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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: orcid bw Neubauer, David;
    Neubauer, David
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Neubauer, David in OpenAIRE
    orcid bw Ferrachat, Sylvaine;
    Ferrachat, Sylvaine
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Ferrachat, Sylvaine in OpenAIRE
    Siegenthaler-Le Drian, Colombe; Stoll, Jens; +18 Authors

    Project: Coupled Model Intercomparison Project Phase 6 (CMIP6) datasets - These data have been generated as part of the internationally-coordinated Coupled Model Intercomparison Project Phase 6 (CMIP6; see also GMD Special Issue: http://www.geosci-model-dev.net/special_issue590.html). The simulation data provides a basis for climate research designed to answer fundamental science questions and serves as resource for authors of the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC-AR6). CMIP6 is a project coordinated by the Working Group on Coupled Modelling (WGCM) as part of the World Climate Research Programme (WCRP). Phase 6 builds on previous phases executed under the leadership of the Program for Climate Model Diagnosis and Intercomparison (PCMDI) and relies on the Earth System Grid Federation (ESGF) and the Centre for Environmental Data Analysis (CEDA) along with numerous related activities for implementation. The original data is hosted and partially replicated on a federated collection of data nodes, and most of the data relied on by the IPCC is being archived for long-term preservation at the IPCC Data Distribution Centre (IPCC DDC) hosted by the German Climate Computing Center (DKRZ). The project includes simulations from about 120 global climate models and around 45 institutions and organizations worldwide. Summary: These data include the subset used by IPCC AR6 WGI authors of the datasets originally published in ESGF for 'CMIP6.CMIP.HAMMOZ-Consortium.MPI-ESM-1-2-HAM.historical' with the full Data Reference Syntax following the template 'mip_era.activity_id.institution_id.source_id.experiment_id.member_id.table_id.variable_id.grid_label.version'. The MPI-ESM1.2-HAM climate model, released in 2017, includes the following components: aerosol: HAM2.3, atmos: ECHAM6.3 (spectral T63; 192 x 96 longitude/latitude; 47 levels; top level 0.01 hPa), atmosChem: sulfur chemistry (unnamed), land: JSBACH 3.20, ocean: MPIOM1.63 (bipolar GR1.5, approximately 1.5deg; 256 x 220 longitude/latitude; 40 levels; top grid cell 0-12 m), ocnBgchem: HAMOCC6, seaIce: unnamed (thermodynamic (Semtner zero-layer) dynamic (Hibler 79) sea ice model). The model was run by the ETH Zurich, Switzerland; Max Planck Institut fur Meteorologie, Germany; Forschungszentrum Julich, Germany; University of Oxford, UK; Finnish Meteorological Institute, Finland; Leibniz Institute for Tropospheric Research, Germany; Center for Climate Systems Modeling (C2SM) at ETH Zurich, Switzerland (HAMMOZ-Consortium) in native nominal resolutions: aerosol: 250 km, atmos: 250 km, atmosChem: 250 km, land: 250 km, ocean: 250 km, ocnBgchem: 250 km, seaIce: 250 km.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ World Data Center fo...arrow_drop_down
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    World Data Center for Climate
    Dataset . 2023
    License: CC BY
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ World Data Center fo...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      World Data Center for Climate
      Dataset . 2023
      License: CC BY
      Data sources: Datacite
      addClaim
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    Authors: Murray, David; Kainz, Martin; Hebberecht, Laura; Sales, Kris; +2 Authors

    Triploidy could prevent escaped farm salmon breeding in the wild, while also improving nutrient quality within farmed fillets. Despite these potential advantages, triploid Atlantic salmon have not been widely used in aquaculture, and their reproductive function has yet to be fully evaluated. Here, we compare reproductive function and fillet composition between triploid and diploid farm salmon under standard aquaculture rearing conditions. We show that female triploids are sterile and do not develop gonads. In contrast, males produce large numbers of motile spermatozoa capable of fertilising wild salmon eggs. However, compared with diploids, reproductive development and survival rates of eggs fertilised by triploid males were significantly reduced, with less than 1% of eggs sired by triploid males reaching late eyed stages of development. Analyses of fillets showed that total lipid and fatty acid quantities were significantly lower in triploid compared to diploid Atlantic salmon fillets. However, when fatty acids were normalized to total lipid content, triploid fillets had significantly higher relative levels of important omega-3 Long Chain Polyunsaturated Fatty Acids. Our results show that: (1) escaped triploid farm salmon are very unlikely to reproduce in the wild; and (2) if able to match diploid fillet lipid content, triploid farm salmon could achieve better fillet quality in terms of essential fatty acids. Comparisons between diploid and triploid Atlantic salmonExcel file containing all the data collected during the investigation into the reproductive maturation of triploid Atlantic salmon, their fatty acid biochemistry and how they compare to diploid conspecifics

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    ZENODO
    Dataset . 2018
    License: CC 0
    Data sources: ZENODO
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    B2FIND
    Dataset . 2018
    Data sources: B2FIND
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    EASY
    Dataset . 2018
    Data sources: EASY
    DRYAD
    Dataset . 2018
    License: CC 0
    Data sources: Datacite
    addClaim
    0
    citations0
    popularityAverage
    influenceAverage
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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      ZENODO
      Dataset . 2018
      License: CC 0
      Data sources: ZENODO
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      B2FIND
      Dataset . 2018
      Data sources: B2FIND
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      EASY
      Dataset . 2018
      Data sources: EASY
      DRYAD
      Dataset . 2018
      License: CC 0
      Data sources: Datacite
      addClaim
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: orcid bw Warren-Thomas, Eleanor;
    Warren-Thomas, Eleanor
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Warren-Thomas, Eleanor in OpenAIRE
    Nelson, Luke; Juthong, Watinee; Bumrungsri, Sara; +7 Authors

    Monocultural rubber plantations have replaced tropical forest, causing biodiversity loss. While protecting intact or semi-intact biodiverse forest is paramount, improving biodiversity value within the 11.4 million hectares of existing rubber plantations could offer important conservation benefits, if yields are also maintained. Some farmers practice agroforestry with high-yielding clonal rubber varieties to increase and diversify incomes. Here, we ask whether such rubber agroforestry improves biodiversity value or affects rubber yields relative to monoculture. We surveyed birds, fruit-feeding butterflies and reptiles in 25 monocultural and 39 agroforest smallholder rubber plots in Thailand, the world’s biggest rubber producer. Management and vegetation structure data were collected from each plot, and landscape composition around plots was quantified. Rubber yield data were collected for a separate set of 34 monocultural and 47 agroforest rubber plots in the same region. Reported rubber yields did not differ between agroforests and monocultures, meaning adoption of agroforestry in this context should not increase land demand for natural rubber. Butterfly richness was greater in agroforests, where richness increased with greater natural forest extent in the landscape. Bird and reptile richness were similar between agroforests and monocultures, but bird richness increased with the height of herbaceous vegetation inside rubber plots. Species composition of butterflies differed between agroforests and monocultures, and in response to natural forest extent, while bird composition was influenced by herbaceous vegetation height within plots, the density of non-rubber trees within plots (representing agroforestry complexity), and natural forest extent in the landscape. Reptile composition was influenced by canopy cover and open habitat extent in the landscape. Conservation priority and forest-dependent birds were not supported within rubber. Synthesis and applications. Rubber agroforestry using clonal varieties provides modest biodiversity benefits relative to monocultures, without compromising yields. Agroforests may also generate ecosystem service and livelihood benefits. Management of monocultural rubber production to increase inter-row vegetation height and complexity may further benefit biodiversity. However, biodiversity losses from encroachment of rubber onto forests will not be offset by rubber agroforestry or rubber plot management. This evidence is important for developing guidelines around biodiversity-friendly rubber and sustainable supply chains, and for farmers interested in diversifying rubber production. The accompanying ReadMe.txt file explains the contents of each .csv file, including definitions of each column. Sampling protocols are outlined in the paper in Journal of Applied Ecology.

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    ZENODO
    Dataset . 2019
    License: CC 0
    Data sources: ZENODO
    DRYAD
    Dataset . 2019
    License: CC 0
    Data sources: Datacite
    addClaim
    0
    citations0
    popularityAverage
    influenceAverage
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    visibility12
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
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      ZENODO
      Dataset . 2019
      License: CC 0
      Data sources: ZENODO
      DRYAD
      Dataset . 2019
      License: CC 0
      Data sources: Datacite
      addClaim
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Kunz, Friedrich; orcid bw Weibezahn, Jens;
    Weibezahn, Jens
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Weibezahn, Jens in OpenAIRE
    orcid bw Hauser, Philip;
    Hauser, Philip
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Hauser, Philip in OpenAIRE
    Heidari, Sina; +8 Authors

    This reference data set representing the status quo of the German electricity, heat, and natural gas sectors was compiled within the research project ‘LKD-EU’ (Long-term planning and short-term optimization of the German electricity system within the European framework: Further development of methods and models to analyze the electricity system including the heat and gas sector). While the focus is on the electricity sector, the heat and natural gas sectors are covered as well. With this reference data set, we aim to increase the transparency of energy infrastructure data in Germany. Where not otherwise stated, the data included in this report is given with reference to the year 2015 for Germany. The data set is documented in DIW Data Documentation 92 (see references). The project is a joined effort by the German Institute for Economic Research (DIW Berlin), the Workgroup for Infrastructure Policy (WIP) at Technische Universität Berlin (TUB), the Chair of Energy Economics (EE2) at Technische Universität Dresden (TUD), and the House of Energy Markets & Finance at University of Duisburg-Essen. The project was funded by the German Federal Ministry for Economic Affairs and Energy through the grant ‘LKD-EU’, FKZ 03ET4028A-D. {"references": ["Kunz, Friedrich et. al. (2017). Electricity, Heat and Gas Sector Data for Modeling the German System. DIW Data Documentation 92."]}

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    ZENODO
    Dataset . 2017
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    ZENODO
    Dataset . 2017
    Data sources: Datacite
    ZENODO
    Dataset . 2017
    Data sources: ZENODO
    addClaim
    10
    citations10
    popularityTop 10%
    influenceAverage
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      ZENODO
      Dataset . 2017
      Data sources: Datacite
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      ZENODO
      Dataset . 2017
      Data sources: Datacite
      ZENODO
      Dataset . 2017
      Data sources: ZENODO
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    Authors: orcid bw Stoico, Vincenzo;
    Stoico, Vincenzo
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Stoico, Vincenzo in OpenAIRE
    orcid bw Cortellessa, Vittorio;
    Cortellessa, Vittorio
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Cortellessa, Vittorio in OpenAIRE
    orcid bw Malavolta, Ivano;
    Malavolta, Ivano
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Malavolta, Ivano in OpenAIRE
    orcid bw Di Pompeo, Daniele;
    Di Pompeo, Daniele
    ORCID
    Derived by OpenAIRE algorithms or harvested from 3rd party repositories

    Di Pompeo, Daniele in OpenAIRE
    +2 Authors

    Replication package of the paper titled "An approach using performance models for supporting energy analysis of software systems". Usage instructions are contained in the README.md file.

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    ZENODO
    Dataset . 2023
    Data sources: Datacite
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    ZENODO
    Dataset . 2023
    Data sources: Datacite
    ZENODO
    Dataset . 2023
    Data sources: ZENODO
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      ZENODO
      Dataset . 2023
      Data sources: Datacite
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      ZENODO
      Dataset . 2023
      Data sources: Datacite
      ZENODO
      Dataset . 2023
      Data sources: ZENODO
      addClaim
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    Authors: orcid Anna B. Harper;
    Anna B. Harper
    ORCID
    Harvested from ORCID Public Data File

    Anna B. Harper in OpenAIRE
    orcid Peter M. Cox;
    Peter M. Cox
    ORCID
    Harvested from ORCID Public Data File

    Peter M. Cox in OpenAIRE
    orcid Pierre Friedlingstein;
    Pierre Friedlingstein
    ORCID
    Harvested from ORCID Public Data File

    Pierre Friedlingstein in OpenAIRE
    Andy J. Wiltshire; +17 Authors

    Abstract. Dynamic global vegetation models are used to predict the response of vegetation to climate change. They are essential for planning ecosystem management, understanding carbon cycle–climate feedbacks, and evaluating the potential impacts of climate change on global ecosystems. JULES (the Joint UK Land Environment Simulator) represents terrestrial processes in the UK Hadley Centre family of models and in the first generation UK Earth System Model. Previously, JULES represented five plant functional types (PFTs): broadleaf trees, needle-leaf trees, C3 and C4 grasses, and shrubs. This study addresses three developments in JULES. First, trees and shrubs were split into deciduous and evergreen PFTs to better represent the range of leaf life spans and metabolic capacities that exists in nature. Second, we distinguished between temperate and tropical broadleaf evergreen trees. These first two changes result in a new set of nine PFTs: tropical and temperate broadleaf evergreen trees, broadleaf deciduous trees, needle-leaf evergreen and deciduous trees, C3 and C4 grasses, and evergreen and deciduous shrubs. Third, using data from the TRY database, we updated the relationship between leaf nitrogen and the maximum rate of carboxylation of Rubisco (Vcmax), and updated the leaf turnover and growth rates to include a trade-off between leaf life span and leaf mass per unit area.Overall, the simulation of gross and net primary productivity (GPP and NPP, respectively) is improved with the nine PFTs when compared to FLUXNET sites, a global GPP data set based on FLUXNET, and MODIS NPP. Compared to the standard five PFTs, the new nine PFTs simulate a higher GPP and NPP, with the exception of C3 grasses in cold environments and C4 grasses that were previously over-productive. On a biome scale, GPP is improved for all eight biomes evaluated and NPP is improved for most biomes – the exceptions being the tropical forests, savannahs, and extratropical mixed forests where simulated NPP is too high. With the new PFTs, the global present-day GPP and NPP are 128 and 62 Pg C year−1, respectively. We conclude that the inclusion of trait-based data and the evergreen/deciduous distinction has substantially improved productivity fluxes in JULES, in particular the representation of GPP. These developments increase the realism of JULES, enabling higher confidence in simulations of vegetation dynamics and carbon storage.

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    Geoscientific Model Development (GMD)
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    Geoscientific Model Development
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    Geoscientific Model Development
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    Wageningen Staff Publications
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      Wageningen Staff Publications
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    Authors: orcid Dries L. T. Hegger;
    Dries L. T. Hegger
    ORCID
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    Dries L. T. Hegger in OpenAIRE
    orcid Piotr Matczak;
    Piotr Matczak
    ORCID
    Harvested from ORCID Public Data File

    Piotr Matczak in OpenAIRE
    orcid Maria Kaufmann;
    Maria Kaufmann
    ORCID
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    Maria Kaufmann in OpenAIRE
    C. Larrue; +4 Authors

    Abstract Floods are challenging the resilience of societies all over the world. In many countries there are discussions on diversifying the strategies for flood risk management, which implies some sort of policy change. To understand the possibilities of such change, a thorough understanding of the forces of stability and change of underlying governance arrangements is required. It follows from the path dependency literature that countries which rely strongly on flood infrastructures, as part of flood defense strategies, would be more path dependent. Consequently there is a higher chance to find more incremental change in these countries than in countries that have a more diversified set of strategies. However, comparative and detailed empirical studies that may help scrutinize this assumption are lacking. To address this knowledge gap, this paper investigates how six European countries (Belgium, England, France, The Netherlands, Poland and Sweden) essentially differ with regard to their governance of flood risks. To analyze stability and change, we focus on how countries are responding to certain societal and ecological driving forces (ecological turn; climate change discourses; European policies; and the increasing prevalence of economic rationalizations) that potentially affect the institutional arrangements for flood risk governance. Taking both the variety of flood risk governance in countries and their responses to driving forces into account, we can clarify the conditions of stability or change of flood risk governance arrangements more generally. The analysis shows that the national-level impact of driving forces is strongly influenced by the flood risk governance arrangements in the six countries. Path dependencies are indeed visible in countries with high investments in flood infrastructure accompanied by strongly institutionalized governance arrangements (Poland, the Netherlands) but not only there. Also more diversified countries that are less dependent on flood infrastructure and flood defense only (England) show path dependencies and mostly incremental change. More substantial changes are visible in countries that show moderate diversification of strategies (Belgium, France) or countries that ‘have no strong path yet’ in comprehensive flood risk governance (Sweden). This suggests that policy change can be expected when there is both the internal need and will to change and a barrage of (external) driving forces pushing for change.

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    Global Environmental Change
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    Authors: Peter K. Snyder; Brian Walker; Brian Walker; orcid Hans Joachim Schellnhuber;
    Hans Joachim Schellnhuber
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    New approach proposed for defining preconditions for human development Crossing certain biophysical thresholds could have disastrous consequences for humanity Three of nine interlinked planetary boundaries have already been overstepped

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      Nature
      Article . 2009
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    A mechanistic model is presented that describes the respiro-fermentative physiology of yeast. The model assumes the presence of multiple types of glucose carriers and multiple assimilation pathways. Respiro-fermentative physiology is explained by the mechanistic response of the different types of carriers and assimilation pathways on the substrate concentration. At low substrate concentrations, glucose is taken up mainly via a high affinity carrier with a low maximum uptake rate. At high substrate concentrations, this carrier becomes saturated and the main pathway for glucose uptake is via a low affinity carrier with a high maximum uptake rate. The price to pay for the high uptake rate is a lowered assimilation efficiency, resulting in a low biomass yield. Product formation occurs via the pathway with the high uptake rate. The model explains the link between substrate concentration and product formation generally observed in the literature on yeast and bacteria. Model parameter values are estimated by fitting data from the literature. The model distinguishes itself from other models in that it does not rely on the presence of switches, such as the 'critical dilution rate', or on the assumption that the respiratory capacity reaches its maximum during respiro-fermentative metabolism. The present theory is not designed exclusively for the phenomenon of respiro-fermentative physiology: it describes the degradation of substances by heterotrophic micro-organisms in general.

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    DSpace at VU
    Article . 2000
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    Yeast
    Article . 2000 . Peer-reviewed
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    Yeast
    Article . 2000 . Peer-reviewed
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    Yeast
    Article . 2000
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      DSpace at VU
      Article . 2000
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      Yeast
      Article . 2000 . Peer-reviewed
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      Yeast
      Article . 2000 . Peer-reviewed
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      Yeast
      Article . 2000
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    Authors: orcid Kaag, A.M.;
    Kaag, A.M.
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    Kaag, A.M. in OpenAIRE
    Schulte, M.H.J.; Jansen, J.M; orcid van Wingen, G.;
    van Wingen, G.
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    van Wingen, G. in OpenAIRE
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    Neuroimaging studies have demonstrated gray matter (GM) volume abnormalities in substance users. While the majority of substance users are polysubstance users, very little is known about the relation between GM volume abnormalities and polysubstance use.In this study we assessed the relation between GM volume, and the use of alcohol, tobacco, cocaine and cannabis as well as the total number of substances used, in a sample of 169 males: 15 non-substance users, 89 moderate drinkers, 27 moderate drinkers who also smoke tobacco, 13 moderate drinkers who also smoke tobacco and use cocaine, 10 heavy drinkers who smoke tobacco and use cocaine and 15 heavy drinkers who smoke tobacco, cannabis and use cocaine.Regression analyses showed that there was a negative relation between the number of substances used and volume of the dorsal medial prefrontal cortex (mPFC) and the ventral mPFC. Without controlling for the use of other substances, the volume of the dorsal mPFC was negatively associated with the use of alcohol, tobacco, and cocaine. After controlling for the use of other substances, a negative relation was found between tobacco and cocaine and volume of the thalami and ventrolateral PFC, respectively.These findings indicate that mPFC alterations may not be substance-specific, but rather related to the number of substances used, whereas, thalamic and ventrolateral PFC pathology is specifically associated with tobacco and cocaine use, respectively. These findings are important, as the differential alterations in GM volume may underlie different cognitive deficits associated with substance use disorders.

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    Drug and Alcohol Dependence
    Article . 2018 . Peer-reviewed
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    Drug and Alcohol Dependence
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      Drug and Alcohol Dependence
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      Drug and Alcohol Dependence
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