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description Publicationkeyboard_double_arrow_right Article , Other literature type 2023Embargo end date: 19 Nov 2024 Germany, SpainPublisher:Springer Science and Business Media LLC Funded by:DFGDFGMaji, Ranjan Kumar; Czepukojc, Beate; Scherer, Michael; Tierling, Sascha; Cadenas, Cristina; Gianmoena, Kathrin; Gasparoni, Nina; Nordström, Karl; Gasparoni, Gilles; Laggai, Stephan; Yang, Xinyi; Sinha, Anupam; Ebert, Peter; Falk-Paulsen, Maren; Kinkley, Sarah; Hoppstädter, Jessica; Chung, Ho-Ryun; Rosenstiel, Philip; Hengstler, Jan G; Walter, Jörn Erik; Schulz, Marcel H.; Kessler, Sonja M.; Kiemer, Alexandra;pmid: 37415213
pmc: PMC10324225
AbstractFatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average 
Powered by BIP!more_vert Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Embargo end date: 19 Nov 2024 Germany, SpainPublisher:Springer Science and Business Media LLC Funded by:DFGDFGMaji, Ranjan Kumar; Czepukojc, Beate; Scherer, Michael; Tierling, Sascha; Cadenas, Cristina; Gianmoena, Kathrin; Gasparoni, Nina; Nordström, Karl; Gasparoni, Gilles; Laggai, Stephan; Yang, Xinyi; Sinha, Anupam; Ebert, Peter; Falk-Paulsen, Maren; Kinkley, Sarah; Hoppstädter, Jessica; Chung, Ho-Ryun; Rosenstiel, Philip; Hengstler, Jan G; Walter, Jörn Erik; Schulz, Marcel H.; Kessler, Sonja M.; Kiemer, Alexandra;pmid: 37415213
pmc: PMC10324225
AbstractFatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
description Publicationkeyboard_double_arrow_right Article , Other literature type 2023Embargo end date: 19 Nov 2024 Germany, SpainPublisher:Springer Science and Business Media LLC Funded by:DFGDFGMaji, Ranjan Kumar; Czepukojc, Beate; Scherer, Michael; Tierling, Sascha; Cadenas, Cristina; Gianmoena, Kathrin; Gasparoni, Nina; Nordström, Karl; Gasparoni, Gilles; Laggai, Stephan; Yang, Xinyi; Sinha, Anupam; Ebert, Peter; Falk-Paulsen, Maren; Kinkley, Sarah; Hoppstädter, Jessica; Chung, Ho-Ryun; Rosenstiel, Philip; Hengstler, Jan G; Walter, Jörn Erik; Schulz, Marcel H.; Kessler, Sonja M.; Kiemer, Alexandra;pmid: 37415213
pmc: PMC10324225
AbstractFatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Embargo end date: 19 Nov 2024 Germany, SpainPublisher:Springer Science and Business Media LLC Funded by:DFGDFGMaji, Ranjan Kumar; Czepukojc, Beate; Scherer, Michael; Tierling, Sascha; Cadenas, Cristina; Gianmoena, Kathrin; Gasparoni, Nina; Nordström, Karl; Gasparoni, Gilles; Laggai, Stephan; Yang, Xinyi; Sinha, Anupam; Ebert, Peter; Falk-Paulsen, Maren; Kinkley, Sarah; Hoppstädter, Jessica; Chung, Ho-Ryun; Rosenstiel, Philip; Hengstler, Jan G; Walter, Jörn Erik; Schulz, Marcel H.; Kessler, Sonja M.; Kiemer, Alexandra;pmid: 37415213
pmc: PMC10324225
AbstractFatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Epigenetics & Ch... arrow_drop_down Fachrepositorium LebenswissenschaftenArticle . 2023License: CC BYData sources: Fachrepositorium LebenswissenschaftenScientific documents from the Saarland UniversityArticle . 2024License: CC BYData sources: Scientific documents from the Saarland UniversityMACO (Monografies Acadèmiques Catalanes en Obert)Article . 2025License: CC BYData sources: MACO (Monografies Acadèmiques Catalanes en Obert)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13072-023-00504-8&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu