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  • ZENODO

  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: orcid bw Arif Ullah;
    Arif Ullah
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Arif Ullah in OpenAIRE
    orcid bw Shakeel Ahmad Khan;
    Shakeel Ahmad Khan
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Shakeel Ahmad Khan in OpenAIRE
    orcid bw Tanweer Alam;
    Tanweer Alam
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Tanweer Alam in OpenAIRE
    Shkurte Luma-Osmani; +1 Authors

    <span>In the health sector, the computer-aided diagnosis (CAD) system is a rapidly growing technology because medical diagnostic systems make a huge change as compared to the traditional system. Now a day huge availability of medical data and it needs a proper system to extract them into useful knowledge. Heart disease accounts to be the leading cause of death worldwide. Heuristic algorithms have been exposed to be operative in supporting making decisions and classification from the large quantity of data produced by the healthcare sector. Classification is a prevailing heuristic approach which is commonly used for classification purpose some heuristic algorithm predicts accurate result according to the marks whereas some others exhibit limited accuracy. This paper is used to categorize the attendance of heart disease with a compact number of aspects. Original, 13 attributes are involved in classifying heart disease. A reasonable analysis of these techniques was done to conclude how the cooperative techniques can be applied for improving prediction accuracy in heart disease. Four main classifiers used to construct heart disease prediction based on the experimental results demonstrate that support vector machine, artificial bee colony (ABC), Bat algorithm, and memory-based learner (MBL) provide efficient results. The accuracy differs between 13 features and 8 features in the training dataset is 1.9% and in the validation, dataset is 0.92% of vector machine which is the most accurate heuristic algorithm. </span>

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
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    International Journal of Advances in Applied Sciences
    Article . 2022 . Peer-reviewed
    License: CC BY SA
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      International Journal of Advances in Applied Sciences
      Article . 2022 . Peer-reviewed
      License: CC BY SA
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Article . 2022
      License: CC BY
      Data sources: ZENODO
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: orcid Trevon Fuller;
    Trevon Fuller
    ORCID
    Harvested from ORCID Public Data File

    Trevon Fuller in OpenAIRE
    Anne W. Rimoin; Nathan D. Wolfe; Nathan D. Wolfe; +23 Authors

    (Uploaded by Plazi for the Bat Literature Project) Climate change is predicted to result in changes in the geographic ranges and local prevalence of infectious diseases, either through direct effects on the pathogen, or indirectly through range shifts in vector and reservoir species. To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future climate conditions, we used ecological niche modeling techniques in conjunction with climate and remote-sensing variables. We first created spatially explicit probability distributions of its candidate reservoir species in Africa's Congo Basin. Reservoir species distributions were subsequently used to model current and projected future distributions of human monkeypox (MPX). Results indicate that forest clearing and climate are significant driving factors of the transmission of MPX from wildlife to humans under current climate conditions. Models under contemporary climate conditions performed well, as indicated by high values for the area under the receiver operator curve (AUC), and tests on spatially randomly and non-randomly omitted test data. Future projections were made on IPCC 4(th) Assessment climate change scenarios for 2050 and 2080, ranging from more conservative to more aggressive, and representing the potential variation within which range shifts can be expected to occur. Future projections showed range shifts into regions where MPX has not been recorded previously. Increased suitability for MPX was predicted in eastern Democratic Republic of Congo. Models developed here are useful for identifying areas where environmental conditions may become more suitable for human MPX; targeting candidate reservoir species for future screening efforts; and prioritizing regions for future MPX surveillance efforts.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ PLoS ONEarrow_drop_down
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    PLoS ONE
    Article . 2013 . Peer-reviewed
    License: CC 0
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    PLoS ONE
    Article
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    PLoS ONE
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    PLoS ONE
    Article . 2014
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    PLoS ONE
    Article . 2013
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    ZENODO
    Article . 2013
    Data sources: Datacite
    ZENODO
    Article . 2013
    Data sources: ZENODO
    ZENODO
    Article . 2013
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ PLoS ONEarrow_drop_down
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      PLoS ONE
      Article . 2013 . Peer-reviewed
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      PLoS ONE
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      PLoS ONE
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      PLoS ONE
      Article . 2014
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Article . 2013
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      ZENODO
      Article . 2013
      Data sources: Datacite
      ZENODO
      Article . 2013
      Data sources: ZENODO
      ZENODO
      Article . 2013
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: orcid Javier Gil-Quintana;
    Javier Gil-Quintana
    ORCID
    Harvested from ORCID Public Data File

    Javier Gil-Quintana in OpenAIRE
    Viviana Malvasi; orcid bw Bárbara Castillo-Abdul;
    Bárbara Castillo-Abdul
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Bárbara Castillo-Abdul in OpenAIRE
    orcid bw Luis M. Romero-Rodríguez;
    Luis M. Romero-Rodríguez
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Luis M. Romero-Rodríguez in OpenAIRE

    Youth is increasingly learning in non-conventional contexts, such as social networks or video platforms, courses, and tutorials. This research aims to diagnose the role of participatory culture, digital resources, social networks, and, specifically, YouTube, in learning processes and the acquisition of Science, Technology, Engineering, and Mathematics (STEM) skills, specifically in mathematics, also analyzing the role of youtubers and, in contrast, teachers, both learning leaders in the formation of these skills. In order to accomplish this, mixed methods (quantitative and qualitative) were used, based on a survey applied to 4845 Italian adolescents, as well as a content analysis of the videos and YouTube channel of the Italian educational influencer Elia Bombardelli, one of the most followed and best rated in this country. Also, an in-depth interview has been applied to 12 Italian secondary school teachers. Among the main findings, it is highlighted that all adolescents value YouTube videos as a key resource to improve their school performance, rating youtubers better than teachers. However, it is remarkable that in the processes of learning and acquisition of STEM competencies, they prefer to interact with teachers rather than with youtubers.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Arias Montano, Repos...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sustainability
    Article . 2020 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sustainability
    Article
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Journal . 2020
    License: CC BY
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Journal . 2020
    License: CC BY
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Sustainability
    Article . 2020
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Arias Montano, Repos...arrow_drop_down
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      Sustainability
      Article . 2020 . Peer-reviewed
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      ZENODO
      Journal . 2020
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      Data sources: Datacite
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      ZENODO
      Journal . 2020
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      Article . 2020
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    Authors: Przemyslaw Galek; orcid Elzbieta Frackowiak;
    Elzbieta Frackowiak
    ORCID
    Harvested from ORCID Public Data File

    Elzbieta Frackowiak in OpenAIRE
    orcid Krzysztof Fic;
    Krzysztof Fic
    ORCID
    Harvested from ORCID Public Data File

    Krzysztof Fic in OpenAIRE

    This paper reports on the “water-in-salt” electrolyte concept, applying CsF as an ionic compound in a symmetric electrochemical capacitor. CsF has been selected as a highly soluble inorganic salt that allows the amount of free water in the electrolyte to be significantly reduced. Several activated carbons with various microtextural parameters have been investigated to identify the most suitable electrode material. A wide range of electrolyte concentrations have been investigated in terms of conductivity, pH and viscosity. The electrochemical characteristics have been determined for three electrolyte concentrations and indicate critical changes in the electrolyte physicochemical properties. It seems that ion-solvent interactions, residual water content, electrolyte viscosity and charging/discharging conditions remarkably affect the electrochemical performance of capacitors with elevated concentrations of electrolyte. In addition to the capacitance increase, a positive impact on the self-discharge and charge/discharge efficiency has been observed for higher CsF concentrations.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Electrochimica Actaarrow_drop_down
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    Electrochimica Acta
    Article . 2020 . Peer-reviewed
    License: CC BY NC ND
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    Electrochimica Acta
    Article
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    Electrochimica Acta
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      Electrochimica Acta
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      Electrochimica Acta
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      Electrochimica Acta
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    Authors: Brouder, Patrick; Teoh, Simon; orcid Salazar, Noel B.;
    Salazar, Noel B.
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    Salazar, Noel B. in OpenAIRE
    Mostafanezhad, Mary; +6 Authors

    The large number of commentaries in this special issue reflect the need that so many people have to express themselves as a way of releasing the anxieties and integrating the hopes that the COVID-1...

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    Authors: orcid Marcantonio Vera;
    Marcantonio Vera
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    Marcantonio Vera in OpenAIRE
    orcid Bocci Enrico;
    Bocci Enrico
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    Bocci Enrico in OpenAIRE
    Jan Pieter Ouweltjes; orcid Luca Del Zotto;
    Luca Del Zotto
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    Luca Del Zotto in OpenAIRE
    +1 Authors

    Abstract Biomass gasification is a promising technology to produce secondary fuels or heat and power, offering considerable advantages over fossil fuels. An important aspect in the usage of producer gas is the removal of harmful contaminants from the raw syngas. Thus, the object of this study is the development of a simulation model for a gasifier including gas clean-up, for which a fluidized-bed gasifier for biomass-derived syngas production was considered, based on a quasi-equilibrium approach through Gibbs free energy minimisation, and including an innovative hot gas cleaning, constituted by a combination of catalyst sorbents inside the gasification reactor, catalysts in the freeboard and subsequent sorbent reactors, by using Aspen Plus software. The gas cleaning chain simulates the raw syngas clean-up for several organic and inorganic contaminants, i.e. toluene, benzene, naphthalene, hydrogen sulphide, hydrogen chloride and ammonia. The tar and inorganic contaminants final values achieved are under 1 g/Nm3 and 1 ppm respectively.

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    International Journal of Hydrogen Energy
    Article . 2020 . Peer-reviewed
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    International Journal of Hydrogen Energy
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      International Journal of Hydrogen Energy
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      International Journal of Hydrogen Energy
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    Authors: Green, Ridgely Fisk; Stoler, Joan Marilyn;

    Fetal alcohol syndrome (FAS), 1 of the most common developmental disabilities in the United States, occurs at a rate of 0.5-2.0:1000 live births. Animal model, family, and twin studies suggest a genetic component to FAS susceptibility. Alcohol dehydrogenases (ADHs) catalyze the rate-limiting step in alcohol metabolism. Studies of genetic associations with FAS have focused on the alcohol dehydrogenase 1B (ADH1B) gene, comparing mothers and children with the alleles ADH1B*2 or ADH1B*3, associated with faster ethanol metabolism, with those homozygous for ADH1B*1. While most studies have found a protective effect for genotypes containing ADH1B*2 or ADH1B*3, results have been conflicting, and further investigation into the association between the ADH1B genotype and FAS is needed. Whether increased alcohol intake accounts for the elevated risk reported for the ADH1B*1/ADH1B*1 genotype should be addressed, and future studies would benefit from consistent case definitions, enhanced exposure measurements, larger sample sizes, and careful study design.

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    American Journal of Obstetrics and Gynecology
    Article . 2007 . Peer-reviewed
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      American Journal of Obstetrics and Gynecology
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    Authors: Hina Khan; orcid Sadaf Ahmed;
    Sadaf Ahmed
    ORCID
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    Sadaf Ahmed in OpenAIRE

    Background: An accumulating body of research studies have presented effects of climate change on human health. The current state of climate change supports the notion of elevated incidences of heat waves in future. The understanding of role of increasing temperatures and heat waves on altered mental health conditions stands crucial, in light of wide spectrum of effects warming climate imparts on mental health and well-being status. Methodology: Research studies with findings related to increasing temperatures, mental health and behavioural alterations, and psychopathological outcomes are highlighted in this review. Articles were searched using Google Scholar from the year 2005 to 2018 by entering keywords; increasing temperature and mental health, heat waves and mental health, heat waves and behavioural disorders, climate change and mental health, and, global warming and mental health. Studies were also selected from reference lists of the articles emerging out from these keywords provided. Newspaper articles and reports with details of heat waves in Pakistan are also included. Results: Extreme heat exposure event is found to result in adverse mental, mood and behavioural consequences; including anxiety, aggression, and violence. Heat waves are found to potentiate risk for hospital admission, also due to mental disorders. Heat-associated mental health alterations may be attributed to compromised thermoregulation, pre-existing mental illness, old age, substance abuse and prescription medications effects, and up-regulation in release of stress hormones. Conclusion: Keeping in view the impact of warming climate on mental and behavioural disorders, it appears significantly important to promote research aiming to decipher heat-induced mental health outcomes. In particular, studies are encouraged to be carried out to understand effects of increasing temperatures and heat waves on impaired mental health and psychological well-being state, develop heat-associated mental health mass awareness campaigns, and plan mental health response actions in Pakistan, which currently remain under-represented.

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    Annals of Psychophysiology
    Article . 2018 . Peer-reviewed
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    Annals of Psychophysiology
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    Annals of Psychophysiology
    Article . 2018
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      Annals of Psychophysiology
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  • Laboratory-reared males of the cactophilic Drosophila pachea exhibit a spontaneous and sex-specific suppression of alcohol dehydrogenase (ADH) activity within 4 days after eclosion. A lack of ADH activity also is usually seen in wild-caught males, although relatively high activity is always seen in female flies. In the present study we examined the effectiveness of different alcohols and related compounds, including several found naturally in necroses of the host cactus, to induce suppressed ADH activity in wild males of D. pachea and to serve as enzyme substrates. The primary alcohols (methanol, ethanol, 1-propanol, 1-butanol, and 1-pentanol), and the secondary alcohols (2-propanol and 2-butanol), each induced activity after 24 h exposure, although to different degrees. 1,2-Propanediol was usually effective as an inducer, but 2,3-butanediol usually was ineffective. Little or no induction was seen with 1-octanol, 2-pentanol, 3-methyl-1-butanol, 3-hydroxy-2-butanone, or acetaldehyde. Although the compounds tested varied in their ability to function as ADH substrates, methanol was the only alcohol that showed no activity staining. Ethanol induction of ADH activity was apparent after 3-6 h exposure and induced activity decreased dramatically within 1 week of flies being placed in an alcohol-free environment. Ethanol exposure did not induce ADH in adult female D. pachea, or in adult males and females of D. acutilabella in which control males show reduced ADH activity compared to females. The implications of the loss of ADH activity in adult males of D. pachea, as they relate to feeding ecology and fitness, are discussed.

    Biochemical Geneticsarrow_drop_down
    Biochemical Genetics
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    Authors: orcid Laura Sánchez-Marín;
    Laura Sánchez-Marín
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    Laura Sánchez-Marín in OpenAIRE
    orcid David Ladrón de Guevara-Miranda;
    David Ladrón de Guevara-Miranda
    ORCID
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    David Ladrón de Guevara-Miranda in OpenAIRE
    orcid M. Carmen Mañas-Padilla;
    M. Carmen Mañas-Padilla
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    Harvested from ORCID Public Data File

    M. Carmen Mañas-Padilla in OpenAIRE
    Francisco Alén; +10 Authors

    The systemic administration of lysophosphatidic acid (LPA) LPA1/3 receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA1 receptor-null mice engage in increased ethanol consumption, we evaluated the effects of systemic administration of an LPA1/3 receptor antagonist (intraperitoneal ki16425, 20 mg/kg) on ethanol-related behaviors as well as on brain and plasma correlates. Acute administration of ki16425 reduced motivation for ethanol but not for saccharine in ethanol self-administering Wistar rats. Mouse experiments were conducted in two different strains. In Swiss mice, ki16425 treatment reduced both ethanol-induced sedation (loss of righting reflex, LORR) and ethanol reward (escalation in ethanol consumption and ethanol-induced conditioned place preference, CPP). Furthermore, in the CPP-trained Swiss mice, ki16425 prevented the effects of ethanol on basal c-Fos expression in the medial prefrontal cortex and on adult neurogenesis in the hippocampus. In the c57BL6/J mouse strain, however, no effects of ki16425 on LORR or voluntary drinking were observed. The c57BL6/J mouse strain was then evaluated for ethanol withdrawal symptoms, which were attenuated when ethanol was preceded by ki16425 administration. In these animals, ki16425 modulated the expression of glutamate-related genes in brain limbic regions after ethanol exposure; and peripheral LPA signaling was dysregulated by either ki16425 or ethanol. Overall, these results suggest that LPA1/3 receptor antagonists might be a potential new class of drugs that are suitable for treating or preventing alcohol use disorders. A pharmacokinetic study revealed that systemic ki16425 showed poor brain penetration, suggesting the involvement of peripheral events to explain its effects.

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Neuropharmacology
    Article . 2018 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      ZENODO
      Article . 2018
      License: CC BY
      Data sources: ZENODO
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Neuropharmacology
      Article . 2018 . Peer-reviewed
      License: Elsevier TDM
      Data sources: Crossref
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