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AbstractLarge conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders. However, whether the action of ethanol at BK α influences the motivation to drink alcohol remains to be determined. To address this question, we first tested the effect of systemically administered BK channel modulators on voluntary alcohol consumption in C57BL/6J males. Penitrem A (blocker) exerted dose-dependent effects on moderate alcohol intake, while paxilline (blocker) and BMS-204352 (opener) were ineffective. Because pharmacological manipulations are inherently limited by non-specific effects, we then sought to investigate the behavioral relevance of ethanol’s direct interaction with BK α by introducing in the mouse genome a point mutation known to render BK channels insensitive to ethanol while preserving their physiological function. The BK α K361N substitution prevented ethanol from reducing spike threshold in medial habenula neurons. However, it did not alter acute responses to ethanol in vivo, including ataxia, sedation, hypothermia, analgesia, and conditioned place preference. Furthermore, the mutation did not have reproducible effects on alcohol consumption in limited, continuous, or intermittent access home cage two-bottle choice paradigms conducted in both males and females. Notably, in contrast to previous observations made in mice missing BK channel auxiliary β subunits, the BK α K361N substitution had no significant impact on ethanol intake escalation induced by chronic intermittent alcohol vapor inhalation. It also did not affect the metabolic and locomotor consequences of chronic alcohol exposure. Altogether, these data suggest that the direct interaction of ethanol with BK α does not mediate the alcohol-related phenotypes examined here in mice.

The impedance-based stability criteria are widely adopted for small-signal stability analysis of power systems. Among them, the determinant-based multi-input multi-output (MIMO) Nyquist criterion is particularly attractive since it simplifies the stability determination process without calculating the eigenvalues of MIMO systems. However, it is found in this letter that the determinant-based Nyquist criterion can potentially result in incorrect stability analysis results with pure inductance models in the MIMO models of the power network. This letter illustrates the issue and its root cause through mathematical derivation and numerical analysis. Then, the issue is demonstrated through an example system, and the corresponding solutions are provided as well.

This deliverable includes the methodology in EnergyPROSPECTS for an in-depth study of energy citizenship. It features the criteria used for selecting the cases for indepth study, the list of cases selected for in-depth study as well as key research foci and empirical research questions.

The Sulphurdale Geothermal Field is located in Beaver County Utah, within the boundaries of the Cove Fort--Sulphurdale Known Geothermal Resource Area (KGRA). During the past year, three wells drilled in Section 7, T-26-S, R-6-W, have produced dry steam from a fractured volcanic formation located at a depth of about 1100 feet. Two of these three wells are currently prepared to supply steam to a power plant, and one well has been plugged and abandoned. ThermaSource, Inc. was retained by Mother Earth Industries, the operator of the field, to conduct well tests and render an opinion as to the nature of the geothermal reserves and assess the commercial potential of these reserves. Because of the limited area that has been explored to date, there can be no assurance that the reserves estimate will prove accurate. Project economics are based on parameters believed to be accurate, but there is no assurance that such cash flow projections will be realized.

Considering recent environmental regulations, the need to adapt domestic biomass combustion systems to models that generate less emissions has gained relative importance. The present research proposes an analysis of the bed cooling effects on emission patterns, specifically focusing on the concentration, typology and morphological aspects of the released particles. The study was carried out by comparing the behaviour of a small-scale pilot plant with air stratification, with and without bed cooling. The results revealed an optimal behaviour of the facility with distributions of 30% primary-70% secondary air, accompanied by a significant decrease in emissions due to the reduction in the operating temperatures. More than 75% of the particles were retained in the bed on the cooled surfaces due to the effect of the prominent temperature gradient that was produced. Among the types of emitted particles (mostly with sizes below 0.1 μm), the presence of partial biomass degradation remnants was observed, representing three-quarters of the total collected matter. To a lesser extent, the presence of carbonaceous agglomerates was detected and usually in very compact clusters; however, in cases of high primary air supply, large amounts of immature soot were observed. Agencia Estatal de Investigación | Ref. RTI2018-100765-B-I00

Abstract The Seed-and-Blanket (SB it is few percent higher than that of the 2-stage PWR-ABR system. Approximately 7% of the thorium fed to the blanket is converted into energy, which makes the thorium fuel utilization approximately 12 times the utilization of natural uranium in PWRs. A comprehensive fuel cycle evaluation performed with the methodology developed by the recent U.S Department of Energy’s Nuclear Fuel Cycle Evaluation and Screening campaign concludes that the PWR-S&B system has similar fuel cycle performance characteristics as the PWR-ABR system. The S&B concept may potentially feature improved economics and resource utilization relative to the ABR.