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Considerable attention has been paid to heavy episodic or “binge” drinking among college youth in the United States. Despite widespread use, the binge measure is perceived by some as a low intervention threshold. We use data from the Harvard School of Public Health College Alcohol Study ( n = 49,163) to describe patterns of consumption and harms along a continuum including the binge measure to demonstrate the validity of the binge threshold and prevention paradox in college. While the heaviest drinkers are at greatest risk for harm, they are relatively few and generate proportionately small amounts of all drinking-harms. The risk of harms is not zero among lower level drinkers in college. Because they are numerous, they account for the majority of harms. This paradoxical pattern suggests we moderate consumption among the majority using environmental approaches, the efficacy of which are described using case study data from a national prevention demonstration. Implications for prevention policy, programming, and media advocacy are discussed.

Alarm bells are sounding internationally as climate change impacts planet Earth and its inhabitants. Health care organizations must consider the role they play in working toward environmental sustainability in terms of mitigation, resilience, leadership, and equity. Institutions need to address the effects of climate change on the physical health and mental well-being of patients and their families as well as employees. Awareness of the complexities of sustainability initiatives and disaster management related to inclement weather and weather-related events is critical for health care organizations to avoid precipitating the illnesses and diseases they endeavor to prevent and heal.

Up to 100 billion devices will be seeking to visually map out our existence over the internet by 2020 (UK Government Chief Scientific Adviser 2014). Just as the urban is a forcefield "of spatial transformations... that takes many different morphological forms” (Brenner 2014), this paper explores another underlying forcefield: our visual relationship with data. The most important piece of data, the individual, exists in the city as both prey and predator; having evolved from a "passive aesthetic view of the city” (Appleyard 1979, 144); transformed through shared territory (Evans and Jones 2008); and forged into impressively intricate sets of power relations through collective intentionality (Searle 2011). Through the presentation of self (Goffman, 1969, cited in Appleyard 1979, 146) we inhabit another home: the digital; in which we are simultaneously co-existent and removed by synchronisation of data. Traditionally, the software authoring the physical production of ‘space/hardware' has been value driven (Raban, 1974, 128, cited in Appleyard 1979, 146). In a parallel universe, algorithms drive the data. For Ellis (2012) it is in the software, that meaning resides. What then is the allure of data to the individual? And what is the allure of the individual to data? It lies arguably in the perception of power and control through meaning (Appleyard, Searle et al.). We seek in the new reality to "discover where the real power lies” (Appleyard 1979, 146). Curiously, the power of data appears to increase the irrelevancy of ownership, between "ours” and "theirs” (Appleyard 1979, 152). This paper analyses past, present, and future states of data production. The data we get from data; data produced from objects; and objects produced from data. In closing, a speculative working hypothesis is presented of visual data production, which hopefully encourages further research reconciling data with meaning in the context of visual sustainability.

Background: Dopamine concentrations in the nucleus accumbens fluctuate on phasic (subsecond) and tonic (over minutes) timescales in awake rats. Acute ethanol increases tonic concentrations of dopamine, but its effect on subsecond dopamine transients has not been fully explored.Methods: We measured tonic and phasic dopamine fluctuations in the nucleus accumbens of rats in response to ethanol (within‐subject cumulative dosing, 0.125 to 2 g/kg, i.v.).Results: Microdialysis samples yielded significant tonic increases in dopamine concentrations at 1 to 2 g/kg ethanol in each rat, while repeated saline infusions had no effect. When monitored with fast scan cyclic voltammetry, ethanol increased the frequency of dopamine transients in 6 of 16 recording sites, in contrast to the uniform effect of ethanol as measured with microdialysis. In the remaining 10 recording sites that were unresponsive to ethanol, dopamine transients either decreased in frequency or were unaffected by cumulative ethanol infusions, patterns also observed during repeated saline infusions. The responsiveness of particular recording sites to ethanol was not correlated with either core versus shell placement of the electrodes or the basal rate of dopamine transients. Importantly, the phasic response pattern to a single dose of ethanol at a particular site was qualitatively reproduced when a second dose of ethanol was administered, suggesting that the variable between‐site effects reflected specific pharmacology at that recording site.Conclusions: These data demonstrate that the relatively uniform dopamine concentrations obtained with microdialysis can mask a dramatic heterogeneity of phasic dopamine release within the accumbens.

A 45 year old man with metastatic colon cancer presented with uncontrollable abdominal wall pain. Transversus abdominis plane (TAP) block with ropivacaine and methylprednisolone was performed with excellent pain relief, which allowed a significant weaning of the patient's opioid requirements. A second TAP block was performed with a 33% ethanol solution (ethanol and ropivacaine) with excellent pain relief. The neurolytic block appeared to offer better pain control for more than 5 days after placement until the patient finally succumbed to his illness.

The role of peripherally and centrally acting acetaldehyde in ethanol‐induced conditioned taste aversion (CTA) was investigated using various enzyme manipulations. Cyanamide, an aldehyde dehydrogenase inhibitor (ALDH) elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4‐methylpyrazole (4MP), an alcohol dehydrogenase inhibitor, prevents peripheral accumulation of acetaldehyde by cyanamide. Under both treatment conditions brain and liver ALDH activity is inhibited. Water‐deprived rats were pretreated 4 hr prior to fluid presentation with intraperitoneal injections of saline (S+S), 4‐methylpyrazole (4MP+S), cyanamide (S+C), or 4‐methylpyrazole + cyanamide (4MP+C). Subsequently, animals were presented with a novel saccharin solution followed immediately by intraperitoneal injection of one of three doses of ethanol (0.4, 0.8, or 1.2 g/kg) or saline vehicle on four occasions. Results suggested that animals pretreated with cyanamide (groups S+C and 4MP+C) drank significantly less saccharin after conditioning with a subthreshold dose of ethanol (0.4 g/kg) in comparison to groups S+S and 4MP+S. Moreover, at the conditioning dose of 1.2 g/kg, cyanamide‐treated animals demonstrated an attenuation of CTA compared to the other two groups. These effects cannot be attributed to elevated blood acetaldehyde levels since pretreatment with 4MP+C prevented peripheral acetaldehyde accumulation. A characteristic common to both cyanamide‐treated groups was the inhibition of brain ALDH. It is therefore suggested that brain ALDH may play a role in the mediation of ethanol‐induced CTAs. It is conceivable that ALDH plays this role by regulating the levels of acetaldehyde in brain.

As the wind farm sector grows and becomes an established renewable energy source, it introduces new materials, technologies and processes that expose workers to increased and unique occupational risks. In this paper, we performed a generic review of scientific and industry literature on online scientific databases and search engines to identify the extent to which occupational health hazards and risks specific to wind farms have been considered. Our review revealed noise, electromagnetic fields, shadow flicker, epoxy and styrene and physical stress have been the focus of limited research, mainly including self-reported data from offshore wind farm employees. Factors such as vibration, welding fumes and other possibly harmful substances, weather conditions and biological hazards have not been addressed by studies, although their presence and combinations could be of concern. Therefore, there is a need for further research on unique and combined risks and hazards faced by workers across all lifecycle stages of wind energy production. This would improve knowledge and provide the opportunity to manage health hazards in current and newly constructed installations and inform future regulatory and other preventative measures.

Background: Chronic alcohol consumption has been demonstrated to be deleterious to bone health. However, binge drinking is the prevalent form of drinking in young people, which was the impetus for the present study to determine the effect of week‐end and week‐long binge drinking on bone health in a young actively growing animal model. Methods: Four‐week‐old, female, Sprague‐Dawley rats were given the amount of 5% alcohol by gavage to be equivalent to a 63 kg woman drinking six beers a day for either 2 or 5 consecutive days per week. Results: There were no changes in the 5‐day binge animals, but the 2‐day binge animals were hypocalcemia Similarly, 2‐day binge animals had slightly increased bone chemistry and histomorphometric values for both tibia and femur, but only femur length, dry weight, and ash weight as well as femur density, presented either as g/ml or ash weight per unit volume, were increased by a statistically significant level. Cross‐section periosteal Mineral Apposition Rate (MAR) was significantly decreased in the 2‐day alcohol fed animals. Conclusions: Actively growing rats given 5% alcohol by gavage for 2 days per week have an increased bone length, bone weight, and bone density. The interpretation of these results must be viewed with great caution because studies of chronic alcohol consumption, and many studies of acute drinking, clearly indicate deleterious effects of alcohol on bone health. Those fed alcohol for 5 days per week showed no change.