-reviewed
    License: IOP Copyright Policies
    Data sources: Crossref
    Claim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    3
    citations3
    popularityTop 10%
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of The Elect...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of The Electrochemical Society
      Article . 2023 . Peer-reviewed
      License: IOP Copyright Policies
      Data sources: Crossref
      Claim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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Advanced search in Research products
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Simple Search
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The following results are related to Energy Research. Are you interested to view more results? Visit OpenAIRE - Explore.
1 Research products
download

  • Biocompatibility of Poly-Lactic Acid/Nanohydroxyapatite/Graphene Nanocomposites for Load Bearing Bone Implants

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    descriptionPublicationkeyboard_double_arrow_right Article 2023Publisher:The Electrochemical Society
    Authors: Feven Mattews Michael; Lim Siew Shee; Gunasundari Raju; Sarvesh Rustagi; +3 Authors

    doi: 10.1149/1945-7111/acb7a2

    In this study, poly-lactic acid (PLA), nanohydroxyapatite (NHA), and graphene nanoplatelets (GNP) were blended to develop a nanocomposite material suitable for load-bearing bone implants with the potential for strain-sensing applications. The tensile properties and impact strength of the PLA-NHA nanocomposite were analyzed, as these are crucial biomechanical properties for load-bearing and strain-sensing applications. It was found that the impact strength decreased by 7.9% (0.05 wt% GNP) and 25.7% (0.1 wt% GNP) with increasing GNP loading compared to 0.01 wt% GNP. Besides, the biocompatibility of nanocomposites (PLA-NHA, PLA-mNHA, and PLA-mNHA-GNP) was evaluated through in-vitro analysis by attaching MG63 cells to the nanocomposites and observing their proliferation and differentiation over 7 and 21 days of incubation. The biocompatibility of the prepared nanocomposites was determined based on their ability to attach with MG63 cells, thus allowing the cells to proliferate and enhance their ability to differentiate. Results showed that the PLA-5wt%NHA nanocomposite provided better cell spreading compared to pure PLA, while the PLA-5wt%mNHA nanocomposite had the highest rate of cell proliferation. The biocompatibility of the nanocomposites was further confirmed by field emission scanning electron microscope (FESEM) imaging, MTT assays, and alkaline phosphatase (ALP) assays.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of The Elect...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Journal of The Electrochemical Society
    Article . 2023 . Peer-reviewed
    License: IOP Copyright Policies
    Data sources: Crossref
    Claim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    3
    citations3
    popularityTop 10%
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of The Elect...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of The Electrochemical Society
      Article . 2023 . Peer-reviewed
      License: IOP Copyright Policies
      Data sources: Crossref
      Claim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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