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Climate change is an emerging global health crisis, disproportionately affecting low- and middle-income countries (LMICs) where health outcomes are increasingly compromised by environmental stressors such as pollution, natural disasters, and human migration. With a focus on promoting health equity, Global Surgery advocates for expanding access to surgical care and enhancing health outcomes, particularly in resource-limited and disaster-affected areas like LMICs. The healthcare industry—and more specifically, surgical care—significantly contributes to the global carbon footprint, primarily through resource-intensive settings, i.e. operating rooms that generate greenhouse gases and substantial medical waste. Therefore, Global Surgery efforts aimed at improving surgical access through an increase in surgical volumes may inadvertently exacerbate health challenges for vulnerable populations by further contributing to environmental degradation. This predicament is particularly pronounced in LMICs, who already suffer from a disproportionate share of the global burden of disease, and where the demand for surgery is rising without corresponding resilient infrastructure. LMICs face a double jeopardy of health inequity coupled with climate vulnerability. As a movement positioned to improve health around the world, Global Surgery has an increasingly significant role in envisioning and ensuring a sustainable future. Global Surgery initiatives must prioritise sustainable infrastructure in both high-income countries (HICs) and LMICs, all while accounting for the unequal polluting contributions between HICs and LMICs and, consequently, moral responsibilities moving forward. Moreover, through targeting upstream causes of poor health at urban and perioperative levels, Global Surgery’s interventions may help to reduce the global burden of disease—avoiding preventable surgeries and their carbon footprints from the outset. Altogether, Global Surgery and climate change are two matters of social justice whose solutions must synergistically centralise the health of both the planet and its most vulnerable people.

Les conséquences du changement climatique sont particulièrement aiguës au Kenya, où 80 % des terres sont arides ou semi-arides. Quelle perspective critique et constructive le concept d’habitabilité peut-il offrir dans ce contexte ? Fondé sur un travail de terrain réalisé au Kenya en 2022 et 2023, cet article entend affiner une définition in situ de l’habitabilité, en utilisant exclusivement des données qualitatives issues de deux phases de recherche, complétées par des exercices de vidéo-cartographie. Loin de proposer une lecture positiviste de l’habitabilité, portée par une conception exclusivement mécanique et linéaire des dynamiques de mobilité, cette étude propose de mieux relier l’habitabilité aux pratiques quotidiennes, aux habitudes, aux solidarités, voire aux résistances qui constituent la vie ordinaire des habitants des communautés et des personnes déplacées. L’habitabilité se situerait alors au cœur de l’intrication entre socialité et spatialité, entre social et biologique, qui définit – selon Stanley Cavell – la forme de vie humaine. The consequences of climate change are particularly acute in Kenya, where 80% of the land is arid or semi-arid. What critical and constructive perspective can the concept of habitability offer in this context? Based on fieldwork carried out in Kenya in 2022 and 2023, this article aims to refine an in-situ definition of habitability, using exclusively qualitative data from two research phases, supplemented by video-mapping exercises. Far from proposing a positivist reading of habitability, driven by an exclusively mechanical and linear conception of mobility dynamics, this study proposes to better link habitability to the daily practices, habits, solidarities and even resistances that make up the ordinary lives of community dwellers and displaced persons. Habitability would then lie at the heart of the intricacy between sociality and spatiality, between the social and the biological, which defines – according to Stanley Cavell – “the human form of life.”

Degradation issues correlated to microstructural changes are the main obstacles to solid oxide fuel cell and electrolyser applications, making their identification and understanding fundamental steps. Coupling experimental activities with modelling, this work analyses the state-of-the-art Ni-YSZ (Yttria-Stabilized Zirconia)/YSZ/CGO (Cerium Gadolinium Oxide)/LSCF (Lanthanum Strontium Cobalt Ferrite)-CGO-based cell after 1000 h of galvanostatic electrolysis operation at fixed temperature and high steam composition in the inlet gas. Following a multiscale approach, the system behaviour is characterized through electrochemical impedance spectra and polarization curves as well as studying microstructure evolution, with a focus on Ni-cermet functional layer in view of Ni instability detected as the main degradation cause. A comparison with a cell consisting of the same initial geometrical structure and materials but aged in fuel cell mode allows to highlight the influence of operating mode and parameters on Ni-YSZ microstructure. Ni particle size and phase fraction variations experimentally observed on the electrode surface are correlated to water content and applied polarization simulated local values. Ni uneven distribution at the electrolyte interface and particle coarsening, above all, lead to an increase in polarization loss under electrolysis and fuel cell mode, respectively, since both penalise the charge transfer reaction and migration.

AbstractThe summer of 2018 was characterized by prolonged heatwaves over Northern Europe, associated with persistent atmospheric blocking, and an unusually northward jet stream location over Scandinavia. Whilst event attribution studies tend to focus on the change in probability or magnitude of the extreme temperatures themselves, we provide context to these studies by examining whether there are human induced trends in the atmospheric circulation that might affect the likelihood of similar extreme circulation patterns and associated heat waves occurring in the future. We examine trends and variability in summer jet latitude, blocking frequency and overall circulation pattern over the Scandinavian sector in a variety of reanalyses and climate model ensembles. Both the number of blocked days, and the average jet location for summer 2018 were unprecedented in the reanalyses, and rare in climate model simulations. We found no robust evidence of past or future externally forced changes in summer blocking frequency over Scandinavia in model simulations, whilst trends in circulation analogs were also largely insignificant. Trends in jet latitude were dependent on the time period examined, models included and other analysis choices. Overall, we found no robust evidence for systematic trends in average or extreme years toward Summer 2018‐like conditions for any of the three indices, nor in the frequency of co‐occurring extreme northward jet latitude and high blocking frequency. We conclude that Summer 2018s circulation can likely be explained by internal atmospheric variability.

Materials and design 254, 114021 (2025). doi:10.1016/j.matdes.2025.114021 Published by Elsevier Science, Amsterdam [u.a.]

Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries. This manuscript presents selected key variables that represent the Alcohol Exposome. The primary variables that make up the Alcohol Exposome can include comorbidities such as cigarettes, poor diet, occupational hazards, environmental hazards, infectious agents, and aging. In addition to representing multiple factors, the Alcohol Exposome examines the various types of intercellular communications that are carried from one organ system to another and may greatly impact the types of injuries and metabolites caused by alcohol exposure. The intent of defining the Alcohol Exposome is to bring the newly expanded definition of Exposomics, meaning the study of the exposome, to the field of alcohol research and to emphasize the need for examining research results in a non-isolated environment representing a more relevant manner in which all human physiology exists.

For decades, Agrobacterium tumefaciens-mediated plant transformation has played an integral role in advancing fundamental and applied plant biology. The recent omnipresent emergence of synthetic biology, which relies on plant transformation to manipulate plant DNA and gene expression for novel product biosynthesis, has further propelled basic as well as applied interests in plant transformation technologies. The strong demand for a faster design-build-test-learn cycle, the essence of synthetic biology, is, however, still ill-matched with the long-standing issues of high tissue culture recalcitrance and low transformation efficiency of a wide range of plant species especially food, fiber and energy crops. To maximize the utility of plant material and improve the transformation productivity per unit plant form, we studied the regeneration and transformation efficiency of different types of explants, including leaf, stem, petiole, and root from Populus, a woody perennial bioenergy crop. Our results show that root explants, in addition to the above-ground tissues, have considerable regeneration capacity and amenability to A. tumefaciens and, the resulting transformants have largely comparable morphology, reporter gene expression, and transcriptome profile, independent of the explant source tissue. Transcriptome analyses mapped to regeneration stages and transformation efficiencies further revealed the expression of the auxin and cytokinin signaling and various developmental pathway genes in leaf and root explants undergoing early organogenesis. We further report high-potential candidate genes that may potentially be associated with higher regeneration and transformation efficiency. Overall, our study shows that explants from above- and belowground organs of a Populus plant are suitable for genetic transformation and tissue culture regeneration, and together with the underlying transcriptome data open new routes to maximize plant explant utilization, stable transformation productivity, and plant transformation efficiency.