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This data publication offers updated data about low-carbon energy technology (LCET) patents and citations links to the scientific literature. Compared to a [previous version](https://doi.org/10.4119/unibi/2941555), it also contains data on biofuels and fuels from waste technologies. The updated version also contains the code (R-scripts) that have been used to (1) compile the data and (2) to reproduce the statistical analysis including figures and tables presented in the final paper Hötte, Pichler, Lafond (2021): "The rise of science in low-carbon energy technologies", RSER. DOI: [10.1016/j.rser.2020.110654](10.1016/j.rser.2020.110654). This data publication contains different data sets (in .RData and (long-term archivable) .tsv format). Further information about each data set is provided in more detail below. - "all_papers.RData" : Data on scientific papers from Microsoft Academic Graph (MAG), 3 columns: Paper ID, Paper year, cited (binary 0-1, indicates whether the paper is cited by a patent). - "all_patents.RData" : Data on USPTO utility patents, 6 columns: Patent number, Patent year (grant year), CPC class, Patent date, Patent title, citing_to_science (binary 0-1, indicates whether the patent is citing to science). - "LCET_patents.RData" : Subset of LCET patents, 6 columns: Patent number, Patent year (grant year), Technology type, CPC class, Patent date, Patent title. - "LCET_patent_citations.RData" : Citations from LCET patents to other patents, 2 columns: citing, cited (Patent numbers). - "LCET_subset_with_metainfo_final.RData" : Citations from LCET patents to scientific papers from MAG, complemented by meta-information on patents and papers, 18 columns: Patent number, Paper ID, Patent year, Paper year, Technology type, WoS field, Patent title, Paper title, DOI, Confidence Score, Citation type, Reference type, Journal/ Conf. name, Journal ID, Conference ID, CPC class, Patent date, US patent. - "patent:citations.RData": Patent citations among all patents (not only LCET), 2 columns: citing, cited (Patent numbers). Moreover, this data publication contains a folder "code" with 2 subfolders: - "R_code_create_data" contains the R-scripts used to create the data sample. - "R_code_plots_and_figures" contains all R-scripts used to make the statistical analyses presented in the text (including figures and tables). Please check the read-me documents in the code folder for further detail. ### License and terms of use ### This data is licensed under the CC BY 4.0 license. See: https://creativecommons.org/licenses/by/4.0/legalcode Please find the full license text below. If you want to use the data, do not forget to give appropriate credit by citing this article: Kerstin Hötte, Anton Pichler, François Lafond, The rise of science in low-carbon energy technologies, Renewable and Sustainable Energy Reviews, Volume 139, 2021. https://doi.org/10.1016/j.rser.2020.110654 ### LCET definition and concepts ### LCET are defined by Cooperative Patent Classification (CPC) codes. CPC offers "tags" that are assigned to patents that are useful for the adaptation and mitigation of climate chagen. LCET are identified by YO2E codes, i.e. that are assigned to technologies that contribute to the "REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION". Only the subset of Y02E01 ("Energy generation through renewable energy sources"), Y02E03 ("Energy generation of nuclear origin") and Y02E5 ("Technologies for the production of fuel of non-fossil origin") technologies are used. 10 different LCET are distinguished: Solar PV, Wind, Solar thermal, Ocean power, Hydroelectric, Geothermal, Biofuels, Fuels from waste, Nuclear fission and Nuclear fusion. More information about the Y02-tags can be found in: Veefkind, Victor, et al. "A new EPO classification scheme for climate change mitigation technologies." World Patent Information 34.2 (2012): 106-111. DOI: [https://doi.org/10.1016/j.wpi.2011.12.004](https://doi.org/10.1016/j.wpi.2011.12.004) ### Data sources and compilation ### The data was generated by the merge of different data sets. 1.) Patent data from USPTO was downloaded here: https://bulkdata.uspto.gov/ 2.) Complementary data on grant year and patent title was taken from: https://cloud.google.com/blog/products/gcp/google-patents-public-datasets-connecting-public-paid-and-private-patent-data 3.) Citations to science come from the Reliance on Science (RoS) data set https://zenodo.org/record/3685972 (v23, Feb. 24, 2020) DOI: 10.5281/zenodo.3685972 The directory ("code") offers the R-scripts that were used to process MAG data and to link it to patent data. The header of the R-scripts offer additional technical information about the subsetting procedures and data retrieval. For more information about the patent data, see: Pichler, A., Lafond, F. & J, F. D. (2020), Technological interdependencies predict innovation dynamics, Working paper pp. 1–33. URL: [https://arxiv.org/abs/2003.00580](https://arxiv.org/abs/2003.00580) For more information about MAG data, see: Marx, Matt, and Aaron Fuegi. "Reliance on science: Worldwide front‐page patent citations to scientific articles." Strategic Management Journal 41.9 (2020): 1572-1594. DOI: [https://doi.org/10.1002/smj.3145](https://doi.org/10.1002/smj.3145) Marx, Matt and Fuegi, Aaron, Reliance on Science: Worldwide Front-Page Patent Citations to Scientific Articles. Boston University Questrom School of Business Research Paper No. 3331686. DOI: [http://dx.doi.org/10.2139/ssrn.3331686 ](http://dx.doi.org/10.2139/ssrn.3331686 ) ### Detailed information about the data ### - "all_papers.RData" : Data on scientific papers from Microsoft Academic Graph (MAG), 3 columns: Paper ID: Unique paper-identifier used by MAG Paper year: Year of publication cited: binary 0-1, indicates whether the paper is cited by a patent, citation links are made in the text body and front-page of the patent, and added by examiners and applicants. - "all_patents.RData" : Data on USPTO utility patents, 6 columns: Patent number: Number given by USPTO. Can be used for manual patent search in http://patft.uspto.gov/netahtml/PTO/srchnum.htm (numeric) Patent year: Year when the patent was granted (numeric) CPC class: Detailed 8-digit CPC code (numeric) Patent date: Exact date of patent granting (numeric) Patent title: Short title (character) citing_to_science: binary 0-1, indicates whether the patent is citing to science as identified by citation links in RoS. (numeric) - "LCET_patents.RData" : Subset of LCET patents, 6 columns: Patent number: (numeric) Patent year: (numeric) Technology type: Short code used to tag 10 different types of LCET (pv, (nuclear) fission, (solar) thermal, (nuclear) fusion, wind, geo(termal), sea (ocean power), hydro, biofuels, (fuels from) waste) (character) CPC class: Detailed 8-digit CPC code (character) Patent date: (numeric) Patent title: (numeric) - "LCET_patent_citations.RData" : Citations from LCET patents to other patents, 2 columns: citing: Number of citing patent (numeric) cited: Number of cited patent (numeric) - "LCET_subset_with_metainfo_final.RData" : Citations from LCET patents to scientific papers from MAG, complemented by meta-information on patents and papers, 18 columns: Patent number: see above (numeric) Paper ID: see above (numeric) Patent year: see above (numeric) Paper year: see above (numeric) Technology type: see above (character) WoS field: Web of Science field of research, WoS fields were probabilistically assigned to papers and are used as given by RoS (character) Patent title: see above (character) Paper title: Title of scientific article (character) DOI: Paper DOI if available (character) Confidence Score: Reliability score of citation link (numeric). Links were probabilistically assigned. See Marx and Fuegi 2019 for further detail. Citation type: Indicates whether citation made in text body of patent document or its front page (character) Reference type: Examiner or applicant added citation link (or unknown). (character) Journal/ Conf. name: Name of journal or conference proceeding where the cited paper was published (character) Journal ID: Journal identifier in MAG (numeric) Conference ID: Conference identifier in MAG (numeric) CPC class: see above (character) Patent date: see above (numeric) US patent: binary US-patent indicator as provided by RoS (numeric) - "patent:citations.RData": Patent citations among all patents (not only LCET), 2 columns: citing: Number of citing patent (numeric) cited: Number of cited patent (numeric) **Note:** The citation links were probabilistically retrieved. During the analysis, we identified manually some false-positives are removed them from the "LCET_subset_with_metainfo_final.RData" data set. The list is available, too: "list_of_false_positives.tsv" We do not claim to have a perfect coverage, but expect a precision of >98% as described by Marx and Fuegi 2019. ### Statistics about the data ### Full data set: - #papers in MAG: 179,083,029 - #all patents: 10,160,667 - #citing patents: 2,058,233 - #cited papers: 4,404,088 - #citation links from patents to papers: 34,959,193 LCET subset: - #LCET patents: 65,305 - #citing LCET patents: 22,017 - #cited papers: 103,645 - #citation links from LCET patents to papers: 396,504 Meta-information: Papers: - Publication year, 251 Web-of-Science (WoS) categories, Journal/ conference proceedings name, DOI, Paper title Patents: - Grant year, >240,000 hierarchical CPC classes, 10 LCET types Citation links: - Reference type, citation type, reliability score If you have further questions about the data or suggestions, please contact: **kerstin.hotte@oxfordmartin.ox.ac.uk** ### Acknowledgements ### The authors want to thank the Center for Research Data Management of Bielefeld University and in particular Cord Wiljes for excellent support. ### License issues ### Terms of use of the source data: - Reliance on Science data [https://zenodo.org/record/3685972](https://zenodo.org/record/3685972), Open Data Commons Attribution License (ODC-By) v1.0, https://opendatacommons.org/licenses/by/1.0/ - "Google Patents Public Data” by IFI CLAIMS Patent Services and Google (https://cloud.google.com/blog/products/gcp/google-patents-public-datasets-connecting-public-paid-and-private-patent-data), Creative Commons Attribution 4.0 International License (CC BY 4.0), https://console.cloud.google.com/marketplace/details/google_patents_public_datasets/google-patents-public-data - USPTO patent data (https://bulkdata.uspto.gov/), see: https://bulkdata.uspto.gov/data/2020TermsConditions.docx

#### Note: #### An updated version of these data including data on biofuels and fuels from waste is available [here](https://pub.uni-bielefeld.de/record/2950291). The extended version also offers a package of R-scripts that have been used to reproduce the statistical analysis presented in [Hötte, Pichler, Lafond (2021): The rise of science in low-carbon energy technologies](https://doi.org/10.1016/j.rser.2020.110654). This data publication offers data about low-carbon energy technology (LCET) patents and citations links to the scientific literature. This data publication contains different data sets (in .RData and (long-term archivable) .tsv format). Further information about each data set is provided in more detail below. - "all_papers.RData" : Data on scientific papers from Microsoft Academic Graph (MAG), 3 columns: Paper ID, Paper year, cited (binary 0-1, indicates whether the paper is cited by a patent). - "all_patents.RData" : Data on USPTO utility patents, 6 columns: Patent number, Patent year (grant year), CPC class, Patent date, Patent title, citing_to_science (binary 0-1, indicates whether the patent is citing to science). - "LCET_patents.RData" : Subset of LCET patents, 6 columns: Patent number, Patent year (grant year), Technology type, CPC class, Patent date, Patent title. - "LCET_patent_citations.RData" : Citations from LCET patents to other patents, 2 columns: citing, cited (Patent numbers). - "LCET_subset_with_metainfo_final.RData" : Citations from LCET patents to scientific papers from MAG, complemented by meta-information on patents and papers, 18 columns: Patent number, Paper ID, Patent year, Paper year, Technology type, WoS field, Patent title, Paper title, DOI, Confidence Score, Citation type, Reference type, Journal/ Conf. name, Journal ID, Conference ID, CPC class, Patent date, US patent. ### License and terms of use ### This data is licensed under the CC BY 4.0 license. See: [https://creativecommons.org/licenses/by/4.0/legalcode](https://creativecommons.org/licenses/by/4.0/legalcode) Please find the full license text below. If you want to use the data, do not forget to give appropriate credit by citing this data publication and the following paper. Kerstin Hötte, Anton Pichler, François Lafond: *The rise of science in low-carbon energy technologies*, Renewable and Sustainable Energy Reviews, Volume 139, 2021 [https://doi.org/10.1016/j.rser.2020.110654](https://doi.org/10.1016/j.rser.2020.110654) ### LCET definition and concepts ### LCET are defined by Cooperative Patent Classification (CPC) codes. CPC offers "tags" that are assigned to patents that are useful for the adaptation and mitigation of climate change. LCET are identified by YO2E codes, i.e. that are assigned to technologies that contribute to the "REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION". Only the subset of Y02E01 ("Energy generation through renewable energy sources") and Y02E03 ("Energy generation of nuclear origin") technologies are used. 8 different LCET are distinguished: Solar PV, Wind, Solar thermal, Ocean power, Hydroelectric, Geothermal, Nuclear fission and Nuclear fusion. More information about the Y02-tags can be found in: Veefkind, Victor, et al. "A new EPO classification scheme for climate change mitigation technologies." World Patent Information 34.2 (2012): 106-111. DOI: [https://doi.org/10.1016/j.wpi.2011.12.004](https://doi.org/10.1016/j.wpi.2011.12.004) ### Data sources and compilation ### The data was generated by the merge of different data sets. 1.) Patent data from USPTO was downloaded here: https://bulkdata.uspto.gov/ 2.) Complementary data on grant year and patent title was taken from: https://cloud.google.com/blog/products/gcp/google-patents-public-datasets-connecting-public-paid-and-private-patent-data 3.) Citations to science come from the Reliance on Science (RoS) data set https://zenodo.org/record/3685972 (v23, Feb. 24, 2020) DOI: [10.5281/zenodo.3685972](10.5281/zenodo.3685972) The directory ("code") offers the R-scripts that were used to process MAG data and to link it to patent data. The header of the R-scripts offer additional technical information about the subsetting procedures and data retrieval. For more information about the patent data, see: Pichler, A., Lafond, F. & J, F. D. (2020), Technological interdependencies predict innovation dynamics, Working paper pp. 1–33. URL: [https://arxiv.org/abs/2003.00580](https://arxiv.org/abs/2003.00580) For more information about MAG data, see: Marx, Matt, and Aaron Fuegi. "Reliance on science: Worldwide front‐page patent citations to scientific articles." Strategic Management Journal 41.9 (2020): 1572-1594. DOI: [https://doi.org/10.1002/smj.3145](https://doi.org/10.1002/smj.3145) Marx, Matt and Fuegi, Aaron, Reliance on Science: Worldwide Front-Page Patent Citations to Scientific Articles. Boston University Questrom School of Business Research Paper No. 3331686. DOI: [http://dx.doi.org/10.2139/ssrn.3331686 ](http://dx.doi.org/10.2139/ssrn.3331686 ) ### Detailed information about the data ### - "all_papers.RData" : Data on scientific papers from Microsoft Academic Graph (MAG), 3 columns: Paper ID: Unique paper-identifier used by MAG Paper year: Year of publication cited: binary 0-1, indicates whether the paper is cited by a patent, citation links are made in the text body and front-page of the patent, and added by examiners and applicants. - "all_patents.RData" : Data on USPTO utility patents, 6 columns: Patent number: Number given by USPTO. Can be used for manual patent search in http://patft.uspto.gov/netahtml/PTO/srchnum.htm (numeric) Patent year: Year when the patent was granted (numeric) CPC class: Detailed 8-digit CPC code (numeric) Patent date: Exact date of patent granting (numeric) Patent title: Short title (character) citing_to_science: binary 0-1, indicates whether the patent is citing to science as identified by citation links in RoS. (numeric) - "LCET_patents.RData" : Subset of LCET patents, 6 columns: Patent number: (numeric) Patent year: (numeric) Technology type: Short code used to tag 8 different types of LCET (pv, (nuclear) fission, (solar) thermal, (nuclear) fusion, wind, geo(termal), sea (ocean power), hydro) (character) CPC class: Detailed 8-digit CPC code (character) Patent date: (numeric) Patent title: (numeric) - "LCET_patent_citations.RData" : Citations from LCET patents to other patents, 2 columns: citing: Number of citing patent (numeric) cited: Number of cited patent (numeric) - "LCET_subset_with_metainfo_final.RData" : Citations from LCET patents to scientific papers from MAG, complemented by meta-information on patents and papers, 18 columns: Patent number: see above (numeric) Paper ID: see above (numeric) Patent year: see above (numeric) Paper year: see above (numeric) Technology type: see above (character) WoS field: Web of Science field of research, WoS fiels were probabilistically assigned to papers and are used as given by RoS (character) Patent title: see above (character) Paper title: Title of scientific article (character) DOI: Paper DOI if available (character) Confidence Score: Reliability score of citation link (numeric). Links were probabilistically assiged. See Marx and Fuegi 2019 for further detail. Citation type: Indicates whether citation made in text body of patent document or its front page (character) Reference type: Examiner or applicant added citation link (or unknown). (character) Journal/ Conf. name: Name of journal or conference proceeding where the cited paper was published (character) Journal ID: Journal identifier in MAG (numeric) Conference ID: Conference identifier in MAG (numeric) CPC class: see above (character) Patent date: see above (numeric) US patent: binary US-patent indicator as provided by RoS (numeric) #### Note: #### The citation links were probabilistically retrieved. During the analysis, we identified manually some false-positives are removed them from the "LCET_subset_with_metainfo_final.RData" data set. The list is available, too: "list_of_false_positives.tsv" We do not claim to have a perfect coverage but expect a precision of >98% as described by Marx and Fuegi 2019. ### Statistics about the data ### Full data set: - Number of papers in MAG: 179,083,029 - Number of all patents: 10,160,667 - Number of citing patents: 2,058,233 - Number of cited papers: 4,404,088 - Number of citation links from patents to papers: 34,959,193 LCET subset: - Number of LCET patents: 57,530 - Number of citing LCET patents: 16,674 - Number of cited papers: 53,509 - Number of citation links from LCET patents to papers: 151,253 - Number of citation links from LCET patents to other patents: 567,274 Meta-information: Papers: - Publication year, 251 Web-of-Science (WoS) categories, Journal/ conference proceedings name, DOI, Paper title Patents: - Grant year, >250,000 hierarchical CPC classes, 8 LCET types Citation links: - Reference type, citation type, reliability score #### If you have further questions about the data or suggestions, please contact: kerstin.hotte@oxfordmartin.ox.ac.uk ### License issues ### Terms of use of the source data: - Reliance on Science data [https://zenodo.org/record/3685972](https://zenodo.org/record/3685972), Open Data Commons Attribution License (ODC-By) v1.0, https://opendatacommons.org/licenses/by/1.0/ - "Google Patents Public Data” by IFI CLAIMS Patent Services and Google (https://cloud.google.com/blog/products/gcp/google-patents-public-datasets-connecting-public-paid-and-private-patent-data), Creative Commons Attribution 4.0 International License (CC BY 4.0), https://console.cloud.google.com/marketplace/details/google_patents_public_datasets/google-patents-public-data - USPTO patent data (https://bulkdata.uspto.gov/), see: https://bulkdata.uspto.gov/data/2020TermsConditions.docx

Comprehensive and reliable information on anthropogenic sources of greenhouse gas emissions is required to track progress towards keeping warming well below 2°C as agreed upon in the Paris Agreement. Here we provide a dataset on anthropogenic GHG emissions 1970-2019 with a broad country and sector coverage. We build the dataset from recent releases from the “Emissions Database for Global Atmospheric Research” (EDGAR) for CO2 emissions from fossil fuel combustion and industry (FFI), CH4 emissions, N2O emissions, and fluorinated gases and use a well-established fast-track method to extend this dataset from 2018 to 2019. We complement this with information on net CO2 emissions from land use, land-use change and forestry (LULUCF) from three available bookkeeping models.

QTDIAN - Quantification of Technological DIffusion and sociAl constraiNts - is a toolbox of qualitative and quantitative descriptions of socio-technical and political aspects of the energy transition that influence the overall potential, the rate of energy-related technology and service diffusion and the design of the future energy system. The output of QTIDIAN is empirically founded datasets of social and political drivers and barriers of the transition, both in the form of raw data describing past and current developments and manipulated to constitute consistent quantifications of the storylines. Here you can download the data for six QTDIAN themes: Socially feasible scaling of energy technologies Policy preferences & dynamics Barriers to infrastructural development (wind energy, grid development) Citizen energy Private energy demand Further information on the QTDIAN modelling toolbox and the data can be found in the SENTINEL Deliverable 2.3 and Deliverable 2.4: S��sser, D., al Rakouki, H., & Lilliestam, J.(2021). The QTDIAN modelling toolbox���Quantification of social drivers and constraints of the diffusion of energy technologies. Deliverable 2.3. Sustainable Energy Transitions Laboratory (SENTINEL) project. Potsdam: Institute for Advanced Sustainability Studies (IASS). S��sser, D., Pickering, B., Chatterjee, S., Oreggioni, G., Stavrakas, V., & Lilliestam, J.(2021). Integration of socio-technological transition constraints into energy demand and systems models. Deliverable 2.5. Sustainable Energy Transitions Laboratory (SENTINEL) project. Potsdam: Institute for Advanced Sustainability Studies (IASS).

Avoiding irreversible climate change as effectively as possible is one of the most pressing challenges of society. Carbon pricing that is uniformly valid on a global and cross-sectoral basis represents a cost-efficient policy tool to meet this challenge. Carbon pricing allows external costs to be allocated or internalized on a polluter-pays principle. It is shown that a global emissions cap-and-trade system is the most suitable market-based instrument for reducing global emissions levels, in line with the temperature goal set by the Paris Agreement. A proposal for its design is presented in this paper. This instrument encourages worldwide measures, with the lowest marginal abatement cost, according to a pre-defined reduction path. Thereby, it ensures compliance with a specified remaining carbon budget to meet a certain temperature limit in a cost-efficient manner. Possible reduction paths are presented in this paper. Weaknesses in the design of existing emissions trading systems (ETS), such as the EU ETS, are identified and avoided in the proposed instrument. The framework solves several problems of today’s climate change policies, like the free rider problem, carbon leakage, rebound effects or the green paradox. The introduction of a global uniform carbon pricing instrument and its concrete design should be the subject of policy, especially at the United Nations climate change conferences, as soon as possible in order to allow for rapid implementation. If a global ETS with a uniform carbon price could be introduced, additional governmental regulations with regard to carbon emissions would become obsolete.

Pour obtenir un aperçu spécifique des rôles que les micro-organismes pourraient jouer dans la stéatose hépatique non alcoolique (NAFLD), certaines bactéries intestinales et lactiques et une levure (Anaerostipes caccae, Bacteroides thetaiotaomicron, Bifidobacterium longum, Enterococcus fecalis, Escherichia coli, Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus plantarum, Weissella confusa, Saccharomyces cerevisiae) ont été caractérisées par une chromatographie liquide haute performance pour la production d'éthanol lorsqu'elles sont cultivées sur différents glucides : hexoses (glucose et fructose), pentoses (arabinose et ribose), disaccharides (lactose et lactulose) et inuline. Les quantités les plus élevées d'éthanol ont été produites par S. cerevisiae, L. fermentum et W. confusa sur le glucose et par S. cerevisiae et W. confusa sur le fructose. En raison de la mannitol-déshydrogénase exprimée dans L. fermentum, la production d'éthanol sur le fructose a été significativement réduite (P < 0,05). Le pyruvate et le citrate, deux accepteurs d'électrons potentiels pour la régénération du NAD+/NADP+, ont considérablement réduit la production d'éthanol avec de l'acétate produit à la place dans L. fermentum cultivé sur glucose et W. confusa cultivé sur glucose et fructose, respectivement. Dans les boues fécales préparées à partir des matières fécales de quatre volontaires en surpoids, on a constaté que l'éthanol était produit lors de l'ajout de fructose. L'ajout d'A. caccae, L. acidophilus, L. fermentum, ainsi que de citrate et de pyruvate, respectivement, a aboli la production d'éthanol. Cependant, l'ajout de W. confusa a entraîné une augmentation significative (P < 0,05) de la production d'éthanol. Ces résultats indiquent que des micro-organismes comme W. confusa, une bactérie lactique hétéro-fermentaire, négative à la mannitol-déshydrogénase, peuvent favoriser la NAFLD par l'éthanol produit à partir de la fermentation du sucre, tandis que d'autres bactéries intestinales et des bactéries lactiques homo- et hétéro-fermentaires mais positives à la mannitol-déshydrogénase peuvent ne pas favoriser la NAFLD. En outre, nos études indiquent que les facteurs alimentaires interférant avec le microbiote gastro-intestinal et le métabolisme microbien peuvent être importants dans la prévention ou la promotion de la NAFLD. Para obtener información específica sobre los roles que podrían desempeñar los microorganismos en la enfermedad del hígado graso no alcohólico (NAFLD, por sus siglas en inglés), algunas bacterias intestinales y del ácido láctico y una levadura (Anaerostipes caccae, Bacteroides thetaiotaomicron, Bifidobacterium longum, Enterococcus fecalis, Escherichia coli, Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus plantarum, Weissella confusa, Saccharomyces cerevisiae) se caracterizaron por cromatografía líquida de alto rendimiento para la producción de etanol cuando se cultivaron en diferentes carbohidratos: hexosas (glucosa y fructosa), pentosas (arabinosa y ribosa), disacáridos (lactosa y lactulosa) e inulina. Las cantidades más altas de etanol fueron producidas por S. cerevisiae, L. fermentum y W. confusa en glucosa y por S. cerevisiae y W. confusa en fructosa. Debido a la manitol-deshidrogenasa expresada en L. fermentum, la producción de etanol en fructosa se redujo significativamente (P < 0.05). El piruvato y el citrato, dos aceptores de electrones potenciales para la regeneración de NAD+/NADP+, redujeron drásticamente la producción de etanol con acetato producido en su lugar en L. fermentum cultivado en glucosa y W. confusa cultivado en glucosa y fructosa, respectivamente. En suspensiones fecales preparadas a partir de heces de cuatro voluntarios con sobrepeso, se encontró que el etanol se producía tras la adición de fructosa. La adición de A. caccae, L. acidophilus, L. fermentum, así como citrato y piruvato, respectivamente, abolió la producción de etanol. Sin embargo, la adición de W. confusa resultó en un aumento significativo (P < 0.05) de la producción de etanol. Estos resultados indican que microorganismos como W. confusa, una bacteria de ácido láctico hetero-fermentativa, negativa para manitol-deshidrogenasa, pueden promover NAFLD a través del etanol producido a partir de la fermentación de azúcar, mientras que otras bacterias intestinales y bacterias de ácido láctico homo- y hetero-fermentativas pero positivas para manitol-deshidrogenasa pueden no promover NAFLD. Además, nuestros estudios indican que los factores dietéticos que interfieren con la microbiota gastrointestinal y el metabolismo microbiano pueden ser importantes para prevenir o promover la EHGNA. To gain some specific insight into the roles microorganisms might play in non-alcoholic fatty liver disease (NAFLD), some intestinal and lactic acid bacteria and one yeast (Anaerostipes caccae, Bacteroides thetaiotaomicron, Bifidobacterium longum, Enterococcus fecalis, Escherichia coli, Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus plantarum, Weissella confusa, Saccharomyces cerevisiae) were characterized by high performance liquid chromatography for production of ethanol when grown on different carbohydrates: hexoses (glucose and fructose), pentoses (arabinose and ribose), disaccharides (lactose and lactulose), and inulin. Highest amounts of ethanol were produced by S. cerevisiae, L. fermentum and W. confusa on glucose and by S. cerevisiae and W. confusa on fructose. Due to mannitol-dehydrogenase expressed in L. fermentum, ethanol production on fructose was significantly (P < 0.05) reduced. Pyruvate and citrate, two potential electron acceptors for regeneration of NAD+/NADP+, drastically reduced ethanol production with acetate produced instead in L. fermentum grown on glucose and W. confusa grown on glucose and fructose, respectively. In fecal slurries prepared from feces of four overweight volunteers, ethanol was found to be produced upon addition of fructose. Addition of A. caccae, L. acidophilus, L. fermentum, as well as citrate and pyruvate, respectively, abolished ethanol production. However, addition of W. confusa resulted in significantly (P < 0.05) increased production of ethanol. These results indicate that microorganisms like W. confusa, a hetero-fermentative, mannitol-dehydrogenase negative lactic acid bacterium, may promote NAFLD through ethanol produced from sugar fermentation, while other intestinal bacteria and homo- and hetero-fermentative but mannitol-dehydrogenase positive lactic acid bacteria may not promote NAFLD. Also, our studies indicate that dietary factors interfering with gastrointestinal microbiota and microbial metabolism may be important in preventing or promoting NAFLD. لاكتساب بعض الأفكار المحددة حول الأدوار التي قد تلعبها الكائنات الحية الدقيقة في مرض الكبد الدهني غير الكحولي (NAFLD)، تميزت بعض بكتيريا حمض الأمعاء واللاكتيك وخميرة واحدة (Anaerostipes caccae، Bacteroides thetaiotaomicron، Bifidobacterium longum، Enterococcus fecalis، Escherichia coli، Lactobacillus acidophilus، Lactobacillus fermentum، Lactobacillus plantarum، Weissella confusa، Saccharomyces cerevisiae) بتصوير سائل عالي الأداء لإنتاج الإيثانول عند زراعته على كربوهيدرات مختلفة: hexoses (الجلوكوز والفركتوز)، pentoses (الأرابينوز والريبوز)، disaccharides (اللاكتوز واللاكتولوز)، و inulin. تم إنتاج أعلى كميات من الإيثانول بواسطة S. cerevisiae و L. fermentum و W. confusa على الجلوكوز و S. cerevisiae و W. confusa على الفركتوز. بسبب نازعة هيدروجين المانيتول المعبر عنها في L. fermentum، انخفض إنتاج الإيثانول على الفركتوز بشكل كبير (P < 0.05). قلل البيروفات والسيترات، وهما مستقبلان محتملان للإلكترون لتجديد NAD +/NADP+، بشكل كبير من إنتاج الإيثانول مع الأسيتات المنتجة بدلاً من ذلك في L. fermentum المزروع على الجلوكوز و W. confusa المزروع على الجلوكوز والفركتوز، على التوالي. في الملاط البرازي الذي تم تحضيره من براز أربعة متطوعين يعانون من زيادة الوزن، وجد أن الإيثانول يتم إنتاجه عند إضافة الفركتوز. إضافة A. caccae، L. acidophilus، L. fermentum، وكذلك السترات والبيروفات، على التوالي، ألغت إنتاج الإيثانول. ومع ذلك، أدت إضافة W. confusa إلى زيادة كبيرة في إنتاج الإيثانول (P < 0.05). تشير هذه النتائج إلى أن الكائنات الحية الدقيقة مثل W. confusa، وهي بكتيريا حمض اللاكتيك السلبية غير المتجانسة، قد تعزز NAFLD من خلال الإيثانول المنتج من تخمير السكر، في حين أن البكتيريا المعوية الأخرى وبكتيريا حمض اللاكتيك الإيجابية غير المتجانسة ولكن غير المتجانسة قد لا تعزز NAFLD. أيضًا، تشير دراساتنا إلى أن العوامل الغذائية التي تتداخل مع الكائنات الحية الدقيقة في الجهاز الهضمي والتمثيل الغذائي الميكروبي قد تكون مهمة في منع أو تعزيز NAFLD.

Given the global energy and environmental situation, the European Union has been issuing directives with increasingly demanding requirements in term of the energy efficiency in buildings. The international competition of sustainable houses, Solar Decathlon Europe (SDE), is aligned with these European objectives. SDE houses are low energy solar buildings that must reach the near to zero energy houses’ goal. In the 2012 edition, in order to emphasize its significance, the Energy Efficiency Contest was added. SDE houses’ interior comfort, functioning and energy performance is monitored. The monitoring data can give an idea about the efficiency of the houses. However, a jury comprised by international experts is responsible for carrying out the houses energy efficiency evaluation. Passive strategies and houses services are analyzed. Additionally, the jury's assessment has been compared with the behavior of the houses during the monitoring period. Comparative studies make emphasis on the energy aspects, houses functioning and their interior comfort. Conclusions include thoughts related with the evaluation process, the results of the comparative studies and suggestions for the next competitions.

AbstractObjective: The marked increase in the prevalence of obesity in the United States has recently been attributed to the increased fructose consumption. To determine if and how fructose might promote obesity in an animal model, we measured body composition, energy intake, energy expenditure, substrate oxidation, and several endocrine parameters related to energy homeostasis in mice consuming fructose.Research Methods and Procedures: We compared the effects of ad libitum access to fructose (15% solution in water), sucrose (10%, popular soft drink), and artificial sweetener (0% calories, popular diet soft drink) on adipogenesis and energy metabolism in mice.Results: Exposure to fructose water increased adiposity, whereas increased fat mass after consumption of soft drinks or diet soft drinks did not reach statistical significance (n = 9 each group). Total intake of energy was unaltered, because mice proportionally reduced their caloric intake from chow. There was a trend toward reduced energy expenditure and increased respiratory quotient, albeit not significant, in the fructose group. Furthermore, fructose produced a hepatic lipid accumulation with a characteristic pericentral pattern.Discussion: These data are compatible with the conclusion that a high intake of fructose selectively enhances adipogenesis, possibly through a shift of substrate use to lipogenesis.