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Ethanol is the most common human teratogen, and its consumption during pregnancy can produce a wide range of abnormalities in infants known as fetal alcohol spectrum disorder (FASD). The major characteristics of FASD can be divided into: (i) growth retardation, (ii) craniofacial abnormalities, and (iii) central nervous system (CNS) dysfunction. FASD is the most common cause of nongenetic mental retardation in Western countries. Although the underlying molecular mechanisms of ethanol neurotoxicity are not completely determined, the induction of oxidative stress is believed to be one central process linked to the development of the disease. Currently, there is no known effective strategy for prevention (other than alcohol avoidance) or treatment. In the present review we will provide the state of art in the evidence for the use of antioxidants as a potential therapeutic strategy for the treatment using whole‐embryo and culture cells models of FASD. We conclude that the imbalance of the intracellular redox state contributes to the pathogenesis observed in FASD models, and we suggest that antioxidant therapy can be considered a new efficient strategy to mitigate the effects of prenatal ethanol exposure. Birth Defects Research (Part A) 103:163–177, 2015. © 2014 Wiley Periodicals, Inc.

The global energy system subsumes both extreme wealth (and waste) and extreme poverty. A minority of the global population is consuming the majority of the fossil fuel-based energy and causing global warming. While the mature industrialized economies maintain their high levels of energy consumption, the emerging economies are rapidly expanding their fossil energy systems, emulating traditional patterns of industrialization. We take a global, socio-metabolic perspective on the energy transition phases—take-off, maturation, and completion—of 142 countries between 1971 and 2015. Even within our global fossil energy system, the transition to fossil energy is still ongoing; many countries are in the process of replacing renewable energy with fossil energy. However, due to globally limited supplies and sinks, continuing the fossil energy transition is not an indefinite option. Rather than a “Big Push” for renewable energy within pockets of the fossil energy system, a sustainability transformation is required that would change far more than patterns of energy supply and use. Where this far-reaching change requires pushing back against the fossil energy system, the energy underdogs—the latecomers to the fossil energy transition—just might come out on top.

In this paper we follow the tradition of applied general equilibrium modelling of the Walrasian static variety to study the empirical viability of a double dividend (green, welfare, and employment) in the Spanish economy. We consider a counterfactual scenario in which an ecotax is levied on the intermediate and final use of energy goods. Under a revenue neutral assumption, we evaluate the real income and employment impact of lowering payroll taxes. To appraise to what extent the model structure and behavioural assumptions may influence the results, we perform simulations under a range of alternative model and policy scenarios. We conclude that a double dividend –better environmental quality, as measured by reduced CO2 emissions, and improved levels of employment– may be an achievable goal of economic policy.

Land use is central to addressing sustainability issues, including biodiversity conservation, climate change, food security, poverty alleviation, and sustainable energy. In this paper, we synthesize knowledge accumulated in land system science, the integrated study of terrestrial social-ecological systems, into 10 hard truths that have strong, general, empirical support. These facts help to explain the challenges of achieving sustainability in land use and thus also point toward solutions. The 10 facts are as follows: 1) Meanings and values of land are socially constructed and contested; 2) land systems exhibit complex behaviors with abrupt, hard-to-predict changes; 3) irreversible changes and path dependence are common features of land systems; 4) some land uses have a small footprint but very large impacts; 5) drivers and impacts of land-use change are globally interconnected and spill over to distant locations; 6) humanity lives on a used planet where all land provides benefits to societies; 7) land-use change usually entails trade-offs between different benefits—"win–wins" are thus rare; 8) land tenure and land-use claims are often unclear, overlapping, and contested; 9) the benefits and burdens from land are unequally distributed; and 10) land users have multiple, sometimes conflicting, ideas of what social and environmental justice entails. The facts have implications for governance, but do not provide fixed answers. Instead they constitute a set of core principles which can guide scientists, policy makers, and practitioners toward meeting sustainability challenges in land use.

Different studies have estimated cities’ contribution to total greenhouse gas (GHG) emissions at between forty and seventy percent. According to the so-called Compact City Approach, high density and centrality should lead to low GHG. This study compares the effect of the urban density and spatial structure (monocentrism, polycentrism, and dispersion) of the main U.S. cities on their greenhouse gas emissions from mobility and housing. The estimated models include control variables in order to improve the statistical adjustment, these variables are grouped into three categories: basic controls as temperature and Gross Domestic Product (GDP); historical-demographic controls since 1900; and geographic-urban planning controls. The results detect an environmentally positive effect, albeit a moderate one, associated with monocentric and polycentric spatial structures as compared to dispersed structures. Within the tradition of urban planning, these results can be used as an argument to stop the dispersed decentralization of cities. However, the efficacy of some policies encouraging density should be accompanied by specific policies which increase the energy efficiency of housing and promote the use of public transport.

Supporting small farmer livelihoods in fragile, biodiverse regions, such as tropical forests, is a priority for many development agencies and national governments. These regions tend to be characterized by recent human settlements, increasing populations and infrastructure development, as well as competitive land use activities, which exert pressure on fragile ecosystems. Improvement in livelihood strategies often focuses on increasing yields by improving productivity, but without taking into account alternative methods, such as better agricultural practices and their dependence on agrochemical inputs, changing land use through crop substitution, or improving product commercialization. In this research, we use household types, defined according to different land use patterns, in the Northern Amazon region of Ecuador to explore the limitations of, and identify future options for, improving livelihood strategies based on small-scale coffee and cocoa production. The results of the different types are discussed in order to highlight the methods' utility and identify benefits in terms of environmental and social objectives versus economic profitability. Lessons are drawn that could be useful in applications of public policy aimed at the betterment of small coffee grower and cocoa farmer livelihood strategies, which involve thousands of families in the Amazon region of Ecuador, without compromising the environment.

In spite of having been first introduced in the last half of the ninetieth century, the debate about the possible rebound effects from energy efficiency improvements is still an open question in the economic literature. This paper contributes to the existing research on this issue proposing an unbiased measure for economy-wide rebound effects. The novelty of this economy-wide rebound measure stems from the fact that not only actual energy savings but also potential energy savings are quantified under general equilibrium conditions. Our findings indicate that the use of engineering savings instead of general equilibrium potential savings downward biases economy-wide rebound effects and upward-biases backfire effects. The discrepancies between the traditional indicator and our proposed measure are analysed in the context of the Spanish economy.