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  • Energy Research

  • Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Article , Journal 2017 United Kingdom, Singapore Publisher:Royal Society of Chemistry (RSC)Funded by:EC | Immuno-NanoDecoder, UKRI | Studies on the organelle-...
    Authors: Rajamani Lakshminarayanan; Ishwar Singh; Stephen H. Prior; Abhishek Iyer; +10 Authors

    doi: 10.1039/c7sc03241b

    pmid: 29568465

    pmc: PMC5855875

    Leu10-teixobactin and Ile10-teixobactin have shown comparable activity to natural teixobactin.

    downloadFull-Text
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ University of Lincol...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    University of Lincoln: Lincoln Repository
    Article . 2017
    Full-Text: https://eprints.lincoln.ac.uk/id/eprint/28993/1/etaylor_35.pdf
    Data sources: Bielefeld Academic Search Engine (BASE)
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ScholarBank@NUS
    Article . 2017
    License: CC BY
    Full-Text: https://scholarbank.nus.edu.sg/handle/10635/179747
    Data sources: Bielefeld Academic Search Engine (BASE)
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Chemical Science
    Article . 2017 . Peer-reviewed
    License: CC BY
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Chemical Science
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    https://pubmed.ncbi.nlm.nih.go...
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    http://dx.doi.org/10.1039/c7sc...
    Article . 2017 . Peer-reviewed
    Data sources: European Union Open Data Portal
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ University of Lincol...arrow_drop_down
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      University of Lincoln: Lincoln Repository
      Article . 2017
      Full-Text: https://eprints.lincoln.ac.uk/id/eprint/28993/1/etaylor_35.pdf
      Data sources: Bielefeld Academic Search Engine (BASE)
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ScholarBank@NUS
      Article . 2017
      License: CC BY
      Full-Text: https://scholarbank.nus.edu.sg/handle/10635/179747
      Data sources: Bielefeld Academic Search Engine (BASE)
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Chemical Science
      Article . 2017 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Chemical Science
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      https://pubmed.ncbi.nlm.nih.go...
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      http://dx.doi.org/10.1039/c7sc...
      Article . 2017 . Peer-reviewed
      Data sources: European Union Open Data Portal
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  • Real time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin binding proteins

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Article , Journal , Other literature type 2020 United Kingdom Publisher:Cold Spring Harbor LaboratoryFunded by:UKRI | Membrane steps in bacteri..., EC | SELFORGANICELL
    Authors: Víctor M Hernández-Rocamora; Natalia Baranova; Katharina Peters; Eefjan Breukink; +2 Authors

    doi: 10.1101/2020.08.02.233189 , 10.7554/elife.61525

    pmid: 33625355

    pmc: PMC7943195

    ABSTRACTPeptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis. Class A penicillin binding proteins are bifunctional membrane-bound peptidoglycan synthases that polymerize glycan chains and connect adjacent stem peptides by transpeptidation. How these enzymes work in their physiological membrane environment is poorly understood. Here we developed a novel FRET-based assay to follow in real time both reactions of class A PBPs reconstituted in liposomes or supported lipid bilayers and we demonstrate this assay with PBP1B homologues fromEscherichia coli, Pseudomonas aeruginosaandAcinetobacter baumanniiin the presence or absence of their cognate lipoprotein activator. Our assay allows unravelling the mechanisms of peptidoglycan synthesis in a lipid-bilayer environment and can be further developed to be used for high throughput screening for new antimicrobials.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.1...arrow_drop_down
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    https://doi.org/10.1101/2020.0...
    Article . 2020 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://www.biorxiv.org/conten...
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    License: CC BY
    Data sources: UnpayWall
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    eLife
    Article . 2021 . Peer-reviewed
    License: CC BY
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    eLife
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    eLife
    Article . 2022
    Data sources: Europe PubMed Central
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    eLife
    Article . 2021
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.1...arrow_drop_down
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      https://doi.org/10.1101/2020.0...
      Article . 2020 . Peer-reviewed
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      eLife
      Article . 2021 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      eLife
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The following results are related to Energy Research. Are you interested to view more results? Visit OpenAIRE - Explore.
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  • Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Article , Journal 2017 United Kingdom, Singapore Publisher:Royal Society of Chemistry (RSC)Funded by:EC | Immuno-NanoDecoder, UKRI | Studies on the organelle-...
    Authors: Rajamani Lakshminarayanan; Ishwar Singh; Stephen H. Prior; Abhishek Iyer; +10 Authors

    doi: 10.1039/c7sc03241b

    pmid: 29568465

    pmc: PMC5855875

    Leu10-teixobactin and Ile10-teixobactin have shown comparable activity to natural teixobactin.

    downloadFull-Text
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ University of Lincol...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    University of Lincoln: Lincoln Repository
    Article . 2017
    Full-Text: https://eprints.lincoln.ac.uk/id/eprint/28993/1/etaylor_35.pdf
    Data sources: Bielefeld Academic Search Engine (BASE)
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ScholarBank@NUS
    Article . 2017
    License: CC BY
    Full-Text: https://scholarbank.nus.edu.sg/handle/10635/179747
    Data sources: Bielefeld Academic Search Engine (BASE)
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Chemical Science
    Article . 2017 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Chemical Science
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    https://pubmed.ncbi.nlm.nih.go...
    Article
    Data sources: Europe PubMed Central
    https://biblio.ugent.be/public...
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    Data sources: Microsoft Academic Graph
    http://dx.doi.org/10.1039/c7sc...
    Article . 2017 . Peer-reviewed
    Data sources: European Union Open Data Portal
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    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
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      downloadFull-Text
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ University of Lincol...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      University of Lincoln: Lincoln Repository
      Article . 2017
      Full-Text: https://eprints.lincoln.ac.uk/id/eprint/28993/1/etaylor_35.pdf
      Data sources: Bielefeld Academic Search Engine (BASE)
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ScholarBank@NUS
      Article . 2017
      License: CC BY
      Full-Text: https://scholarbank.nus.edu.sg/handle/10635/179747
      Data sources: Bielefeld Academic Search Engine (BASE)
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Chemical Science
      Article . 2017 . Peer-reviewed
      License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Chemical Science
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      https://pubmed.ncbi.nlm.nih.go...
      Article
      Data sources: Europe PubMed Central
      https://biblio.ugent.be/public...
      Journal
      Data sources: Microsoft Academic Graph
      http://dx.doi.org/10.1039/c7sc...
      Article . 2017 . Peer-reviewed
      Data sources: European Union Open Data Portal
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      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.

  • Real time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin binding proteins

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    descriptionPublicationkeyboard_double_arrow_right Article , Journal , Other literature type 2020 United Kingdom Publisher:Cold Spring Harbor LaboratoryFunded by:UKRI | Membrane steps in bacteri..., EC | SELFORGANICELL
    Authors: Víctor M Hernández-Rocamora; Natalia Baranova; Katharina Peters; Eefjan Breukink; +2 Authors

    doi: 10.1101/2020.08.02.233189 , 10.7554/elife.61525

    pmid: 33625355

    pmc: PMC7943195

    ABSTRACTPeptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis. Class A penicillin binding proteins are bifunctional membrane-bound peptidoglycan synthases that polymerize glycan chains and connect adjacent stem peptides by transpeptidation. How these enzymes work in their physiological membrane environment is poorly understood. Here we developed a novel FRET-based assay to follow in real time both reactions of class A PBPs reconstituted in liposomes or supported lipid bilayers and we demonstrate this assay with PBP1B homologues fromEscherichia coli, Pseudomonas aeruginosaandAcinetobacter baumanniiin the presence or absence of their cognate lipoprotein activator. Our assay allows unravelling the mechanisms of peptidoglycan synthesis in a lipid-bilayer environment and can be further developed to be used for high throughput screening for new antimicrobials.

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