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Energy Research
clinical medicine
German
Arzneimittelforschung

[Resorption, organ distribution and metabolism of orally administered diethylamino-ethanol in rats].
descriptionPublicationkeyboard_double_arrow_right Article 1973
Authors: K E, Schulte; E, Dreymann; H, Möllmann;
pmid: 4678400
pmid: 4678400
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1973
Data sources: Europe PubMed Central
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[Electroencephalographic determination of vigilance following DL-propiramfumarate].
descriptionPublicationkeyboard_double_arrow_right Article 1974
Authors: J, Kugler; R, Wittmann; A, Doenicke; T, Konrad; +1 Authors
J, Kugler; R, Wittmann; A, Doenicke; T, Konrad; M, Laub;
pmid: 4599962
pmid: 4599962
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Arzneimittelforschung
Article . 1974
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[An animal test model for evaluating drugs with anti-mass-psychotic activity].
descriptionPublicationkeyboard_double_arrow_right Article 1975
Authors: O, Lemmingson; H, Lüllmann; H, Prooter; R, de Voss;
pmid: 4480286
pmid: 4480286
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1975
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[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].
descriptionPublicationkeyboard_double_arrow_right Article 1982
Authors: R, Meiss; J, Rassat; H, Themann;
pmid: 6802144
pmid: 6802144
Polychlorinated biphenyls, pentachlorophenol, d-galactosamine or alcohol are well known substances which produce toxic liver damage in animal experiments. Of special significance is the toxic fatty infiltration in the live parenchyma of these models. The effects following (+)-Cyanidanol-3 (Catergen)--application after liver damage was studied by qualitative and quantitative electron microscopy. (+)-Cyanidanol-3 reduces the volume density of intracytoplasmatic fat following intoxication significantly to normal values.
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Article . 1982
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[Psychoexperimental studies on the effect of a valepotriate combination as well as the combined effects of valtratum and alcohol].
descriptionPublicationkeyboard_double_arrow_right Article 1975
Authors: B, Mayer; E, Springer;
pmid: 4615718
pmid: 4615718
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Arzneimittelforschung
Article . 1975
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[Pharmacological effect of substituted helveticoside and helveticosol derivatives with special reference to cyclopentanonehelveticoside and light-induced transformation products of strophantidine].
descriptionPublicationkeyboard_double_arrow_right Article 1973
Authors: R, Graebner; B, Geisel;
pmid: 4679055
pmid: 4679055
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Arzneimittelforschung
Article . 1973
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[Histological changes in guinea pig lungs following inhalation of irritating gas and radiation and their treatment with 0-( -hydroxyethyl)-rutoside].
descriptionPublicationkeyboard_double_arrow_right Article 1971
Authors: W, Otte; K, Kröpelin; J, Afkham;
pmid: 5109499
pmid: 5109499
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Article . 1971
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[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].
descriptionPublicationkeyboard_double_arrow_right Article 1972
Authors: K, Besserer; H J, Mallach; D, Schoene;
pmid: 5068214
pmid: 5068214
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Article . 1972
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[Interaction of the analgesic substance tenoxicam with alcohol and its influence on psychometrically measurable performance].
descriptionPublicationkeyboard_double_arrow_right Article 1986
Authors: P W, Lücker; D, Gertken; S, Ahrens; H J, Scholz;
pmid: 3778567
pmid: 3778567
Tenoxicam (Ro 12-0068) is a thienothiacine derivate, which proved to be a potent analgesic in preclinical and clinical trials. An interaction of analgesics, especially those with a possible central origin, with the simultaneous intake of alcohol can never be excluded. For this purpose a study was carried out with 12 volunteers, who had given their informed consent, investigating the influence of alcohol on psychometric parameters like reaction time, memory, ability to concentrate, psychomotor skills. The study led to the result that the simultaneous intake of a realistic volume of alcohol has no influence on the psychometrically measurable performance of the volunteers.
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Article . 1986
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[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].
descriptionPublicationkeyboard_double_arrow_right Article 1979
Authors: M, Staak; A, Moosmayer;
pmid: 39573
pmid: 39573
Pharmacokinetic investigations concerning possible interactions of an orally administered single dosage of 20 mg dipotassium clorazepate and ethanol were conducted with 14 male subjects. Blood alcohol concentrations did not appear to be influenced by dipotassium clorazepate or its metabolites nordiazepam and oxazepam. The increase in oxazepam glucuronide excreted in the urine, however, was statistically significant. Nordiazepam concentration in the serum differed considerably between the group with ethanol administration and the control group. This metabolization pattern is apparently the result of the inhibitory effect of ethanol on hydroxylization processes during biotransformation of the metabolite nordiazepam.
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43 Research products

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[Resorption, organ distribution and metabolism of orally administered diethylamino-ethanol in rats].
descriptionPublicationkeyboard_double_arrow_right Article 1973
Authors: K E, Schulte; E, Dreymann; H, Möllmann;
pmid: 4678400
pmid: 4678400
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1973
Data sources: Europe PubMed Central
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[Electroencephalographic determination of vigilance following DL-propiramfumarate].
descriptionPublicationkeyboard_double_arrow_right Article 1974
Authors: J, Kugler; R, Wittmann; A, Doenicke; T, Konrad; +1 Authors
J, Kugler; R, Wittmann; A, Doenicke; T, Konrad; M, Laub;
pmid: 4599962
pmid: 4599962
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1974
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[An animal test model for evaluating drugs with anti-mass-psychotic activity].
descriptionPublicationkeyboard_double_arrow_right Article 1975
Authors: O, Lemmingson; H, Lüllmann; H, Prooter; R, de Voss;
pmid: 4480286
pmid: 4480286
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Article . 1975
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[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].
descriptionPublicationkeyboard_double_arrow_right Article 1982
Authors: R, Meiss; J, Rassat; H, Themann;
pmid: 6802144
pmid: 6802144
Polychlorinated biphenyls, pentachlorophenol, d-galactosamine or alcohol are well known substances which produce toxic liver damage in animal experiments. Of special significance is the toxic fatty infiltration in the live parenchyma of these models. The effects following (+)-Cyanidanol-3 (Catergen)--application after liver damage was studied by qualitative and quantitative electron microscopy. (+)-Cyanidanol-3 reduces the volume density of intracytoplasmatic fat following intoxication significantly to normal values.
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Article . 1982
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[Psychoexperimental studies on the effect of a valepotriate combination as well as the combined effects of valtratum and alcohol].
descriptionPublicationkeyboard_double_arrow_right Article 1975
Authors: B, Mayer; E, Springer;
pmid: 4615718
pmid: 4615718
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1975
Data sources: Europe PubMed Central
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Article . 1975
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[Pharmacological effect of substituted helveticoside and helveticosol derivatives with special reference to cyclopentanonehelveticoside and light-induced transformation products of strophantidine].
descriptionPublicationkeyboard_double_arrow_right Article 1973
Authors: R, Graebner; B, Geisel;
pmid: 4679055
pmid: 4679055
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1973
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Arzneimittelforschung
Article . 1973
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[Histological changes in guinea pig lungs following inhalation of irritating gas and radiation and their treatment with 0-( -hydroxyethyl)-rutoside].
descriptionPublicationkeyboard_double_arrow_right Article 1971
Authors: W, Otte; K, Kröpelin; J, Afkham;
pmid: 5109499
pmid: 5109499
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1971
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Arzneimittelforschung
Article . 1971
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[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].
descriptionPublicationkeyboard_double_arrow_right Article 1972
Authors: K, Besserer; H J, Mallach; D, Schoene;
pmid: 5068214
pmid: 5068214
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1972
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Article . 1972
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[Interaction of the analgesic substance tenoxicam with alcohol and its influence on psychometrically measurable performance].
descriptionPublicationkeyboard_double_arrow_right Article 1986
Authors: P W, Lücker; D, Gertken; S, Ahrens; H J, Scholz;
pmid: 3778567
pmid: 3778567
Tenoxicam (Ro 12-0068) is a thienothiacine derivate, which proved to be a potent analgesic in preclinical and clinical trials. An interaction of analgesics, especially those with a possible central origin, with the simultaneous intake of alcohol can never be excluded. For this purpose a study was carried out with 12 volunteers, who had given their informed consent, investigating the influence of alcohol on psychometric parameters like reaction time, memory, ability to concentrate, psychomotor skills. The study led to the result that the simultaneous intake of a realistic volume of alcohol has no influence on the psychometrically measurable performance of the volunteers.
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1986
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Arzneimittelforschung
Article . 1986
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[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].
descriptionPublicationkeyboard_double_arrow_right Article 1979
Authors: M, Staak; A, Moosmayer;
pmid: 39573
pmid: 39573
Pharmacokinetic investigations concerning possible interactions of an orally administered single dosage of 20 mg dipotassium clorazepate and ethanol were conducted with 14 male subjects. Blood alcohol concentrations did not appear to be influenced by dipotassium clorazepate or its metabolites nordiazepam and oxazepam. The increase in oxazepam glucuronide excreted in the urine, however, was statistically significant. Nordiazepam concentration in the serum differed considerably between the group with ethanol administration and the control group. This metabolization pattern is apparently the result of the inhibitory effect of ethanol on hydroxylization processes during biotransformation of the metabolite nordiazepam.
Arzneimittelforschun...arrow_drop_down
Arzneimittelforschung
Article . 1979
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Arzneimittelforschung

[Resorption, organ distribution and metabolism of orally administered diethylamino-ethanol in rats].

[Electroencephalographic determination of vigilance following DL-propiramfumarate].

[An animal test model for evaluating drugs with anti-mass-psychotic activity].

[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].

[Psychoexperimental studies on the effect of a valepotriate combination as well as the combined effects of valtratum and alcohol].

[Pharmacological effect of substituted helveticoside and helveticosol derivatives with special reference to cyclopentanonehelveticoside and light-induced transformation products of strophantidine].

[Histological changes in guinea pig lungs following inhalation of irritating gas and radiation and their treatment with 0-( -hydroxyethyl)-rutoside].

[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].

[Interaction of the analgesic substance tenoxicam with alcohol and its influence on psychometrically measurable performance].

[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].

[Resorption, organ distribution and metabolism of orally administered diethylamino-ethanol in rats].

[Electroencephalographic determination of vigilance following DL-propiramfumarate].

[An animal test model for evaluating drugs with anti-mass-psychotic activity].

[The effect of (+)-cyanidanol-3 on toxic fatty infiltration of liver parenchyma (author's transl)].

[Psychoexperimental studies on the effect of a valepotriate combination as well as the combined effects of valtratum and alcohol].

[Pharmacological effect of substituted helveticoside and helveticosol derivatives with special reference to cyclopentanonehelveticoside and light-induced transformation products of strophantidine].

[Histological changes in guinea pig lungs following inhalation of irritating gas and radiation and their treatment with 0-( -hydroxyethyl)-rutoside].

[Effect of ethyl alcohol on pharmacokinetics of N,N-dimethyl-dibenzo(b,f)thiepine-10-methylamine-hydrochloride (GP 41 299) in man].

[Interaction of the analgesic substance tenoxicam with alcohol and its influence on psychometrically measurable performance].

[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].

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