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Development of environmentally sustainable and economically viable technologies for plant cell wall deconstruction to fermentable sugars has been impeded due to native plant cell wall recalcitrance to thermochemical and biological based processing. Lower severity alkaline-based pretreatment processes like Ammonia Fiber Expansion (AFEX™) can overcome several limitations of traditional pretreatment approaches (e.g., acidic pretreatments) to producing cellulosic biofuels and biochemicals. Here, we give an overview of chemical reactions taking place during alkaline pretreatments including reactions between ammonia and polysaccharides/lignin (e.g., ammonolysis, hydrolysis and Maillard-type reactions). AFEX™ based pretreatments enhance enzymatic digestibility and fermentability of lignocellulosic biomass through various chemical and ultra-structural modifications within the cell wall. An improved mechanistic understanding of the AFEX™ process has led to the development of novel alkaline pretreatments that are briefly discussed in this review.

SARS-COV-2, the etiologic agent of COVID-19 is able to infect cells through its Spike protein (SPp) which must first bind to its receptor ACE2. Most currently developed vaccines target the SARS-COV-2 encoded Spike protein. Many SARS-COV-2 variants have been identified that exhibit several mutations in their Spike protein. SARS-COV-2 variant, B.1.526 was identified in New York, U.S.A. [Annavajhala, M.K. (2021) medRxiv, DOI: 10.1101/2020.02.23.21) and shown to contain the mutations, L5F, T95I, D253G, E484K, S477N, D614G and A701V. T95 and S477 of SPp are phosphorylation sites for a number of Protein kinases, including Cdk1 and GSK-3. Here, through Computerized Structure Model Analysis and Thermodynamic Calculations, it is shown that phosphorylations of T95 and S477 increases the stabilities of SARS-COV-2 encoded SPp-ACE2 and SPp-DC-SIGN complexes with very marginal effects on the binding efficiencies between the components of the complexes, and mutations T95I and S477N antagonize the effects of the phosphorylations of T95 and S477. Thus, it appears that SARS-COV-2 variant, B.1.526 has adapted to exploit the protein phosphorylation apparatus of its host cells to its advantage, and the effects of phosphorylation of of T95 and S477 are blunted through random mutation. Whether Neutralizing Antibodies that target SPp can recognize the phosphorylated forms of SPp is currently unknown.

In 1971, Garrett Hardin published an editorial entitled _Nobody Ever Dies of Overpopulation based on the cyclone that struck East Bengal and killed an estimated 500,000 people. Overcrowding forced people to live in a dangerous place like the Gangetic Delta which is barely above sea level. Now, 37 years later, a similar situation is unfolding in the Ganges River Delta in Bangladesh. This delta is also barely above sea level, and the water keeps rising due to global warming. If a large storm were to create hurricanes in this area housing and agricultural areas would be destroyed as well as power lines and water supply which would interfere with food deliveries and medical assistance. In a worst case scenario environmental refugees could reach 25 million and the death toll could be in the millions. If global climate change was one of the antecedent causes to this worst case scenario, would seal level rise and sever weather truly be the cause of deaths?

The current paradigm of global economics with exponential and continuous economic growth is unsustainable as far as Earth system ecology is concerned. To support the Earth system and boost sustainable development, a functional and operational linkage between global ecology and economics should be established – which we term ‘carbonomics’. The simple basis of ‘carbonomics’ is that the more fossil and non-fossil carbon one has as stocks, and not flows, of carbon, the richer one is. This opinion piece makes some suggestions about how we might establish such a balanced relationship. Consilience, No 17 (2017): Issue Seventeen: 2017

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Anthroposophen in der Zeit der Nationalsozialismus 1933-1945. Muenchen: Verlag R. Oldenberg.", "Willer, H., & Lernoud, J. (Eds.). (2014). The World of Organic Agriculture: Statistics and Emerging Trends 2014: Frick, Switzerland: Research Institute of Organic Agriculture (FiBL) & Bonn: International Federation of Organic Agriculture Movements (IFOAM).", "Wrench, G. T. (1946). Reconstruction by Way of the Soil. London: Faber and Faber."]} It was Lord Northbourne (Walter James; 1896-1982) who gifted to the world the term ‘organic farming’. His 1940 book Look to the Land is a manifesto of organic agriculture. In it he mooted a contest of “organic versus chemical farming” which he foresaw as a clash of world views that may last for generations. Northbourne’s ideas were foundational in launching the worldwide organics movement, and the book was a turning point in his own life. This biography relies on primary sources to draw a picture of Lord Northbourne. He was a very shy man, a talented artist, a capable linguist, a keen sportsman and an Olympic silver medallist, a graduate and lecturer in agriculture of the University of Oxford, a lifelong farmer, he was profoundly spiritual, an accomplished author, and as a wordsmith he could be a compelling advocate for his cause as Look to the Land shows. His interest in biodynamics led him to visit Switzerland in 1939 to invite the leading advocate of the times, Dr Ehrenfried Pfeiffer, to present the first conference on biodynamic farming in Britain, and it was in the following year that Look to the Land appeared. Rather than the mechanics or the practices of organics, Northbourne’s book presents the philosophy, the rationale, and the imperative of organic farming. The ideas of his organics manifesto took on a life of their own and were quickly spread globally, with early uptakes in the USA and Australia. Meanwhile, while maintaining lifelong interests and commitments to agriculture and education, Northbourne became progressively more engaged with spiritual matters, and his subsequent writings reflect his growing interest in metaphysics. He translated books by leading perennialist authors Frithjof Schuon, René Guénon, and Titus Burckhardt. Northbourne led a full life, but it is Look to the Land that is his enduring ideological legacy. This biography examines: firstly, the book, its ideas, history, uptake and impact; secondly, Northbourne’s life before Look to the Land; and thirdly, his life after Look to the Land. "He was a man of great vision, decisiveness, quiet humour and kindly authority … who brought to every facet of his widely ranging life a rare sense of harmony and balanced purpose. Above all he was a widely read man of very considerable scholarship with deep philosophical understanding … He was a man of great faith and rare belief who saw 'through a glass darkly' so much more than is given to most of us to see and experience" Duncan Skilbeck (1983, pp.78-79).

The United States, which has been the poster child for car culture, has been warned of the unparalleled prospect of trillion-dollar deficits for years to come. Most state governments face severe reduction in tax monies, which will mean fewer funds for road and bridge repair, as well as reductions in other services. Personal debt is very high and home values have declined sharply, reducing the _nest egg of many families for retirement. In addition, the stock market decline has had deleterious effects on retirement funds. The car culture was built on cheap fuel, financing of car purchases, and a convenient national system of mostly free roads connecting nearly all parts of the United States. Personal transportation with cars has been the norm. Petroleum prices are down dramatically at the end of 2008, but people are driving less to pay off personal debt or because they have lost their jobs. Electric cars seemed promising until problems with coal-generated electricity became more generally known. In short, the car culture has passed a tipping point and alternative public transportation is not adequate for probable future needs. One characteristic of passing a tipping point is that return to the pre-tipping point conditions is very unlikely.

Some claim that humans are too numerous to become extinct. However, passenger pigeon, once the most numerous birds on the planet, are now extinct. For years, humankind has been damaging its habitat, discharging toxic chemicals into the environment, and having harmful effects on agricultural productivity due to climate change. Humankind s extinction depends on the continuation of various human activities including economic growth, addiction to fossil fuel, over consumption, overpopulation, ocean acidification, and use of toxicants. If humankind wants to remain on this planet, it must start preparing for a vastly different environment on Earth.

Scientists and inventors have proposed a variety of technologies to avoid further increases in the Earth s temperature by greenhouse gases. The two most popular technological approaches are: reflecting solar energy back into space and sequestering and storing carbon to prevent it from reentering the atmosphere. These last ditch efforts are now being referred to as _Hail Mary technologies, or efforts made in desperation with only a small chance of success. However, humankind due to the severity of the situation, has given these _Hail Mary technologies a serious consideration, even though these approaches have not be adequately researched to address one component of a much larger problem.

Maintaining bodies of knowledge specific to coastal towns can be crucial to maintaining environmental sustainability. It can build relationships of trust while generating social norms and rules about how to interact with the surrounding environment. This report explores the disintegration of social capital in Nags Head, North Carolina over time and how improving the transfer of local knowledge in the town can help to generate sustainable growth in the future. The researchers interviewed past residents of the town to gather information about how people used to interact with the environment in order to compare it to the present. Nine resources were explored; this report focuses on the resource of knowledge and its transfer. Consilience, No 6 (2011): Issue Six: 2011

The alternative animal product arena is complex and quite var­ied. Some plant-based alternative meat products are derived entirely from plants. Other entrepreneurs are using cultivated cells of animal origin to derive a product structurally similar to meat and milk and comprised of animal proteins. Many of these endeavors use a combination of both approaches with the plant-based product providing filler for the cultivated meat or milk product. Most of the discussion around alternative meats has focused on bovine alternatives because of the iconic position of cattle in many climate and sustainability discussions. A consid­erable amount of capital has been raised based on the envisioned market share of these products, although estimates vary widely, and the high profile initial public offering of Beyond Meat shares in May 2019 which saw share prices soar from $75 to $235, has this year seen share prices plummet to about one-tenth of that highest price. Proponents of alternative meats suggest these production systems are more sustainable based on antici­patory greenhouse gas emission (GHG) and land use life-cycle assessment (LCA)/kilogram (kg) of product, as compared to LCA metrics for ruminant meat. Much of the rationale invokes a simplistic narrative around GHG/kg of protein. The GHG “sustainability” metric will invariably reflect poorly on ruminants as they are uniquely able to digest cellulose through their rumen microbes, and the methanogens produces methane which is a potent but short-lived greenhouse gas. And because ruminants are typically grazing in marginal land unsuitable for producing crops, they also have a high land use m2/kg of protein. However, there is no reason to conclude that food production on well-managed pasture and rangeland is, a priori, less sustainable than food production of well-managed arable cropland. More­over, the other sustainability externalities of ruminant meat production systems such as the provision of ecosystem services and biodiversity conservation, the consumption of inedible food waste and cellulose, manure, transportation, contributions to the livelihoods and food security of 1.3 billion livestock keepers, the fact that meat provides nutrients in addition to protein, and that existing harvesting systems utilize everything but the “moo” are often ignored or simply disregarded. American Association of Bovine Practitioners Conference Proceedings, No. 55 (2022): 2022 Annual Conference Proceedings