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description Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2020 Finland, Italy, Italy, France, Italy, Italy, Netherlands, FrancePublisher:Oxford University Press (OUP) Publicly fundedEEr Hehua; Elena Ciani; Johannes A. Lenstra; Min Shen;Song-Song Xu;
Ondřej Štěpánek; Xing-Long Xie; Xinhua Wang;Song-Song Xu
Song-Song Xu in OpenAIREDavid W. Coltman;
Feng-Hua Lv; Feng-Hua Lv; Ping Zhou;David W. Coltman
David W. Coltman in OpenAIRET.E. Deniskova;
T.E. Deniskova
T.E. Deniskova in OpenAIREAli Esmailizadeh;
Juha Kantanen; Mostafa Dehghani-Qanatqestani; C. Weimann;Ali Esmailizadeh
Ali Esmailizadeh in OpenAIREZijian Sim;
Michael William Bruford; Lei Gao;Zijian Sim
Zijian Sim in OpenAIREHosein Salehian-Dehkordi;
Georg Erhardt; Olivier Hanotte; Olivier Hanotte; Olivier Hanotte; Arsen V Dotsev; Peng-Cheng Wan; Jian-Lin Han;Hosein Salehian-Dehkordi
Hosein Salehian-Dehkordi in OpenAIREAbulgasim Ahbara;
Hua Yang;Abulgasim Ahbara
Abulgasim Ahbara in OpenAIREMario Barbato;
Natalia A Zinovieva; Gottfried Brem; Pi Wenhui; Joshua M. Miller; Joram M. Mwacharo;Mario Barbato
Mario Barbato in OpenAIREMeng-Hua Li;
Meng-Hua Li; Yin-Hong Cao; Zhang Yunsheng; Ze-Hui Chen; James Kijas; Donagh P. Berry; Yang Jingquan; Liu Changbin;Meng-Hua Li
Meng-Hua Li in OpenAIREMaryam Nosrati;
Maryam Nosrati
Maryam Nosrati in OpenAIREAbstract How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here, we conducted a comprehensive genomic analysis of diversity, interspecies introgression, and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600K and 50K genome-wide single nucleotide polymorphism data from 3,447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn, and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248,302,667–248,306,614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale della Ricerca- Università degli Studi di MessinaArticle . 2021License: CC BY NCCGIAR CGSpace (Consultative Group on International Agricultural Research)Article . 2020License: CC BY NCFull-Text: https://hdl.handle.net/10568/110111Data sources: Bielefeld Academic Search Engine (BASE)Università degli Studi di Bari Aldo Moro: CINECA IRISArticle . 2021Full-Text: https://hdl.handle.net/11586/456416Data sources: Bielefeld Academic Search Engine (BASE)Molecular Biology and EvolutionArticle . 2020 . Peer-reviewedLicense: CC BY NCData sources: CrossrefMolecular Biology and EvolutionArticle . 2021License: CC BY NCData sources: Pure Utrecht Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale della Ricerca- Università degli Studi di MessinaArticle . 2021License: CC BY NCCGIAR CGSpace (Consultative Group on International Agricultural Research)Article . 2020License: CC BY NCFull-Text: https://hdl.handle.net/10568/110111Data sources: Bielefeld Academic Search Engine (BASE)Università degli Studi di Bari Aldo Moro: CINECA IRISArticle . 2021Full-Text: https://hdl.handle.net/11586/456416Data sources: Bielefeld Academic Search Engine (BASE)Molecular Biology and EvolutionArticle . 2020 . Peer-reviewedLicense: CC BY NCData sources: CrossrefMolecular Biology and EvolutionArticle . 2021License: CC BY NCData sources: Pure Utrecht Universityadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/molbev/msaa236&type=result"></script>'); --> </script>
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