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description Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United StatesPublisher:Springer Science and Business Media LLC Funded by:NIH | 1/2-The West Africa-Michi...NIH| 1/2-The West Africa-Michigan CHARTER II for GEOHealth-USAAuthors:Thomas Peprah Agyekum;
Thomas Peprah Agyekum
Thomas Peprah Agyekum in OpenAIREJohn Arko-Mensah;
John Arko-Mensah
John Arko-Mensah in OpenAIREPaul Kingsley Botwe;
Jonathan Nartey Hogarh; +6 AuthorsPaul Kingsley Botwe
Paul Kingsley Botwe in OpenAIREThomas Peprah Agyekum;
Thomas Peprah Agyekum
Thomas Peprah Agyekum in OpenAIREJohn Arko-Mensah;
John Arko-Mensah
John Arko-Mensah in OpenAIREPaul Kingsley Botwe;
Jonathan Nartey Hogarh;Paul Kingsley Botwe
Paul Kingsley Botwe in OpenAIREIbrahim Issah;
Ibrahim Issah
Ibrahim Issah in OpenAIRESamuel Kweku Dadzie;
Duah Dwomoh; Maxwell Kelvin Billah; Thomas Robins;Samuel Kweku Dadzie
Samuel Kweku Dadzie in OpenAIREJulius Najah Fobil;
Julius Najah Fobil
Julius Najah Fobil in OpenAIREAbstract Background Malaria remains one of the most devastating diseases globally, and the control of mosquitoes as the vector is mainly dependent on chemical insecticides. Elevated temperatures associated with future warmer climates could affect mosquitoes' metabolic enzyme expression and increase insecticide resistance, making vector control difficult. Understanding how mosquito rearing temperatures influence their susceptibility to insecticide and expression of metabolic enzymes could aid in the development of novel tools and strategies to control mosquitoes in a future warmer climate. This study evaluated the effects of temperature on the susceptibility of Anopheles gambiae sensu lato (s.l.) mosquitoes to pyrethroids and their expression of metabolic enzymes. Methods Anopheles gambiae s.l. eggs obtained from laboratory-established colonies were reared under eight temperature regimes (25, 28, 30, 32, 34, 36, 38, and 40 °C). Upon adult emergence, 3- to 5-day-old female non-blood-fed mosquitoes were used for susceptibility tests following the World Health Organization (WHO) bioassay protocol. Batches of 20–25 mosquitoes from each temperature regime (25–34 °C) were exposed to two pyrethroid insecticides (0.75% permethrin and 0.05% deltamethrin). In addition, the levels of four metabolic enzymes (α-esterase, β-esterase, glutathione S-transferase [GST], and mixed-function oxidase [MFO]) were examined in mosquitoes that were not exposed and those that were exposed to pyrethroids. Results Mortality in An. gambiae s.l. mosquitoes exposed to deltamethrin and permethrin decreased at temperatures above 28 °C. In addition, mosquitoes reared at higher temperatures were more resistant and had more elevated enzyme levels than those raised at low temperatures. Overall, mosquitoes that survived after being exposed to pyrethroids had higher levels of metabolic enzymes than those that were not exposed to pyrethroids. Conclusions This study provides evidence that elevated temperatures decreased An. gambiae s.l. mosquitoes' susceptibility to pyrethroids and increased the expression of metabolic enzymes. This evidence suggests that elevated temperatures projected in a future warmer climate could increase mosquitoes' resistance to insecticides and complicate malaria vector control measures. This study therefore provides vital information, and suggests useful areas of future research, on the effects of temperature variability on mosquitoes that could guide vector control measures in a future warmer climate. Graphical Abstract
Parasites & Vect... arrow_drop_down University of Michigan: Deep BlueArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Parasites & Vect... arrow_drop_down University of Michigan: Deep BlueArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Publisher:Springer Science and Business Media LLC Funded by:NIH | Role of BK Channel Intera..., NIH | Activation of the parasub..., NIH | CORE--BIOCHEMICAL CORENIH| Role of BK Channel Interactome in Excessive Ethanol Drinking ,NIH| Activation of the parasubthalamic nucleus in alcohol dependence ,NIH| CORE--BIOCHEMICAL COREAuthors: Agbonlahor Okhuarobo; Max Kreifeldt;Pauravi J. Gandhi;
Catherine Lopez; +9 AuthorsPauravi J. Gandhi
Pauravi J. Gandhi in OpenAIREAgbonlahor Okhuarobo; Max Kreifeldt;Pauravi J. Gandhi;
Catherine Lopez; Briana Martinez;Pauravi J. Gandhi
Pauravi J. Gandhi in OpenAIREKiera Fleck;
Michal Bajo;Kiera Fleck
Kiera Fleck in OpenAIREPushpita Bhattacharyya;
Alex M. Dopico;Pushpita Bhattacharyya
Pushpita Bhattacharyya in OpenAIREMarisa Roberto;
Amanda J. Roberts;Marisa Roberto
Marisa Roberto in OpenAIREGregg E. Homanics;
Gregg E. Homanics
Gregg E. Homanics in OpenAIRECandice Contet;
Candice Contet
Candice Contet in OpenAIREAbstractLarge conductance potassium (BK) channels are among the most sensitive molecular targets of ethanol and genetic variations in the channel-forming α subunit have been nominally associated with alcohol use disorders. However, whether the action of ethanol at BK α influences the motivation to drink alcohol remains to be determined. To address this question, we first tested the effect of systemically administered BK channel modulators on voluntary alcohol consumption in C57BL/6J males. Penitrem A (blocker) exerted dose-dependent effects on moderate alcohol intake, while paxilline (blocker) and BMS-204352 (opener) were ineffective. Because pharmacological manipulations are inherently limited by non-specific effects, we then sought to investigate the behavioral relevance of ethanol’s direct interaction with BK α by introducing in the mouse genome a point mutation known to render BK channels insensitive to ethanol while preserving their physiological function. The BK α K361N substitution prevented ethanol from reducing spike threshold in medial habenula neurons. However, it did not alter acute responses to ethanol in vivo, including ataxia, sedation, hypothermia, analgesia, and conditioned place preference. Furthermore, the mutation did not have reproducible effects on alcohol consumption in limited, continuous, or intermittent access home cage two-bottle choice paradigms conducted in both males and females. Notably, in contrast to previous observations made in mice missing BK channel auxiliary β subunits, the BK α K361N substitution had no significant impact on ethanol intake escalation induced by chronic intermittent alcohol vapor inhalation. It also did not affect the metabolic and locomotor consequences of chronic alcohol exposure. Altogether, these data suggest that the direct interaction of ethanol with BK α does not mediate the alcohol-related phenotypes examined here in mice.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-023-02346-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-023-02346-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2021Publisher:American Association for the Advancement of Science (AAAS) Funded by:NIH | Mechanisms of Sensory Mod..., NIH | The role of neural signal..., NIH | Modulation of aging throu...NIH| Mechanisms of Sensory Modulation of Aging in Drosophila ,NIH| The role of neural signaling pathways in costs of reproduction on aging ,NIH| Modulation of aging through mechanisms of nutrient demand and rewardAuthors:Yuan Luo;
Yuan Luo
Yuan Luo in OpenAIREJacob C. Johnson;
Tuhin S. Chakraborty;Jacob C. Johnson
Jacob C. Johnson in OpenAIREAustin Piontkowski;
+2 AuthorsAustin Piontkowski
Austin Piontkowski in OpenAIREYuan Luo;
Yuan Luo
Yuan Luo in OpenAIREJacob C. Johnson;
Tuhin S. Chakraborty;Jacob C. Johnson
Jacob C. Johnson in OpenAIREAustin Piontkowski;
Austin Piontkowski
Austin Piontkowski in OpenAIREChristi M. Gendron;
Christi M. Gendron
Christi M. Gendron in OpenAIREScott D. Pletcher;
Scott D. Pletcher
Scott D. Pletcher in OpenAIREYeast volatiles double starvation survival in Drosophila .
Science Advances arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciadv.abf8896&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Science Advances arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciadv.abf8896&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2021 United StatesPublisher:American Physiological Society Funded by:NIH | Hepatic stellate cell mic..., NIH | Modeling Multiscale Contr..., NIH | Ethanol Effects on the Tr... +1 projectsNIH| Hepatic stellate cell microRNA networks in ethanol-impaired liver regeneration ,NIH| Modeling Multiscale Control of Liver Regeneration ,NIH| Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration - ,NIH| Alcoholic Tissue InjuryAuthors: Austin Parrish;Ankita Srivastava;
Egle Juskeviciute; Jan B. Hoek; +1 AuthorsAnkita Srivastava
Ankita Srivastava in OpenAIREAustin Parrish;Ankita Srivastava;
Egle Juskeviciute; Jan B. Hoek;Ankita Srivastava
Ankita Srivastava in OpenAIRERajanikanth Vadigepalli;
Rajanikanth Vadigepalli
Rajanikanth Vadigepalli in OpenAIREImpaired liver regeneration has been considered as a hallmark of progression of alcohol-associated liver disease. Our previous studies demonstrated that in vivo inhibition of the microRNA (miRNA) miR21 can restore regenerative capacity of the liver in chronic ethanol-fed animals. The present study focuses on the role of microRNA regulatory networks that are likely to mediate the miR-21 action. Rats were chronically fed an ethanol-enriched diet along with pair-fed control animals and treated with AM21 (anti-miR-21), a locked nucleic acid antisense to miR-21. Partial hepatectomy (PHx) was performed and miRNA expression profiling over the course of liver regeneration was assessed. Our results showed dynamic expression changes in several miRNAs after PHx, notably with altered miRNA expression profiles between ethanol and control groups. We found that in vivo inhibition of miR-21 led to correlated differential expression of miR-340-5p and anticorrelated expression of miR-365, let-7a, miR-1224, and miR-146a across all sample groups after PHx. Gene set enrichment analysis identified a miRNA signature significantly associated with hepatic stellate cell activation within whole liver tissue data. We hypothesized that at least part of the PHx-induced miRNA network changes responsive to miR-21 inhibition is localized to hepatic stellate cells. We validated this hypothesis using AM21 and TGF-β treatments in LX-2 human hepatic stellate cells in culture and measured expression levels of select miRNAs by quantitative RT-PCR. Based on the in vivo and in vitro results, we propose a hepatic stellate cell miRNA regulatory network as contributing to the restoration of liver regenerative capacity by miR-21 inhibition.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/physiolgenomics.00113.2021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1152/physiolgenomics.00113.2021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2010Publisher:Elsevier BV Funded by:NIH | CONFORMATIONAL CHANGES IN..., NSF | Photobiology of Vision & ..., NSF | PFC: Center for the Physi...NIH| CONFORMATIONAL CHANGES INVOLVED IN ELECTRON TRANSFER IN CYTOCHROME BC1 COMPLEXES ,NSF| Photobiology of Vision & Photosynthesis ,NSF| PFC: Center for the Physics of Living CellsAuthors:Arvi Freiberg;
Melih Sener; Johan Strümpfer; Klaus Schulten; +2 AuthorsArvi Freiberg
Arvi Freiberg in OpenAIREArvi Freiberg;
Melih Sener; Johan Strümpfer; Klaus Schulten; C. Neil Hunter; John A. Timney;Arvi Freiberg
Arvi Freiberg in OpenAIREPhotosynthetic chromatophore vesicles found in some purple bacteria constitute one of the simplest light-harvesting systems in nature. The overall architecture of chromatophore vesicles and the structural integration of vesicle function remain poorly understood despite structural information being available on individual constituent proteins. An all-atom structural model for an entire chromatophore vesicle is presented, which improves upon earlier models by taking into account the stoichiometry of core and antenna complexes determined by the absorption spectrum of intact vesicles in Rhodobacter sphaeroides, as well as the well-established curvature-inducing properties of the dimeric core complex. The absorption spectrum of low-light-adapted vesicles is shown to correspond to a light-harvesting-complex 2 to reaction center ratio of 3:1. A structural model for a vesicle consistent with this stoichiometry is developed and used in the computation of excitonic properties. Considered also is the packing density of antenna and core complexes that is high enough for efficient energy transfer and low enough for quinone diffusion from reaction centers to cytochrome bc(1) complexes.
Biophysical Journal arrow_drop_down Biophysical JournalArticle . 2010License: Elsevier Non-CommercialData sources: BASE (Open Access Aggregator)Biophysical JournalArticle . 2010 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bpj.2010.04.013&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 60 citations 60 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Biophysical Journal arrow_drop_down Biophysical JournalArticle . 2010License: Elsevier Non-CommercialData sources: BASE (Open Access Aggregator)Biophysical JournalArticle . 2010 . Peer-reviewedLicense: Elsevier Non-CommercialData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bpj.2010.04.013&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Elsevier BV Funded by:NIH | Pregnancy Exposures to Ch..., NIH | Project 5: Green Remediat..., FCT | D4 +5 projectsNIH| Pregnancy Exposures to Chemical Mixtures and Later Metabolic Health and Endocrine Function Among Women in the Puerto Rico PROTECT Cohort ,NIH| Project 5: Green Remediation by Solar Energy Conversion Into Electrolysis ,FCT| D4 ,NIH| Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO) ,NIH| Michigan Center on Lifestage Environmental Exposures and Disease ,NIH| Applying and advancing modern approaches for studying the joint impacts of environmental chemicals on pregnancy outcomes ,NIH| Pilot Project Program ,NIH| ECHO Coordinating CenterAuthors:Seonyoung Park;
Seonyoung Park
Seonyoung Park in OpenAIREAmber L. Cathey;
Amber L. Cathey
Amber L. Cathey in OpenAIREWei Hao;
Lixia Zeng; +8 AuthorsWei Hao
Wei Hao in OpenAIRESeonyoung Park;
Seonyoung Park
Seonyoung Park in OpenAIREAmber L. Cathey;
Amber L. Cathey
Amber L. Cathey in OpenAIREWei Hao;
Lixia Zeng;Wei Hao
Wei Hao in OpenAIRESubramaniam Pennathur;
Max T. Aung; Zaira Rosario-Pabón;Subramaniam Pennathur
Subramaniam Pennathur in OpenAIRECarmen M. Vélez-Vega;
Carmen M. Vélez-Vega
Carmen M. Vélez-Vega in OpenAIREJosé F. Cordero;
Akram Alshawabkeh; Deborah J. Watkins;José F. Cordero
José F. Cordero in OpenAIREJohn D. Meeker;
John D. Meeker
John D. Meeker in OpenAIREHumans are exposed to complex mixtures of phthalates. Gestational exposure to phthalates has been linked to preeclampsia and preterm birth through potential pathways such as endocrine disruption, oxidative stress, and inflammation. Eicosanoids are bioactive signaling lipids that are related to a variety of homeostatic and inflammatory processes. We investigated associations between urinary phthalates and their mixtures with plasma eicosanoid levels during pregnancy using the PROTECT cohort in Puerto Rico (N = 655). After adjusting for covariates, we estimated pair-wise associations between the geometric mean of individual phthalate metabolite concentrations across pregnancy and eicosanoid biomarkers using multivariable linear regression. We used bootstrapping of adaptive elastic net regression (adENET) to evaluate phthalate mixtures associated with eicosanoids and subsequently create environmental risk scores (ERS) to represent weighted sums of phthalate exposure for each individual. After adjusting for false-discovery, in single-pollutant analysis, 14 of 20 phthalate metabolites or parent compound indices showed significant and primarily negative associations with multiple eicosanoids. In our mixture analysis, associations with several metabolites of low molecular weight phthalates - DEP, DBP, and DIBP - became prominent. Additionally, MEHHTP and MECPTP, metabolites of a new phthalate replacement, DEHTP, were selected as important predictors for determining the concentrations of multiple eicosanoids from different pathway groups. A unit increase in phthalate ERS derived from bootstrapping of adENET was positively associated with several eicosanoids mainly from Cytochrome P450 pathway. For example, an increase in ERS was associated with 11(S)-HETE (β = 1.6, 95% CI: 0.020, 3.180), (±)11,12-DHET (β = 2.045, 95% CI: 0.250, 3.840), 20(S)-HETE (β = 0.813, 95% CI: 0.147, 1.479), and 9 s-HODE (β = 2.381, 95% CI: 0.657, 4.104). Gestational exposure to phthalates and phthalate mixtures were associated with eicosanoid levels during pregnancy. Results from the mixture analyses underscore the complexity of physiological impacts of phthalate exposure and call for further in-depth studies to examine these relationships.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 8 citations 8 popularity Average influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2024Publisher:International Society of Global Health Funded by:NIH | Development of a Mobile H...NIH| Development of a Mobile Health Personalized Physiologic Analytics Tool for Pediatric Patients with SepsisMamun, Gazi MS; Moretti, Katelyn; Afroze, Farzana; Brintz, Ben J; Rahman, Abu SMMH; Gainey, Monique; Sarmin, Monira; Shaima, Shamsun N; Chisti, Mohammod J; Levine, Adam C; Garbern, Stephanie C;Sepsis is a leading cause of paediatric mortality worldwide, disproportionately affecting children in low- and middle-income countries. The impacts of climate change on the burden and outcomes of sepsis in low- and middle-income countries, particularly in paediatric populations, remain poorly understood. We aimed to assess the associations between climate variables (temperature and precipitation) and paediatric sepsis incidence and mortality in Bangladesh, one of the countries most affected by climate change.We conducted retrospective analyses of patient-level data from the International Centre for Diarrhoeal Disease Research, Bangladesh, and environmental data from the National Oceanic and Atmospheric Administration. Using random forests, we assessed associations between sepsis incidence and sepsis mortality with temperature and precipitation between 2009-22.A nonlinear relationship between temperature and sepsis incidence and mortality was identified. The lowest incidence occurred at an optimum temperature of 26.6°C with a gradual increase below and a sharp rise above this temperature. Higher precipitation levels showed a general trend of increased sepsis incidence. A similar distribution for sepsis mortality was identified with an optimum temperature of 28°C.Findings suggest that environmental temperature and precipitation play a role in paediatric sepsis incidence and sepsis mortality in Bangladesh. As children are particularly vulnerable to climate impacts, it is important to consider climate change in health care planning and resource allocation, especially in resource-limited settings, to allow for surge capacity planning during warmer and wetter seasons. Further prospective research from more globally representative data sets will provide more robust evidence on the nature of the relationships between climate variables and paediatric sepsis worldwide.
Journal of Global He... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7189/jogh.14.04107&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert Journal of Global He... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 United StatesPublisher:Springer Science and Business Media LLC Funded by:NIH | Training Grant on Genetic..., NIH | Ethanol and nicotine co-a..., NIH | Center on Genetic Determi... +1 projectsNIH| Training Grant on Genetic Aspects of Alcoholism ,NIH| Ethanol and nicotine co-abuse: cross sensitization of their reinforcing actions ,NIH| Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol ,NIH| CNS Sites for the Rewarding Actions of AlcoholAuthors: Deehan, Gerald A.; Hauser, Sheketha R.;Waeiss, R. Aaron;
Knight, Christopher P.; +4 AuthorsWaeiss, R. Aaron
Waeiss, R. Aaron in OpenAIREDeehan, Gerald A.; Hauser, Sheketha R.;Waeiss, R. Aaron;
Knight, Christopher P.;Waeiss, R. Aaron
Waeiss, R. Aaron in OpenAIREToalston, Jamie E.;
Truitt, William A.; McBride, William J.; Rodd, Zachary A.;Toalston, Jamie E.
Toalston, Jamie E. in OpenAIREThe co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse.The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH + NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system.Alcohol-preferring (P) rats self-administered EtOH, Sacc + NIC, or EtOH + NIC combined for 10 weeks. The reinforcing properties of 0.1-3.0 μM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2-3-week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc + NIC, or EtOH + NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined.Binge intake of EtOH (96-100 mg%) and NIC (21-27 mg/mL) were attained. All groups of P rats self-infused 3.0 μM NIC directly into the AcbSh, whereas only animals in the EtOH + NIC co-abuse group self-infused the 0.3 and 1.0 μM NIC concentrations. Additionally, self-administration of EtOH + NIC, but not EtOH, Sacc or Sacc + NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC.Overall, the co-abuse of EtOH + NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2010 United StatesPublisher:Public Library of Science (PLoS) Funded by:NIH | Model of Chronic Daily He..., NIH | Alcohol-Induced Headaches...NIH| Model of Chronic Daily Headache in Rat ,NIH| Alcohol-Induced Headaches: An Animal ModelAuthors: Maxwell, Christina R; Spangenberg, Rebecca Jay;Hoek, Jan B;
Silberstein, Stephen D; +1 AuthorsHoek, Jan B
Hoek, Jan B in OpenAIREMaxwell, Christina R; Spangenberg, Rebecca Jay;Hoek, Jan B;
Silberstein, Stephen D;Hoek, Jan B
Hoek, Jan B in OpenAIREOshinsky, Michael L;
Oshinsky, Michael L
Oshinsky, Michael L in OpenAIREThe mechanism of veisalgia cephalgia or hangover headache is unknown. Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache.We used a chronic headache model to examine how pure ethanol produces increased sensitivity for nociceptive behaviors in normally hydrated rats.Ethanol initially decreased sensitivity to mechanical stimuli on the face (analgesia), followed 4 to 6 hours later by inflammatory pain. Inhibiting alcohol dehydrogenase extended the analgesia whereas inhibiting aldehyde dehydrogenase decreased analgesia. Neither treatment had nociceptive effects. Direct administration of acetate increased nociceptive behaviors suggesting that acetate, not acetaldehyde, accumulation results in hangover-like hypersensitivity in our model. Since adenosine accumulation is a result of acetate formation, we administered an adenosine antagonist that blocked hypersensitivity.Our study shows that acetate contributes to hangover headache. These findings provide insight into the mechanism of hangover headache and the mechanism of headache induction.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0015963&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2009 SwitzerlandPublisher:EDP Sciences Funded by:NIH | Transition Pathways for B...NIH| Transition Pathways for Biomolecular Systems: Theory and ComputationAuthors: Hairer, Ernst;McLachlan, Robert I.;
Skeel, Robert D.;McLachlan, Robert I.
McLachlan, Robert I. in OpenAIREIn long-time numerical integration of Hamiltonian systems, and especially in molecular dynamics simulation, it is important that the energy is well conserved. For symplectic integrators applied with sufficiently small step size, this is guaranteed by the existence of a modified Hamiltonian that is exactly conserved up to exponentially small terms. This article is concerned with the simplified Takahashi-Imada method, which is a modification of the Störmer-Verlet method that is as easy to implement but has improved accuracy. This integrator is symmetric and volume-preserving, but no longer symplectic. We study its long-time energy conservation and give theoretical arguments, supported by numerical experiments, which show the possibility of a drift in the energy (linear or like a random walk). With respect to energy conservation, this article provides empirical and theoretical data concerning the importance of using a symplectic integrator.
ESAIM Mathematical M... arrow_drop_down ESAIM Mathematical Modelling and Numerical AnalysisArticle . 2009 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 22 citations 22 popularity Top 10% influence Top 10% impulse Average Powered by BIP!
more_vert ESAIM Mathematical M... arrow_drop_down ESAIM Mathematical Modelling and Numerical AnalysisArticle . 2009 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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