• Energy Research

Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90 %, 80 %, and 80 % of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1 %, 6.4 %, 37.7 %, and 35.9 %, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log−linear model of Yalkowsky with the OMRD of 53.8 %.

Experimental solubilities of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25 °C are reported. The solubility of salbutamol was found to increase with the addition of ethanol, and reached a maximum value at an ethanol volume fraction of 0.8. The solubility of salbutamol sulphate decreased with increasing ethanol concentration, and reached a minimum value in ethanol. The Jouyban-Acree model correlated the measured salbutamol and salbutamol sulphate solubility data to within mean relative deviations (MRD) of 3.4 and 13.4, respectively. Solubilities were predicted using previously trained models developed for crystalline non-electrolyte and electrolyte solutes. The trained models for non-electrolytes and electrolytes produced the prediction MRDs of 22.4 and 19.8, respectively. Crown Copyright © 2012 Published by Elsevier B.V. All rights reserved.