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description Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2016 AustraliaPublisher:Springer Science and Business Media LLC Funded by:NHMRC | Improving the long-term q..., NHMRC | Asking QUestions about Al..., NHMRC | Research FellowshipNHMRC| Improving the long-term quality of life for preterm children ,NHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetus ,NHMRC| Research FellowshipSharon Lewis; Susan Donath; Jane Halliday; Francesca Orsini; Peter J. Anderson; Evelyne Muggli; Catherine Nagle; Colleen O'Leary; Elizabeth J Elliott; Della Forster; Della Forster; Jeffrey M. Craig;Background: This paper presents drinking patterns in a prospective study of a population-based cohort of 1570 pregnant women using a combination of dose and timing to give best estimates of prenatal alcohol exposure (PAE). Novel assessments include women's special occasion drinking and alcohol use prior to pregnancy recognition. Methods: Information on up to nine types of alcoholic drink, with separate frequencies and volumes, including drinking on special occasions outside a 'usual' pattern, was collected for the periconceptional period and at four pregnancy time points. Weekly total and maximum alcohol consumption on any one occasion was calculated and categorised. Drinking patterns are described in the context of predictive maternal characteristics. Results: 41.3 % of women did not drink during pregnancy, 27 % drank in first trimester only; most of whom stopped once they realised they were pregnant (87 %). When compared to women who abstained from alcohol when pregnant, those who drank in the first trimester only were more likely to have an unplanned pregnancy and not feel the effects of alcohol quickly. Almost a third of women continued to drink alcohol at some level throughout pregnancy (27 %), around half of whom never drank more than at low or moderate levels. When compared with abstainers and to women who only drank in trimester one, those who drank throughout pregnancy tended to be in their early to mid-thirties, smoke, have a higher income and educational attainment. Overall, almost one in five women (18.5 %) binge drank prior to pregnancy recognition, a third of whom were identified with a question about 'special occasion' drinking. Women whose age at first intoxication was less than 18 years (the legal drinking age in Australia), were significantly more likely to drink in pregnancy and at binge levels prior to pregnancy recognition. Conclusions: We have identified characteristics of pregnant women who either abstain, drink until pregnancy awareness or drink throughout pregnancy. These may assist in targeting strategies to enhance adherence to an abstinence policy and ultimately allow for appropriate follow-up and interpretation of adverse child outcomes. Our methodology also produced important information to reduce misclassification of occasional binge drinking episodes and ensure clearly defined comparison groups.
The University of Ad... arrow_drop_down The University of Adelaide: Digital LibraryArticle . 2016Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2016Full-Text: http://dx.doi.org/10.1186/s12889-016-3354-9Data sources: Bielefeld Academic Search Engine (BASE)The University of Melbourne: Digital RepositoryArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/11343/260004Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-016-3354-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 100 citations 100 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
more_vert The University of Ad... arrow_drop_down The University of Adelaide: Digital LibraryArticle . 2016Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2016Full-Text: http://dx.doi.org/10.1186/s12889-016-3354-9Data sources: Bielefeld Academic Search Engine (BASE)The University of Melbourne: Digital RepositoryArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/11343/260004Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-016-3354-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021Publisher:Informa UK Limited Funded by:NHMRC | Asking QUestions about Al..., NHMRC | Research Fellowship, NHMRC | Practitioner Fellowship +1 projectsNHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetus ,NHMRC| Research Fellowship ,NHMRC| Practitioner Fellowship ,NHMRC| Epigenetics of childhood development and diseaseJeffrey M. Craig; Jeffrey M. Craig; Jane Halliday; Elizabeth J Elliott; Elizabeth J Elliott; Joanne Ryan; Richard Saffery; Sharon Lewis; Evelyne Muggli; Yuk Jing Loke;pmid: 34841896
Background: Binge-level prenatal alcohol exposure (PAE) causes developmental abnormalities, which may be mediated in part by epigenetic mechanisms. Despite this, few studies have characterised the association of binge PAE with DNA methylation in offspring. Methods: We investigated the association between binge PAE and genome-wide DNA methylation profiles in a sex-specific manner in neonatal buccal and placental samples. Results: We identified no differentially methylated CpGs or differentially methylated regions (DMRs) at false discovery rate <0.05. However, using a sum-of-ranks approach, we identified a DMR in each tissue of female offspring. The DMR identified in buccal samples is located near regions with previously-reported associations to fetal alcohol spectrum disorder (FASD) and binge PAE. Conclusion: Our findings warrant further replication and highlight a potential epigenetic link between binge PAE and FASD.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2217/epi-2021-0285&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2217/epi-2021-0285&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2014 AustraliaPublisher:Springer Science and Business Media LLC Funded by:NHMRC | Asking QUestions about Al...NHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetusPeter J. Anderson; Sharon Lewis; Sharon Lewis; Della Forster; Della Forster; Evelyne Muggli; Evelyne Muggli; Colleen O'Leary; Susan Donath; Elizabeth J Elliott; Jeffrey M. Craig; Jeffrey M. Craig; Jane Halliday; Jane Halliday; Cate Nagle;Background: Despite extensive research, a direct correlation between low to moderate prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorders has been elusive. Conflicting results are attributed to a lack of accurate and detailed data on PAE and incomplete information on contributing factors. The public health effectiveness of policies recommending complete abstinence from alcohol during pregnancy is challenged by the high frequency of unplanned pregnancies, where many women consumed some alcohol prior to pregnancy recognition. There is a need for research evidence emphasizing timing and dosage of PAE and its effects on child development.Methods/Design: Asking QUestions about Alcohol (AQUA) is a longitudinal cohort aiming to clarify the complex effects of low to moderate PAE using specifically developed and tested questions incorporating dose, pattern and timing of exposure. From 2011, 2146 pregnant women completed a questionnaire at 8-18 weeks of pregnancy. Further prenatal data collection took place via a questionnaire at 26-28 weeks and 35 weeks gestation. Extensive information was obtained on a large number of risk factors to assist in understanding the heterogeneous nature of PAE effects. 1571 women (73%) completed all three pregnancy questionnaires. A biobank of DNA from maternal and infant buccal cells, placental biopsies and cord blood mononuclear cells will be used to examine epigenetic state at birth as well as genetic factors in the mother and child. Participants will be followed up at 12 and 24 months after birth to assess child health and measure infant behavioural and sensory difficulties, as well as family environment and parenting styles. A subgroup of the cohort will have 3D facial photography of their child at 12 months and a comprehensive developmental assessment (Bayley Scales of Infant & Toddler Development, Bayley-III) at two years of age. Discussion: Using detailed, prospective methods of data collection, the AQUA study will comprehensively examine the effects of low to moderate alcohol consumption throughout pregnancy on child health and development, including the role of key mediators and confounders. These data will ultimately contribute to policy review and development, health professional education and information about alcohol consumption for pregnant women in the future.
The University of Me... arrow_drop_down The University of Melbourne: Digital RepositoryArticle . 2014License: CC BYFull-Text: http://hdl.handle.net/11343/263300Data sources: Bielefeld Academic Search Engine (BASE)The University of Adelaide: Digital LibraryArticle . 2014Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2014Full-Text: http://dx.doi.org/10.1186/1471-2393-14-302Data sources: Bielefeld Academic Search Engine (BASE)BMC Pregnancy and ChildbirthArticle . 2014 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2393-14-302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert The University of Me... arrow_drop_down The University of Melbourne: Digital RepositoryArticle . 2014License: CC BYFull-Text: http://hdl.handle.net/11343/263300Data sources: Bielefeld Academic Search Engine (BASE)The University of Adelaide: Digital LibraryArticle . 2014Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2014Full-Text: http://dx.doi.org/10.1186/1471-2393-14-302Data sources: Bielefeld Academic Search Engine (BASE)BMC Pregnancy and ChildbirthArticle . 2014 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2393-14-302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:eLife Sciences Publications, Ltd Mitchell Bestry; Alexander N Larcombe; Nina Kresoje; Emily K Chivers; Chloe Bakker; James P Fitzpatrick; Elizabeth J Elliott; Jeffrey M Craig; Evelyne Muggli; Jane Halliday; Delyse Hutchinson; Sam Buckberry; Ryan Lister; Martyn Symons; David Martino;Alcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure (PAE) resembling common patterns of alcohol consumption in pregnancy in humans. Early moderate PAE was sufficient to affect site-specific DNA methylation in newborn pups without altering behavioural outcomes in adult littermates. Whole-genome bisulfite sequencing of neonatal brain and liver revealed stochastic influence on DNA methylation that was mostly tissue-specific, with some perturbations likely originating as early as gastrulation. DNA methylation differences were enriched in non-coding genomic regions with regulatory potential indicative of broad effects of alcohol on genome regulation. Replication studies in human cohorts with fetal alcohol spectrum disorder suggested some effects were metastable at genes linked to disease-relevant traits including facial morphology, intelligence, educational attainment, autism, and schizophrenia. In our murine model, a maternal diet high in folate and choline protected against some of the damaging effects of early moderate PAE on DNA methylation. Our studies demonstrate that early moderate exposure is sufficient to affect fetal genome regulation even in the absence of overt phenotypic changes and highlight a role for preventative maternal dietary interventions.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.92135.3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.92135.3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
description Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2016 AustraliaPublisher:Springer Science and Business Media LLC Funded by:NHMRC | Improving the long-term q..., NHMRC | Asking QUestions about Al..., NHMRC | Research FellowshipNHMRC| Improving the long-term quality of life for preterm children ,NHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetus ,NHMRC| Research FellowshipSharon Lewis; Susan Donath; Jane Halliday; Francesca Orsini; Peter J. Anderson; Evelyne Muggli; Catherine Nagle; Colleen O'Leary; Elizabeth J Elliott; Della Forster; Della Forster; Jeffrey M. Craig;Background: This paper presents drinking patterns in a prospective study of a population-based cohort of 1570 pregnant women using a combination of dose and timing to give best estimates of prenatal alcohol exposure (PAE). Novel assessments include women's special occasion drinking and alcohol use prior to pregnancy recognition. Methods: Information on up to nine types of alcoholic drink, with separate frequencies and volumes, including drinking on special occasions outside a 'usual' pattern, was collected for the periconceptional period and at four pregnancy time points. Weekly total and maximum alcohol consumption on any one occasion was calculated and categorised. Drinking patterns are described in the context of predictive maternal characteristics. Results: 41.3 % of women did not drink during pregnancy, 27 % drank in first trimester only; most of whom stopped once they realised they were pregnant (87 %). When compared to women who abstained from alcohol when pregnant, those who drank in the first trimester only were more likely to have an unplanned pregnancy and not feel the effects of alcohol quickly. Almost a third of women continued to drink alcohol at some level throughout pregnancy (27 %), around half of whom never drank more than at low or moderate levels. When compared with abstainers and to women who only drank in trimester one, those who drank throughout pregnancy tended to be in their early to mid-thirties, smoke, have a higher income and educational attainment. Overall, almost one in five women (18.5 %) binge drank prior to pregnancy recognition, a third of whom were identified with a question about 'special occasion' drinking. Women whose age at first intoxication was less than 18 years (the legal drinking age in Australia), were significantly more likely to drink in pregnancy and at binge levels prior to pregnancy recognition. Conclusions: We have identified characteristics of pregnant women who either abstain, drink until pregnancy awareness or drink throughout pregnancy. These may assist in targeting strategies to enhance adherence to an abstinence policy and ultimately allow for appropriate follow-up and interpretation of adverse child outcomes. Our methodology also produced important information to reduce misclassification of occasional binge drinking episodes and ensure clearly defined comparison groups.
The University of Ad... arrow_drop_down The University of Adelaide: Digital LibraryArticle . 2016Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2016Full-Text: http://dx.doi.org/10.1186/s12889-016-3354-9Data sources: Bielefeld Academic Search Engine (BASE)The University of Melbourne: Digital RepositoryArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/11343/260004Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-016-3354-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 100 citations 100 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
more_vert The University of Ad... arrow_drop_down The University of Adelaide: Digital LibraryArticle . 2016Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2016Full-Text: http://dx.doi.org/10.1186/s12889-016-3354-9Data sources: Bielefeld Academic Search Engine (BASE)The University of Melbourne: Digital RepositoryArticle . 2016License: CC BYFull-Text: http://hdl.handle.net/11343/260004Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-016-3354-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021Publisher:Informa UK Limited Funded by:NHMRC | Asking QUestions about Al..., NHMRC | Research Fellowship, NHMRC | Practitioner Fellowship +1 projectsNHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetus ,NHMRC| Research Fellowship ,NHMRC| Practitioner Fellowship ,NHMRC| Epigenetics of childhood development and diseaseJeffrey M. Craig; Jeffrey M. Craig; Jane Halliday; Elizabeth J Elliott; Elizabeth J Elliott; Joanne Ryan; Richard Saffery; Sharon Lewis; Evelyne Muggli; Yuk Jing Loke;pmid: 34841896
Background: Binge-level prenatal alcohol exposure (PAE) causes developmental abnormalities, which may be mediated in part by epigenetic mechanisms. Despite this, few studies have characterised the association of binge PAE with DNA methylation in offspring. Methods: We investigated the association between binge PAE and genome-wide DNA methylation profiles in a sex-specific manner in neonatal buccal and placental samples. Results: We identified no differentially methylated CpGs or differentially methylated regions (DMRs) at false discovery rate <0.05. However, using a sum-of-ranks approach, we identified a DMR in each tissue of female offspring. The DMR identified in buccal samples is located near regions with previously-reported associations to fetal alcohol spectrum disorder (FASD) and binge PAE. Conclusion: Our findings warrant further replication and highlight a potential epigenetic link between binge PAE and FASD.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2217/epi-2021-0285&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2217/epi-2021-0285&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2014 AustraliaPublisher:Springer Science and Business Media LLC Funded by:NHMRC | Asking QUestions about Al...NHMRC| Asking QUestions about Alcohol in pregnancy (AQUA): Longitudinal cohort study of the effects of low and moderate doses of alcohol exposure on the fetusPeter J. Anderson; Sharon Lewis; Sharon Lewis; Della Forster; Della Forster; Evelyne Muggli; Evelyne Muggli; Colleen O'Leary; Susan Donath; Elizabeth J Elliott; Jeffrey M. Craig; Jeffrey M. Craig; Jane Halliday; Jane Halliday; Cate Nagle;Background: Despite extensive research, a direct correlation between low to moderate prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorders has been elusive. Conflicting results are attributed to a lack of accurate and detailed data on PAE and incomplete information on contributing factors. The public health effectiveness of policies recommending complete abstinence from alcohol during pregnancy is challenged by the high frequency of unplanned pregnancies, where many women consumed some alcohol prior to pregnancy recognition. There is a need for research evidence emphasizing timing and dosage of PAE and its effects on child development.Methods/Design: Asking QUestions about Alcohol (AQUA) is a longitudinal cohort aiming to clarify the complex effects of low to moderate PAE using specifically developed and tested questions incorporating dose, pattern and timing of exposure. From 2011, 2146 pregnant women completed a questionnaire at 8-18 weeks of pregnancy. Further prenatal data collection took place via a questionnaire at 26-28 weeks and 35 weeks gestation. Extensive information was obtained on a large number of risk factors to assist in understanding the heterogeneous nature of PAE effects. 1571 women (73%) completed all three pregnancy questionnaires. A biobank of DNA from maternal and infant buccal cells, placental biopsies and cord blood mononuclear cells will be used to examine epigenetic state at birth as well as genetic factors in the mother and child. Participants will be followed up at 12 and 24 months after birth to assess child health and measure infant behavioural and sensory difficulties, as well as family environment and parenting styles. A subgroup of the cohort will have 3D facial photography of their child at 12 months and a comprehensive developmental assessment (Bayley Scales of Infant & Toddler Development, Bayley-III) at two years of age. Discussion: Using detailed, prospective methods of data collection, the AQUA study will comprehensively examine the effects of low to moderate alcohol consumption throughout pregnancy on child health and development, including the role of key mediators and confounders. These data will ultimately contribute to policy review and development, health professional education and information about alcohol consumption for pregnant women in the future.
The University of Me... arrow_drop_down The University of Melbourne: Digital RepositoryArticle . 2014License: CC BYFull-Text: http://hdl.handle.net/11343/263300Data sources: Bielefeld Academic Search Engine (BASE)The University of Adelaide: Digital LibraryArticle . 2014Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2014Full-Text: http://dx.doi.org/10.1186/1471-2393-14-302Data sources: Bielefeld Academic Search Engine (BASE)BMC Pregnancy and ChildbirthArticle . 2014 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2393-14-302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert The University of Me... arrow_drop_down The University of Melbourne: Digital RepositoryArticle . 2014License: CC BYFull-Text: http://hdl.handle.net/11343/263300Data sources: Bielefeld Academic Search Engine (BASE)The University of Adelaide: Digital LibraryArticle . 2014Data sources: Bielefeld Academic Search Engine (BASE)James Cook University, Australia: ResearchOnline@JCUArticle . 2014Full-Text: http://dx.doi.org/10.1186/1471-2393-14-302Data sources: Bielefeld Academic Search Engine (BASE)BMC Pregnancy and ChildbirthArticle . 2014 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/1471-2393-14-302&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:eLife Sciences Publications, Ltd Mitchell Bestry; Alexander N Larcombe; Nina Kresoje; Emily K Chivers; Chloe Bakker; James P Fitzpatrick; Elizabeth J Elliott; Jeffrey M Craig; Evelyne Muggli; Jane Halliday; Delyse Hutchinson; Sam Buckberry; Ryan Lister; Martyn Symons; David Martino;Alcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure (PAE) resembling common patterns of alcohol consumption in pregnancy in humans. Early moderate PAE was sufficient to affect site-specific DNA methylation in newborn pups without altering behavioural outcomes in adult littermates. Whole-genome bisulfite sequencing of neonatal brain and liver revealed stochastic influence on DNA methylation that was mostly tissue-specific, with some perturbations likely originating as early as gastrulation. DNA methylation differences were enriched in non-coding genomic regions with regulatory potential indicative of broad effects of alcohol on genome regulation. Replication studies in human cohorts with fetal alcohol spectrum disorder suggested some effects were metastable at genes linked to disease-relevant traits including facial morphology, intelligence, educational attainment, autism, and schizophrenia. In our murine model, a maternal diet high in folate and choline protected against some of the damaging effects of early moderate PAE on DNA methylation. Our studies demonstrate that early moderate exposure is sufficient to affect fetal genome regulation even in the absence of overt phenotypic changes and highlight a role for preventative maternal dietary interventions.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.92135.3&type=result"></script>'); --> </script>
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.92135.3&type=result"></script>'); --> </script>
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