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Hypoxia has occurred intermittently over the Holocene in the Baltic Sea, but the recent expansion from less than 10 000 km(2) before 1950 to >60 000 km(2) since 2000 is mainly caused by enhanced nutrient inputs from land and atmosphere. With worsening hypoxia, the role of sediments changes from nitrogen removal to nitrogen release as ammonium. At present, denitrification in the water column and sediments is equally important. Phosphorus is currently buried in sediments mainly in organic form, with an additional contribution of reduced Fe-phosphate minerals in the deep anoxic basins. Upon the transition to oxic conditions, a significant proportion of the organic phosphorus will be remineralized, with the phosphorus then being bound to iron oxides. This iron-oxide bound phosphorus is readily released to the water column upon the onset of hypoxia again. Important ecosystems services carried out by the benthic fauna, including biogeochemical feedback-loops and biomass production, are also lost with hypoxia. The results provide quantitative knowledge of nutrient release and recycling processes under various environmental conditions in support of decision support tools underlying the Baltic Sea Action Plan.

In this paper we report the set-up and results of the Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) organized in conjunction with the MICCAI 2012 and 2013 conferences. Twenty state-of-the-art tumor segmentation algorithms were applied to a set of 65 multi-contrast MR scans of low- and high-grade glioma patients - manually annotated by up to four raters - and to 65 comparable scans generated using tumor image simulation software. Quantitative evaluations revealed considerable disagreement between the human raters in segmenting various tumor sub-regions (Dice scores in the range 74-85%), illustrating the difficulty of this task. We found that different algorithms worked best for different sub-regions (reaching performance comparable to human inter-rater variability), but that no single algorithm ranked in the top for all subregions simultaneously. Fusing several good algorithms using a hierarchical majority vote yielded segmentations that consistently ranked above all individual algorithms, indicating remaining opportunities for further methodological improvements. The BRATS image data and manual annotations continue to be publicly available through an online evaluation system as an ongoing benchmarking resource.

In the past few decades, major public health advances have happened in Europe, with drastic decreases in premature mortality and a life expectancy increase of almost 9 years since 1980. European countries have some of the best health-care systems in the world. However, Europe is challenged with unprecedented and overlapping crises that are detrimental to human health and livelihoods and threaten adaptive capacity, including the COVID-19 pandemic, the Russian invasion of Ukraine, the fastest-growing migrant crisis since World War 2, population displacement, environmental degradation, and deepening inequalities. Compared with pre-industrial times, the mean average European surface air temperature increase has been almost 1°C higher than the average global temperature increase, and 2022 was the hottest European summer on record. As the world's third largest economy and a major contributor to global cumulative greenhouse gas emissions, Europe is a key stakeholder in the world's response to climate change and has a global responsibility and opportunity to lead the transition to becoming a low-carbon economy and a healthier, more resilient society. Peer Reviewed Article signat per 44 autors/autores: Institute for Global Health (K R van Daalen MPhil, M Romanello PhD), Institute for Sustainable Resources (P Drummond MSc, D Scamman EngD), and Energy Institute (Prof I Hamilton PhD, H Kennard PhD), University College London, London, UK; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Cambridge University, Cambridge, UK (K R van Daalen); Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany (Prof J Rocklöv PhD, Prof J C Semenza PhD); Department of Public Health and Clinical Medicine (Prof J Rocklöv, Z Farooq MSc, M O Sewe PhD, H Sjödin PhD) and Department of Epidemiology and Global Health (Prof M Nilsson PhD), Umeå University, Umeå, Sweden; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain (C Tonne ScD, H Achebak PhD, J Ballester PhD, S J Lloyd PhD, C Milà MSc, Prof J C Minx PhD, Prof M Nieuwenhuijsen PhD, M Quijal-Zamorano MSc, Prof J M Anto MD); Universitat Pompeu Fabra (UPF), Barcelona, Spain (C Tonne, C Milà, M Nieuwenhuijsen, M Quijal-Zamorano, J M Anto); CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain (C Tonne, C Milà, J C Minx, M Nieuwenhuijsen, J M Anto); BC3 Basque Centre for Climate Change, Bilbao, Spain (Prof A Markandya PhD); School of Government, University of Birmingham, Birmingham, UK (N Dasandi PhD); Data Science Lab, Hertie School, Berlin, Germany (Prof S Jankin PhD, H Bechara PhD, O Gasparyan PhD); Priestley International Centre for Climate, University of Leeds, Leeds, UK (M W Callaghan MPP); Mercator Research Institute on Global Commons and Climate Change, Berlin, Germany (M W Callaghan); Energy Efficiency Group, Institute for Environmental Sciences (ISE), University of Geneva, Switzerland (J Chambers PhD); Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC), Venice, Italy (S Dasgupta PhD); Grantham Research Institute on Climate Change and the Environment, London School of Economics and Political Sciences (LSE), UK (S Dasgupta, Prof E J Z Robinson PhD); Barcelona Supercomputing Center (BSC), Barcelona, Spain (N Gonzalez-Reviriego PhD, B Solaraju-Murali MSc, Prof R Lowe PhD, M Lotto Batista MSc); Finnish Meteorological Institute (FMI), Helsinki, Finland (R Hänninen DSci, J Palamarchuk PhD, M Sofiev PhD); European Environment Agency, Copenhagen, Denmark (A Kazmierczak PhD); European Centre for Environment and Health, WHO Regional Office for Europe, Bonn, Germany (V Kendrovski PhD, O Schmoll Dipl Ing); Air Quality and Greenhouse Gases Programme, International Institute for Applied Systems Analysis, Laxenburg, Austria (G Kiesewetter PhD); Helmholtz Centre for Infection Research, Department of Epidemiology, Brunswick, Germany (M Lotto Batista); Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain (Prof J Martinez-Urtaza PhD); Oxford Martin Programme on the Future of Food and Nuffield Department of Population Health, University of Oxford, Oxford, UK (M Springmann PhD); Department of Electronics and Computer Science, Universidade de Santiago de Compostela, Santiago, Spain (J Triñanes PhD); Centre for Climate Change and Planetary Health, London School of Hygiene and Tropical Medicine (LSHTM), London, UK (Prof R Lowe); Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain (Prod R Lowe)

Air pollution is an important environmental factor associated with health impacts in Europe and considerable resources are used to reduce exposure to air pollution through emission reductions. These reductions will have non-linear effects on exposure due, e.g., to interactions between climate and atmospheric chemistry. By using an integrated assessment model, we quantify the effect of changes in climate, emissions and population demography on exposure and health impacts in Europe. The sensitivity to the changes is assessed by investigating the differences between the decades 2000–2009, 2050–2059 and 2080–2089. We focus on the number of premature deaths related to atmospheric ozone, Secondary Inorganic Aerosols and primary PM. For the Nordic region we furthermore include a projection on how population exposure might develop due to changes in building stock with increased energy efficiency. Reductions in emissions cause a large significant decrease in mortality, while climate effects on chemistry and emissions only affects premature mortality by a few percent. Changes in population demography lead to a larger relative increase in chronic mortality than the relative increase in population. Finally, the projected changes in building stock and infiltration rates in the Nordic indicate that this factor may be very important for assessments of population exposure in the future.