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Oskarshamn is one of the municipalities being discussed as a possible site for disposal of nuclear waste from the Swedish nuclear power plants, and there has been inquiries made for a pilot study in the area. In view of this the local council of Oskarshamn appointed a ´Youth team´, consisting of ten young politicians from all political parties represented in the local council. The aim of the team was to inform and create debate among adolescents about how to store the radioactive waste from nuclear power plants. The purpose of this survey, addressed to young people in Oskarshamn, was to shed light on their opinion towards a pilot study and possible disposal of nuclear waste in Oskarshamn. The respondents had to answer questions about their opinion on the use of nuclear power in Sweden, if they believed nuclear power to be abolished by year 2010, and about their general interest in issues concerning energy and nuclear power. Other questions concerned risks associated with nuclear power, the influence different groups have/ought to have when it comes to disposal of nuclear waste, and if the respondent would accept a decision to dispose nuclear waste in Oskarshamn. A number of questions dealt with the suggested pilot study; if the respondent was for or against a pilot study; who should decide about the pilot study; if there had been enough information about the study; and if the respondent had attended any meeting, signed any petition, contacted any politician, contacted or participated in mass media, or tried to influence anyone´s opinion on any issue concerning the pilot study. The respondents also had to state the issues they considered to be important to study in a pilot study. Furthermore the respondents had to give their opinion about a number of risks discussed in connection with disposal of nuclear waste in Oskarshamn. Other questions concerned the influence on job opportunities and tourism. Demographic items include age, gender, marital status, children, education, occupation, and trade union membership. Oskarshamn is one of the municipalities being discussed as a possible site for disposal of nuclear waste from the Swedish nuclear power plants, and there has been inquiries made for a pilot study in the area. In view of this the local council of Oskarshamn appointed a 'Youth team', consisting of ten young politicians from all political parties represented in the local council. The aim of the team was to inform and create debate among adolescents about how to store the radioactive waste from nuclear power plants. The purpose of this survey, addressed to young people in Oskarshamn, was to shed light on their opinion towards a pilot study and possible disposal of nuclear waste in Oskarshamn. The respondents had to answer questions about their opinion on the use of nuclear power in Sweden, if they believed nuclear power to be abolished by year 2010, and about their general interest in issues concerning energy and nuclear power. Other questions concerned risks associated with nuclear power, the influence different groups have/ought to have when it comes to disposal of nuclear waste, and if the respondent would accept a decision to dispose nuclear waste in Oskarshamn. A number of questions dealt with the suggested pilot study; if the respondent was for or against a pilot study; who should decide about the pilot study; if there had been enough information about the study; and if the respondent had attended any meeting, signed any petition, contacted any politician, contacted or participated in mass media, or tried to influence anyone's opinion on any issue concerning the pilot study. The respondents also had to state the issues they considered to be important to study in a pilot study. Furthermore the respondents had to give their opinion about a number of risks discussed in connection with disposal of nuclear waste in Oskarshamn. Other questions concerned the influence on job opportunities and tourism. Demographic items include age, gender, marital status, children, education, occupation, and trade union membership.

The perinate is particularly risk-prone to chemical species which have the potential of inducing neuronal apoptosis or necrosis and thereby adversely altering development of the brain, to produce life-long functional and behavioral deficits. This paper is an overview for many substances of abuse, but the purview is much more broadened by the realization that even elevated levels of estrogens and corticosteroids in the pregnant mother can act as neuroteratogens, by passing via the placenta and altering neural development or inducing apoptosis in the perinate. Finally, therapeutic risks of anesthetics are highlighted, as these too induce neuronal apoptosis in the neonate by either blocking N-methyl-D-aspartate receptors or by acting as gamma-aminobutyric acid agonists. By understanding the mechanisms involved it may ultimately be possible to interrupt the mechanistic scheme and thereby prevent neuroteratological processes.

Background: Sodium oxybate (SMO) has been shown to be effective in the maintenance of abstinence (MoA) in alcohol-dependent patients in a series of small randomized controlled trials (RCTs). These results needed to be confirmed by a large trial investigating the treatment effect and its sustainability after medication discontinuation. Aims: To confirm the SMO effect on (sustained) MoA in detoxified alcohol-dependent patients. Methods: Large double-blind, randomized, placebo-controlled trial in detoxified adult alcohol-dependent outpatients (80% men) from 11 sites in four European countries. Patients were randomized to 6 months SMO (3.3–3.9 g/day) or placebo followed by a 6-month medication-free period. Primary outcome was the cumulative abstinence duration (CAD) during the 6-month treatment period defined as the number of days with no alcohol use. Secondary outcomes included CAD during the 12-month study period. Results: Of the 314 alcohol-dependent patients randomized, 154 received SMO and 160 received placebo. Based on the pre-specified fixed-effect two-way analysis of variance including the treatment-by-site interaction, SMO showed efficacy in CAD during the 6-month treatment period: mean difference +43.1 days, 95% confidence interval (17.6–68.5; p = 0.001). Since significant heterogeneity of effect across sites and unequal sample sizes among sites ( n = 3–66) were identified, a site-level random meta-analysis was performed with results supporting the pre-specified analysis: mean difference +32.4 days, p = 0.014. The SMO effect was sustained during the medication-free follow-up period. SMO was well-tolerated. Conclusions: Results of this large RCT in alcohol-dependent patients demonstrated a significant and clinically relevant sustained effect of SMO on CAD. Trial registration: ClinicalTrials.gov Identifier: NCT04648423

The ocean provides resources key to human health and well-being, including food, oxygen, livelihoods, blue spaces, and medicines. The global threat to these resources posed by accelerating ocean acidification is becoming increasingly evident as the world’s oceans absorb carbon dioxide emissions. While ocean acidification was initially perceived as a threat only to the marine realm, here we argue that it is also an emerging human health issue. Specifically, we explore how ocean acidification affects the quantity and quality of resources key to human health and well-being in the context of: (1) malnutrition and poisoning, (2) respiratory issues, (3) mental health impacts, and (4) development of medical resources. We explore mitigation and adaptation management strategies that can be implemented to strengthen the capacity of acidifying oceans to continue providing human health benefits. Importantly, we emphasize that the cost of such actions will be dependent upon the socioeconomic context; specifically, costs will likely be greater for socioeconomically disadvantaged populations, exacerbating the current inequitable distribution of environmental and human health challenges. Given the scale of ocean acidification impacts on human health and well-being, recognizing and researching these complexities may allow the adaptation of management such that not only are the harms to human health reduced but the benefits enhanced.

The associations between generalized obesity measured as body mass index (BMI), or adipose tissue distribution, measured as the waist/hip circumference ratio (WHR), on one hand, and a number of socioeconomic, somatic as well as psychologic and mental health variables on the other, were analysed in a population study of women (1462 participants, aged 38-60 years, participation rate 90.1%). The anthropometric measurements were adjusted for their influence on each other. BMI, but not WHR, was negatively associated with socioeconomic status and education. Increased WHR correlated to a number of somatic diseases from different organ systems, including diabetes mellitus, infectious respiratory and abdominal diseases. Even more striking were strong correlations to a number of variables indicating accident proneness as well as mental disorder, and increased use of antidepressants and tranquilizers. BMI and WHR were also associated to different personality profiles. Furthermore, the use of alcohol and smoking were positively correlated to the WHR. In contrast, most of these associations were not seen with the BMI--sometimes even negative correlations were found. Exceptions were, however, varicose veins, joint problems and surgery for gall bladder disease, which were positively correlated to BMI only. Blood pressure, plasma triglycerides and uric acid were positively correlated to both BMI and the WHR, plasma cholesterol, however, only to the WHR. Obesity (high BMI) and abdominal adipose tissue distribution (high WHR) clearly show differences in their associations to various health variables. It is hypothesized that an arousal syndrome might be a contributing factor to cause symptoms of psychological maladjustment, including psychosomatic disease. Hypothetically, in parallel, an accumulation of depot fat in the abdominal depot, might follow as a consequence of neuroendocrine dysregulation of endocrine secretions.

AbstractThe Environmental Effects Assessment Panel of the Montreal Protocol under the United Nations Environment Programme evaluates effects on the environment and human health that arise from changes in the stratospheric ozone layer and concomitant variations in ultraviolet (UV) radiation at the Earth’s surface. The current update is based on scientific advances that have accumulated since our last assessment (Photochem and Photobiol Sci 20(1):1–67, 2021). We also discuss how climate change affects stratospheric ozone depletion and ultraviolet radiation, and how stratospheric ozone depletion affects climate change. The resulting interlinking effects of stratospheric ozone depletion, UV radiation, and climate change are assessed in terms of air quality, carbon sinks, ecosystems, human health, and natural and synthetic materials. We further highlight potential impacts on the biosphere from extreme climate events that are occurring with increasing frequency as a consequence of climate change. These and other interactive effects are examined with respect to the benefits that the Montreal Protocol and its Amendments are providing to life on Earth by controlling the production of various substances that contribute to both stratospheric ozone depletion and climate change.

Climate change can have detrimental effects on child health and wellbeing. Despite the imperative for a fuller understanding of how climate change affects child health and wellbeing, a systematic approach and focus solely on children (aged <18 years) has been lacking. In this Scoping Review, we did a literature search on the impacts of climate change on child health from January, 2000, to June, 2019. The included studies explicitly linked an alteration of an exposure to a risk factor for child health to climate change or climate variability. In total, 2970 original articles, reviews, and other documents were identified, of which 371 were analysed. Employing an expanded framework, our analysis showed that the effects of climate change on child health act through direct and indirect pathways, with implications for determinants of child health as well as morbidity and mortality from a range of diseases. This understanding can be further enhanced by using a broader range of research methods, studying overlooked populations and geographical regions, investigating the costs and benefits of mitigation and adaptation for child health, and considering the position of climate change and child health within the UN Sustainable Development Goals. Present and future generations of children bear and will continue to bear an unacceptably high disease burden from climate change.