- NIH| 1/2-The West Africa-Michigan CHARTER II for GEOHealth-USA
Thomas Peprah Agyekum; Thomas Peprah Agyekum
Harvested from ORCID Public Data FileThomas Peprah Agyekum in OpenAIRE John Arko-Mensah; John Arko-Mensah
Harvested from ORCID Public Data FileJohn Arko-Mensah in OpenAIRE
Paul Kingsley Botwe; Jonathan Nartey Hogarh; +6 AuthorsPaul Kingsley Botwe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesPaul Kingsley Botwe in OpenAIRE Thomas Peprah Agyekum; Thomas Peprah Agyekum
Harvested from ORCID Public Data FileThomas Peprah Agyekum in OpenAIRE John Arko-Mensah; John Arko-Mensah
Harvested from ORCID Public Data FileJohn Arko-Mensah in OpenAIRE Paul Kingsley Botwe; Jonathan Nartey Hogarh;Paul Kingsley Botwe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesPaul Kingsley Botwe in OpenAIRE Ibrahim Issah; Ibrahim Issah
Harvested from ORCID Public Data FileIbrahim Issah in OpenAIRE Samuel Kweku Dadzie; Duah Dwomoh; Maxwell Kelvin Billah; Thomas Robins;Samuel Kweku Dadzie
Harvested from ORCID Public Data FileSamuel Kweku Dadzie in OpenAIRE Julius Najah Fobil; Julius Najah Fobil
Harvested from ORCID Public Data FileJulius Najah Fobil in OpenAIREAbstract Background Malaria remains one of the most devastating diseases globally, and the control of mosquitoes as the vector is mainly dependent on chemical insecticides. Elevated temperatures associated with future warmer climates could affect mosquitoes' metabolic enzyme expression and increase insecticide resistance, making vector control difficult. Understanding how mosquito rearing temperatures influence their susceptibility to insecticide and expression of metabolic enzymes could aid in the development of novel tools and strategies to control mosquitoes in a future warmer climate. This study evaluated the effects of temperature on the susceptibility of Anopheles gambiae sensu lato (s.l.) mosquitoes to pyrethroids and their expression of metabolic enzymes. Methods Anopheles gambiae s.l. eggs obtained from laboratory-established colonies were reared under eight temperature regimes (25, 28, 30, 32, 34, 36, 38, and 40 °C). Upon adult emergence, 3- to 5-day-old female non-blood-fed mosquitoes were used for susceptibility tests following the World Health Organization (WHO) bioassay protocol. Batches of 20–25 mosquitoes from each temperature regime (25–34 °C) were exposed to two pyrethroid insecticides (0.75% permethrin and 0.05% deltamethrin). In addition, the levels of four metabolic enzymes (α-esterase, β-esterase, glutathione S-transferase [GST], and mixed-function oxidase [MFO]) were examined in mosquitoes that were not exposed and those that were exposed to pyrethroids. Results Mortality in An. gambiae s.l. mosquitoes exposed to deltamethrin and permethrin decreased at temperatures above 28 °C. In addition, mosquitoes reared at higher temperatures were more resistant and had more elevated enzyme levels than those raised at low temperatures. Overall, mosquitoes that survived after being exposed to pyrethroids had higher levels of metabolic enzymes than those that were not exposed to pyrethroids. Conclusions This study provides evidence that elevated temperatures decreased An. gambiae s.l. mosquitoes' susceptibility to pyrethroids and increased the expression of metabolic enzymes. This evidence suggests that elevated temperatures projected in a future warmer climate could increase mosquitoes' resistance to insecticides and complicate malaria vector control measures. This study therefore provides vital information, and suggests useful areas of future research, on the effects of temperature variability on mosquitoes that could guide vector control measures in a future warmer climate. Graphical Abstract
Access RoutesGreen gold 9 citations 9 popularity Top 10% influence Average impulse Top 10% 
Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13071-022-05273-z&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| 1/2-The West Africa-Michigan CHARTER II for GEOHealth-USA Thomas Peprah Agyekum;
Thomas Peprah Agyekum
Harvested from ORCID Public Data FileThomas Peprah Agyekum in OpenAIRE John Arko-Mensah; John Arko-Mensah
Harvested from ORCID Public Data FileJohn Arko-Mensah in OpenAIRE Paul Kingsley Botwe; Jonathan Nartey Hogarh; +6 AuthorsPaul Kingsley Botwe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesPaul Kingsley Botwe in OpenAIRE Thomas Peprah Agyekum; Thomas Peprah Agyekum
Harvested from ORCID Public Data FileThomas Peprah Agyekum in OpenAIRE John Arko-Mensah; John Arko-Mensah
Harvested from ORCID Public Data FileJohn Arko-Mensah in OpenAIRE Paul Kingsley Botwe; Jonathan Nartey Hogarh;Paul Kingsley Botwe
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesPaul Kingsley Botwe in OpenAIRE Ibrahim Issah; Ibrahim Issah
Harvested from ORCID Public Data FileIbrahim Issah in OpenAIRE Samuel Kweku Dadzie; Duah Dwomoh; Maxwell Kelvin Billah; Thomas Robins;Samuel Kweku Dadzie
Harvested from ORCID Public Data FileSamuel Kweku Dadzie in OpenAIRE Julius Najah Fobil; Julius Najah Fobil
Harvested from ORCID Public Data FileJulius Najah Fobil in OpenAIREAbstract Background Malaria remains one of the most devastating diseases globally, and the control of mosquitoes as the vector is mainly dependent on chemical insecticides. Elevated temperatures associated with future warmer climates could affect mosquitoes' metabolic enzyme expression and increase insecticide resistance, making vector control difficult. Understanding how mosquito rearing temperatures influence their susceptibility to insecticide and expression of metabolic enzymes could aid in the development of novel tools and strategies to control mosquitoes in a future warmer climate. This study evaluated the effects of temperature on the susceptibility of Anopheles gambiae sensu lato (s.l.) mosquitoes to pyrethroids and their expression of metabolic enzymes. Methods Anopheles gambiae s.l. eggs obtained from laboratory-established colonies were reared under eight temperature regimes (25, 28, 30, 32, 34, 36, 38, and 40 °C). Upon adult emergence, 3- to 5-day-old female non-blood-fed mosquitoes were used for susceptibility tests following the World Health Organization (WHO) bioassay protocol. Batches of 20–25 mosquitoes from each temperature regime (25–34 °C) were exposed to two pyrethroid insecticides (0.75% permethrin and 0.05% deltamethrin). In addition, the levels of four metabolic enzymes (α-esterase, β-esterase, glutathione S-transferase [GST], and mixed-function oxidase [MFO]) were examined in mosquitoes that were not exposed and those that were exposed to pyrethroids. Results Mortality in An. gambiae s.l. mosquitoes exposed to deltamethrin and permethrin decreased at temperatures above 28 °C. In addition, mosquitoes reared at higher temperatures were more resistant and had more elevated enzyme levels than those raised at low temperatures. Overall, mosquitoes that survived after being exposed to pyrethroids had higher levels of metabolic enzymes than those that were not exposed to pyrethroids. Conclusions This study provides evidence that elevated temperatures decreased An. gambiae s.l. mosquitoes' susceptibility to pyrethroids and increased the expression of metabolic enzymes. This evidence suggests that elevated temperatures projected in a future warmer climate could increase mosquitoes' resistance to insecticides and complicate malaria vector control measures. This study therefore provides vital information, and suggests useful areas of future research, on the effects of temperature variability on mosquitoes that could guide vector control measures in a future warmer climate. Graphical Abstract
Access RoutesGreen gold 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13071-022-05273-z&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| Role of BK Channel Interactome in Excessive Ethanol Drinking ,NIH| Activation of the parasubthalamic nucleus in alcohol dependence ,NIH| CORE--BIOCHEMICAL COREAgbonlahor Okhuarobo; Max Kreifeldt; Pauravi J. Gandhi; Catherine Lopez; +9 Authors
Pauravi J. Gandhi
Harvested from ORCID Public Data FilePauravi J. Gandhi in OpenAIREAgbonlahor Okhuarobo; Max Kreifeldt; Pauravi J. Gandhi; Catherine Lopez; Briana Martinez;Pauravi J. Gandhi
Harvested from ORCID Public Data FilePauravi J. Gandhi in OpenAIRE Kiera Fleck; Michal Bajo;Kiera Fleck
Harvested from ORCID Public Data FileKiera Fleck in OpenAIRE Pushpita Bhattacharyya; Alex M. Dopico;Pushpita Bhattacharyya
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesPushpita Bhattacharyya in OpenAIRE Marisa Roberto; Amanda J. Roberts;Marisa Roberto
Harvested from ORCID Public Data FileMarisa Roberto in OpenAIRE Gregg E. Homanics; Gregg E. Homanics
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGregg E. Homanics in OpenAIRE Candice Contet; Candice Contet
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesCandice Contet in OpenAIREAbstractLarge conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders. However, whether the action of ethanol at BK α influences the motivation to drink alcohol remains to be determined. To address this question, we first tested the effect of systemically administered BK channel modulators on voluntary alcohol consumption in C57BL/6J males. Penitrem A (blocker) exerted dose-dependent effects on moderate alcohol intake, while paxilline (blocker) and BMS-204352 (opener) were ineffective. Because pharmacological manipulations are inherently limited by non-specific effects, we then sought to investigate the behavioral relevance of ethanol’s direct interaction with BK α by introducing in the mouse genome a point mutation known to render BK channels insensitive to ethanol while preserving their physiological function. The BK α K361N substitution prevented ethanol from reducing spike threshold in medial habenula neurons. However, it did not alter acute responses to ethanol in vivo, including ataxia, sedation, hypothermia, analgesia, and conditioned place preference. Furthermore, the mutation did not have reproducible effects on alcohol consumption in limited, continuous, or intermittent access home cage two-bottle choice paradigms conducted in both males and females. Notably, in contrast to previous observations made in mice missing BK channel auxiliary β subunits, the BK α K361N substitution had no significant impact on ethanol intake escalation induced by chronic intermittent alcohol vapor inhalation. It also did not affect the metabolic and locomotor consequences of chronic alcohol exposure. Altogether, these data suggest that the direct interaction of ethanol with BK α does not mediate the alcohol-related phenotypes examined here in mice.
Access RoutesGreen hybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-023-02346-y&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| Role of BK Channel Interactome in Excessive Ethanol Drinking ,NIH| Activation of the parasubthalamic nucleus in alcohol dependence ,NIH| CORE--BIOCHEMICAL COREAgbonlahor Okhuarobo; Max Kreifeldt; Pauravi J. Gandhi; Catherine Lopez; +9 Authors
Pauravi J. Gandhi
Harvested from ORCID Public Data FilePauravi J. Gandhi in OpenAIREAgbonlahor Okhuarobo; Max Kreifeldt; Pauravi J. Gandhi; Catherine Lopez; Briana Martinez;Pauravi J. Gandhi
Harvested from ORCID Public Data FilePauravi J. Gandhi in OpenAIRE Kiera Fleck; Michal Bajo;Kiera Fleck
Harvested from ORCID Public Data FileKiera Fleck in OpenAIRE Pushpita Bhattacharyya; Alex M. Dopico;Pushpita Bhattacharyya
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesPushpita Bhattacharyya in OpenAIRE Marisa Roberto; Amanda J. Roberts;Marisa Roberto
Harvested from ORCID Public Data FileMarisa Roberto in OpenAIRE Gregg E. Homanics; Gregg E. Homanics
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGregg E. Homanics in OpenAIRE Candice Contet; Candice Contet
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesCandice Contet in OpenAIREAbstractLarge conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders. However, whether the action of ethanol at BK α influences the motivation to drink alcohol remains to be determined. To address this question, we first tested the effect of systemically administered BK channel modulators on voluntary alcohol consumption in C57BL/6J males. Penitrem A (blocker) exerted dose-dependent effects on moderate alcohol intake, while paxilline (blocker) and BMS-204352 (opener) were ineffective. Because pharmacological manipulations are inherently limited by non-specific effects, we then sought to investigate the behavioral relevance of ethanol’s direct interaction with BK α by introducing in the mouse genome a point mutation known to render BK channels insensitive to ethanol while preserving their physiological function. The BK α K361N substitution prevented ethanol from reducing spike threshold in medial habenula neurons. However, it did not alter acute responses to ethanol in vivo, including ataxia, sedation, hypothermia, analgesia, and conditioned place preference. Furthermore, the mutation did not have reproducible effects on alcohol consumption in limited, continuous, or intermittent access home cage two-bottle choice paradigms conducted in both males and females. Notably, in contrast to previous observations made in mice missing BK channel auxiliary β subunits, the BK α K361N substitution had no significant impact on ethanol intake escalation induced by chronic intermittent alcohol vapor inhalation. It also did not affect the metabolic and locomotor consequences of chronic alcohol exposure. Altogether, these data suggest that the direct interaction of ethanol with BK α does not mediate the alcohol-related phenotypes examined here in mice.
Access RoutesGreen hybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-023-02346-y&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Guoyong Yan; Chunnan Fan; Junqiang Zheng; Guancheng Liu; +23 Authors
Guoyong Yan
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGuoyong Yan in OpenAIRE Guoyong Yan; Chunnan Fan; Junqiang Zheng; Guancheng Liu; Jinghua Yu; Zhongling Guo; Wei Cao; Lihua Wang; Wenjie Wang; Qingfan Meng; Junhui Zhang; Yan Li; Jinping Zheng; Xiaoyang Cui; Xiaochun Wang;Guoyong Yan
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGuoyong Yan in OpenAIRE Lijian Xu; Yan Sun; Zhi Zhang; Xiao-Tao Lü; Ying Zhang; Rongjiu Shi; Guangyou Hao; Yue Feng;Xiao-Tao Lü
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesXiao-Tao Lü in OpenAIRE Jinsheng He; Jinsheng He
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesJinsheng He in OpenAIRE Qinggui Wang; Qinggui Wang
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesQinggui Wang in OpenAIRE Yajuan Xing; Yajuan Xing
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesYajuan Xing in OpenAIRE Shijie Han; Shijie Han
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesShijie Han in OpenAIREAbstractUnderstanding the mechanisms controlling forest carbon accumulation is crucial for predicting and mitigating future climate change. Yet, it remains unclear whether the dominance of ectomycorrhizal (EcM) trees influences the carbon accumulation of entire forests. In this study, we analyzed forest inventory data from over 4000 forest plots across Northeast China. We find that EcM tree dominance consistently exerts a positive effect on tree, soil, and forest carbon stocks. Moreover, we observe that these positive effects are more pronounced during unfavorable climate conditions, at lower tree species richness, and during early successional stages. This underscores the potential of increasing the dominance of native EcM tree species not only to enhance carbon stocks but also to bolster resilience against climate change in high-latitude forests. Here we show that forest managers can make informed decisions to optimize carbon accumulation by considering various factors such as mycorrhizal types, climate, successional stages, and species richness.
Access RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-024-50423-9&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Guoyong Yan; Chunnan Fan; Junqiang Zheng; Guancheng Liu; +23 Authors
Guoyong Yan
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGuoyong Yan in OpenAIRE Guoyong Yan; Chunnan Fan; Junqiang Zheng; Guancheng Liu; Jinghua Yu; Zhongling Guo; Wei Cao; Lihua Wang; Wenjie Wang; Qingfan Meng; Junhui Zhang; Yan Li; Jinping Zheng; Xiaoyang Cui; Xiaochun Wang;Guoyong Yan
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesGuoyong Yan in OpenAIRE Lijian Xu; Yan Sun; Zhi Zhang; Xiao-Tao Lü; Ying Zhang; Rongjiu Shi; Guangyou Hao; Yue Feng;Xiao-Tao Lü
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesXiao-Tao Lü in OpenAIRE Jinsheng He; Jinsheng He
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesJinsheng He in OpenAIRE Qinggui Wang; Qinggui Wang
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesQinggui Wang in OpenAIRE Yajuan Xing; Yajuan Xing
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesYajuan Xing in OpenAIRE Shijie Han; Shijie Han
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesShijie Han in OpenAIREAbstractUnderstanding the mechanisms controlling forest carbon accumulation is crucial for predicting and mitigating future climate change. Yet, it remains unclear whether the dominance of ectomycorrhizal (EcM) trees influences the carbon accumulation of entire forests. In this study, we analyzed forest inventory data from over 4000 forest plots across Northeast China. We find that EcM tree dominance consistently exerts a positive effect on tree, soil, and forest carbon stocks. Moreover, we observe that these positive effects are more pronounced during unfavorable climate conditions, at lower tree species richness, and during early successional stages. This underscores the potential of increasing the dominance of native EcM tree species not only to enhance carbon stocks but also to bolster resilience against climate change in high-latitude forests. Here we show that forest managers can make informed decisions to optimize carbon accumulation by considering various factors such as mycorrhizal types, climate, successional stages, and species richness.
Access RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-024-50423-9&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Access Routes
Green hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.amjmed.2020.05.002&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Access Routes
Green hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.amjmed.2020.05.002&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Laura E Hamon;
Laura E Hamon
Harvested from ORCID Public Data FileLaura E Hamon in OpenAIRE Joel G Kingsolver; Kati J Moore;Joel G Kingsolver
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesJoel G Kingsolver in OpenAIRE Allen H Hurlbert; Allen H Hurlbert
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesAllen H Hurlbert in OpenAIREAbstract Climate change has been repeatedly linked to phenological shifts in many taxa, but the factors that drive variation in phenological sensitivity remain unclear. For example, relatively little is known about phenological responses in areas that have not exhibited a consistent warming trend, making it difficult to project phenological responses in response to future climate scenarios for these regions. We used an extensive community science dataset to examine changes in the adult flight onset dates of 38 butterfly species with interannual variation in spring temperatures in the Piedmont region of North Carolina, a region that did not experience a significant overall warming trend in the second half of the 20th century. We also explored whether voltinism, overwintering stage, and mean adult flight onset dates explain interspecific variation in phenological sensitivity to spring temperature. We found that 12 out of 38 species exhibited a significant advance in adult flight onset dates with higher spring temperatures. In comparison, none of the 38 species exhibited a significant advance with year. There was a significant interaction between mean onset flight date and voltinism, such that late-emerging, multivoltine species tended to be the most sensitive to spring temperature changes. We did not observe a significant correlation between phenological sensitivity and the overwintering stage. These results suggest that butterfly arrival dates may shift as temperatures are projected to rise in the southeastern United States, with late-emerging, multivoltine species potentially exhibiting the greatest shifts in adult flight onset dates.
Access RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ee/nvae110&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Laura E Hamon;
Laura E Hamon
Harvested from ORCID Public Data FileLaura E Hamon in OpenAIRE Joel G Kingsolver; Kati J Moore;Joel G Kingsolver
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesJoel G Kingsolver in OpenAIRE Allen H Hurlbert; Allen H Hurlbert
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesAllen H Hurlbert in OpenAIREAbstract Climate change has been repeatedly linked to phenological shifts in many taxa, but the factors that drive variation in phenological sensitivity remain unclear. For example, relatively little is known about phenological responses in areas that have not exhibited a consistent warming trend, making it difficult to project phenological responses in response to future climate scenarios for these regions. We used an extensive community science dataset to examine changes in the adult flight onset dates of 38 butterfly species with interannual variation in spring temperatures in the Piedmont region of North Carolina, a region that did not experience a significant overall warming trend in the second half of the 20th century. We also explored whether voltinism, overwintering stage, and mean adult flight onset dates explain interspecific variation in phenological sensitivity to spring temperature. We found that 12 out of 38 species exhibited a significant advance in adult flight onset dates with higher spring temperatures. In comparison, none of the 38 species exhibited a significant advance with year. There was a significant interaction between mean onset flight date and voltinism, such that late-emerging, multivoltine species tended to be the most sensitive to spring temperature changes. We did not observe a significant correlation between phenological sensitivity and the overwintering stage. These results suggest that butterfly arrival dates may shift as temperatures are projected to rise in the southeastern United States, with late-emerging, multivoltine species potentially exhibiting the greatest shifts in adult flight onset dates.
Access RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ee/nvae110&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| Mechanisms of Sensory Modulation of Aging in Drosophila ,NIH| The role of neural signaling pathways in costs of reproduction on aging ,NIH| Modulation of aging through mechanisms of nutrient demand and reward Yuan Luo;
Yuan Luo
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesYuan Luo in OpenAIRE Jacob C. Johnson; Tuhin S. Chakraborty;Jacob C. Johnson
Harvested from ORCID Public Data FileJacob C. Johnson in OpenAIRE Austin Piontkowski; +2 AuthorsAustin Piontkowski
Harvested from ORCID Public Data FileAustin Piontkowski in OpenAIRE Yuan Luo; Yuan Luo
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesYuan Luo in OpenAIRE Jacob C. Johnson; Tuhin S. Chakraborty;Jacob C. Johnson
Harvested from ORCID Public Data FileJacob C. Johnson in OpenAIRE Austin Piontkowski; Austin Piontkowski
Harvested from ORCID Public Data FileAustin Piontkowski in OpenAIRE Christi M. Gendron; Christi M. Gendron
Harvested from ORCID Public Data FileChristi M. Gendron in OpenAIRE Scott D. Pletcher; Scott D. Pletcher
Harvested from ORCID Public Data FileScott D. Pletcher in OpenAIREYeast volatiles double starvation survival in Drosophila .
Access RoutesGreen gold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciadv.abf8896&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| Mechanisms of Sensory Modulation of Aging in Drosophila ,NIH| The role of neural signaling pathways in costs of reproduction on aging ,NIH| Modulation of aging through mechanisms of nutrient demand and reward Yuan Luo;
Yuan Luo
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesYuan Luo in OpenAIRE Jacob C. Johnson; Tuhin S. Chakraborty;Jacob C. Johnson
Harvested from ORCID Public Data FileJacob C. Johnson in OpenAIRE Austin Piontkowski; +2 AuthorsAustin Piontkowski
Harvested from ORCID Public Data FileAustin Piontkowski in OpenAIRE Yuan Luo; Yuan Luo
Derived by OpenAIRE algorithms or harvested from 3rd party repositoriesYuan Luo in OpenAIRE Jacob C. Johnson; Tuhin S. Chakraborty;Jacob C. Johnson
Harvested from ORCID Public Data FileJacob C. Johnson in OpenAIRE Austin Piontkowski; Austin Piontkowski
Harvested from ORCID Public Data FileAustin Piontkowski in OpenAIRE Christi M. Gendron; Christi M. Gendron
Harvested from ORCID Public Data FileChristi M. Gendron in OpenAIRE Scott D. Pletcher; Scott D. Pletcher
Harvested from ORCID Public Data FileScott D. Pletcher in OpenAIREYeast volatiles double starvation survival in Drosophila .
Access RoutesGreen gold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciadv.abf8896&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Astrid Berena Herrera López;
Astrid Berena Herrera López
Harvested from ORCID Public Data FileAstrid Berena Herrera López in OpenAIRE Néstor Y. Rojas; Horacio Riojas-Rodríguez; José Luis Texcalac-Sangrador; +5 AuthorsNéstor Y. Rojas
Harvested from ORCID Public Data FileNéstor Y. Rojas in OpenAIRE Astrid Berena Herrera López; Astrid Berena Herrera López
Harvested from ORCID Public Data FileAstrid Berena Herrera López in OpenAIRE Néstor Y. Rojas; Horacio Riojas-Rodríguez; José Luis Texcalac-Sangrador; Carlos A. Torres-Duque; Alejandro Casas Herrera; María Patricia Arbeláez;Néstor Y. Rojas
Harvested from ORCID Public Data FileNéstor Y. Rojas in OpenAIRE Víctor Herrera; Víctor Herrera
Harvested from ORCID Public Data FileVíctor Herrera in OpenAIRE Laura Andrea Rodríguez-Villamizar; Laura Andrea Rodríguez-Villamizar
Harvested from ORCID Public Data FileLaura Andrea Rodríguez-Villamizar in OpenAIRE(1)Background: Evidence on the association between air pollution and the risk of exacerbations of chronic obstructive pulmonary disease (COPD) is scarce and inconsistent. We aimed to analyze the association between long-term exposure to particulate matter with a diameter of less than 2.5 µm (PM2.5) and nitrogen dioxide (NO2) and exacerbation of COPD (COPD-E) in Bogotá, Colombia; (2) Methods: Retrospective cohort study of 722 COPD patients in the AIREPOC program of the Colombian Pneumological Foundation between 2018 and 2021. Exposure to PM2.5 and NO2 was estimated for residential locations using the inverse squared distance weighted regression (IDWR) method. Hazard Ratios (HR) were calculated for the first COPD-E during follow-up using Cox models, adjusted for meteorological, demographic, and clinical variables; (3) Results: COPD-E was associated with long-term exposure to PM2.5 (HR:1.03, 95%CI: 1.02-1.05) and NO2 (HR:1.05, 95%CI: 1.03-1.07) controlling for the effect of quality of life, history of COPD-E, Forced Expiratory Volume in One Second (FEV1) pre-bronchodilator and exposure to solar radiation. An association was found between COPD-E and concentrations ≥ 25µg/m3 of NO2 (HR:1.49, 95%CI: 1.12-1.98) but not with concentrations ≥15 µg/m3 of PM2.5; (4) Conclusions: This study suggests that people with COPD exposed to higher concentrations of PM2.5 and NO2 had an increased risk of COPD-E. Solar radiation was also associated with an increased risk of COPD-E. The results highlight the importance of continuing efforts to reduce air pollution.
Access Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.20944/preprints202410.0075.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Astrid Berena Herrera López;
Astrid Berena Herrera López
Harvested from ORCID Public Data FileAstrid Berena Herrera López in OpenAIRE Néstor Y. Rojas; Horacio Riojas-Rodríguez; José Luis Texcalac-Sangrador; +5 AuthorsNéstor Y. Rojas
Harvested from ORCID Public Data FileNéstor Y. Rojas in OpenAIRE Astrid Berena Herrera López; Astrid Berena Herrera López
Harvested from ORCID Public Data FileAstrid Berena Herrera López in OpenAIRE Néstor Y. Rojas; Horacio Riojas-Rodríguez; José Luis Texcalac-Sangrador; Carlos A. Torres-Duque; Alejandro Casas Herrera; María Patricia Arbeláez;Néstor Y. Rojas
Harvested from ORCID Public Data FileNéstor Y. Rojas in OpenAIRE Víctor Herrera; Víctor Herrera
Harvested from ORCID Public Data FileVíctor Herrera in OpenAIRE Laura Andrea Rodríguez-Villamizar; Laura Andrea Rodríguez-Villamizar
Harvested from ORCID Public Data FileLaura Andrea Rodríguez-Villamizar in OpenAIRE(1)Background: Evidence on the association between air pollution and the risk of exacerbations of chronic obstructive pulmonary disease (COPD) is scarce and inconsistent. We aimed to analyze the association between long-term exposure to particulate matter with a diameter of less than 2.5 µm (PM2.5) and nitrogen dioxide (NO2) and exacerbation of COPD (COPD-E) in Bogotá, Colombia; (2) Methods: Retrospective cohort study of 722 COPD patients in the AIREPOC program of the Colombian Pneumological Foundation between 2018 and 2021. Exposure to PM2.5 and NO2 was estimated for residential locations using the inverse squared distance weighted regression (IDWR) method. Hazard Ratios (HR) were calculated for the first COPD-E during follow-up using Cox models, adjusted for meteorological, demographic, and clinical variables; (3) Results: COPD-E was associated with long-term exposure to PM2.5 (HR:1.03, 95%CI: 1.02-1.05) and NO2 (HR:1.05, 95%CI: 1.03-1.07) controlling for the effect of quality of life, history of COPD-E, Forced Expiratory Volume in One Second (FEV1) pre-bronchodilator and exposure to solar radiation. An association was found between COPD-E and concentrations ≥ 25µg/m3 of NO2 (HR:1.49, 95%CI: 1.12-1.98) but not with concentrations ≥15 µg/m3 of PM2.5; (4) Conclusions: This study suggests that people with COPD exposed to higher concentrations of PM2.5 and NO2 had an increased risk of COPD-E. Solar radiation was also associated with an increased risk of COPD-E. The results highlight the importance of continuing efforts to reduce air pollution.
Access Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.20944/preprints202410.0075.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| Hepatic stellate cell microRNA networks in ethanol-impaired liver regeneration ,NIH| Modeling Multiscale Control of Liver Regeneration ,NIH| Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration - ,NIH| Alcoholic Tissue InjuryAustin Parrish; Ankita Srivastava; Egle Juskeviciute; Jan B. Hoek; +1 Authors
Ankita Srivastava
Harvested from ORCID Public Data FileAnkita Srivastava in OpenAIREAustin Parrish; Ankita Srivastava; Egle Juskeviciute; Jan B. Hoek;Ankita Srivastava
Harvested from ORCID Public Data FileAnkita Srivastava in OpenAIRE Rajanikanth Vadigepalli; Rajanikanth Vadigepalli
Harvested from ORCID Public Data FileRajanikanth Vadigepalli in OpenAIREImpaired liver regeneration has been considered as a hallmark of progression of alcohol-associated liver disease. Our previous studies demonstrated that in vivo inhibition of the microRNA (miRNA) miR21 can restore regenerative capacity of the liver in chronic ethanol-fed animals. The present study focuses on the role of microRNA regulatory networks that are likely to mediate the miR-21 action. Rats were chronically fed an ethanol-enriched diet along with pair-fed control animals and treated with AM21 (anti-miR-21), a locked nucleic acid antisense to miR-21. Partial hepatectomy (PHx) was performed and miRNA expression profiling over the course of liver regeneration was assessed. Our results showed dynamic expression changes in several miRNAs after PHx, notably with altered miRNA expression profiles between ethanol and control groups. We found that in vivo inhibition of miR-21 led to correlated differential expression of miR-340-5p and anticorrelated expression of miR-365, let-7a, miR-1224, and miR-146a across all sample groups after PHx. Gene set enrichment analysis identified a miRNA signature significantly associated with hepatic stellate cell activation within whole liver tissue data. We hypothesized that at least part of the PHx-induced miRNA network changes responsive to miR-21 inhibition is localized to hepatic stellate cells. We validated this hypothesis using AM21 and TGF-β treatments in LX-2 human hepatic stellate cells in culture and measured expression levels of select miRNAs by quantitative RT-PCR. Based on the in vivo and in vitro results, we propose a hepatic stellate cell miRNA regulatory network as contributing to the restoration of liver regenerative capacity by miR-21 inhibition.
Access RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/physiolgenomics.00113.2021&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - NIH| Hepatic stellate cell microRNA networks in ethanol-impaired liver regeneration ,NIH| Modeling Multiscale Control of Liver Regeneration ,NIH| Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration - ,NIH| Alcoholic Tissue InjuryAustin Parrish; Ankita Srivastava; Egle Juskeviciute; Jan B. Hoek; +1 Authors
Ankita Srivastava
Harvested from ORCID Public Data FileAnkita Srivastava in OpenAIREAustin Parrish; Ankita Srivastava; Egle Juskeviciute; Jan B. Hoek;Ankita Srivastava
Harvested from ORCID Public Data FileAnkita Srivastava in OpenAIRE Rajanikanth Vadigepalli; Rajanikanth Vadigepalli
Harvested from ORCID Public Data FileRajanikanth Vadigepalli in OpenAIREImpaired liver regeneration has been considered as a hallmark of progression of alcohol-associated liver disease. Our previous studies demonstrated that in vivo inhibition of the microRNA (miRNA) miR21 can restore regenerative capacity of the liver in chronic ethanol-fed animals. The present study focuses on the role of microRNA regulatory networks that are likely to mediate the miR-21 action. Rats were chronically fed an ethanol-enriched diet along with pair-fed control animals and treated with AM21 (anti-miR-21), a locked nucleic acid antisense to miR-21. Partial hepatectomy (PHx) was performed and miRNA expression profiling over the course of liver regeneration was assessed. Our results showed dynamic expression changes in several miRNAs after PHx, notably with altered miRNA expression profiles between ethanol and control groups. We found that in vivo inhibition of miR-21 led to correlated differential expression of miR-340-5p and anticorrelated expression of miR-365, let-7a, miR-1224, and miR-146a across all sample groups after PHx. Gene set enrichment analysis identified a miRNA signature significantly associated with hepatic stellate cell activation within whole liver tissue data. We hypothesized that at least part of the PHx-induced miRNA network changes responsive to miR-21 inhibition is localized to hepatic stellate cells. We validated this hypothesis using AM21 and TGF-β treatments in LX-2 human hepatic stellate cells in culture and measured expression levels of select miRNAs by quantitative RT-PCR. Based on the in vivo and in vitro results, we propose a hepatic stellate cell miRNA regulatory network as contributing to the restoration of liver regenerative capacity by miR-21 inhibition.
Access RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/physiolgenomics.00113.2021&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Pinto Calaça, Irene Zasimowicz; Carneiro de Freitas, Patrícia Jorge; da Silva, Sérgio Augusto; Maluf, Fabiano;
Maluf, Fabiano
Harvested from ORCID Public Data FileMaluf, Fabiano in OpenAIRELas filosofías de la Pachamama y del Buen Vivir son puntos de referencia de los pueblos indígenas y están presentes en las constituciones de Ecuador (2008) y Bolivia (2009), con el fin de armonizar las diferencias culturales y añadir las tradiciones a la política local. Las filosofías toman por base un mito andino, el que cree ser la naturaleza un organismo vivo y sujeto de derechos, y se abren espacio a la visión biocéntrica del mundo, compartida por la Bioética Global. La naturaleza ya no logra recomponerse por las innovaciones biotecnológicas impuestas por el hombre, lo que obliga la humanidad a encontrar nuevos paradigmas – el Nuevo Constitucionalismo Latinoamericano, representado por las constituciones de Ecuador e Bolivia, es uno de ellos. En este artículo se describe y analiza críticamente estas dos constituciones, relacionándolas con la visión de mundo de la Pachamama y de la filosofía del Buen Vivir en el contexto de la Bioética Global.
Access RoutesGreen gold 19 citations 19 popularity Top 10% influence Top 10% impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.18359/rlbi.3030&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - Pinto Calaça, Irene Zasimowicz; Carneiro de Freitas, Patrícia Jorge; da Silva, Sérgio Augusto; Maluf, Fabiano;
Maluf, Fabiano
Harvested from ORCID Public Data FileMaluf, Fabiano in OpenAIRELas filosofías de la Pachamama y del Buen Vivir son puntos de referencia de los pueblos indígenas y están presentes en las constituciones de Ecuador (2008) y Bolivia (2009), con el fin de armonizar las diferencias culturales y añadir las tradiciones a la política local. Las filosofías toman por base un mito andino, el que cree ser la naturaleza un organismo vivo y sujeto de derechos, y se abren espacio a la visión biocéntrica del mundo, compartida por la Bioética Global. La naturaleza ya no logra recomponerse por las innovaciones biotecnológicas impuestas por el hombre, lo que obliga la humanidad a encontrar nuevos paradigmas – el Nuevo Constitucionalismo Latinoamericano, representado por las constituciones de Ecuador e Bolivia, es uno de ellos. En este artículo se describe y analiza críticamente estas dos constituciones, relacionándolas con la visión de mundo de la Pachamama y de la filosofía del Buen Vivir en el contexto de la Bioética Global.
Access RoutesGreen gold 19 citations 19 popularity Top 10% influence Top 10% impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.18359/rlbi.3030&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - DFG Lisa Männer;
Lisa Männer
Harvested from ORCID Public Data FileLisa Männer in OpenAIRE Carolin Mundinger; Carolin Mundinger
Harvested from ORCID Public Data FileCarolin Mundinger in OpenAIRE Martin Haase; Martin Haase
Harvested from ORCID Public Data FileMartin Haase in OpenAIREAbstractClimate change may force organisms to adapt genetically or plastically to new environmental conditions. Invasive species show remarkable potential for rapid adaptation. The ovoviviparous New Zealand mud snail (NZMS),Potamopyrgus antipodarum, has successfully established across Europe with two clonally reproducing mitochondrial lineages since its arrival in the first half of the 19th century. Its remarkable variation in shell morphology was shown to be fitness relevant. We investigated the effects of temperature on shell morphology across 11 populations from Germany and the Iberian Peninsula in a common garden across three temperatures. We analyzed size and shape using geometric morphometrics. For both, we compared reaction norms and estimated heritabilities. For size, the interaction of temperature and haplotype explained about 50% of the total variance. We also observed more genotype by environment interactions indicating a higher degree of population differentiation than in shape. Across the three temperatures, size followed the expectations of the temperature‐size rule, with individuals growing larger in cold environments. Changes in shape may have compensated for changes in size affecting space for brooding embryos. Heritability estimates were relatively high. As indicated by the very low coefficients of variation for clonal repeatability (CVA), they can probably not be compared in absolute terms. However, they showed some sensitivity to temperature, in haplotype t more so than in z, which was only found in Portugal. The lowCVAvalues indicate that genetic variation among European populations is still restricted with a low potential to react to selection. A considerable fraction of the genetic variation was due to differences between the clonal lineages. The NZMS has apparently not been long enough in Europe to accumulate significant genetic variation relevant for morphological adaptation. As temperature is obviously not the sole factor influencing shell morphology, their interaction will probably not be a factor limiting population persistence under a warming climate in Europe.
Access RoutesGreen gold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ece3.9314&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu - DFG Lisa Männer;
Lisa Männer
Harvested from ORCID Public Data FileLisa Männer in OpenAIRE Carolin Mundinger; Carolin Mundinger
Harvested from ORCID Public Data FileCarolin Mundinger in OpenAIRE Martin Haase; Martin Haase
Harvested from ORCID Public Data FileMartin Haase in OpenAIREAbstractClimate change may force organisms to adapt genetically or plastically to new environmental conditions. Invasive species show remarkable potential for rapid adaptation. The ovoviviparous New Zealand mud snail (NZMS),Potamopyrgus antipodarum, has successfully established across Europe with two clonally reproducing mitochondrial lineages since its arrival in the first half of the 19th century. Its remarkable variation in shell morphology was shown to be fitness relevant. We investigated the effects of temperature on shell morphology across 11 populations from Germany and the Iberian Peninsula in a common garden across three temperatures. We analyzed size and shape using geometric morphometrics. For both, we compared reaction norms and estimated heritabilities. For size, the interaction of temperature and haplotype explained about 50% of the total variance. We also observed more genotype by environment interactions indicating a higher degree of population differentiation than in shape. Across the three temperatures, size followed the expectations of the temperature‐size rule, with individuals growing larger in cold environments. Changes in shape may have compensated for changes in size affecting space for brooding embryos. Heritability estimates were relatively high. As indicated by the very low coefficients of variation for clonal repeatability (CVA), they can probably not be compared in absolute terms. However, they showed some sensitivity to temperature, in haplotype t more so than in z, which was only found in Portugal. The lowCVAvalues indicate that genetic variation among European populations is still restricted with a low potential to react to selection. A considerable fraction of the genetic variation was due to differences between the clonal lineages. The NZMS has apparently not been long enough in Europe to accumulate significant genetic variation relevant for morphological adaptation. As temperature is obviously not the sole factor influencing shell morphology, their interaction will probably not be a factor limiting population persistence under a warming climate in Europe.
Access RoutesGreen gold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.<script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ece3.9314&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
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