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description Publicationkeyboard_double_arrow_right Article , Journal 2009 United KingdomPublisher:Inter-Research Science Center Susan F. Walker; Susan F. Walker; Claudio Soto-Azat; Andrew A. Cunningham; Barry T. Clarke; Matthew C. Fisher;Chytridiomycosis, an emerging infectious disease of amphibians caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd), is associated with amphibian population declines worldwide. Investigation of the origin and spread of the pathogen requires examination of archived museum specimens of amphibians. Examination for Bd infection is usually done using histological techniques, which are often too destructive for valuable museum material. Three alternative methods for Bd detection (skin swabbing, brushing and scraping) were evaluated for ability to yield Bd DNA and destructiveness to specimens. Archived amphibians known to be Bd positive and which had been preserved in either formalin or ethanol for many years were used. Samples were analysed using a Bd-specific quantitative real-time Taqman PCR (qPCR) assay. There was no difference in the ability of each of the techniques to detect Bd infection, with the pathogen being detected in 75 to 81% of the 16 ethanol-fixed frogs examined. Visible evidence of sampling was left by scraping, but not by swabbing or brushing. The brush-qPCR technique detected higher counts of genomic equivalents than the other 2 sampling methods, although differences were not statistically significant. The qPCR assay did not detect Bd from any of the 6 formalin-fixed frogs examined, regardless of the sampling method. Nondestructive sampling techniques enable qPCR analysis of ethanol-preserved museum specimens for Bd. Recently, the incorporation of DNA cleanup steps allowed the detection of Bd in destructively sampled tissues from formalin preserved specimens. Further studies using nondestructive sampling incorporating DNA cleanup steps for the detection of Bd in formalin preserved specimens are warranted.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 33 citations 33 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Denmark, Italy, FrancePublisher:Elsevier BV Funded by:UKRI | MRC Centre for Global Inf..., ANR | FishMEUKRI| MRC Centre for Global Infectious Disease Analysis ,ANR| FishMESchmeller, Dirk; Urbach, Davnah; Bates, Kieran; Catalan, Jordi; Cogălniceanu, Dan; Fisher, Matthew; Friesen, Jan; Füreder, Leopold; Gaube, Veronika; Haver, Marilen; Jacobsen, Dean; Le Roux, Gaël; Lin, Yu-Pin; Loyau, Adeline; Machate, Oliver; Mayer, Andreas; Palomo, Ignacio; Plutzar, Christoph; Sentenac, Hugo; Sommaruga, Ruben; Tiberti, Rocco; Ripple, William;Mountains are an essential component of the global life-support system. They are characterized by a rugged, heterogenous landscape with rapidly changing environmental conditions providing myriad ecological niches over relatively small spatial scales. Although montane species are well adapted to life at extremes, they are highly vulnerable to human derived ecosystem threats. Here we build on the manifesto 'World Scientists' Warning to Humanity', issued by the Alliance of World Scientists, to outline the major threats to mountain ecosystems. We highlight climate change as the greatest threat to mountain ecosystems, which are more impacted than their lowland counterparts. We further discuss the cascade of "knock-on" effects of climate change such as increased UV radiation, altered hydrological cycles, and altered pollution profiles; highlighting the biological and socio-economic consequences. Finally, we present how intensified use of mountains leads to overexploitation and abstraction of water, driving changes in carbon stock, reducing biodiversity, and impacting ecosystem functioning. These perturbations can provide opportunities for invasive species, parasites and pathogens to colonize these fragile habitats, driving further changes and losses of micro- and macro-biodiversity, as well further impacting ecosystem services. Ultimately, imbalances in the normal functioning of mountain ecosystems will lead to changes in vital biological, biochemical, and chemical processes, critically reducing ecosystem health with widespread repercussions for animal and human wellbeing. Developing tools in species/habitat conservation and future restoration is therefore essential if we are to effectively mitigate against the declining health of mountains.
HAL-IRD arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniversity of Copenhagen: ResearchArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)The Science of The Total EnvironmentArticle . 2022 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefArchivio Istituzionale dell'Università della CalabriaArticle . 2022Data sources: Archivio Istituzionale dell'Università della Calabriaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 64 citations 64 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert HAL-IRD arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniversity of Copenhagen: ResearchArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)The Science of The Total EnvironmentArticle . 2022 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefArchivio Istituzionale dell'Università della CalabriaArticle . 2022Data sources: Archivio Istituzionale dell'Università della Calabriaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United States, FrancePublisher:Oxford University Press (OUP) Funded by:UKRI | RootDetect: Remote Detect..., NIH | INITIATION OF THE IMMUNE ..., NIH | The Genetic Basis of Viru... +18 projectsUKRI| RootDetect: Remote Detection and Precision Management of Root Health ,NIH| INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUS ,NIH| The Genetic Basis of Virulence in Cryptococcus Neoformans ,NIH| Functions of Cryptococcus neoformans mating type loci ,NIH| Evolutionary multispecies transcriptomics to reveal genes that govern fungal spore germination and pathogenesis ,WT| Understanding and mitigating the impact of emerging antifungal resistance ,NIH| Chytrid fungi and the functional specification of actin networks ,NIH| The mycobiota, bone marrow transplantation, and clinical outcomes ,NIH| Elucidating the mechanism of macrophage death during infection with the AIDS-associated opportunistic pathogen Histoplasma capsulatum ,NSERC ,NSF| CAREER: The developmental response of a parasitic chytrid fungus to amphibian mucus ,NIH| Genetics of Cryptococcus sexual reproduction ,UKRI| MRC Centre for Global Infectious Disease Analysis ,NIH| Gene circuits that control morphology in Histoplasma ,NIH| Antifungal Immunity and the Mechanism of Fungal Programmed Cell Death ,NSF| DIMENSIONS: Collaborative Research: The Making of Biodiversity Across the Yeast Subphylum ,NSF| Collaborative Research: RoL: The Evolution of the Genotype-Phenotype Map across Budding Yeasts ,NIH| Targeting Hsp90 in cryptococcal fungal pathogenesis ,NIH| Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal Pathogen ,NIH| MOUSE GENETICS ,CIHRCase, Nicola; Berman, Judith; Blehert, David; Cramer, Robert; Cuomo, Christina; Currie, Cameron; Ene, Iuliana; Fisher, Matthew; Fritz-Laylin, Lillian; Gerstein, Aleeza; Glass, N Louise; Gow, Neil; Gurr, Sarah; Hittinger, Chris Todd; Hohl, Tobias; Iliev, Iliyan; James, Timothy; Jin, Hailing; Klein, Bruce; Kronstad, James; Lorch, Jeffrey; Mcgovern, Victoria; Mitchell, Aaron; Segre, Julia; Shapiro, Rebecca; Sheppard, Donald; Sil, Anita; Stajich, Jason; Stukenbrock, Eva; Taylor, John; Thompson, Dawn; Wright, Gerard; Heitman, Joseph; Cowen, Leah;pmid: 36179219
pmc: PMC9635647
Abstract The fungal kingdom represents an extraordinary diversity of organisms with profound impacts across animal, plant, and ecosystem health. Fungi simultaneously support life, by forming beneficial symbioses with plants and producing life-saving medicines, and bring death, by causing devastating diseases in humans, plants, and animals. With climate change, increased antimicrobial resistance, global trade, environmental degradation, and novel viruses altering the impact of fungi on health and disease, developing new approaches is now more crucial than ever to combat the threats posed by fungi and to harness their extraordinary potential for applications in human health, food supply, and environmental remediation. To address this aim, the Canadian Institute for Advanced Research (CIFAR) and the Burroughs Wellcome Fund convened a workshop to unite leading experts on fungal biology from academia and industry to strategize innovative solutions to global challenges and fungal threats. This report provides recommendations to accelerate fungal research and highlights the major research advances and ideas discussed at the meeting pertaining to 5 major topics: (1) Connections between fungi and climate change and ways to avert climate catastrophe; (2) Fungal threats to humans and ways to mitigate them; (3) Fungal threats to agriculture and food security and approaches to ensure a robust global food supply; (4) Fungal threats to animals and approaches to avoid species collapse and extinction; and (5) Opportunities presented by the fungal kingdom, including novel medicines and enzymes.
University of Califo... arrow_drop_down University of California: eScholarshipArticle . 2022License: CC BYFull-Text: https://escholarship.org/uc/item/5bj6r10zData sources: Bielefeld Academic Search Engine (BASE)eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/g3journal/jkac224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert University of Califo... arrow_drop_down University of California: eScholarshipArticle . 2022License: CC BYFull-Text: https://escholarship.org/uc/item/5bj6r10zData sources: Bielefeld Academic Search Engine (BASE)eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/g3journal/jkac224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2025Publisher:Springer Science and Business Media LLC Funded by:NIH | Targeting the casein kina..., NIH | Stress-induced transposon..., NSF | Collaborative Research: M... +27 projectsNIH| Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesis ,NIH| Stress-induced transposon mobilization in the human fungal pathogen Cryptococcus ,NSF| Collaborative Research: MIM: Gut-inhabiting fungi influence structure and function of herptile microbiomes through horizontal gene transfer and novel metabolic function ,NIH| Calcineurin signaling cascades governing Cryptococcus virulence ,NIH| RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesis ,NSF| Development and application of innovative tools to mitigate White Nose Syndrome, a lethal fungal disease decimating North American bat populations ,NIH| Regulation and function of mucosal IgA immune responses to mycobiota in the gut. ,ARC| Industrial Transformation Research Hubs - Grant ID: IH190100022 ,NIH| Functions of Cryptococcus neoformans mating type loci ,NIH| Targeting Hsp90 in cryptococcal fungal pathogenesis ,NIH| Protective Immune Responses to Blastomyces Dermatitidis ,NIH| Malassezia and Candida auris: skin microbiome dysbiosis and de-regulation of cutaneous homeostasis ,NIH| Conjugate vaccines for prevention and treatment of cryptococcosis ,NIH| Commensal fungal communities in the regulation of immunity and intestinal inflammation. ,NIH| Cross-kingdom RNA communications between plant and fungal pathogens ,NIH| Novel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell Memory ,NSF| Develop innovative stable RNA-based anti-fungal reagents to control plant fungal diseases ,NIH| The Genetic Basis of Virulence in Cryptococcus Neoformans ,NIH| Microbes in Health and Disease Training Program ,NIH| Mechanisms of vaccine immunity against coccidioidomycosis ,CIHR ,NIH| Biology of Fungal Melanin ,NIH| Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal Pathogen ,NIH| Evolved Heterogeneity Contributes to Chronic Fungal Lung Infections ,NIH| IMMUNOSUPPRESSANT TARGETS IN CRYPTOCOCCUS NEOFORMANS ,NIH| Molecular Pathogenesis of Blastomycosis ,NIH| Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity. ,NIH| Synergy of Host Defense Mechanisms in the Lung ,NIH| Evolution of Aspergillus fumigatus virulence ,NSF| CAREER: When do mycorrhizal fungi influence plant community dynamics?Nicola T. Case; Sarah J. Gurr; Matthew C. Fisher; David S. Blehert; Charles Boone; Arturo Casadevall; Anuradha Chowdhary; Christina A. Cuomo; Cameron R. Currie; David W. Denning; Iuliana V. Ene; Lillian K. Fritz-Laylin; Aleeza C. Gerstein; Neil A. R. Gow; Asiya Gusa; Iliyan D. Iliev; Timothy Y. James; Hailing Jin; Regine Kahmann; Bruce S. Klein; James W. Kronstad; Kyla S. Ost; Kabir G. Peay; Rebecca S. Shapiro; Donald C. Sheppard; Neta Shlezinger; Jason E. Stajich; Eva H. Stukenbrock; John W. Taylor; Gerard D. Wright; Leah E. Cowen; Joseph Heitman; Julia A. Segre;Over the past billion years, the fungal kingdom has diversified to more than two million species, with over 95% still undescribed. Beyond the well-known macroscopic mushrooms and microscopic yeast, fungi are heterotrophs that feed on almost any organic carbon, recycling nutrients through the decay of dead plants and animals and sequestering carbon into Earth's ecosystems. Human-directed applications of fungi extend from leavened bread, alcoholic beverages and biofuels to pharmaceuticals, including antibiotics and psychoactive compounds. Conversely, fungal infections pose risks to ecosystems ranging from crops to wildlife to humans; these risks are driven, in part, by human and animal movement, and might be accelerating with climate change. Genomic surveys are expanding our knowledge of the true biodiversity of the fungal kingdom, and genome-editing tools make it possible to imagine harnessing these organisms to fuel the bioeconomy. Here, we examine the fungal threats facing civilization and investigate opportunities to use fungi to combat these threats.
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For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2016 Spain, United KingdomPublisher:The Royal Society Funded by:UKRI | Relationship between envi...UKRI| Relationship between environmental, ecological and genetic drivers of emergence in amphibian chytridiomycosis.Olivia Daniel; Marcus Rowcliffe; J B Halder; Thibaut Jombart; Adeline Loyau; Jaime Bosch; Frances C. Clare; Mikhail A. Semenov; Trenton W. J. Garner; Jon Bielby; Dirk S. Schmeller; Dirk S. Schmeller; Matthew C. Fisher; Andrew A. Cunningham;Changes in the timings of seasonality as a result of anthropogenic climate change are predicted to occur over the coming decades. While this is expected to have widespread impacts on the dynamics of infectious disease through environmental forcing, empirical data are lacking. Here, we investigated whether seasonality, specifically the timing of spring ice-thaw, affected susceptibility to infection by the emerging pathogenic fungus Batrachochytrium dendrobatidis ( Bd ) across a montane community of amphibians that are suffering declines and extirpations as a consequence of this infection. We found a robust temporal association between the timing of the spring thaw and Bd infection in two host species, where we show that an early onset of spring forced high prevalences of infection. A third highly susceptible species (the midwife toad, Alytes obstetricans ) maintained a high prevalence of infection independent of time of spring thaw. Our data show that perennially overwintering midwife toad larvae may act as a year-round reservoir of infection with variation in time of spring thaw determining the extent to which infection spills over into sympatric species. We used future temperature projections based on global climate models to demonstrate that the timing of spring thaw in this region will advance markedly by the 2050s, indicating that climate change will further force the severity of infection. Our findings on the effect of annual variability on multi-host infection dynamics show that the community-level impact of fungal infectious disease on biodiversity will need to be re-evaluated in the face of climate change. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
Imperial College Lon... arrow_drop_down Imperial College London: SpiralArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/10044/1/40522Data sources: Bielefeld Academic Search Engine (BASE)Philosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesConference objectData sources: OpenAPC Global InitiativeRecolector de Ciencia Abierta, RECOLECTAArticle . 2016 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2017Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2015.0454&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 57 citations 57 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 47visibility views 47 download downloads 97 Powered bymore_vert Imperial College Lon... arrow_drop_down Imperial College London: SpiralArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/10044/1/40522Data sources: Bielefeld Academic Search Engine (BASE)Philosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesConference objectData sources: OpenAPC Global InitiativeRecolector de Ciencia Abierta, RECOLECTAArticle . 2016 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2017Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2015.0454&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Journal 2009 United KingdomPublisher:Inter-Research Science Center Susan F. Walker; Susan F. Walker; Claudio Soto-Azat; Andrew A. Cunningham; Barry T. Clarke; Matthew C. Fisher;Chytridiomycosis, an emerging infectious disease of amphibians caused by the chytrid fungus Batrachochytrium dendrobatidis (Bd), is associated with amphibian population declines worldwide. Investigation of the origin and spread of the pathogen requires examination of archived museum specimens of amphibians. Examination for Bd infection is usually done using histological techniques, which are often too destructive for valuable museum material. Three alternative methods for Bd detection (skin swabbing, brushing and scraping) were evaluated for ability to yield Bd DNA and destructiveness to specimens. Archived amphibians known to be Bd positive and which had been preserved in either formalin or ethanol for many years were used. Samples were analysed using a Bd-specific quantitative real-time Taqman PCR (qPCR) assay. There was no difference in the ability of each of the techniques to detect Bd infection, with the pathogen being detected in 75 to 81% of the 16 ethanol-fixed frogs examined. Visible evidence of sampling was left by scraping, but not by swabbing or brushing. The brush-qPCR technique detected higher counts of genomic equivalents than the other 2 sampling methods, although differences were not statistically significant. The qPCR assay did not detect Bd from any of the 6 formalin-fixed frogs examined, regardless of the sampling method. Nondestructive sampling techniques enable qPCR analysis of ethanol-preserved museum specimens for Bd. Recently, the incorporation of DNA cleanup steps allowed the detection of Bd in destructively sampled tissues from formalin preserved specimens. Further studies using nondestructive sampling incorporating DNA cleanup steps for the detection of Bd in formalin preserved specimens are warranted.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3354/dao02029&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 33 citations 33 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3354/dao02029&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, Denmark, Italy, FrancePublisher:Elsevier BV Funded by:UKRI | MRC Centre for Global Inf..., ANR | FishMEUKRI| MRC Centre for Global Infectious Disease Analysis ,ANR| FishMESchmeller, Dirk; Urbach, Davnah; Bates, Kieran; Catalan, Jordi; Cogălniceanu, Dan; Fisher, Matthew; Friesen, Jan; Füreder, Leopold; Gaube, Veronika; Haver, Marilen; Jacobsen, Dean; Le Roux, Gaël; Lin, Yu-Pin; Loyau, Adeline; Machate, Oliver; Mayer, Andreas; Palomo, Ignacio; Plutzar, Christoph; Sentenac, Hugo; Sommaruga, Ruben; Tiberti, Rocco; Ripple, William;Mountains are an essential component of the global life-support system. They are characterized by a rugged, heterogenous landscape with rapidly changing environmental conditions providing myriad ecological niches over relatively small spatial scales. Although montane species are well adapted to life at extremes, they are highly vulnerable to human derived ecosystem threats. Here we build on the manifesto 'World Scientists' Warning to Humanity', issued by the Alliance of World Scientists, to outline the major threats to mountain ecosystems. We highlight climate change as the greatest threat to mountain ecosystems, which are more impacted than their lowland counterparts. We further discuss the cascade of "knock-on" effects of climate change such as increased UV radiation, altered hydrological cycles, and altered pollution profiles; highlighting the biological and socio-economic consequences. Finally, we present how intensified use of mountains leads to overexploitation and abstraction of water, driving changes in carbon stock, reducing biodiversity, and impacting ecosystem functioning. These perturbations can provide opportunities for invasive species, parasites and pathogens to colonize these fragile habitats, driving further changes and losses of micro- and macro-biodiversity, as well further impacting ecosystem services. Ultimately, imbalances in the normal functioning of mountain ecosystems will lead to changes in vital biological, biochemical, and chemical processes, critically reducing ecosystem health with widespread repercussions for animal and human wellbeing. Developing tools in species/habitat conservation and future restoration is therefore essential if we are to effectively mitigate against the declining health of mountains.
HAL-IRD arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniversity of Copenhagen: ResearchArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)The Science of The Total EnvironmentArticle . 2022 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefArchivio Istituzionale dell'Università della CalabriaArticle . 2022Data sources: Archivio Istituzionale dell'Università della Calabriaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2022.158611&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 64 citations 64 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert HAL-IRD arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniversity of Copenhagen: ResearchArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)The Science of The Total EnvironmentArticle . 2022 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefArchivio Istituzionale dell'Università della CalabriaArticle . 2022Data sources: Archivio Istituzionale dell'Università della Calabriaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United States, FrancePublisher:Oxford University Press (OUP) Funded by:UKRI | RootDetect: Remote Detect..., NIH | INITIATION OF THE IMMUNE ..., NIH | The Genetic Basis of Viru... +18 projectsUKRI| RootDetect: Remote Detection and Precision Management of Root Health ,NIH| INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUS ,NIH| The Genetic Basis of Virulence in Cryptococcus Neoformans ,NIH| Functions of Cryptococcus neoformans mating type loci ,NIH| Evolutionary multispecies transcriptomics to reveal genes that govern fungal spore germination and pathogenesis ,WT| Understanding and mitigating the impact of emerging antifungal resistance ,NIH| Chytrid fungi and the functional specification of actin networks ,NIH| The mycobiota, bone marrow transplantation, and clinical outcomes ,NIH| Elucidating the mechanism of macrophage death during infection with the AIDS-associated opportunistic pathogen Histoplasma capsulatum ,NSERC ,NSF| CAREER: The developmental response of a parasitic chytrid fungus to amphibian mucus ,NIH| Genetics of Cryptococcus sexual reproduction ,UKRI| MRC Centre for Global Infectious Disease Analysis ,NIH| Gene circuits that control morphology in Histoplasma ,NIH| Antifungal Immunity and the Mechanism of Fungal Programmed Cell Death ,NSF| DIMENSIONS: Collaborative Research: The Making of Biodiversity Across the Yeast Subphylum ,NSF| Collaborative Research: RoL: The Evolution of the Genotype-Phenotype Map across Budding Yeasts ,NIH| Targeting Hsp90 in cryptococcal fungal pathogenesis ,NIH| Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal Pathogen ,NIH| MOUSE GENETICS ,CIHRCase, Nicola; Berman, Judith; Blehert, David; Cramer, Robert; Cuomo, Christina; Currie, Cameron; Ene, Iuliana; Fisher, Matthew; Fritz-Laylin, Lillian; Gerstein, Aleeza; Glass, N Louise; Gow, Neil; Gurr, Sarah; Hittinger, Chris Todd; Hohl, Tobias; Iliev, Iliyan; James, Timothy; Jin, Hailing; Klein, Bruce; Kronstad, James; Lorch, Jeffrey; Mcgovern, Victoria; Mitchell, Aaron; Segre, Julia; Shapiro, Rebecca; Sheppard, Donald; Sil, Anita; Stajich, Jason; Stukenbrock, Eva; Taylor, John; Thompson, Dawn; Wright, Gerard; Heitman, Joseph; Cowen, Leah;pmid: 36179219
pmc: PMC9635647
Abstract The fungal kingdom represents an extraordinary diversity of organisms with profound impacts across animal, plant, and ecosystem health. Fungi simultaneously support life, by forming beneficial symbioses with plants and producing life-saving medicines, and bring death, by causing devastating diseases in humans, plants, and animals. With climate change, increased antimicrobial resistance, global trade, environmental degradation, and novel viruses altering the impact of fungi on health and disease, developing new approaches is now more crucial than ever to combat the threats posed by fungi and to harness their extraordinary potential for applications in human health, food supply, and environmental remediation. To address this aim, the Canadian Institute for Advanced Research (CIFAR) and the Burroughs Wellcome Fund convened a workshop to unite leading experts on fungal biology from academia and industry to strategize innovative solutions to global challenges and fungal threats. This report provides recommendations to accelerate fungal research and highlights the major research advances and ideas discussed at the meeting pertaining to 5 major topics: (1) Connections between fungi and climate change and ways to avert climate catastrophe; (2) Fungal threats to humans and ways to mitigate them; (3) Fungal threats to agriculture and food security and approaches to ensure a robust global food supply; (4) Fungal threats to animals and approaches to avoid species collapse and extinction; and (5) Opportunities presented by the fungal kingdom, including novel medicines and enzymes.
University of Califo... arrow_drop_down University of California: eScholarshipArticle . 2022License: CC BYFull-Text: https://escholarship.org/uc/item/5bj6r10zData sources: Bielefeld Academic Search Engine (BASE)eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/g3journal/jkac224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert University of Califo... arrow_drop_down University of California: eScholarshipArticle . 2022License: CC BYFull-Text: https://escholarship.org/uc/item/5bj6r10zData sources: Bielefeld Academic Search Engine (BASE)eScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/g3journal/jkac224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2025Publisher:Springer Science and Business Media LLC Funded by:NIH | Targeting the casein kina..., NIH | Stress-induced transposon..., NSF | Collaborative Research: M... +27 projectsNIH| Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesis ,NIH| Stress-induced transposon mobilization in the human fungal pathogen Cryptococcus ,NSF| Collaborative Research: MIM: Gut-inhabiting fungi influence structure and function of herptile microbiomes through horizontal gene transfer and novel metabolic function ,NIH| Calcineurin signaling cascades governing Cryptococcus virulence ,NIH| RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesis ,NSF| Development and application of innovative tools to mitigate White Nose Syndrome, a lethal fungal disease decimating North American bat populations ,NIH| Regulation and function of mucosal IgA immune responses to mycobiota in the gut. ,ARC| Industrial Transformation Research Hubs - Grant ID: IH190100022 ,NIH| Functions of Cryptococcus neoformans mating type loci ,NIH| Targeting Hsp90 in cryptococcal fungal pathogenesis ,NIH| Protective Immune Responses to Blastomyces Dermatitidis ,NIH| Malassezia and Candida auris: skin microbiome dysbiosis and de-regulation of cutaneous homeostasis ,NIH| Conjugate vaccines for prevention and treatment of cryptococcosis ,NIH| Commensal fungal communities in the regulation of immunity and intestinal inflammation. ,NIH| Cross-kingdom RNA communications between plant and fungal pathogens ,NIH| Novel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell Memory ,NSF| Develop innovative stable RNA-based anti-fungal reagents to control plant fungal diseases ,NIH| The Genetic Basis of Virulence in Cryptococcus Neoformans ,NIH| Microbes in Health and Disease Training Program ,NIH| Mechanisms of vaccine immunity against coccidioidomycosis ,CIHR ,NIH| Biology of Fungal Melanin ,NIH| Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal Pathogen ,NIH| Evolved Heterogeneity Contributes to Chronic Fungal Lung Infections ,NIH| IMMUNOSUPPRESSANT TARGETS IN CRYPTOCOCCUS NEOFORMANS ,NIH| Molecular Pathogenesis of Blastomycosis ,NIH| Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity. ,NIH| Synergy of Host Defense Mechanisms in the Lung ,NIH| Evolution of Aspergillus fumigatus virulence ,NSF| CAREER: When do mycorrhizal fungi influence plant community dynamics?Nicola T. Case; Sarah J. Gurr; Matthew C. Fisher; David S. Blehert; Charles Boone; Arturo Casadevall; Anuradha Chowdhary; Christina A. Cuomo; Cameron R. Currie; David W. Denning; Iuliana V. Ene; Lillian K. Fritz-Laylin; Aleeza C. Gerstein; Neil A. R. Gow; Asiya Gusa; Iliyan D. Iliev; Timothy Y. James; Hailing Jin; Regine Kahmann; Bruce S. Klein; James W. Kronstad; Kyla S. Ost; Kabir G. Peay; Rebecca S. Shapiro; Donald C. Sheppard; Neta Shlezinger; Jason E. Stajich; Eva H. Stukenbrock; John W. Taylor; Gerard D. Wright; Leah E. Cowen; Joseph Heitman; Julia A. Segre;Over the past billion years, the fungal kingdom has diversified to more than two million species, with over 95% still undescribed. Beyond the well-known macroscopic mushrooms and microscopic yeast, fungi are heterotrophs that feed on almost any organic carbon, recycling nutrients through the decay of dead plants and animals and sequestering carbon into Earth's ecosystems. Human-directed applications of fungi extend from leavened bread, alcoholic beverages and biofuels to pharmaceuticals, including antibiotics and psychoactive compounds. Conversely, fungal infections pose risks to ecosystems ranging from crops to wildlife to humans; these risks are driven, in part, by human and animal movement, and might be accelerating with climate change. Genomic surveys are expanding our knowledge of the true biodiversity of the fungal kingdom, and genome-editing tools make it possible to imagine harnessing these organisms to fuel the bioeconomy. Here, we examine the fungal threats facing civilization and investigate opportunities to use fungi to combat these threats.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-024-08419-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eumore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41586-024-08419-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2016 Spain, United KingdomPublisher:The Royal Society Funded by:UKRI | Relationship between envi...UKRI| Relationship between environmental, ecological and genetic drivers of emergence in amphibian chytridiomycosis.Olivia Daniel; Marcus Rowcliffe; J B Halder; Thibaut Jombart; Adeline Loyau; Jaime Bosch; Frances C. Clare; Mikhail A. Semenov; Trenton W. J. Garner; Jon Bielby; Dirk S. Schmeller; Dirk S. Schmeller; Matthew C. Fisher; Andrew A. Cunningham;Changes in the timings of seasonality as a result of anthropogenic climate change are predicted to occur over the coming decades. While this is expected to have widespread impacts on the dynamics of infectious disease through environmental forcing, empirical data are lacking. Here, we investigated whether seasonality, specifically the timing of spring ice-thaw, affected susceptibility to infection by the emerging pathogenic fungus Batrachochytrium dendrobatidis ( Bd ) across a montane community of amphibians that are suffering declines and extirpations as a consequence of this infection. We found a robust temporal association between the timing of the spring thaw and Bd infection in two host species, where we show that an early onset of spring forced high prevalences of infection. A third highly susceptible species (the midwife toad, Alytes obstetricans ) maintained a high prevalence of infection independent of time of spring thaw. Our data show that perennially overwintering midwife toad larvae may act as a year-round reservoir of infection with variation in time of spring thaw determining the extent to which infection spills over into sympatric species. We used future temperature projections based on global climate models to demonstrate that the timing of spring thaw in this region will advance markedly by the 2050s, indicating that climate change will further force the severity of infection. Our findings on the effect of annual variability on multi-host infection dynamics show that the community-level impact of fungal infectious disease on biodiversity will need to be re-evaluated in the face of climate change. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
Imperial College Lon... arrow_drop_down Imperial College London: SpiralArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/10044/1/40522Data sources: Bielefeld Academic Search Engine (BASE)Philosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesConference objectData sources: OpenAPC Global InitiativeRecolector de Ciencia Abierta, RECOLECTAArticle . 2016 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2017Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2015.0454&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 57 citations 57 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 47visibility views 47 download downloads 97 Powered bymore_vert Imperial College Lon... arrow_drop_down Imperial College London: SpiralArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/10044/1/40522Data sources: Bielefeld Academic Search Engine (BASE)Philosophical Transactions of the Royal Society B Biological SciencesArticleLicense: CC BYData sources: UnpayWallPhilosophical Transactions of the Royal Society B Biological SciencesConference objectData sources: OpenAPC Global InitiativeRecolector de Ciencia Abierta, RECOLECTAArticle . 2016 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2016 . Peer-reviewedLicense: Royal Society Data Sharing and AccessibilityData sources: CrossrefPhilosophical Transactions of the Royal Society B Biological SciencesArticle . 2017Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1098/rstb.2015.0454&type=result"></script>'); --> </script>
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