In the course of monitoring near the chemical weapons storage and destruction plant "Maradykovsky", more than 100 strains of Streptomyces were stated from the soil surfaces into the pure culture. In order to find the strains which are tolerant to chemical weapons degradation products, the response of natural isolates of actinomycetes to sodium pyrophosphate, methylphosphonic acid, and arsenic concentration gradient was studied. For each pollutant a special dose was set, which could stimulate and inhibit either the growth of actinomycetes at the stage of spores and at the stage of vegetative growth, or their metabolic activity consisting in production of antibiotics, or cellulose decomposition. Actinomycetes cultures were found, which are promising for creating microbial inoculants for remediation of soils impacted with arsenic and phosphorus xenobiotics.