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description Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type 2022Embargo end date: 08 Mar 2022 South Africa, Spain, Singapore, Spain, Spain, Spain, South Africa, Morocco, South Africa, United Kingdom, United States, Switzerland, Germany, United Kingdom, South AfricaPublisher:Springer Science and Business Media LLC Werner Brack; Damià Barceló i Cullerés; Alistair Boxall; Hélène Budzinski; Sara Castiglioni; Adrian Covaci; Valeria Dulio; Beate I. Escher; Peter Fantke; Faith Jebiwot Kandie; Despo Fatta‐Kassinos; Félix Hernández; Klára Hilscherová; Juliane Hollender; Henner Hollert; Annika Jahnke; Barbara Kasprzyk‐Hordern; Stuart J. Khan; Andreas Kortenkamp; Klaus Kümmerer; Brice Lalonde; M.H. Lamoree; Yves Lévi; Pablo Lara Martín; Cassiana Carolina Montagner; Christian Mougin; Titus A.M. Msagati; Jörg Oehlmann; Leo Posthuma; Malcolm J. Reid; Martin Reinhard; Susan D. Richardson; Paweł Rostkowski; Emma Schymanski; Flurina Schneider; Jaroslav Slobodnı́k; Yasuyuki Shibata; Shane A. Snyder; Fernando F. Sodré; Ivana Teodorović; Kevin V. Thomas; Gisela de Aragão Umbuzeiro; Pham Hung Viet; Karina Gin Yew-Hoong; Xiaowei Zhang; Ettore Zuccato;doi: 10.1186/s12302-022-00602-6 , 10.60692/eyeyh-pn911 , 10.3929/ethz-b-000538002 , 10.60692/sr146-34d30 , 10.18154/rwth-2022-03147
pmid: 35281760
pmc: PMC8902847
handle: 10261/266909 , 10356/164988 , 10500/28665 , 10900/144141
doi: 10.1186/s12302-022-00602-6 , 10.60692/eyeyh-pn911 , 10.3929/ethz-b-000538002 , 10.60692/sr146-34d30 , 10.18154/rwth-2022-03147
pmid: 35281760
pmc: PMC8902847
handle: 10261/266909 , 10356/164988 , 10500/28665 , 10900/144141
AbstractThe chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science–policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science–policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health.
DR-NTU (Digital Repo... arrow_drop_down DR-NTU (Digital Repository at Nanyang Technological University, Singapore)Article . 2022License: CC BYFull-Text: https://hdl.handle.net/10356/164988Data sources: Bielefeld Academic Search Engine (BASE)Brunel University London: Brunel University Research Archive (BURA)Article . 2022License: CC BYFull-Text: http://bura.brunel.ac.uk/handle/2438/24497Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2022License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2022License: CC BY SAData sources: Repositori Institucional de la Universitat Jaume IRepositorio de Objetos de Docencia e Investigación de la Universidad de CádizArticle . 2022License: CC BYUniversity of South Carolina Libraries: Scholar CommonsArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Eberhard Karls University Tübingen: Publication SystemArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12302-022-00602-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 53 citations 53 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
visibility 39visibility views 39 download downloads 48 Powered bymore_vert DR-NTU (Digital Repo... arrow_drop_down DR-NTU (Digital Repository at Nanyang Technological University, Singapore)Article . 2022License: CC BYFull-Text: https://hdl.handle.net/10356/164988Data sources: Bielefeld Academic Search Engine (BASE)Brunel University London: Brunel University Research Archive (BURA)Article . 2022License: CC BYFull-Text: http://bura.brunel.ac.uk/handle/2438/24497Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2022License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2022License: CC BY SAData sources: Repositori Institucional de la Universitat Jaume IRepositorio de Objetos de Docencia e Investigación de la Universidad de CádizArticle . 2022License: CC BYUniversity of South Carolina Libraries: Scholar CommonsArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Eberhard Karls University Tübingen: Publication SystemArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12302-022-00602-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013 AustraliaPublisher:Elsevier BV Junho Jeon; Juliane Hollender; Juliane Hollender; Andreas Kretschmann; Beate I. Escher; Beate I. Escher;pmid: 24139064
The inhibition of acetylcholinesterase (AChE) activity and energy allocation in the freshwater organism Daphnia magna exposed to carbaryl and potential recovery from the effects was examined. The binding of carbaryl-AChE was characterized through in vitro assays. To evaluate the recovery from inhibition and the alteration in energy budget, in vivo exposure and recovery regime tests were conducted. In comparison to diazoxon, the active metabolite of the insecticide diazinon, the stability of enzyme-carbaryl complex was fifteen times lower and the reactivity toward the active site was two times lower, resulting in approximately 30 times lower overall inhibition rate than for diazoxon. The in vitro reactivation rate constant of the inhibited enzyme and the in vivo recovery rate constant of AChE activity were 1.9 h⁻¹ and 0.12 h⁻¹ for carbaryl, respectively, which are much higher than the corresponding rate constants for diazoxon. The lower AChE inhibition and greater reactivation/recovery rates are in accordance with the lower toxicity of carbaryl compared to diazinon. Carbaryl exposure also altered the profile of the energy reserve: the decrease in lipid and glycogen and the increase in protein content resulted in the reduction of the total energy budget by about 45 mJ/g(ww). This corresponds to 26 percent of the available energy, which might allocate for external stressors. The mechanistic model of AChE inhibition is helpful to get an insight into (eco-)toxicological effects of AChE inhibitors on freshwater crustaceans under environmentally realistic conditions.
Ecotoxicology and En... arrow_drop_down The University of Queensland: UQ eSpaceArticle . 2013Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ecoenv.2013.09.033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Ecotoxicology and En... arrow_drop_down The University of Queensland: UQ eSpaceArticle . 2013Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ecoenv.2013.09.033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
description Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type 2022Embargo end date: 08 Mar 2022 South Africa, Spain, Singapore, Spain, Spain, Spain, South Africa, Morocco, South Africa, United Kingdom, United States, Switzerland, Germany, United Kingdom, South AfricaPublisher:Springer Science and Business Media LLC Werner Brack; Damià Barceló i Cullerés; Alistair Boxall; Hélène Budzinski; Sara Castiglioni; Adrian Covaci; Valeria Dulio; Beate I. Escher; Peter Fantke; Faith Jebiwot Kandie; Despo Fatta‐Kassinos; Félix Hernández; Klára Hilscherová; Juliane Hollender; Henner Hollert; Annika Jahnke; Barbara Kasprzyk‐Hordern; Stuart J. Khan; Andreas Kortenkamp; Klaus Kümmerer; Brice Lalonde; M.H. Lamoree; Yves Lévi; Pablo Lara Martín; Cassiana Carolina Montagner; Christian Mougin; Titus A.M. Msagati; Jörg Oehlmann; Leo Posthuma; Malcolm J. Reid; Martin Reinhard; Susan D. Richardson; Paweł Rostkowski; Emma Schymanski; Flurina Schneider; Jaroslav Slobodnı́k; Yasuyuki Shibata; Shane A. Snyder; Fernando F. Sodré; Ivana Teodorović; Kevin V. Thomas; Gisela de Aragão Umbuzeiro; Pham Hung Viet; Karina Gin Yew-Hoong; Xiaowei Zhang; Ettore Zuccato;doi: 10.1186/s12302-022-00602-6 , 10.60692/eyeyh-pn911 , 10.3929/ethz-b-000538002 , 10.60692/sr146-34d30 , 10.18154/rwth-2022-03147
pmid: 35281760
pmc: PMC8902847
handle: 10261/266909 , 10356/164988 , 10500/28665 , 10900/144141
doi: 10.1186/s12302-022-00602-6 , 10.60692/eyeyh-pn911 , 10.3929/ethz-b-000538002 , 10.60692/sr146-34d30 , 10.18154/rwth-2022-03147
pmid: 35281760
pmc: PMC8902847
handle: 10261/266909 , 10356/164988 , 10500/28665 , 10900/144141
AbstractThe chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science–policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond data-rich regions (e.g., Europe and North America), (ii) to cover the entirety of hazardous chemicals, mixtures and wastes, (iii) to follow a one-health perspective considering the risks posed by chemicals and waste on ecosystem and human health, and (iv) to strive for solution-oriented assessments based on systems thinking. Based on multiple evidence on urgent action on a global scale, we call scientists and practitioners to mobilize their scientific networks and to intensify science–policy interaction with national governments to support the negotiations on the establishment of an intergovernmental body based on scientific knowledge explaining the anticipated benefit for human and environmental health.
DR-NTU (Digital Repo... arrow_drop_down DR-NTU (Digital Repository at Nanyang Technological University, Singapore)Article . 2022License: CC BYFull-Text: https://hdl.handle.net/10356/164988Data sources: Bielefeld Academic Search Engine (BASE)Brunel University London: Brunel University Research Archive (BURA)Article . 2022License: CC BYFull-Text: http://bura.brunel.ac.uk/handle/2438/24497Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2022License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2022License: CC BY SAData sources: Repositori Institucional de la Universitat Jaume IRepositorio de Objetos de Docencia e Investigación de la Universidad de CádizArticle . 2022License: CC BYUniversity of South Carolina Libraries: Scholar CommonsArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Eberhard Karls University Tübingen: Publication SystemArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12302-022-00602-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 53 citations 53 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
visibility 39visibility views 39 download downloads 48 Powered bymore_vert DR-NTU (Digital Repo... arrow_drop_down DR-NTU (Digital Repository at Nanyang Technological University, Singapore)Article . 2022License: CC BYFull-Text: https://hdl.handle.net/10356/164988Data sources: Bielefeld Academic Search Engine (BASE)Brunel University London: Brunel University Research Archive (BURA)Article . 2022License: CC BYFull-Text: http://bura.brunel.ac.uk/handle/2438/24497Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2022License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTARepositori Institucional de la Universitat Jaume IArticle . 2022License: CC BY SAData sources: Repositori Institucional de la Universitat Jaume IRepositorio de Objetos de Docencia e Investigación de la Universidad de CádizArticle . 2022License: CC BYUniversity of South Carolina Libraries: Scholar CommonsArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Eberhard Karls University Tübingen: Publication SystemArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12302-022-00602-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013 AustraliaPublisher:Elsevier BV Junho Jeon; Juliane Hollender; Juliane Hollender; Andreas Kretschmann; Beate I. Escher; Beate I. Escher;pmid: 24139064
The inhibition of acetylcholinesterase (AChE) activity and energy allocation in the freshwater organism Daphnia magna exposed to carbaryl and potential recovery from the effects was examined. The binding of carbaryl-AChE was characterized through in vitro assays. To evaluate the recovery from inhibition and the alteration in energy budget, in vivo exposure and recovery regime tests were conducted. In comparison to diazoxon, the active metabolite of the insecticide diazinon, the stability of enzyme-carbaryl complex was fifteen times lower and the reactivity toward the active site was two times lower, resulting in approximately 30 times lower overall inhibition rate than for diazoxon. The in vitro reactivation rate constant of the inhibited enzyme and the in vivo recovery rate constant of AChE activity were 1.9 h⁻¹ and 0.12 h⁻¹ for carbaryl, respectively, which are much higher than the corresponding rate constants for diazoxon. The lower AChE inhibition and greater reactivation/recovery rates are in accordance with the lower toxicity of carbaryl compared to diazinon. Carbaryl exposure also altered the profile of the energy reserve: the decrease in lipid and glycogen and the increase in protein content resulted in the reduction of the total energy budget by about 45 mJ/g(ww). This corresponds to 26 percent of the available energy, which might allocate for external stressors. The mechanistic model of AChE inhibition is helpful to get an insight into (eco-)toxicological effects of AChE inhibitors on freshwater crustaceans under environmentally realistic conditions.
Ecotoxicology and En... arrow_drop_down The University of Queensland: UQ eSpaceArticle . 2013Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ecoenv.2013.09.033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Ecotoxicology and En... arrow_drop_down The University of Queensland: UQ eSpaceArticle . 2013Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ecoenv.2013.09.033&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu