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description Publicationkeyboard_double_arrow_right Article , Journal 2021Publisher:Informa UK Limited Funded by:NHMRC | Practitioner Fellowship, NHMRC | Research Fellowship, NHMRC | Epigenetics of childhood ... +1 projectsNHMRC| Practitioner Fellowship ,NHMRC| Research Fellowship ,NHMRC| Epigenetics of childhood development and disease ,NHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetusAuthors:Jeffrey M. Craig;
Jeffrey M. Craig;Jeffrey M. Craig
Jeffrey M. Craig in OpenAIREJane Halliday;
Jane Halliday
Jane Halliday in OpenAIREElizabeth J Elliott;
+6 AuthorsElizabeth J Elliott
Elizabeth J Elliott in OpenAIREJeffrey M. Craig;
Jeffrey M. Craig;Jeffrey M. Craig
Jeffrey M. Craig in OpenAIREJane Halliday;
Jane Halliday
Jane Halliday in OpenAIREElizabeth J Elliott;
Elizabeth J Elliott;Elizabeth J Elliott
Elizabeth J Elliott in OpenAIREJoanne Ryan;
Joanne Ryan
Joanne Ryan in OpenAIRERichard Saffery;
Richard Saffery
Richard Saffery in OpenAIRESharon Lewis;
Sharon Lewis
Sharon Lewis in OpenAIREEvelyne Muggli;
Evelyne Muggli
Evelyne Muggli in OpenAIREYuk Jing Loke;
Yuk Jing Loke
Yuk Jing Loke in OpenAIREpmid: 34841896
Background: Binge-level prenatal alcohol exposure (PAE) causes developmental abnormalities, which may be mediated in part by epigenetic mechanisms. Despite this, few studies have characterised the association of binge PAE with DNA methylation in offspring. Methods: We investigated the association between binge PAE and genome-wide DNA methylation profiles in a sex-specific manner in neonatal buccal and placental samples. Results: We identified no differentially methylated CpGs or differentially methylated regions (DMRs) at false discovery rate <0.05. However, using a sum-of-ranks approach, we identified a DMR in each tissue of female offspring. The DMR identified in buccal samples is located near regions with previously-reported associations to fetal alcohol spectrum disorder (FASD) and binge PAE. Conclusion: Our findings warrant further replication and highlight a potential epigenetic link between binge PAE and FASD.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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