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description Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2020 Belgium, Netherlands, France, United KingdomPublisher:Copernicus GmbH Frédéric Chevallier; Pierre Regnier; Julia Pongratz; Atul K. Jain; Roxana Petrescu; Robert J. Scholes; Pep Canadell; Masayuki Kondo; Hui Yang; Marielle Saunois; Bo Zheng; Wouter Peters; Wouter Peters; Benjamin Poulter; Benjamin Poulter; Benjamin Poulter; Matthew W. Jones; Hanqin Tian; Xuhui Wang; Shilong Piao; Shilong Piao; Ronny Lauerwald; Ronny Lauerwald; Ingrid T. Luijkx; Anatoli Shvidenko; Anatoli Shvidenko; Gustaf Hugelius; Celso von Randow; Chunjing Qiu; Robert B. Jackson; Robert B. Jackson; Prabir K. Patra; Philippe Ciais; Ana Bastos;Abstract. Regional land carbon budgets provide insights on the spatial distribution of the land uptake of atmospheric carbon dioxide, and can be used to evaluate carbon cycle models and to define baselines for land-based additional mitigation efforts. The scientific community has been involved in providing observation-based estimates of regional carbon budgets either by downscaling atmospheric CO2 observations into surface fluxes with atmospheric inversions, by using inventories of carbon stock changes in terrestrial ecosystems, by upscaling local field observations such as flux towers with gridded climate and remote sensing fields or by integrating data-driven or process-oriented terrestrial carbon cycle models. The first coordinated attempt to collect regional carbon budgets for nine regions covering the entire globe in the RECCAP-1 project has delivered estimates for the decade 2000–2009, but these budgets were not comparable between regions, due to different definitions and component fluxes reported or omitted. The recent recognition of lateral fluxes of carbon by human activities and rivers, that connect CO2 uptake in one area with its release in another also requires better definition and protocols to reach harmonized regional budgets that can be summed up to the globe and compared with the atmospheric CO2 growth rate and inversion results. In this study, for the international initiative RECCAP-2 coordinated by the Global Carbon Project, which aims as an update of regional carbon budgets over the last two decades based on observations, for 10 regions covering the globe, with a better harmonization that the precursor project, we provide recommendations for using atmospheric inversions results to match bottom-up carbon accounting and models, and we define the different component fluxes of the net land atmosphere carbon exchange that should be reported by each research group in charge of each region. Special attention is given to lateral fluxes, inland water fluxes and land use fluxes.
Université de Versai... arrow_drop_down Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)University of East Anglia: UEA Digital RepositoryArticle . 2022License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.5194/gmd-20...Article . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefGeoscientific Model Development (GMD)Article . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefWageningen Staff PublicationsArticle . 2022License: CC BYData sources: Wageningen Staff Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/gmd-2020-259&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 46 citations 46 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
visibility 7visibility views 7 download downloads 13 Powered bymore_vert Université de Versai... arrow_drop_down Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)University of East Anglia: UEA Digital RepositoryArticle . 2022License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.5194/gmd-20...Article . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefGeoscientific Model Development (GMD)Article . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefWageningen Staff PublicationsArticle . 2022License: CC BYData sources: Wageningen Staff Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/gmd-2020-259&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2005Publisher:Elsevier BV Authors: H. Näfe;Abstract Recently, the oxygen potential dependence of the signal of a potentiometric CO 2 sensor, based on a cation conductor with carbonate as gas sensitive layer, has been interpreted as caused by electronic transference through the electrolyte. Though this interpretation is quite correct, the relationships on the basis of which the effect of electronic conductivity has been discussed are wrong and so are the conclusions on the electronic conduction parameter of the electrolyte material under consideration, i.e. of the lithium ion conductor Li 3 PO 4 + SiO 2 (5 mol%). In what follows, the questionable points will be corrected and the role of the electronic conductivity for the understanding of the behaviour of a CO 2 sensor will be re-examined.
Sensors and Actuator... arrow_drop_down Sensors and Actuators B ChemicalArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.snb.2004.10.025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 8 citations 8 popularity Average influence Average impulse Average Powered by BIP!
more_vert Sensors and Actuator... arrow_drop_down Sensors and Actuators B ChemicalArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.snb.2004.10.025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020Publisher:Elsevier BV Authors: Javier López Prol; Sungmin O;As COVID-19 spreads worldwide, governments have been implementing a wide range of measures to contain it, from movement restrictions to economy-wide shutdowns. Understanding their impacts is essential to support better policies for countries still experiencing outbreaks or in case of emergence of subsequent pandemic waves. Here we show that the cumulative decline in electricity consumption within the 5 months following the stay-home orders ranges between 3% and 12% in the most affected EU countries and USA states, except Florida, which shows no significant impact. Italy, France, Spain, California, Austria, and New York have recovered baseline consumption by the end of July, whereas Great Britain and Germany remain below baseline levels. We also show that the relationship between measures stringency and daily decline in electricity consumption is nonlinear. These results illustrate the severity of the crisis across countries and can support further research on the effect of specific measures.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2020.101639&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 52 citations 52 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2020.101639&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2019Embargo end date: 16 Mar 2019 Japan, Germany, France, France, France, Japan, Spain, France, Switzerland, United Kingdom, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | HELIX, EC | IMPACT2CEC| HELIX ,EC| IMPACT2CJeroen Steenbeek; Erwin Schmid; Tyler D. Eddy; Tyler D. Eddy; Tyler D. Eddy; Derek P. Tittensor; Derek P. Tittensor; Rene Orth; Rene Orth; Yadu Pokhrel; Joshua Elliott; Yusuke Satoh; Yusuke Satoh; Christian Folberth; Louis François; Andrew D. Friend; Catherine Morfopoulos; Nikolay Khabarov; Peter Lawrence; Naota Hanasaki; Michelle T. H. van Vliet; Akihiko Ito; Sonia I. Seneviratne; Veronika Huber; Thomas A. M. Pugh; Jinfeng Chang; Tobias Stacke; Philippe Ciais; Lila Warszawski; Jan Volkholz; Matthias Büchner; Yoshihide Wada; Christopher P. O. Reyer; Xuhui Wang; Xuhui Wang; Xuhui Wang; Dieter Gerten; Dieter Gerten; Sebastian Ostberg; Qiuhong Tang; Gen Sakurai; David A. Carozza; David A. Carozza; Christoph Müller; Jacob Schewe; Lutz Breuer; Delphine Deryng; Heike K. Lotze; Hannes Müller Schmied; Robert Vautard; Hyungjun Kim; Fang Zhao; Allard de Wit; Jörg Steinkamp; Katja Frieler; Simon N. Gosling; Lukas Gudmundsson; Marta Coll; Hanqin Tian;doi: 10.1038/s41467-019-08745-6 , 10.17863/cam.37807 , 10.60692/8dj48-81382 , 10.3929/ethz-b-000330244 , 10.60692/8mcvk-e7225
pmid: 30824763
pmc: PMC6397256
handle: 10261/181642
doi: 10.1038/s41467-019-08745-6 , 10.17863/cam.37807 , 10.60692/8dj48-81382 , 10.3929/ethz-b-000330244 , 10.60692/8mcvk-e7225
pmid: 30824763
pmc: PMC6397256
handle: 10261/181642
AbstractGlobal impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first time, systematically across many important systems, how well such impact models capture the impacts of extreme climate conditions. Using the 2003 European heat wave and drought as a historical analogue for comparable events in the future, we find that a majority of models underestimate the extremeness of impacts in important sectors such as agriculture, terrestrial ecosystems, and heat-related human mortality, while impacts on water resources and hydropower are overestimated in some river basins; and the spread across models is often large. This has important implications for economic assessments of climate change impacts that rely on these models. It also means that societal risks from future extreme events may be greater than previously thought.
Hyper Article en Lig... arrow_drop_down Université Jean Monnet – Saint-Etienne: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)École Polytechnique, Université Paris-Saclay: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Publication Database PIK (Potsdam Institute for Climate Impact Research)Article . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2019 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTAWageningen Staff PublicationsArticle . 2019License: CC BYData sources: Wageningen Staff PublicationsHochschulschriftenserver - Universität Frankfurt am MainArticle . 2019Data sources: Hochschulschriftenserver - Universität Frankfurt am MainPublication Server of Goethe University Frankfurt am MainArticle . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-08745-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 186 citations 186 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!
more_vert Hyper Article en Lig... arrow_drop_down Université Jean Monnet – Saint-Etienne: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)École Polytechnique, Université Paris-Saclay: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Publication Database PIK (Potsdam Institute for Climate Impact Research)Article . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2019 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTAWageningen Staff PublicationsArticle . 2019License: CC BYData sources: Wageningen Staff PublicationsHochschulschriftenserver - Universität Frankfurt am MainArticle . 2019Data sources: Hochschulschriftenserver - Universität Frankfurt am MainPublication Server of Goethe University Frankfurt am MainArticle . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-08745-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Journal 2017 United StatesPublisher:American Chemical Society (ACS) Funded by:DFG | INUIT - Ice Nuclei resear...,DFG| INUIT - Ice Nuclei research UnIT ,[no funder available]Senchao Lai; Michael G. Weller; Iris Bellinghausen; Kira Ziegler; Kurt Lucas; Pascale S. J. Lakey; Manabu Shiraiwa; Janine Fröhlich-Nowoisky; Joachim Saloga; Rossella Sgarbanti; Naama Lang-Yona; Detlef Schuppan; Detlef Schuppan; Kathrin Reinmuth-Selzle; Christopher J. Kampf; Fangxia Shen; Bettina Weber; Anna T. Kunert; Fobang Liu; Albert Duschl; Ulrich Pöschl;Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochemical reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.
Environmental Scienc... arrow_drop_down Harvard University: DASH - Digital Access to Scholarship at HarvardArticle . 2017Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.est.6b04908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 221 citations 221 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Environmental Scienc... arrow_drop_down Harvard University: DASH - Digital Access to Scholarship at HarvardArticle . 2017Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.est.6b04908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1999Publisher:Springer Science and Business Media LLC Authors: Sabine M. Hölter; Rainer Spanagel;pmid: 10460312
Opiate antagonists are promising pharmacotherapeutic agents for the treatment of alcohol dependence, reducing craving and relapse rates in weaned alcoholics. However, preclinical findings indicate that they can also increase ethanol consumption and preference in animals with a strong liking for ethanol, depending on the dose and treatment regimen.The present study examined the effects of chronic, intermittent and acute opiate antagonist treatment on the alcohol deprivation effect (ADE) in long-term ethanol- experienced rats, which is an animal model of craving and relapse.Long-term ethanol-experienced rats were either implanted with mini-osmotic pumps delivering 0, 0.5 or 1 mg/kg per hour naloxone (chronic treatment) or received intermittent naltrexone injections (2x5 mg/kg per day SC). Effects of chronic and intermittent treatment on the ADE were studied in a four-bottle home cage drinking paradigm. In a second experiment, long-term ethanol-experienced rats trained in an operant ethanol self-administration paradigm received acute naltrexone treatment (0, 0.1, 1 or 10 mg/kg SC) before a 23-h session either during basal drinking or during the ADE.Chronic naloxone treatment increased ethanol preference during the ADE. Intermittent naltrexone treatment at a dose comparable to the lower dose of chronic treatment moderately attenuated the ADE. Acute naltrexone treatment selectively reduced lever pressing for ethanol both during the ADE and during basal drinking only at the lowest dose, whereas higher doses also suppressed water intake. The ethanol-specific suppressant effect on the ADE was long lasting. Concerning basal drinking, however, naltrexone had a long lasting reductive effect only on lever pressing for water.A low dose of naltrexone and an intermittent treatment regimen seem to be necessary to maintain a specific reduction in ethanol intake in individuals with a high motivation to consume ethanol. These findings are consistent with the notion that, at low doses, opiate antagonists reduce the reward value of reinforcers.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s002130051069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 109 citations 109 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s002130051069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal , Other literature type 2012Publisher:Informa UK Limited Funded by:DFG | Exploiting the Potential ..., DFG | Redox-Regulation: Generat..., EC | MITOTARGET +2 projectsDFG| Exploiting the Potential of Natural Compounds: Myxobacteria as Source for Leads, Tools, and Therapeutics in Cancer Research ,DFG| Redox-Regulation: Generatorsysteme und funktionelle Konsequenzen ,EC| MITOTARGET ,NIH| Pharmacogenetics of Membrane Transporters ,EC| FIGHTINGDRUGFAILUREKlaus Golka; Silvia Selinski; Matthias W. Haenel; Meinolf Blaszkewicz; Marie-Louise Lehmann; Oliver Moormann; Daniel Ovsiannikov; Jan G. Hengstler;In the 1990s, an uncommonly high percentage of glutathione S-transferase M1 (GSTM1) negative bladder cancer cases (70%) was reported in the greater Dortmund area. The question arose as to whether this uncommonly high percentage of GSTM1 negative bladder cancer cases was due to environmental and/or occupational exposure decades ago. Thus, 15 years later, another study on bladder cancer was performed in the same area after the coal, iron, and steel industries had finally closed in the 1990s. In total 196 bladder cancer patients from the St.-Josefs-Hospital Dortmund-Hörde and 235 controls with benign urological diseases were assessed by questionnaire and genotyped for GSTM1, glutathione S-transferase T1 (GSTT1), and the N-acetyltransferase 2 (NAT2) tag SNP rs1495741. The frequency of the GSTM1 negative genotype was 52% in bladder cancer cases and thus lower compared to a previous study performed from 1992 to 1995 in the same area (70%). NAT2 genotypes were distributed equally among cases and controls (63% slow acetylators). Fewer GSTT1 negative genotypes were present in cases (17%) than in controls (20%).
Naunyn-Schmiedeberg ... arrow_drop_down Naunyn-Schmiedeberg s Archives of PharmacologyArticle . 2012 . Peer-reviewedLicense: Springer TDMData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012 . Peer-reviewedData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15287394.2012.675308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 58 citations 58 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Naunyn-Schmiedeberg ... arrow_drop_down Naunyn-Schmiedeberg s Archives of PharmacologyArticle . 2012 . Peer-reviewedLicense: Springer TDMData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012 . Peer-reviewedData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15287394.2012.675308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 United StatesPublisher:Springer Science and Business Media LLC Funded by:EC | C8EC| C8Lelieveld, J.; Evans, John S.; Fnais, M.; Giannadaki, D.; Pozzer, A.;doi: 10.1038/nature15371
pmid: 26381985
Assessment of the global burden of disease is based on epidemiological cohort studies that connect premature mortality to a wide range of causes, including the long-term health impacts of ozone and fine particulate matter with a diameter smaller than 2.5 micrometres (PM2.5). It has proved difficult to quantify premature mortality related to air pollution, notably in regions where air quality is not monitored, and also because the toxicity of particles from various sources may vary. Here we use a global atmospheric chemistry model to investigate the link between premature mortality and seven emission source categories in urban and rural environments. In accord with the global burden of disease for 2010 (ref. 5), we calculate that outdoor air pollution, mostly by PM2.5, leads to 3.3 (95 per cent confidence interval 1.61-4.81) million premature deaths per year worldwide, predominantly in Asia. We primarily assume that all particles are equally toxic, but also include a sensitivity study that accounts for differential toxicity. We find that emissions from residential energy use such as heating and cooking, prevalent in India and China, have the largest impact on premature mortality globally, being even more dominant if carbonaceous particles are assumed to be most toxic. Whereas in much of the USA and in a few other countries emissions from traffic and power generation are important, in eastern USA, Europe, Russia and East Asia agricultural emissions make the largest relative contribution to PM2.5, with the estimate of overall health impact depending on assumptions regarding particle toxicity. Model projections based on a business-as-usual emission scenario indicate that the contribution of outdoor air pollution to premature mortality could double by 2050.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2018Publisher:Public Library of Science (PLoS) Funded by:EC | StrainBoosterEC| StrainBoosterAuthors: Oliver Hädicke; Axel von Kamp; Timur Aydogan; Steffen Klamt;Constraint-based modeling techniques have become a standard tool for the in silico analysis of metabolic networks. To further improve their accuracy, recent methodological developments focused on integration of thermodynamic information in metabolic models to assess the feasibility of flux distributions by thermodynamic driving forces. Here we present OptMDFpathway, a method that extends the recently proposed framework of Max-min Driving Force (MDF) for thermodynamic pathway analysis. Given a metabolic network model, OptMDFpathway identifies both the optimal MDF for a desired phenotypic behavior as well as the respective pathway itself that supports the optimal driving force. OptMDFpathway is formulated as a mixed-integer linear program and is applicable to genome-scale metabolic networks. As an important theoretical result, we also show that there exists always at least one elementary mode in the network that reaches the maximal MDF. We employed our new approach to systematically identify all substrate-product combinations in Escherichia coli where product synthesis allows for concomitant net CO2 assimilation via thermodynamically feasible pathways. Although biomass synthesis cannot be coupled to net CO2 fixation in E. coli we found that as many as 145 of the 949 cytosolic carbon metabolites contained in the genome-scale model iJO1366 enable net CO2 incorporation along thermodynamically feasible pathways with glycerol as substrate and 34 with glucose. The most promising products in terms of carbon assimilation yield and thermodynamic driving forces are orotate, aspartate and the C4-metabolites of the tricarboxylic acid cycle. We also identified thermodynamic bottlenecks frequently limiting the maximal driving force of the CO2-fixing pathways. Our results indicate that heterotrophic organisms like E. coli hold a possibly underestimated potential for CO2 assimilation which may complement existing biotechnological approaches for capturing CO2. Furthermore, we envision that the developed OptMDFpathway approach can be used for many other applications within the framework of constrained-based modeling and for rational design of metabolic networks.
PLoS Computational B... arrow_drop_down PLoS Computational BiologyArticle . 2018 . Peer-reviewedData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert PLoS Computational B... arrow_drop_down PLoS Computational BiologyArticle . 2018 . Peer-reviewedData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pcbi.1006492&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1989Publisher:Elsevier BV Authors: Marcella Cappadonia; Karl Doblhofer;Abstract Electrodes were coated with a perfluorosulfonate polymer (NAFION). After equilibration in liquid electrolytes they were withdrawn from the electrolytes under potentiostatic control (“emersed”). The apparent work functions of the emersed coated electrodes were determined from measurements of Volta potential differences. They were conducted with Kelvin's method of the vibrating capacitor plate. The apparent work functions at constant emersion potential show the linear correlation with the logarithm of the solution concentration expected for the equilibrium potential drop across the membrane-electrolyte interface (the Donnan potential). From comparison with the apparent work function of the electrolyte, at the same potential, the surface dipole potential of the solvated polymer after the emersion is derived.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 7 citations 7 popularity Average influence Top 10% impulse Average Powered by BIP!
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description Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2020 Belgium, Netherlands, France, United KingdomPublisher:Copernicus GmbH Frédéric Chevallier; Pierre Regnier; Julia Pongratz; Atul K. Jain; Roxana Petrescu; Robert J. Scholes; Pep Canadell; Masayuki Kondo; Hui Yang; Marielle Saunois; Bo Zheng; Wouter Peters; Wouter Peters; Benjamin Poulter; Benjamin Poulter; Benjamin Poulter; Matthew W. Jones; Hanqin Tian; Xuhui Wang; Shilong Piao; Shilong Piao; Ronny Lauerwald; Ronny Lauerwald; Ingrid T. Luijkx; Anatoli Shvidenko; Anatoli Shvidenko; Gustaf Hugelius; Celso von Randow; Chunjing Qiu; Robert B. Jackson; Robert B. Jackson; Prabir K. Patra; Philippe Ciais; Ana Bastos;Abstract. Regional land carbon budgets provide insights on the spatial distribution of the land uptake of atmospheric carbon dioxide, and can be used to evaluate carbon cycle models and to define baselines for land-based additional mitigation efforts. The scientific community has been involved in providing observation-based estimates of regional carbon budgets either by downscaling atmospheric CO2 observations into surface fluxes with atmospheric inversions, by using inventories of carbon stock changes in terrestrial ecosystems, by upscaling local field observations such as flux towers with gridded climate and remote sensing fields or by integrating data-driven or process-oriented terrestrial carbon cycle models. The first coordinated attempt to collect regional carbon budgets for nine regions covering the entire globe in the RECCAP-1 project has delivered estimates for the decade 2000–2009, but these budgets were not comparable between regions, due to different definitions and component fluxes reported or omitted. The recent recognition of lateral fluxes of carbon by human activities and rivers, that connect CO2 uptake in one area with its release in another also requires better definition and protocols to reach harmonized regional budgets that can be summed up to the globe and compared with the atmospheric CO2 growth rate and inversion results. In this study, for the international initiative RECCAP-2 coordinated by the Global Carbon Project, which aims as an update of regional carbon budgets over the last two decades based on observations, for 10 regions covering the globe, with a better harmonization that the precursor project, we provide recommendations for using atmospheric inversions results to match bottom-up carbon accounting and models, and we define the different component fluxes of the net land atmosphere carbon exchange that should be reported by each research group in charge of each region. Special attention is given to lateral fluxes, inland water fluxes and land use fluxes.
Université de Versai... arrow_drop_down Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)University of East Anglia: UEA Digital RepositoryArticle . 2022License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.5194/gmd-20...Article . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefGeoscientific Model Development (GMD)Article . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefWageningen Staff PublicationsArticle . 2022License: CC BYData sources: Wageningen Staff Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/gmd-2020-259&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 46 citations 46 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
visibility 7visibility views 7 download downloads 13 Powered bymore_vert Université de Versai... arrow_drop_down Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)University of East Anglia: UEA Digital RepositoryArticle . 2022License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2022Full-Text: https://hal.science/hal-03604087Data sources: Bielefeld Academic Search Engine (BASE)https://doi.org/10.5194/gmd-20...Article . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefGeoscientific Model Development (GMD)Article . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefWageningen Staff PublicationsArticle . 2022License: CC BYData sources: Wageningen Staff Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/gmd-2020-259&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2005Publisher:Elsevier BV Authors: H. Näfe;Abstract Recently, the oxygen potential dependence of the signal of a potentiometric CO 2 sensor, based on a cation conductor with carbonate as gas sensitive layer, has been interpreted as caused by electronic transference through the electrolyte. Though this interpretation is quite correct, the relationships on the basis of which the effect of electronic conductivity has been discussed are wrong and so are the conclusions on the electronic conduction parameter of the electrolyte material under consideration, i.e. of the lithium ion conductor Li 3 PO 4 + SiO 2 (5 mol%). In what follows, the questionable points will be corrected and the role of the electronic conductivity for the understanding of the behaviour of a CO 2 sensor will be re-examined.
Sensors and Actuator... arrow_drop_down Sensors and Actuators B ChemicalArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.snb.2004.10.025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 8 citations 8 popularity Average influence Average impulse Average Powered by BIP!
more_vert Sensors and Actuator... arrow_drop_down Sensors and Actuators B ChemicalArticle . 2005 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.snb.2004.10.025&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020Publisher:Elsevier BV Authors: Javier López Prol; Sungmin O;As COVID-19 spreads worldwide, governments have been implementing a wide range of measures to contain it, from movement restrictions to economy-wide shutdowns. Understanding their impacts is essential to support better policies for countries still experiencing outbreaks or in case of emergence of subsequent pandemic waves. Here we show that the cumulative decline in electricity consumption within the 5 months following the stay-home orders ranges between 3% and 12% in the most affected EU countries and USA states, except Florida, which shows no significant impact. Italy, France, Spain, California, Austria, and New York have recovered baseline consumption by the end of July, whereas Great Britain and Germany remain below baseline levels. We also show that the relationship between measures stringency and daily decline in electricity consumption is nonlinear. These results illustrate the severity of the crisis across countries and can support further research on the effect of specific measures.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2020.101639&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 52 citations 52 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2020.101639&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2019Embargo end date: 16 Mar 2019 Japan, Germany, France, France, France, Japan, Spain, France, Switzerland, United Kingdom, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:EC | HELIX, EC | IMPACT2CEC| HELIX ,EC| IMPACT2CJeroen Steenbeek; Erwin Schmid; Tyler D. Eddy; Tyler D. Eddy; Tyler D. Eddy; Derek P. Tittensor; Derek P. Tittensor; Rene Orth; Rene Orth; Yadu Pokhrel; Joshua Elliott; Yusuke Satoh; Yusuke Satoh; Christian Folberth; Louis François; Andrew D. Friend; Catherine Morfopoulos; Nikolay Khabarov; Peter Lawrence; Naota Hanasaki; Michelle T. H. van Vliet; Akihiko Ito; Sonia I. Seneviratne; Veronika Huber; Thomas A. M. Pugh; Jinfeng Chang; Tobias Stacke; Philippe Ciais; Lila Warszawski; Jan Volkholz; Matthias Büchner; Yoshihide Wada; Christopher P. O. Reyer; Xuhui Wang; Xuhui Wang; Xuhui Wang; Dieter Gerten; Dieter Gerten; Sebastian Ostberg; Qiuhong Tang; Gen Sakurai; David A. Carozza; David A. Carozza; Christoph Müller; Jacob Schewe; Lutz Breuer; Delphine Deryng; Heike K. Lotze; Hannes Müller Schmied; Robert Vautard; Hyungjun Kim; Fang Zhao; Allard de Wit; Jörg Steinkamp; Katja Frieler; Simon N. Gosling; Lukas Gudmundsson; Marta Coll; Hanqin Tian;doi: 10.1038/s41467-019-08745-6 , 10.17863/cam.37807 , 10.60692/8dj48-81382 , 10.3929/ethz-b-000330244 , 10.60692/8mcvk-e7225
pmid: 30824763
pmc: PMC6397256
handle: 10261/181642
doi: 10.1038/s41467-019-08745-6 , 10.17863/cam.37807 , 10.60692/8dj48-81382 , 10.3929/ethz-b-000330244 , 10.60692/8mcvk-e7225
pmid: 30824763
pmc: PMC6397256
handle: 10261/181642
AbstractGlobal impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first time, systematically across many important systems, how well such impact models capture the impacts of extreme climate conditions. Using the 2003 European heat wave and drought as a historical analogue for comparable events in the future, we find that a majority of models underestimate the extremeness of impacts in important sectors such as agriculture, terrestrial ecosystems, and heat-related human mortality, while impacts on water resources and hydropower are overestimated in some river basins; and the spread across models is often large. This has important implications for economic assessments of climate change impacts that rely on these models. It also means that societal risks from future extreme events may be greater than previously thought.
Hyper Article en Lig... arrow_drop_down Université Jean Monnet – Saint-Etienne: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)École Polytechnique, Université Paris-Saclay: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Publication Database PIK (Potsdam Institute for Climate Impact Research)Article . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2019 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTAWageningen Staff PublicationsArticle . 2019License: CC BYData sources: Wageningen Staff PublicationsHochschulschriftenserver - Universität Frankfurt am MainArticle . 2019Data sources: Hochschulschriftenserver - Universität Frankfurt am MainPublication Server of Goethe University Frankfurt am MainArticle . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-08745-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 186 citations 186 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!
more_vert Hyper Article en Lig... arrow_drop_down Université Jean Monnet – Saint-Etienne: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)École Polytechnique, Université Paris-Saclay: HALArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Publication Database PIK (Potsdam Institute for Climate Impact Research)Article . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Institut national des sciences de l'Univers: HAL-INSUArticle . 2019Full-Text: https://hal.science/hal-02895259Data sources: Bielefeld Academic Search Engine (BASE)Recolector de Ciencia Abierta, RECOLECTAArticle . 2019 . Peer-reviewedData sources: Recolector de Ciencia Abierta, RECOLECTAWageningen Staff PublicationsArticle . 2019License: CC BYData sources: Wageningen Staff PublicationsHochschulschriftenserver - Universität Frankfurt am MainArticle . 2019Data sources: Hochschulschriftenserver - Universität Frankfurt am MainPublication Server of Goethe University Frankfurt am MainArticle . 2019License: CC BYData sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41467-019-08745-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Journal 2017 United StatesPublisher:American Chemical Society (ACS) Funded by:DFG | INUIT - Ice Nuclei resear...,DFG| INUIT - Ice Nuclei research UnIT ,[no funder available]Senchao Lai; Michael G. Weller; Iris Bellinghausen; Kira Ziegler; Kurt Lucas; Pascale S. J. Lakey; Manabu Shiraiwa; Janine Fröhlich-Nowoisky; Joachim Saloga; Rossella Sgarbanti; Naama Lang-Yona; Detlef Schuppan; Detlef Schuppan; Kathrin Reinmuth-Selzle; Christopher J. Kampf; Fangxia Shen; Bettina Weber; Anna T. Kunert; Fobang Liu; Albert Duschl; Ulrich Pöschl;Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochemical reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.
Environmental Scienc... arrow_drop_down Harvard University: DASH - Digital Access to Scholarship at HarvardArticle . 2017Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.est.6b04908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 221 citations 221 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Environmental Scienc... arrow_drop_down Harvard University: DASH - Digital Access to Scholarship at HarvardArticle . 2017Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.est.6b04908&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1999Publisher:Springer Science and Business Media LLC Authors: Sabine M. Hölter; Rainer Spanagel;pmid: 10460312
Opiate antagonists are promising pharmacotherapeutic agents for the treatment of alcohol dependence, reducing craving and relapse rates in weaned alcoholics. However, preclinical findings indicate that they can also increase ethanol consumption and preference in animals with a strong liking for ethanol, depending on the dose and treatment regimen.The present study examined the effects of chronic, intermittent and acute opiate antagonist treatment on the alcohol deprivation effect (ADE) in long-term ethanol- experienced rats, which is an animal model of craving and relapse.Long-term ethanol-experienced rats were either implanted with mini-osmotic pumps delivering 0, 0.5 or 1 mg/kg per hour naloxone (chronic treatment) or received intermittent naltrexone injections (2x5 mg/kg per day SC). Effects of chronic and intermittent treatment on the ADE were studied in a four-bottle home cage drinking paradigm. In a second experiment, long-term ethanol-experienced rats trained in an operant ethanol self-administration paradigm received acute naltrexone treatment (0, 0.1, 1 or 10 mg/kg SC) before a 23-h session either during basal drinking or during the ADE.Chronic naloxone treatment increased ethanol preference during the ADE. Intermittent naltrexone treatment at a dose comparable to the lower dose of chronic treatment moderately attenuated the ADE. Acute naltrexone treatment selectively reduced lever pressing for ethanol both during the ADE and during basal drinking only at the lowest dose, whereas higher doses also suppressed water intake. The ethanol-specific suppressant effect on the ADE was long lasting. Concerning basal drinking, however, naltrexone had a long lasting reductive effect only on lever pressing for water.A low dose of naltrexone and an intermittent treatment regimen seem to be necessary to maintain a specific reduction in ethanol intake in individuals with a high motivation to consume ethanol. These findings are consistent with the notion that, at low doses, opiate antagonists reduce the reward value of reinforcers.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s002130051069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 109 citations 109 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s002130051069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal , Other literature type 2012Publisher:Informa UK Limited Funded by:DFG | Exploiting the Potential ..., DFG | Redox-Regulation: Generat..., EC | MITOTARGET +2 projectsDFG| Exploiting the Potential of Natural Compounds: Myxobacteria as Source for Leads, Tools, and Therapeutics in Cancer Research ,DFG| Redox-Regulation: Generatorsysteme und funktionelle Konsequenzen ,EC| MITOTARGET ,NIH| Pharmacogenetics of Membrane Transporters ,EC| FIGHTINGDRUGFAILUREKlaus Golka; Silvia Selinski; Matthias W. Haenel; Meinolf Blaszkewicz; Marie-Louise Lehmann; Oliver Moormann; Daniel Ovsiannikov; Jan G. Hengstler;In the 1990s, an uncommonly high percentage of glutathione S-transferase M1 (GSTM1) negative bladder cancer cases (70%) was reported in the greater Dortmund area. The question arose as to whether this uncommonly high percentage of GSTM1 negative bladder cancer cases was due to environmental and/or occupational exposure decades ago. Thus, 15 years later, another study on bladder cancer was performed in the same area after the coal, iron, and steel industries had finally closed in the 1990s. In total 196 bladder cancer patients from the St.-Josefs-Hospital Dortmund-Hörde and 235 controls with benign urological diseases were assessed by questionnaire and genotyped for GSTM1, glutathione S-transferase T1 (GSTT1), and the N-acetyltransferase 2 (NAT2) tag SNP rs1495741. The frequency of the GSTM1 negative genotype was 52% in bladder cancer cases and thus lower compared to a previous study performed from 1992 to 1995 in the same area (70%). NAT2 genotypes were distributed equally among cases and controls (63% slow acetylators). Fewer GSTT1 negative genotypes were present in cases (17%) than in controls (20%).
Naunyn-Schmiedeberg ... arrow_drop_down Naunyn-Schmiedeberg s Archives of PharmacologyArticle . 2012 . Peer-reviewedLicense: Springer TDMData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012 . Peer-reviewedData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15287394.2012.675308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 58 citations 58 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Naunyn-Schmiedeberg ... arrow_drop_down Naunyn-Schmiedeberg s Archives of PharmacologyArticle . 2012 . Peer-reviewedLicense: Springer TDMData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012 . Peer-reviewedData sources: CrossrefJournal of Toxicology and Environmental Health Part AArticle . 2012Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/15287394.2012.675308&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 United StatesPublisher:Springer Science and Business Media LLC Funded by:EC | C8EC| C8Lelieveld, J.; Evans, John S.; Fnais, M.; Giannadaki, D.; Pozzer, A.;doi: 10.1038/nature15371
pmid: 26381985
Assessment of the global burden of disease is based on epidemiological cohort studies that connect premature mortality to a wide range of causes, including the long-term health impacts of ozone and fine particulate matter with a diameter smaller than 2.5 micrometres (PM2.5). It has proved difficult to quantify premature mortality related to air pollution, notably in regions where air quality is not monitored, and also because the toxicity of particles from various sources may vary. Here we use a global atmospheric chemistry model to investigate the link between premature mortality and seven emission source categories in urban and rural environments. In accord with the global burden of disease for 2010 (ref. 5), we calculate that outdoor air pollution, mostly by PM2.5, leads to 3.3 (95 per cent confidence interval 1.61-4.81) million premature deaths per year worldwide, predominantly in Asia. We primarily assume that all particles are equally toxic, but also include a sensitivity study that accounts for differential toxicity. We find that emissions from residential energy use such as heating and cooking, prevalent in India and China, have the largest impact on premature mortality globally, being even more dominant if carbonaceous particles are assumed to be most toxic. Whereas in much of the USA and in a few other countries emissions from traffic and power generation are important, in eastern USA, Europe, Russia and East Asia agricultural emissions make the largest relative contribution to PM2.5, with the estimate of overall health impact depending on assumptions regarding particle toxicity. Model projections based on a business-as-usual emission scenario indicate that the contribution of outdoor air pollution to premature mortality could double by 2050.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature15371&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 4K citations 4,235 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature15371&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2018Publisher:Public Library of Science (PLoS) Funded by:EC | StrainBoosterEC| StrainBoosterAuthors: Oliver Hädicke; Axel von Kamp; Timur Aydogan; Steffen Klamt;Constraint-based modeling techniques have become a standard tool for the in silico analysis of metabolic networks. To further improve their accuracy, recent methodological developments focused on integration of thermodynamic information in metabolic models to assess the feasibility of flux distributions by thermodynamic driving forces. Here we present OptMDFpathway, a method that extends the recently proposed framework of Max-min Driving Force (MDF) for thermodynamic pathway analysis. Given a metabolic network model, OptMDFpathway identifies both the optimal MDF for a desired phenotypic behavior as well as the respective pathway itself that supports the optimal driving force. OptMDFpathway is formulated as a mixed-integer linear program and is applicable to genome-scale metabolic networks. As an important theoretical result, we also show that there exists always at least one elementary mode in the network that reaches the maximal MDF. We employed our new approach to systematically identify all substrate-product combinations in Escherichia coli where product synthesis allows for concomitant net CO2 assimilation via thermodynamically feasible pathways. Although biomass synthesis cannot be coupled to net CO2 fixation in E. coli we found that as many as 145 of the 949 cytosolic carbon metabolites contained in the genome-scale model iJO1366 enable net CO2 incorporation along thermodynamically feasible pathways with glycerol as substrate and 34 with glucose. The most promising products in terms of carbon assimilation yield and thermodynamic driving forces are orotate, aspartate and the C4-metabolites of the tricarboxylic acid cycle. We also identified thermodynamic bottlenecks frequently limiting the maximal driving force of the CO2-fixing pathways. Our results indicate that heterotrophic organisms like E. coli hold a possibly underestimated potential for CO2 assimilation which may complement existing biotechnological approaches for capturing CO2. Furthermore, we envision that the developed OptMDFpathway approach can be used for many other applications within the framework of constrained-based modeling and for rational design of metabolic networks.
PLoS Computational B... arrow_drop_down PLoS Computational BiologyArticle . 2018 . Peer-reviewedData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pcbi.1006492&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 47 citations 47 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert PLoS Computational B... arrow_drop_down PLoS Computational BiologyArticle . 2018 . Peer-reviewedData sources: European Union Open Data Portaladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pcbi.1006492&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1989Publisher:Elsevier BV Authors: Marcella Cappadonia; Karl Doblhofer;Abstract Electrodes were coated with a perfluorosulfonate polymer (NAFION). After equilibration in liquid electrolytes they were withdrawn from the electrolytes under potentiostatic control (“emersed”). The apparent work functions of the emersed coated electrodes were determined from measurements of Volta potential differences. They were conducted with Kelvin's method of the vibrating capacitor plate. The apparent work functions at constant emersion potential show the linear correlation with the logarithm of the solution concentration expected for the equilibrium potential drop across the membrane-electrolyte interface (the Donnan potential). From comparison with the apparent work function of the electrolyte, at the same potential, the surface dipole potential of the solvated polymer after the emersion is derived.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0013-4686(89)85068-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 7 citations 7 popularity Average influence Top 10% impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0013-4686(89)85068-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu