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description Publicationkeyboard_double_arrow_right Article , Journal 2017 PakistanPublisher:Springer Science and Business Media LLC Authors:Oladiran I. Olateju;
Paul R. Manger;Oladiran I. Olateju
Oladiran I. Olateju in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIRENina Patzke;
+2 AuthorsNina Patzke
Nina Patzke in OpenAIREOladiran I. Olateju;
Paul R. Manger;Oladiran I. Olateju
Oladiran I. Olateju in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIRENina Patzke;
Nina Patzke
Nina Patzke in OpenAIREMuhammad A. Spocter;
Muhammad A. Spocter;Muhammad A. Spocter
Muhammad A. Spocter in OpenAIREpmid: 29164372
We examined the effect of chronic prenatal alcohol exposure (PAE) on the process of adult neurogenesis in C57BL/6J mice at early adulthood (PND 56). Pregnant mice, and their in utero litters, were exposed to alcohol, through oral gavage, on gestational days 7-16, with recorded blood alcohol concentrations averaging 184 mg/dL (CA group). Two control groups, sucrose (CAc) and non-treated (NTc) control groups were also examined. The brains of pups at PND 56 from each experimental group were sectioned in a sagittal plane, and stained for Nissl substance with cresyl violet, and immunostained for Ki-67 which labels proliferative cells and doublecortin (DCX) for immature neurons. Morphologically, the neurogenic pattern was identical in all three groups studied. Populations of Ki-67 immunopositive cells in the dentate gyrus were not statistically significantly different between the experimental groups and there were no differences between the sexes. Thus, the PAE in this study does not appear to have a strong effect on the proliferative process in the adult hippocampus. In contrast, the numbers of immature neurons, labeled with DCX, was statistically significantly lower in the prenatal alcohol exposed mice compared with the two control groups. Alcohol significantly lowered the number of DCX hippocampal cells in the male mice, but not in the female mice. This indicates that the PAE appears to lower the rate of conversion of proliferative cells to immature neurons and this effect of alcohol is sexually dimorphic. This lowered number of immature neurons in the hippocampus appears to mirror hippocampal dysfunctions observed in FASD children.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11011-017-0156-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11011-017-0156-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2017 PakistanPublisher:Springer Science and Business Media LLC Authors:Oladiran I. Olateju;
Paul R. Manger;Oladiran I. Olateju
Oladiran I. Olateju in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIRENina Patzke;
+2 AuthorsNina Patzke
Nina Patzke in OpenAIREOladiran I. Olateju;
Paul R. Manger;Oladiran I. Olateju
Oladiran I. Olateju in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIRENina Patzke;
Nina Patzke
Nina Patzke in OpenAIREMuhammad A. Spocter;
Muhammad A. Spocter;Muhammad A. Spocter
Muhammad A. Spocter in OpenAIREpmid: 29164372
We examined the effect of chronic prenatal alcohol exposure (PAE) on the process of adult neurogenesis in C57BL/6J mice at early adulthood (PND 56). Pregnant mice, and their in utero litters, were exposed to alcohol, through oral gavage, on gestational days 7-16, with recorded blood alcohol concentrations averaging 184 mg/dL (CA group). Two control groups, sucrose (CAc) and non-treated (NTc) control groups were also examined. The brains of pups at PND 56 from each experimental group were sectioned in a sagittal plane, and stained for Nissl substance with cresyl violet, and immunostained for Ki-67 which labels proliferative cells and doublecortin (DCX) for immature neurons. Morphologically, the neurogenic pattern was identical in all three groups studied. Populations of Ki-67 immunopositive cells in the dentate gyrus were not statistically significantly different between the experimental groups and there were no differences between the sexes. Thus, the PAE in this study does not appear to have a strong effect on the proliferative process in the adult hippocampus. In contrast, the numbers of immature neurons, labeled with DCX, was statistically significantly lower in the prenatal alcohol exposed mice compared with the two control groups. Alcohol significantly lowered the number of DCX hippocampal cells in the male mice, but not in the female mice. This indicates that the PAE appears to lower the rate of conversion of proliferative cells to immature neurons and this effect of alcohol is sexually dimorphic. This lowered number of immature neurons in the hippocampus appears to mirror hippocampal dysfunctions observed in FASD children.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11011-017-0156-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu20 citations 20 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s11011-017-0156-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United KingdomPublisher:eLife Sciences Publications, Ltd Funded by:WTWTAuthors:Kirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
+13 AuthorsCarine Nguemeni
Carine Nguemeni in OpenAIREKirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
Carine Nguemeni
Carine Nguemeni in OpenAIREWael Mohamed;
Wael Mohamed
Wael Mohamed in OpenAIREAmina Abubakar;
Amina Abubakar
Amina Abubakar in OpenAIREMatthew T. Brown;
Raliza Stoyanova;Matthew T. Brown
Matthew T. Brown in OpenAIREAndrew E. Welchman;
Natasha Walker;Andrew E. Welchman
Andrew E. Welchman in OpenAIREAlexis Willett;
Alexis Willett
Alexis Willett in OpenAIRESymon M. Kariuki;
Symon M. Kariuki
Symon M. Kariuki in OpenAIREAnthony Figaji;
Dan J. Stein;Anthony Figaji
Anthony Figaji in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIREWillie M. U. Daniels;
Willie M. U. Daniels
Willie M. U. Daniels in OpenAIRECharles R. Newton;
Charles R. Newton
Charles R. Newton in OpenAIREpmid: 35731202
pmc: PMC9217128
Working in Africa provides neuroscientists with opportunities that are not available in other continents. Populations in this region exhibit the greatest genetic diversity; they live in ecosystems with diverse flora and fauna; and they face unique stresses to brain health, including child brain health and development, due to high levels of traumatic brain injury and diseases endemic to the region. However, the neuroscience community in Africa has yet to reach its full potential. In this article we report the outcomes from a series of meetings at which the African neuroscience community came together to identify barriers and opportunities, and to discuss ways forward. This exercise resulted in the identification of six domains of distinction in African neuroscience: the diverse DNA of African populations; diverse flora, fauna and ecosystems for comparative research; child brain health and development; the impact of climate change on mental and neurological health; access to clinical populations with important conditions less prevalent in the global North; and resourcefulness in the reuse and adaption of existing technologies and resources to answer new questions. The article also outlines plans to advance the field of neuroscience in Africa in order to unlock the potential of African neuroscientists to address regional and global mental health and neurological problems.
eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United KingdomPublisher:eLife Sciences Publications, Ltd Funded by:WTWTAuthors:Kirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
+13 AuthorsCarine Nguemeni
Carine Nguemeni in OpenAIREKirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
Carine Nguemeni
Carine Nguemeni in OpenAIREWael Mohamed;
Wael Mohamed
Wael Mohamed in OpenAIREAmina Abubakar;
Amina Abubakar
Amina Abubakar in OpenAIREMatthew T. Brown;
Raliza Stoyanova;Matthew T. Brown
Matthew T. Brown in OpenAIREAndrew E. Welchman;
Natasha Walker;Andrew E. Welchman
Andrew E. Welchman in OpenAIREAlexis Willett;
Alexis Willett
Alexis Willett in OpenAIRESymon M. Kariuki;
Symon M. Kariuki
Symon M. Kariuki in OpenAIREAnthony Figaji;
Dan J. Stein;Anthony Figaji
Anthony Figaji in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIREWillie M. U. Daniels;
Willie M. U. Daniels
Willie M. U. Daniels in OpenAIRECharles R. Newton;
Charles R. Newton
Charles R. Newton in OpenAIREpmid: 35731202
pmc: PMC9217128
Working in Africa provides neuroscientists with opportunities that are not available in other continents. Populations in this region exhibit the greatest genetic diversity; they live in ecosystems with diverse flora and fauna; and they face unique stresses to brain health, including child brain health and development, due to high levels of traumatic brain injury and diseases endemic to the region. However, the neuroscience community in Africa has yet to reach its full potential. In this article we report the outcomes from a series of meetings at which the African neuroscience community came together to identify barriers and opportunities, and to discuss ways forward. This exercise resulted in the identification of six domains of distinction in African neuroscience: the diverse DNA of African populations; diverse flora, fauna and ecosystems for comparative research; child brain health and development; the impact of climate change on mental and neurological health; access to clinical populations with important conditions less prevalent in the global North; and resourcefulness in the reuse and adaption of existing technologies and resources to answer new questions. The article also outlines plans to advance the field of neuroscience in Africa in order to unlock the potential of African neuroscientists to address regional and global mental health and neurological problems.
eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019 PakistanPublisher:Elsevier BV Authors:Oladiran I. Olateju;
Oladiran I. Olateju
Oladiran I. Olateju in OpenAIREAmadi O. Ihunwo;
Paul R. Manger;Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIREpmid: 30572114
Children with Fetal Alcohol Spectrum Disorder (FASD) have impaired sensory processing skills as a result of neurodevelopmental anomalies. The somatosensory barrel field of rodent brain is a readily accessible model for studying the effects of alcohol exposure. Within the barrel field, the posterior medial barrel subfield (PMBSF) receives sensory inputs from the large vibrissae on the contralateral face. This study reports on the consequence of prenatal exposure to alcohol on the somatosensory cortices of mice later in life. Two control groups, a sucrose and a non-treated control, were also examined. At postnatal day (PND) 56 the cerebral hemisphere of mice from each group were processed for cytochrome oxidase reactivity. In contrast to previous studies, there were no significant differences in the mean areas of: (I) the PMBSF enclosure, (II) the PMBSF barrels, (III) the individual PMBSF barrels and (IV) the septal portion of the PMBSF in the alcohol group compared to the controls. However barrel sizes in rows D and E in the alcohol group were significantly reduced, indicating an alcohol-induced damage on the barrel development and which may reduce the amount of the cortex devoted to processing somatosensory input- a common defect seen in children with FASD.
Journal of Chemical ... arrow_drop_down Journal of Chemical NeuroanatomyArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jchemneu.2018.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Journal of Chemical ... arrow_drop_down Journal of Chemical NeuroanatomyArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jchemneu.2018.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019 PakistanPublisher:Elsevier BV Authors:Oladiran I. Olateju;
Oladiran I. Olateju
Oladiran I. Olateju in OpenAIREAmadi O. Ihunwo;
Paul R. Manger;Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIREpmid: 30572114
Children with Fetal Alcohol Spectrum Disorder (FASD) have impaired sensory processing skills as a result of neurodevelopmental anomalies. The somatosensory barrel field of rodent brain is a readily accessible model for studying the effects of alcohol exposure. Within the barrel field, the posterior medial barrel subfield (PMBSF) receives sensory inputs from the large vibrissae on the contralateral face. This study reports on the consequence of prenatal exposure to alcohol on the somatosensory cortices of mice later in life. Two control groups, a sucrose and a non-treated control, were also examined. At postnatal day (PND) 56 the cerebral hemisphere of mice from each group were processed for cytochrome oxidase reactivity. In contrast to previous studies, there were no significant differences in the mean areas of: (I) the PMBSF enclosure, (II) the PMBSF barrels, (III) the individual PMBSF barrels and (IV) the septal portion of the PMBSF in the alcohol group compared to the controls. However barrel sizes in rows D and E in the alcohol group were significantly reduced, indicating an alcohol-induced damage on the barrel development and which may reduce the amount of the cortex devoted to processing somatosensory input- a common defect seen in children with FASD.
Journal of Chemical ... arrow_drop_down Journal of Chemical NeuroanatomyArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jchemneu.2018.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Journal of Chemical ... arrow_drop_down Journal of Chemical NeuroanatomyArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jchemneu.2018.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu