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Ethanol is the most common human teratogen, and its consumption during pregnancy can produce a wide range of abnormalities in infants known as fetal alcohol spectrum disorder (FASD). The major characteristics of FASD can be divided into: (i) growth retardation, (ii) craniofacial abnormalities, and (iii) central nervous system (CNS) dysfunction. FASD is the most common cause of nongenetic mental retardation in Western countries. Although the underlying molecular mechanisms of ethanol neurotoxicity are not completely determined, the induction of oxidative stress is believed to be one central process linked to the development of the disease. Currently, there is no known effective strategy for prevention (other than alcohol avoidance) or treatment. In the present review we will provide the state of art in the evidence for the use of antioxidants as a potential therapeutic strategy for the treatment using whole‐embryo and culture cells models of FASD. We conclude that the imbalance of the intracellular redox state contributes to the pathogenesis observed in FASD models, and we suggest that antioxidant therapy can be considered a new efficient strategy to mitigate the effects of prenatal ethanol exposure. Birth Defects Research (Part A) 103:163–177, 2015. © 2014 Wiley Periodicals, Inc.

The marine environment has been in the spotlight of economic development due to the growing demand for areas to promote activities associated with the concept of Blue Economy. This is the case of the renewable energy and aquaculture sectors, whose expansion towards offshore is determined by the increase global demand for energy and food, and by exceeding of the carrying capacity of coastal and terrestrial systems. In this context, the multi-use strategy can be an alternative to minimize conflicts between activities and impacts on the surrounding social-ecological environment. This contribution presents a preliminary approach to identify opportunities for individual exploitation and the possibilities of multi-use between wind energy, wave energy and aquaculture in Brazil?s Exclusive Economic Zone. Technical, operational, and biological aspects were evaluated, through a Suitability Index validated in previous works, to identify zones with favorable conditions for energy exploitation and farming of six fish species. Additionally, overlaps between conservation areas and multi-use zones were considered to analyze possible spatial conflicts. Zones with multi-use possibilities with different combinations between these sectors were identified: i) wave energy and aquaculture presented the largest areas for multi-use, distributed in the south, southeast and northeast; ii) possibility of combining wind energy and aquaculture was identified in the northeast; and iii) multi-use possibilities in the south for marine energies. Zones with multi-use possibilities were identified in protection and conservation areas, such as the combination of wave exploitation and Greater Amberjack farming, with 63% overlap. Therefore, this case study is a guide for future local studies in the marine region of Brazil, mainly in the selection of sites for analysis. The present contribution represents a starting point for the discussion about multi-use in the country C.V.C. Weiss is grateful to the Brazilian National Council for Scientific and Technological Development (CNPq) for the PDJ (Pós-doutorado Junior) fellowship granted (151228/2020–5), and the financial support from the Universidad de Cantabria (UC) through the Agusto González de Linares and Margarita Salas Grants (POS-UC-2019-06 and RMS-04, respectively). J. Bonetti is a Research Fellow of CNPq (Grant 306633/2019–1). Raúl Guanche acknowledges the Grant RYC-2017-23260 funded by MCIN/AEI/10.13039/501100011033 and “ESF Investing in your future”. This work is framed in the project “ACUFLOT”, supported by the Biodiversity Foundation of the Ecological Transition and Demographic Challenge Ministry of Spain and the IHCantabria - Instituto de Hidráulica Ambiental de la Universidad de Cantabria

Innovation Districts are rising as the banners of the new urban, economic, and social paradigm and as a solution to the renaissance of inner cities since they expedite the creation and commercialization of new ideas which leverage the city goals and its technologic and economic attributes. The configuration of accurate indicators to measure the degree of achievement of the innovation district goals is one of the main requirements to ensure district proper development. Even when the study of innovation districts is a topic that is increasingly under study, little is still known about the insight, and it is still needed tools that favor their evolution and development. The aim of this paper is two-fold: on the one hand, it seeks to collect and analyze the indicators that have been used in literature to measure the degree of maturity over the course of the 20-year existence of the 22@Barcelona, an area of innovation that transformed an old industrial district into a knowledge-based one. On the other hand, guided by the four dimensions of the Knowledge Base Urban Development theory and the main actors that make up Triple Helix approach, the paper designs a framework of indicators in the four spheres that shape the regeneration of the district, that is, urban, economic, social and governance. As we shall see, a total of 47 indicators are proposed, indicating for each of them: the environment in which it is applied, the main purpose to which it responds, and the main actor with the greatest power of action over it.

In this study, our aim was to explore the potential energy savings obtainable from the recycling of 1 tonne of Construction and Demolition Waste (C&DW) generated in the Metropolitan City of Naples. The main fraction composing the functional unit are mixed C&DW, soil and stones, concrete, iron, steel and aluminium. The results evidence that the recycling option for the C&DW is better than landfilling as well as that the production of recycled aggregates is environmentally sustainable since the induced energy and environmental impacts are lower than the avoided energy and environmental impacts in the life cycle of recycled aggregates. This LCA study shows that the transition to the Circular Economy offers many opportunities for improving the energy and environmental performances of the construction sector in the life cycle of construction materials by means of internal recycling strategies (recycling C&DW into recycled aggregates, recycled steel, iron and aluminum) as well as external recycling by using input of other sectors (agri-food by-products) for the manufacturing of construction materials. In this way, the C&D sector also contributes to realizing the energy and bioeconomy transition by disentangling itself from fossil fuel dependence.

Abstract Given climate change predictions of a warmer world, there is growing concern that insulation-led improvements in building fabric aimed at reducing carbon emissions will exacerbate overheating. If true, this would seriously affect building regulations all over the world which have moved towards increased insulation regimes. Despite extensive research, the literature has failed to resolve the controversy of insulation performance, primarily due to varied scope and limited comparability of results. We approach this problem through carefully constructed pairwise comparisons designed to isolate the effect of insulation on overheating. We encompass the complete range of relevant variables: latitude, climate, insulation, thermal mass, glazing ratio, shading, occupancy, infiltration, ventilation, orientation, and thermal comfort models — creating 576,000 building variants. Data mining techniques are implemented in a novel framework to analyse this large dataset. To provide confidence, the modelling was validated against data collected from well-insulated dwellings. Our results demonstrate that all parameters have a significant impact on overheating risk. Although insulation is seen to both decrease and increase overheating, depending on the influence of other parameters, parameter ranking shows that insulation only accounts for up to 5% of overall overheating response. Indeed, in cases that are not already overheating through poor design, there is a strong overall tendency for increased insulation to reduce overheating. These results suggest that, in cases with acceptable overheating levels (below 3.7%), the use of improved insulation levels as part of a national climate change mitigation policy is not only sensible, but also helps deliver better indoor thermal environments.

Globalization and the ever-growing presence of technology have paved the way for better developmental opportunities in society. Nonetheless, these have also been to the detriment of the environment as well as sustainable development. The aim of this study is to discover the mediating effect of green innovation with regard to the relationship which exists between green culture and environmental performance in the State of Mexico’s automotive sector. The research hypotheses were formulated following an extensive study of the literature available and were based on resource- and capability-based theory, specifically, the natural-resource view of the firm (NRBV). The design of the study was non-experimental and cross-sectional with a confirmatory reach, applied to a sample of 157 observations. The proposed theoretical model was tested using partial least squares structural equation modeling (PLS-SEM). The findings provide empirical evidence that green innovation acts as a mediator variable on the relationship between green culture and environmental performance. The scientific merit of the study is found in its proposal of a hierarchical second-order model, categorized as reflective-formative, and the study’s confirmation of the role of green innovation as a mediating construct. Therefore, the findings herein can be considered as complementary to the existing body of knowledge in the field. The practical implications derived from this study will contribute to sustainable development and expand knowledge in the following areas: Government institutions, companies that operate in the sector, decision makers, academics, and practitioners who are working on this issue at different levels.

Although recent research has demonstrated that waste orange peel (WOP) is a potentially valuable resource that can be transformed into high value products, heat generation, biomethanisation and composting might be considered the most feasible alternatives in terms of yield. This study revealed that WOP can be successfully valorised through combustion. However, a previous drying step, which generates hazardous wastewater, is required and harmful NOx are emitted with the flue gases. In contrast, a high yield of renewable methane (280LSTPCH4/kg added COD, chemical oxygen demand) and an organic amendment can be obtained through the thermophilic biomethanisation of WOP following the removal of valuable essential oils from the peel. Co-composting of WOP combined at different proportions (17-83%) with the organic fraction of municipal solid waste (OFMSW) was also demonstrated to be suitable. Moreover, a 37% reduction in odour generation was observed in co-composting of WOP compared to single composting of OFMSW.

With the spotlight on smart grid development around the world, it is critical to recognize the key factors contributing to changing power system characteristics. This is more apparent in distribution systems with the integration of renewable energy sources, energy storage, and microgrid development. Utilities are also focusing on the reliability and resiliency of the grid. These activities require distribution automation (DA) strategies that take advantage of available technologies while promoting newer solutions. It is necessary to create a roadmap for holistic DA strategies in a smarter grid. Sustainable and resilient grid development is a paradigm shift requiring a new line of thinking in the engineering, operation, and maintenance of the power system. International perspectives on DA are also addressed, with the understanding that one solution will not fit all. Integrating technical, business, and policy decisions into the challenges will generate the development of technologies, standards, and implementation of the overall solution. The challenges in the development of industry standards are also discussed. This paper explores the challenges and opportunities in the changing landscape of the distribution systems. Evolution of technologies and the business case for infrastructure investment in distribution systems are covered in another paper by the same authors.